-
1
-
-
58449125183
-
Progress in Alzheimer's disease drug discovery: An update
-
Williams M. Progress in Alzheimer's disease drug discovery: an update. Curr Opin Investig Drugs 2009; 10(1): 23-34.
-
(2009)
Curr Opin Investig Drugs
, vol.10
, Issue.1
, pp. 23-34
-
-
Williams, M.1
-
2
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 2001; 293(5534): 1491-5.
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
3
-
-
76549119739
-
Excess beta CTF, not Abeta: The culprit in Alzheimerrelated endocytic dysfunction
-
Griffin WS. Excess beta CTF, not Abeta: the culprit in Alzheimerrelated endocytic dysfunction. Proc Natl Acad Sci USA 2010; 107(4): 1263-1264.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.4
, pp. 1263-1264
-
-
Griffin, W.S.1
-
4
-
-
77956224679
-
The Alzheimer's disease mitochondrial cascade hypothesis
-
Swerdlow RH, Burns JM, Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis 2010; 20(Suppl 2): S265-79.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Swerdlow, R.H.1
Burns, J.M.2
Khan, S.M.3
-
5
-
-
7044238416
-
Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs
-
Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 2004; 10(10): 1055-63.
-
(2004)
Nat Med
, vol.10
, Issue.10
, pp. 1055-1063
-
-
Forman, M.S.1
Trojanowski, J.Q.2
Lee, V.M.3
-
6
-
-
62649174753
-
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
-
Koffie RM, Meyer-Luehmann M, Hashimoto T, et al. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 2009; 106(10): 4012-4017.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.10
, pp. 4012-4017
-
-
Koffie, R.M.1
Meyer-Luehmann, M.2
Hashimoto, T.3
-
7
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
De Strooper B, Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 2000; 113(Pt 11): 1857-70.
-
(2000)
J Cell Sci
, vol.113
, Issue.Pt 11
, pp. 1857-1870
-
-
de Strooper, B.1
Annaert, W.2
-
8
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008; 283(44): 29615-9.
-
(2008)
J Biol Chem
, vol.283
, Issue.44
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
9
-
-
0038045587
-
The production of amyloid beta peptide is a critical requirement for the viability of central neurons
-
Plant LD, Boyle JP, Smith IF, Peers C, Pearson HA. The production of amyloid beta peptide is a critical requirement for the viability of central neurons. J Neurosci 2003; 23(13): 5531-5535.
-
(2003)
J Neurosci
, vol.23
, Issue.13
, pp. 5531-5535
-
-
Plant, L.D.1
Boyle, J.P.2
Smith, I.F.3
Peers, C.4
Pearson, H.A.5
-
10
-
-
61849084232
-
Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide
-
Sevalle J, Amoyel A, Robert P, et al. Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide. J Neurochem 2009; 109(1): 248-256.
-
(2009)
J Neurochem
, vol.109
, Issue.1
, pp. 248-256
-
-
Sevalle, J.1
Amoyel, A.2
Robert, P.3
-
11
-
-
0027367764
-
Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease
-
Selkoe DJ. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 1993; 16(10): 403-9.
-
(1993)
Trends Neurosci
, vol.16
, Issue.10
, pp. 403-409
-
-
Selkoe, D.J.1
-
12
-
-
0034643888
-
The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture
-
Rosenberg RN. The molecular and genetic basis of AD: the end of the beginning: the 2000 Wartenberg lecture. Neurology 2000; 54(11): 2045-2054.
-
(2000)
Neurology
, vol.54
, Issue.11
, pp. 2045-2054
-
-
Rosenberg, R.N.1
-
13
-
-
0027333557
-
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
-
Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 1993; 75(6): 1039-42.
-
(1993)
Cell
, vol.75
, Issue.6
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
14
-
-
4344630985
-
BACE1: The beta-secretase enzyme in Alzheimer's disease
-
Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci 2004; 23(1-2): 105-14.
-
(2004)
J Mol Neurosci
, vol.23
, Issue.1-2
, pp. 105-114
-
-
Vassar, R.1
-
15
-
-
0033621152
-
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
-
Wolfe MS, De Los AJ, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 1999; 38(35): 11223-30.
-
(1999)
Biochemistry
, vol.38
, Issue.35
, pp. 11223-11230
-
-
Wolfe, M.S.1
de Los, A.J.2
Miller, D.D.3
Xia, W.4
Selkoe, D.J.5
-
16
-
-
0036833437
-
Therapeutic strategies for Alzheimer's disease
-
Wolfe MS. Therapeutic strategies for Alzheimer's disease. Nat Rev Drug Discov 2002; 1(11): 859-66.
