Molecular mechanism of cAMP modulation of HCN pacemaker channels

Nature

Volumn 411, Issue 6839, 2001, Pages 805-810

  Wainger, Brian J ^a   Degennaro, Matthew ^b   Santoro, Bina ^a   Siegelbaum, Steven A ^a,b   Tibbs, Gareth R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; POTASSIUM; POTASSIUM CHANNEL;

ARTICLE; HEART REPOLARIZATION; HEART RHYTHM; POTASSIUM CONDUCTANCE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; BINDING SITES; CELL MEMBRANE; CLONING, MOLECULAR; CYCLIC AMP; ELECTROPHYSIOLOGY; ION CHANNEL GATING; ION CHANNELS; MICE; MODELS, MOLECULAR; MUSCLE PROTEINS; MUTAGENESIS; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION;

EID: 0035859090     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35081088     Document Type: Article

References (28)

1. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
2. A family of hyperpolarization-activated mammalian cation channels
3. Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
4. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node
5. The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels
6. Molecular diversity of pacemaker ion channels
7. Pacemaker mechanisms in cardiac tissue
8. Queer current and pacemaker: The hyperpolarization-activated cation current in neurons
9. Structure and function of cyclic nucleotide-gated channels
10. + channel by dual pathways
11. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP
12. Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS
13. Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution
14. Molecular mechanism of cyclic-nucleotide-gated channel activation
15. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels
16. A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site
17. Action of internal pronase on the f-channel kinetics in the rabbit SA node
18. Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels
19. Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels
20. C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating
21. Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel
22. Domains important for gating and cAMP regulation of HCN channels
23. Blocker state dependence and trapping in hyperpolarization-activated cation channels. Evidence for an intracellular activation gate
24. + channel and its structural implications
25. + channels
26. Voltage dependent activation of potassium channels is coupled to T1 domain
27. + channel
28. + channel determined by construction of multimeric cDNAs