Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis

Biochemistry

Volumn 41, Issue 48, 2002, Pages 14272-14280

  Boháč, Michal ^a   Nagata, Yuji ^b   Prokop, Zbyněk ^a   Prokop, Martin ^a   Monincová, Marta ^a   Tsuda, Masataka ^b   Koča, Jaroslav ^a   Damborský, Jiří ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CATALYSIS; ENZYMES; HALOGEN COMPOUNDS; HYDROGEN BONDS; MUTAGENESIS; PROTONS; QUANTUM THEORY;

TRANSITION STATES;

BIOCHEMISTRY;

ALCOHOL; ALIPHATIC COMPOUND; ALKANE DERIVATIVE; ASPARAGINE; ASPARTIC ACID; CARBON; GLUTAMINE; HALIDE; HALOGEN; LEUCINE; PHENYLALANINE; PROTEIN DHAA; PROTEIN DHLA; PROTEIN LINB; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CHEMICAL REACTION; DEHALOGENATION; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME STABILITY; ENZYME STRUCTURE; HYDROGEN BOND; KINETICS; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN PURIFICATION; QUANTUM MECHANICS; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; ANIONS; ASPARAGINE; ELECTROSTATICS; GLUTAMIC ACID; HALOGENS; HISTIDINE; HYDROLASES; ISOLEUCINE; LEUCINE; MATHEMATICAL COMPUTING; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROLINE; QUANTUM THEORY; TRYPTOPHAN; VALINE;

EID: 2242469357     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026427v     Document Type: Article

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