Synthesis, optimization, and evaluation of novel small molecules as antagonists of WDR5-MLL interaction

ACS Medicinal Chemistry Letters

Volumn 4, Issue 3, 2013, Pages 353-357

  Bolshan, Yuri ^a   Getlik, Matthäus ^b   Kuznetsova, Ekaterina ^a   Wasney, Gregory A ^a   Hajian, Taraneh ^a   Poda, Gennadiy ^b   Nguyen, Kong T ^a   Wu, Hong ^a   Dombrovski, Ludmila ^a   Dong, Aiping ^a   Senisterra, Guillermo ^a   Schapira, Matthieu ^a   Arrowsmith, Cheryl H ^a   Brown, Peter J ^a   Al Awar, Rima ^b   Vedadi, Masoud ^a   Smil, David ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

MLL; peptide binding site; SET1 methyltransferase complex; small molecule antagonists; WDR5

Indexed keywords

BENZAMIDE DERIVATIVE; HISTONE H3; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN; PROTEIN WDR5; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DEMETHYLATION; DRUG CONFORMATION; DRUG SYNTHESIS; HYDROGEN BOND; HYDROLYSIS; PH; POLARIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SUZUKI REACTION;

EID: 84875158860     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300467n     Document Type: Article

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