Novel protease inhibitors via computational redesign of subtilisin BPN' propeptide

Biochemistry

Volumn 51, Issue 41, 2012, Pages 8247-8255

  Daugherty, Ashley B ^a   Muthu, Pravin ^a   Lutz, Stefan ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COGNATE PROTEASE; EXPERIMENTAL EVALUATION; FUNCTIONAL PERFORMANCE; INHIBITOR DESIGN; MOLECULAR CHAPERONES; MOLECULAR DYNAMICS SIMULATIONS; PROPEPTIDES; PROTEASE INHIBITOR; ROSETTA; SELF-CLEAVAGE; SPECTROSCOPIC METHOD; STRUCTURAL STABILITIES; STRUCTURAL STABILIZATION; SUBTILISIN; SYNTHETIC PEPTIDE; WILD TYPES;

MOLECULAR DYNAMICS; SPECTROSCOPIC ANALYSIS; STABILITY;

DESIGN;

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; PROTEINASE INHIBITOR; SUBTILISIN; SUBTILISIN BPN; UNCLASSIFIED DRUG;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY; THERMOSTABILITY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEASE INHIBITORS; PROTEOLYSIS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SUBTILISINS;

EID: 84867507934     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300832v     Document Type: Article

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