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.11
, pp. 859-866
-
-
Wolfe, M.S.1
-
17
-
-
77749249568
-
HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons
-
Poduslo JF, Gilles EJ, Ramakrishnan M, et al. HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons. PLoS One 2010; 5(1): e8813.
-
(2010)
PLoS One
, vol.5
, Issue.1
-
-
Poduslo, J.F.1
Gilles, E.J.2
Ramakrishnan, M.3
-
18
-
-
67650224802
-
S655 phosphorylation enhances APP secretory traffic
-
Vieira SI, Rebelo S, Domingues SC, et al. S655 phosphorylation enhances APP secretory traffic. Mol Cell Biochem 2009; 328(1-2): 145-54.
-
(2009)
Mol Cell Biochem
, vol.328
, Issue.1-2
, pp. 145-154
-
-
Vieira, S.I.1
Rebelo, S.2
Domingues, S.C.3
-
19
-
-
77950550447
-
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP- 4 complex
-
Burgos PV, Mardones GA, Rojas AL, et al. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP- 4 complex. Dev Cell 2010; 18(3): 425-36.
-
(2010)
Dev Cell
, vol.18
, Issue.3
, pp. 425-436
-
-
Burgos, P.V.1
Mardones, G.A.2
Rojas, A.L.3
-
20
-
-
0035910374
-
The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands
-
Yao Z, Drieu K, Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res 2001; 889(1-2): 181-90.
-
(2001)
Brain Res
, vol.889
, Issue.1-2
, pp. 181-190
-
-
Yao, Z.1
Drieu, K.2
Papadopoulos, V.3
-
21
-
-
0035993237
-
Abeta toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein WL. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem Int 2002; 41(5): 345-52.
-
(2002)
Neurochem Int
, vol.41
, Issue.5
, pp. 345-352
-
-
Klein, W.L.1
-
22
-
-
37048999406
-
Discovery of ADDL-- targeting small molecule drugs for Alzheimer's disease
-
Look GC, Jerecic J, Cherbavaz DB, et al. Discovery of ADDL-- targeting small molecule drugs for Alzheimer's disease. Curr Alzheimer Res 2007; 4(5): 562-7.
-
(2007)
Curr Alzheimer Res
, vol.4
, Issue.5
, pp. 562-567
-
-
Look, G.C.1
Jerecic, J.2
Cherbavaz, D.B.3
-
23
-
-
84055197949
-
Discovery of a Steroid Drug Candidate to Treat Alzheimer's Disease Based on 22RHydroxycholesterol Structure and Properties
-
Papadopoulos V, Lecanu L. Caprospinol: Discovery of a Steroid Drug Candidate to Treat Alzheimer's Disease Based on 22RHydroxycholesterol Structure and Properties. J Neuroendocrinol 2012; 24(1): 93-101.
-
(2012)
J Neuroendocrinol
, vol.24
, Issue.1
, pp. 93-101
-
-
Papadopoulos, V.1
Caprospinol, L.L.2
-
24
-
-
77956180469
-
Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
-
Prasanthi JR, Dasari B, Marwarha G, et al. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med 2010; 49(7): 1212-20.
-
(2010)
Free Radic Biol Med
, vol.49
, Issue.7
, pp. 1212-1220
-
-
Prasanthi, J.R.1
Dasari, B.2
Marwarha, G.3
-
25
-
-
84655160766
-
Proteolytic processing of Alzheimer's beta-amyloid precursor protein
-
Zhang H, Ma Q, Zhang YW, Xu H. Proteolytic processing of Alzheimer's beta-amyloid precursor protein. J Neurochem 2012; 120(Suppl 1): 9-21.
-
(2012)
J Neurochem
, vol.120
, Issue.SUPPL. 1
, pp. 9-21
-
-
Zhang, H.1
Ma, Q.2
Zhang, Y.W.3
Xu, H.4
-
26
-
-
84655166492
-
The physiology of the beta-amyloid precursor protein intracellular domain AICD
-
Pardossi-Piquard R, Checler F. The physiology of the beta-amyloid precursor protein intracellular domain AICD. J Neurochem 2012; 120(Suppl 1): 109-24.
