The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast

Nature Genetics

Volumn 19, Issue 2, 1998, Pages 192-195

  Ivanova, Alla V ^a   Bonaduce, Michael J ^a   Ivanov, Sergey V ^a   Klar, Amar J S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTROMERE; CHROMATIN STRUCTURE; DNA SEQUENCE; DROSOPHILA; GENE EXPRESSION REGULATION; GENE LOCATION; MAIZE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS; SILENCER GENE; SITE DIRECTED MUTAGENESIS;

EUKARYOTA; MAMMALIA; SCHIZOSACCHAROMYCES POMBE; ZEA MAYS;

EID: 0031865511     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/566     Document Type: Article

References (30)

1. Tschiersch, B. et al. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. CMBO J. 13, 3822-3831 (1994).
2. Csink. A.K. & Henikoff, S. Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature 381, 529-531 (1996).
3. Chan, C.S., Rastelli, L. & Pirrotta, V. A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. CMBO J. 13, 2553-2564 (1994).
4. Lyon, M.F. et al. Lack of inactivation of a mouse X-linked gene physically separated from the inactivation centre. J. Embryol. Exp. Morphol. 97, 75-85 (1986).
5. Ainscough, J.F., Koide, T., Tada, M., Barton, S. & Surani, M.A. Imprinting of Igf2 and H19 from a 130 kb YAC transgene. Development 124, 3621-3632 (1997).
6. Hollick, J.B., Patterson, G.I., Coe. E.H., Jr., Cone, K.C. & Chandler, V. Allelic interactions heritably alter the activity of a metastable maize pl allele. Genetics 141, 709-719 (1995).
7. Braunstein, M., Rose, A.B., Holmes, S.G., Allis, C.D. & Broach, J.R. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7, 592-604 (1993).
8. Klar, A.J.S., Ivanova, A.V., Dalgaard, J.C., Bonaduce M.J. & Grewal, S.I.S. Multiple epigenetic events regulate mating-type switching of fission yeast. In: Epigenetics. (eds Chadwick, D.J. and Casdew, G.) 87-103 (Wiley & Sons, Chichester, 1998).
9. Allshire, R.C. Transcriptional silencing in the fission yeast: a manifestation of higher order chromatin structure and function, in: Epigenetic mechanisms of gene expression, (eds Russo. V.E.A., Martienssen, R.A. & Riggs, A.D.) 443-466 (Cold Spring Harbor Laboratory Press, New York, 1996).
10. Grewal, S.I. & Klar, A.J.S. A recombinationally repressed region between mat2 and mat3 loci shares homology to centromeric repeats and regulates directionality of mating-type switching in fission yeast. Genetics 146, 1221-1238 (1997).
11. Hoheisel J.D. et al. High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell 73, 103-120 (1993).
12. Dingwall, C. & Laskey R.A. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16, 478-481 (1991).
13. Singh, P.B. Molecular mechanisms of cellular determination: their relation to chromatin structure and parental imprinting. J. Cell Sci. 107, 2653-2668 (1994).
14. Platero, J.S., Hartnett, T. & Eissenberg, J.C. Functional analysis of the chromo domain of HP1. EMBO J. 14, 3977-3986 (1995).
15. Messmer, S., Franke, A. & Paro, R. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. 6, 1241-1254 (1992).
16. Ball, L.J. et al. Structure of the chromatin binding (chromo) domain from mouse modifier protein 1. EMBO J. 16, 2473-2481 (1997).
17. Thon, G., Cohen A. & Klar, A.J.S. Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138, 29-38 (1994).
18. Thon, G. & Klar, A.J.S. Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci. Genetics 134, 1045-1054 (1993).
19. - mutants of Schizosaccharomyces pombe. Curr. Genet. 12, 532-542 (1987).
20. Hardy, C.F., Balderes, D. & Shore, D. Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing. Mol. Cell. Biol. 12, 1209-1217 (1992).
21. Liang, P. & Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967-971 (1992).
22. Allshire, R.C., Nimmo, E.R., Ekwall, K., Javerzat, J.P. & Cranston, G. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev. 9, 218-233 (1995).
23. Sawin, K.E. & Nurse, P. Identification of fission yeast nuclear markers using random polypeptide fusions with fluorecsent protein. Proc. Natl. Acad. Sci. USA 94, 15146-15151 (1996).
24. Bryk, M. et al. Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev. 11, 255-269 (1997).
25. Ekwall, K. et al. Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109, 2637-2648 (1996).
26. Jiang. Y.W. & Stillman, D.J. Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevislae. Mol. Cell. Biol. 12, 4503-4514 (1992).
27. Nislow, C., Ray, E. & Pillus, L. SET1, A yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Cell. 8 2421-2436 (1997).
28. Moreno, S., Klar, A.J.S. & Nurse, P. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194, 795-823 (1991).
29. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. & Pease, L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59 (1989).
30. Altshul. S.F., Miller, W., Myers, E.W. & Lipman, D.J. 1990 Basic local alignment search tool. J. Mol. Biol. 215, 404-410 (1990).