Computational library design for increasing haloalkane dehalogenase stability

ChemBioChem

Volumn 15, Issue 11, 2014, Pages 1660-1672

  Floor, Robert J ^a   Wijma, Hein J ^a   Colpa, Dana I ^a   Ramos Silva, Aline ^b   Jekel, Peter A ^a   Szymański, Wiktor ^c   Feringa, Ben L ^c   Marrink, Siewert J ^d   Janssen, Dick B ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

co solvents; computational design; dehalogenases; directed evolution; thermostability; virtual screening

Indexed keywords

ALKANE DERIVATIVE; BETA HEXACHLOROCYCLOHEXANE; ENZYME; HALOALKANE DEHALOGENASE; UNCLASSIFIED DRUG; HYDROLASE;

ARTICLE; BIOCATALYSIS; CONFORMATION; DEHALOGENATION; DIFFERENTIAL SCANNING CALORIMETRY; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME ENGINEERING; ENZYME METABOLISM; HALF LIFE TIME; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; MOLECULAR MECHANICS; MOLECULAR STABILITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN REFOLDING; PROTEIN UNFOLDING; SURFACE CHARGE; TEMPERATURE; THERMOSTABILITY; CHEMISTRY; ENZYME STABILITY; GENETICS; METABOLISM;

ENZYME STABILITY; HYDROLASES; MOLECULAR DYNAMICS SIMULATION;

EID: 84904663068     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402128     Document Type: Article

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