Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Genes and Development

Volumn 16, Issue 12, 2002, Pages 1518-1527

  Ng, Huck Hui ^a   Feng, Qin ^b   Wang, Hengbin ^b   Erdjument Bromage, Hediye ^c   Tempst, Paul ^c   Zhang, Yi ^b   Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chromatin; Gene silencing; Histone methylation; Histone modification; Nucleosomes; Sir proteins

Indexed keywords

DOT1 PROTEIN; HISTONE H3; LYSINE; PROTEIN; SILENT INFORMATION REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN STRUCTURE; EUKARYOTE; GENE MUTATION; GENE SILENCING; METHYLATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; TELOMERE;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CATTLE; CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; GENE SILENCING; HISTONE DEACETYLASES; HISTONES; LYSINE; METHYLATION; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TELOMERE; THYMUS GLAND; TRANS-ACTIVATORS;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037098044     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1001502     Document Type: Article

References (55)

1. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
2. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
3. Methylation at arginine 17 of histone H3 is linked to gene activation
4. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
5. Histone H3 Lys 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae
6. Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism
7. Structure and ligand of a histone acetyl transferase bromodomain
8. Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold
9. Micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis
10. Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer
11. Position effect at S. cerevisiae telomeres: Reversible repression of pol II transcription
12. Molecular model for telomeric heterochromatin in yeast
13. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
14. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain
15. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3
16. Structure and function of a human TAFII250 double bromodomain module
17. Translating the histone code
18. A homeotic mutation in the trithorax SET domain impedes histone binding
19. Type B histone acetyltransferase Hat1p participates in telomeric silencing
20. COMPASS: A histone H3 (Lysine4) methyltransferase required for telomeric silencing of gene expression
21. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
22. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
23. Silencers, silencing, and heritable transcriptional states
24. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays
25. Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
26. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
27. Crystal structure of the nucleosome core particle at 2.8 angstrom resolution
28. Hormone-dependent CARM1-directed,arginine specific methylation of histone H3 on a steroid-regulated promoter
29. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
30. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
31. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
32. S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase
33. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
34. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
35. Yeast chromatin reconstitution system using purified yeast core histones and yeast nucleosome assembly protein-1
36. Regulation of chromatin structure by sitespecific histone H3 methyltransferases
37. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 Lys 4
38. Role for the silencing protein Dot1 in meiotic checkpoint control
39. Universal catalytic domain structure of AdoMet-dependent methyltransferases
40. SETDB1: A novel KAP-1 associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
41. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1
42. Identification of high-copy disruptors of telomeric silencing in Saccaromyces cerevisiae
43. The language of covalent histone modifications
44. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1
45. Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression
46. Set domain-containing protein, G9a, is a novel lysine preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
47. PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells
48. Purification and functional characterization of a histone H3-lysine 4-specific methyl transferase
49. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
50. Isolation and mass spectrometry of transcription factor complexes
51. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
52. A transcriptional switch mediated by cofactor methylation
53. Molecular cloning of ESET, a novel histone H3-specific methyltransferse that interacts with ERG transcription factor
54. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
55. Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails