Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design

Molecular and Cellular Proteomics

Volumn 10, Issue 3, 2011, Pages

  Badireddy, Suguna ^a   Yunfeng, Gao ^a   Ritchie, Mark ^b   Akamine, Pearl ^d   Wu, Jian ^d   Kim, Choel W ^c   Taylor, Susan S ^c   Qingsong, Lin ^a   Swaminathan, Kunchithapadam ^a   Anand, Ganesh S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Waters Pacific Private Ltd   (Singapore)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; OXYGEN; PHOSPHOROTHIOIC ACID DERIVATIVE; APOENZYME; CYCLIC AMP; DRUG DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN SUBUNIT;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVATION; ENZYME CONFORMATION; ION MOBILITY MASS SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEOMICS; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY; ALLOSTERISM; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYME STABILITY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; STATIC ELECTRICITY;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; APOENZYMES; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEUTERIUM EXCHANGE MEASUREMENT; DRUG DESIGN; ENZYME STABILITY; HYDROGEN BONDING; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN SUBUNITS; STATIC ELECTRICITY;

EID: 79953170596     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M110.004390     Document Type: Article

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