-
(2012)
J Neurochem
, vol.120
, Issue.SUPPL. 1
, pp. 109-124
-
-
Pardossi-Piquard, R.1
Checler, F.2
-
27
-
-
77449122733
-
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure
-
Parodi J, Sepulveda FJ, Roa J, et al. Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem 2010; 285(4): 2506-14.
-
(2010)
J Biol Chem
, vol.285
, Issue.4
, pp. 2506-2514
-
-
Parodi, J.1
Sepulveda, F.J.2
Roa, J.3
-
28
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F betaamyloid precursor protein
-
Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F betaamyloid precursor protein. Nature 1995; 373(6514): 523-7.
-
(1995)
Nature
, vol.373
, Issue.6514
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
29
-
-
51349098209
-
Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease
-
Sun KH, de Pablo Y, Vincent F, et al. Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease. Mol Biol Cell 2008; 19(7): 3052-69.
-
(2008)
Mol Biol Cell
, vol.19
, Issue.7
, pp. 3052-3069
-
-
Sun, K.H.1
de Pablo, Y.2
Vincent, F.3
-
30
-
-
33646785408
-
Increased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus
-
Dubelaar EJ, Mufson EJ, ter Meulen WG, et al. Increased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus. J Neuropathol Exp Neurol 2006; 65(3): 257-66.
-
(2006)
J Neuropathol Exp Neurol
, vol.65
, Issue.3
, pp. 257-266
-
-
Dubelaar, E.J.1
Mufson, E.J.2
ter Meulen, W.G.3
-
31
-
-
34250890136
-
The study of Golgi apparatus in Alzheimer's disease
-
Hu Z, Zeng L, Huang Z, Zhang J, Li T. The study of Golgi apparatus in Alzheimer's disease. Neurochem Res 2007; 32(8): 1265-77.
-
(2007)
Neurochem Res
, vol.32
, Issue.8
, pp. 1265-1277
-
-
Hu, Z.1
Zeng, L.2
Huang, Z.3
Zhang, J.4
Li, T.5
-
32
-
-
0034194338
-
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
-
Mancini M, Machamer CE, Roy S, et al. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol 2000; 149(3): 603-12.
-
(2000)
J Cell Biol
, vol.149
, Issue.3
, pp. 603-612
-
-
Mancini, M.1
Machamer, C.E.2
Roy, S.3
-
33
-
-
0024819090
-
Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type
-
Bernstein HG, Bruszis S, Schmidt D, Wiederanders B, Dorn A. Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type. J Hirnforsch 1989; 30(5): 613-8.
-
(1989)
J Hirnforsch
, vol.30
, Issue.5
, pp. 613-618
-
-
Bernstein, H.G.1
Bruszis, S.2
Schmidt, D.3
Wiederanders, B.4
Dorn, A.5
-
34
-
-
0025195944
-
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
-
Cataldo AM, Nixon RA. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc Natl Acad Sci USA 1990; 87(10): 3861-3865.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, Issue.10
, pp. 3861-3865
-
-
Cataldo, A.M.1
Nixon, R.A.2
-
35
-
-
33747388358
-
Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease
-
Nixon RA, Cataldo AM. Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. J Alzheimers Dis 2006; 9(3 Suppl): 277-289.
-
(2006)
J Alzheimers Dis
, vol.9
, Issue.3 SUPPL.
, pp. 277-289
-
-
Nixon, R.A.1
Cataldo, A.M.2
-
36
-
-
67650264904
-
A central role for autophagy in Alzheimertype neurodegeneration
-
Ling D, Salvaterra PM. A central role for autophagy in Alzheimertype neurodegeneration. Autophagy 2009; 5(5): 738-40.
-
(2009)
Autophagy
, vol.5
, Issue.5
, pp. 738-740
-
-
Ling, D.1
Salvaterra, P.M.2
-
38
-
-
76549096350
-
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
-
Jiang Y, Mullaney KA, Peterhoff CM, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci USA 2010; 107(4): 1630-5.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.4
, pp. 1630-1635
-
-
Jiang, Y.1
Mullaney, K.A.2
Peterhoff, C.M.3
-
39
-
-
78650716872
-
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
-
Yang DS, Stavrides P, Mohan PS, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 2011; 134(Pt 1): 258-77.
-
(2011)
Brain
, vol.134
, Issue.Pt 1
, pp. 258-277
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
-
40
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002; 298(5594): 789-91.
