NMR structure determination for larger proteins using backbone-only data

Science

Volumn 327, Issue 5968, 2010, Pages 1014-1018

  Raman, Srivatsan ^a,g   Lange, Oliver F ^a   Rossi, Paolo ^b   Tyka, Michael ^a   Wang, Xu ^c   Aramini, James ^b   Liu, Gaohua ^b   Ramelot, Theresa A ^d   Eletsky, Alexander ^e   Szyperski, Thomas ^e   Kennedy, Michael A ^d   Prestegard, James ^c   Montelione, Gaetano T ^b   Baker, David ^a,f  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d MIAMI UNIVERSITY   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTON;

BIOCHEMISTRY; MOLECULAR ANALYSIS; NUCLEAR MAGNETIC RESONANCE; ORGANIC COMPOUND; PROTEIN;

ARTICLE; ATOM; COMPUTER MODEL; CONFORMATIONAL TRANSITION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

COMPUTER SIMULATION; MODELS, MOLECULAR; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS; SOFTWARE; THERMODYNAMICS;

EID: 77149179401     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1183649     Document Type: Article

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37. and S.R., O.F.L., P.R., G.T.M., and D.B. wrote the manuscript. This work was supported by the Human Frontiers of Science Program (O.F.L), NIH grant GM76222 (D.B.), the HHMI, the National Institutes of General Medical Science Protein Structure Initiative program grant U54 GM074958 (G.T.M.), and the Research Resource grant RR005351 (J.P.). M.T. holds a Sir Henry Wellcome Postdoctoral Fellowship. RDC and Paramagnetic Relaxation Enhancement data as deposited in the Protein Data Bank (PDB) with accession code 2jzc.