Designing thermostable proteins: Ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree

Journal of Molecular Biology

Volumn 355, Issue 4, 2006, Pages 664-674

  Watanabe, Keiko ^a   Ohkuri, Takatoshi ^a,b   Yokobori, Shin Ichi ^a   Yamagishi, Akihiko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

3 isopropylmalate dehydrogenase; Ancestral residue; Commonote; Protein stability; Thermus thermophilus

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; AMINO ACID; ISOCITRATE DEHYDROGENASE; MUTANT PROTEIN; PROTEIN;

AMINO ACID SEQUENCE; ARCHAEBACTERIUM; ARTICLE; BACTERIUM; ENZYME ANALYSIS; METHODOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN STRUCTURE; THERMOSTABILITY;

ARCHAEA; BACTERIA (MICROORGANISMS); THERMUS THERMOPHILUS;

EID: 29144522906     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.10.011     Document Type: Article

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