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 789-791
-
-
Selkoe, D.J.1
-
41
-
-
0034862983
-
Effects of aging and betaamyloid on the properties of brain synaptic and mitochondrial membranes
-
Eckert GP, Wood WG, Muller WE. Effects of aging and betaamyloid on the properties of brain synaptic and mitochondrial membranes. J Neural Transm 2001; 108(8-9): 1051-64.
-
(2001)
J Neural Transm
, vol.108
, Issue.8-9
, pp. 1051-1064
-
-
Eckert, G.P.1
Wood, W.G.2
Muller, W.E.3
-
42
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261(5123): 921-3.
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
43
-
-
0027282035
-
Apolipoprotein E polymorphism and Alzheimer's disease
-
Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993; 342(8873): 697-9.
-
(1993)
Lancet
, vol.342
, Issue.8873
, pp. 697-699
-
-
Poirier, J.1
Davignon, J.2
Bouthillier, D.3
-
44
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo LM, Malester B, LaFrancois J, et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis 2000; 7(4): 321-31.
-
(2000)
Neurobiol Dis
, vol.7
, Issue.4
, pp. 321-331
-
-
Refolo, L.M.1
Malester, B.2
Lafrancois, J.3
-
45
-
-
0028177562
-
Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
-
Sparks DL, Scheff SW, Hunsaker JC III, et al. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol 1994; 126(1): 88-94.
-
(1994)
Exp Neurol
, vol.126
, Issue.1
, pp. 88-94
-
-
Sparks, D.L.1
Scheff, S.W.2
Hunsaker III, J.C.3
-
46
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3- hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3- hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000; 57(10): 1439-43.
-
(2000)
Arch Neurol
, vol.57
, Issue.10
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
47
-
-
77949908687
-
Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
-
Feldman HH, Doody RS, Kivipelto M, et al. Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology 2010; 74(12): 956-64.
-
(2010)
Neurology
, vol.74
, Issue.12
, pp. 956-964
-
-
Feldman, H.H.1
Doody, R.S.2
Kivipelto, M.3
-
48
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998; 95(11): 6460-6464.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.11
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
de Strooper, B.3
-
49
-
-
0036776991
-
Function of beta-amyloid in cholesterol transport: A lead to neurotoxicity
-
Yao ZX, Papadopoulos V. Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB J 2002; 16(12): 1677-9.
-
(2002)
FASEB J
, vol.16
, Issue.12
, pp. 1677-1679
-
-
Yao, Z.X.1
Papadopoulos, V.2
-
50
-
-
77953658771
-
Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5
-
Renner M, Lacor PN, Velasco PT, et al. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron 2010; 66(5): 739-54.
-
(2010)
Neuron
, vol.66
, Issue.5
, pp. 739-754
-
-
Renner, M.1
Lacor, P.N.2
Velasco, P.T.3
-
52
-
-
34547214510
-
Abeta ion channels. Prospects or treating Alzheimer's disease with Abeta channel blockers
-
Arispe N, Diaz JC, Simakova O. Abeta ion channels. Prospects or treating Alzheimer's disease with Abeta channel blockers. Biochim Biophys Acta 2007; 1768(8): 1952-65.
-
(2007)
Biochim Biophys Acta
, vol.1768
, Issue.8
, pp. 1952-1965
-
-
Arispe, N.1
Diaz, J.C.2
Simakova, O.3
-
53
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005; 8(8): 1051-8.
-
(2005)
Nat Neurosci
, vol.8
, Issue.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
-
54
-
-
33846633336
-
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor PN, Buniel MC, Furlow PW, et al. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 2007; 27(4): 796-807.
-
(2007)
J Neurosci
, vol.27
, Issue.4
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
-
55
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007; 8(2): 101-12.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
56
-
-
38549101188
-
Quality control of mitochondria: Protection against neurodegeneration and ageing
-
Tatsuta T, Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J 2008; 27(2): 306-14.
-
(2008)
EMBO J
, vol.27
, Issue.2
, pp. 306-314
-
-
Tatsuta, T.1
Langer, T.2
-
57
-
-
35848931249
-
Increased autophagic degradation of mitochondria in Alzheimer disease
-
Moreira PI, Siedlak SL, Wang X, et al. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 2007; 3(6): 614-5.
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 614-615
-
-
Moreira, P.I.1
Siedlak, S.L.2
Wang, X.3
-
58
-
-
70949097901
-
Cell-derived soluble oligomers of human amyloid-beta peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons
-
Yang TT, Hsu CT, Kuo YM. Cell-derived soluble oligomers of human amyloid-beta peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons. J Neural Transm 2009; 116(12): 1561-9.
-
(2009)
J Neural Transm
, vol.116
, Issue.12
, pp. 1561-1569
-
-
Yang, T.T.1
Hsu, C.T.2
Kuo, Y.M.3
-
59
-
-
79958790879
-
Further evidence on mitochondrial targeting of beta-amyloid and specificity of betaamyloid- induced mitotoxicity in neurons
-
Tillement L, Lecanu L, Papadopoulos V. Further evidence on mitochondrial targeting of beta-amyloid and specificity of betaamyloid- induced mitotoxicity in neurons. Neurodegener Dis 2011; 8(5): 331-44.
-
(2011)
Neurodegener Dis
, vol.8
, Issue.5
, pp. 331-344
-
-
Tillement, L.1
Lecanu, L.2
Papadopoulos, V.3
-
60
-
-
78649983748
-
Alzheimer's disease: Effects of beta-amyloid on mitochondria
-
Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of beta-amyloid on mitochondria. Mitochondrion 2011; 11(1): 13-21.
-
(2011)
Mitochondrion
, vol.11
, Issue.1
, pp. 13-21
-
-
Tillement, L.1
Lecanu, L.2
Papadopoulos, V.3
-
61
-
-
51349110166
-
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
-
Hansson Petersen CA, Alikhani N, Behbahani H, et al. The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci USA 2008; 105(35): 13145-50.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.35
, pp. 13145-13150
-
-
Hansson, P.C.A.1
Alikhani, N.2
Behbahani, H.3
-
62
-
-
67650732998
-
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
-
Wang X, Su B, Lee HG, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 2009; 29(28): 9090-103.
-
(2009)
J Neurosci
, vol.29
, Issue.28
, pp. 9090-9103
-
-
Wang, X.1
Su, B.2
Lee, H.G.3
-
63
-
-
84857034651
-
Less than perfect divorces: Dysregulated mitochondrial fission and neurodegeneration
-
Oettinghaus B, Licci M, Scorrano L, Frank S. Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration. Acta Neuropathol 2012; 123(2): 189-203.
-
(2012)
Acta Neuropathol
, vol.123
, Issue.2
, pp. 189-203
-
-
Oettinghaus, B.1
Licci, M.2
Scorrano, L.3
Frank, S.4
-
64
-
-
77951931900
-
The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease
-
Muirhead KE, Borger E, Aitken L, Conway SJ, Gunn-Moore FJ. The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease. Biochem J 2010; 426(3): 255-70.
-
(2010)
Biochem J
, vol.426
, Issue.3
, pp. 255-270
-
-
Muirhead, K.E.1
Borger, E.2
Aitken, L.3
Conway, S.J.4
Gunn-Moore, F.J.5
-
65
-
-
0034692926
-
Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)
-
Powell AJ, Read JA, Banfield MJ, et al. Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD). J Mol Biol 2000; 303(2): 311-27.
-
(2000)
J Mol Biol
, vol.303
, Issue.2
, pp. 311-327
-
-
Powell, A.J.1
Read, J.A.2
Banfield, M.J.3
-
66
-
-
34249720583
-
Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model
-
Yao J, Taylor M, Davey F, et al. Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. Mol Cell Neurosci 2007; 35(2): 377-82.
-
(2007)
Mol Cell Neurosci
, vol.35
, Issue.2
, pp. 377-382
-
-
Yao, J.1
Taylor, M.2
Davey, F.3
-
67
-
-
53549129483
-
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
-
Du H, Guo L, Fang F, et al. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 2008; 14(10): 1097-105.
-
(2008)
Nat Med
, vol.14
, Issue.10
, pp. 1097-1105
-
-
Du, H.1
Guo, L.2
Fang, F.3
-
68
-
-
4444231383
-
Crystal structure of human ABAD/HSD10 with a bound inhibitor: Implications for design of Alzheimer's disease therapeutics
-
Kissinger CR, Rejto PA, Pelletier LA, et al. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics. J Mol Biol 2004; 342(3): 943-52.
-
(2004)
J Mol Biol
, vol.342
, Issue.3
, pp. 943-952
-
-
Kissinger, C.R.1
Rejto, P.A.2
Pelletier, L.A.3
-
69
-
-
70349517148
-
Mitochondrial kinases and their molecular interaction with cardiolipin
-
Schlattner U, Tokarska-Schlattner M, Ramirez S, et al. Mitochondrial kinases and their molecular interaction with cardiolipin. Biochim Biophys Acta 2009; 1788(10): 2032-47.
-
(2009)
Biochim Biophys Acta
, vol.1788
, Issue.10
, pp. 2032-2047
-
-
Schlattner, U.1
Tokarska-Schlattner, M.2
Ramirez, S.3
-
70
-
-
84873033865
-
Vascular Factors and Mitochondrial Dysfunction: A Central Role in the Pathogenesis of Alzheimer's Disease
-
Orsucci D, Mancuso M, Ienco EC, et al. Vascular Factors and Mitochondrial Dysfunction: a Central Role in the Pathogenesis of Alzheimer's Disease. Curr Neurovasc Res 2012; 10(1): 76-80.
-
(2012)
Curr Neurovasc Res
, vol.10
, Issue.1
, pp. 76-80
-
-
Orsucci, D.1
Mancuso, M.2
Ienco, E.C.3
-
71
-
-
70149093436
-
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
-
Yao J, Irwin RW, Zhao L, et al. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2009; 106(34): 14670-14675.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.34
, pp. 14670-14675
-
-
Yao, J.1
Irwin, R.W.2
Zhao, L.3
-
72
-
-
0026408618
-
Abnormalities of glucose metabolism in Alzheimer's disease
-
Hoyer S. Abnormalities of glucose metabolism in Alzheimer's disease. Ann NY Acad Sci 1991; 640: 53-8.
-
(1991)
Ann NY Acad Sci
, vol.640
, pp. 53-58
-
-
Hoyer, S.1
-
73
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443(7113): 787-95.
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
74
-
-
84860198618
-
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
-
Leuner K, Schutt T, Kurz C, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 2012; 16(12): 1421-33.
-
(2012)
Antioxid Redox Signal
, vol.16
, Issue.12
, pp. 1421-1433
-
-
Leuner, K.1
Schutt, T.2
Kurz, C.3
-
75
-
-
84868127393
-
From mitochondrial dysfunction to amyloid beta formation: Novel insights into the pathogenesis of Alzheimer's disease
-
Leuner K, Muller WE, Reichert AS. From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease. Mol Neurobiol 2012; 46(1): 186-93.
-
(2012)
Mol Neurobiol
, vol.46
, Issue.1
, pp. 186-193
-
-
Leuner, K.1
Muller, W.E.2
Reichert, A.S.3
-
76
-
-
69249211284
-
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
-
Hauptmann S, Scherping I, Drose S, et al. Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 2009; 30(10): 1574-86.
-
(2009)
Neurobiol Aging
, vol.30
, Issue.10
, pp. 1574-1586
-
-
Hauptmann, S.1
Scherping, I.2
Drose, S.3
-
77
-
-
73949142307
-
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
-
Rhein V, Song X, Wiesner A, et al. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci USA 2009; 106(47): 20057-62.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.47
, pp. 20057-20062
-
-
Rhein, V.1
Song, X.2
Wiesner, A.3
-
78
-
-
0033616590
-
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease
-
Ancolio K, Dumanchin C, Barelli H, et al. Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc Natl Acad Sci USA 1999; 96(7): 4119-24.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.7
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
-
79
-
-
54049099305
-
The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease
-
Lee JH, Barral S, Reitz C. The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. Curr Neurol Neurosci Rep 2008; 8(5): 384-91.
-
(2008)
Curr Neurol Neurosci Rep
, vol.8
, Issue.5
, pp. 384-391
-
-
Lee, J.H.1
Barral, S.2
Reitz, C.3
-
80
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009; 41(10): 1088-93.
-
(2009)
Nat Genet
, vol.41
, Issue.10
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
-
81
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009; 41(10): 1094-9.
-
(2009)
Nat Genet
, vol.41
, Issue.10
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
-
82
-
-
74049094091
-
Endophenotypes in normal brain morphology and Alzheimer's disease: A review
-
Reitz C, Mayeux R. Endophenotypes in normal brain morphology and Alzheimer's disease: a review. Neuroscience 2009; 164(1): 174-90.
-
(2009)
Neuroscience
, vol.164
, Issue.1
, pp. 174-190
-
-
Reitz, C.1
Mayeux, R.2
-
83
-
-
70349558418
-
Alzheimer's disease beyond APOE
-
van Es MA, van den Berg LH. Alzheimer's disease beyond APOE. Nat Genet 2009; 41(10): 1047-8.
-
(2009)
Nat Genet
, vol.41
, Issue.10
, pp. 1047-1048
-
-
van Es, M.A.1
van den Berg, L.H.2
-
84
-
-
77953436592
-
NFATs and Alzheimer's Disease
-
Abdul HM, Furman JL, Sama MA, Mathis DM, Norris CM. NFATs and Alzheimer's Disease. Mol Cell Pharmacol 2010; 2(1): 7-14.
-
(2010)
Mol Cell Pharmacol
, vol.2
, Issue.1
, pp. 7-14
-
-
Abdul, H.M.1
Furman, J.L.2
Sama, M.A.3
Mathis, D.M.4
Norris, C.M.5
-
85
-
-
44349140124
-
NFkappaBdependent control of BACE1 promoter transactivation by Abeta42
-
Buggia-Prevot V, Sevalle J, Rossner S, Checler F. NFkappaBdependent control of BACE1 promoter transactivation by Abeta42. J Biol Chem 2008; 283(15): 10037-47.
-
(2008)
J Biol Chem
, vol.283
, Issue.15
, pp. 10037-10047
-
-
Buggia-Prevot, V.1
Sevalle, J.2
Rossner, S.3
Checler, F.4
-
86
-
-
70449623632
-
Amyloidosis and neurodegenerative diseases: Current treatments and new pharmacological options
-
Tillement JP, Lecanu L, Papadopoulos V. Amyloidosis and neurodegenerative diseases: current treatments and new pharmacological options. Pharmacology 2010; 85(1): 1-17.
-
(2010)
Pharmacology
, vol.85
, Issue.1
, pp. 1-17
-
-
Tillement, J.P.1
Lecanu, L.2
Papadopoulos, V.3
-
87
-
-
79960997729
-
Soothing the inflamed brain: Effect of non-steroidal antiinflammatory drugs on Alzheimer's disease pathology
-
Hoozemans JJ, Veerhuis R, Rozemuller JM, Eikelenboom P. Soothing the inflamed brain: effect of non-steroidal antiinflammatory drugs on Alzheimer's disease pathology. CNS Neurol Disord Drug Targets 2011; 10(1): 57-67.
-
(2011)
CNS Neurol Disord Drug Targets
, vol.10
, Issue.1
, pp. 57-67
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Rozemuller, J.M.3
Eikelenboom, P.4
-
88
-
-
58249089520
-
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
-
Haag MD, Hofman A, Koudstaal PJ, Stricker BH, Breteler MM. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J Neurol Neurosurg Psychiatry 2009; 80(1): 13-7.
-
(2009)
J Neurol Neurosurg Psychiatry
, vol.80
, Issue.1
, pp. 13-17
-
-
Haag, M.D.1
Hofman, A.2
Koudstaal, P.J.3
Stricker, B.H.4
Breteler, M.M.5
-
89
-
-
79959953827
-
Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders
-
Butterfield DA, Barone E, Mancuso C. Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders. Pharmacol Res 2011; 64(3): 180-6.
-
(2011)
Pharmacol Res
, vol.64
, Issue.3
, pp. 180-186
-
-
Butterfield, D.A.1
Barone, E.2
Mancuso, C.3
-
90
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak SJ, Yun CY, Oyadomari S, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004; 18(24): 3066-77.
-
(2004)
Genes Dev
, vol.18
, Issue.24
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
-
91
-
-
79952116336
-
Unfolded p53 in the pathogenesis of Alzheimer's disease: Is HIPK2 the link?
-
Stanga S, Lanni C, Govoni S, et al. Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link? Aging 2010; 2(9): 545-54.
-
(2010)
Aging
, vol.2
, Issue.9
, pp. 545-554
-
-
Stanga, S.1
Lanni, C.2
Govoni, S.3
-
92
-
-
77954505297
-
Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease
-
Lanni C, Racchi M, Stanga S, et al. Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease. J Alzheimers Dis 2010; 20(1): 97-104.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.1
, pp. 97-104
-
-
Lanni, C.1
Racchi, M.2
Stanga, S.3
-
93
-
-
74549169836
-
ER stress in Alzheimer's disease: A novel neuronal trigger for inflammation and Alzheimer's pathology
-
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation 2009; 6: 41.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 41
-
-
Salminen, A.1
Kauppinen, A.2
Suuronen, T.3
Kaarniranta, K.4
Ojala, J.5
-
94
-
-
4444298732
-
Induction of neuronal death by ER stress in Alzheimer's disease
-
Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M. Induction of neuronal death by ER stress in Alzheimer's disease. J Chem Neuroanat 2004; 28(1-2): 67-78.
-
(2004)
J Chem Neuroanat
, vol.28
, Issue.1-2
, pp. 67-78
-
-
Katayama, T.1
Imaizumi, K.2
Manabe, T.3
Hitomi, J.4
Kudo, T.5
Tohyama, M.6
-
95
-
-
84855896629
-
Endoplasmic reticulum stress enhances gamma-secretase activity
-
Ohta K, Mizuno A, Li S, et al. Endoplasmic reticulum stress enhances gamma-secretase activity. Biochem Biophys Res Commun 2011; 416(3-4): 362-6.
-
(2011)
Biochem Biophys Res Commun
, vol.416
, Issue.3-4
, pp. 362-366
-
-
Ohta, K.1
Mizuno, A.2
Li, S.3
-
96
-
-
0036892027
-
22RHydroxycholesterol protects neuronal cells from beta-amyloidinduced cytotoxicity by binding to beta-amyloid peptide
-
Yao ZX, Brown RC, Teper G, Greeson J, Papadopoulos V. 22RHydroxycholesterol protects neuronal cells from beta-amyloidinduced cytotoxicity by binding to beta-amyloid peptide. J Neurochem 2002; 83(5): 1110-9.
-
(2002)
J Neurochem
, vol.83
, Issue.5
, pp. 1110-1119
-
-
Yao, Z.X.1
Brown, R.C.2
Teper, G.3
Greeson, J.4
Papadopoulos, V.5
-
97
-
-
84856857478
-
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
-
Menu P, Mayor A, Zhou R, et al. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis 2012; 3: e261.
-
(2012)
Cell Death Dis
, vol.3
-
-
Menu, P.1
Mayor, A.2
Zhou, R.3
-
98
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469(7329): 221-5.
-
(2011)
Nature
, vol.469
, Issue.7329
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
99
-
-
80052164574
-
The inflammasome: An integrated view
-
Gross O, Thomas CJ, Guarda G, Tschopp J. The inflammasome: an integrated view. Immunol Rev 2011; 243(1): 136-51.
-
(2011)
Immunol Rev
, vol.243
, Issue.1
, pp. 136-151
-
-
Gross, O.1
Thomas, C.J.2
Guarda, G.3
Tschopp, J.4
-
100
-
-
84856749852
-
Mitochondrial DNA and inflammatory diseases
-
Escames G, Lopez LC, Garcia JA, et al. Mitochondrial DNA and inflammatory diseases. Hum Genet 2012; 131(2): 161-73.
-
(2012)
Hum Genet
, vol.131
, Issue.2
, pp. 161-173
-
-
Escames, G.1
Lopez, L.C.2
Garcia, J.A.3
-
101
-
-
79955161193
-
Mitochondria: Sovereign of inflammation?
-
Tschopp J. Mitochondria: Sovereign of inflammation? Eur J Immunol 2011; 41(5): 1196-202.
-
(2011)
Eur J Immunol
, vol.41
, Issue.5
, pp. 1196-1202
-
-
Tschopp, J.1
-
102
-
-
77956198871
-
Mitochondria and the link between neuroinflammation and neurodegeneration
-
Di FM, Chiasserini D, Tozzi A, Picconi B, Calabresi P. Mitochondria and the link between neuroinflammation and neurodegeneration. J Alzheimers Dis 2010; 20(Suppl 2): S369-79.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Di, F.M.1
Chiasserini, D.2
Tozzi, A.3
Picconi, B.4
Calabresi, P.5
-
103
-
-
77954452230
-
Depletion of GSH in glial cells induces neurotoxicity: Relevance to aging and degenerative neurological diseases
-
Lee M, Cho T, Jantaratnotai N, et al. Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 2010; 24(7): 2533-45.
-
(2010)
FASEB J
, vol.24
, Issue.7
, pp. 2533-2545
-
-
Lee, M.1
Cho, T.2
Jantaratnotai, N.3
-
104
-
-
27144531055
-
Expression and modulation of an NADPH oxidase in mammalian astrocytes
-
Abramov AY, Jacobson J, Wientjes F, et al. Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci 2005; 25(40): 9176-84.
-
(2005)
J Neurosci
, vol.25
, Issue.40
, pp. 9176-9184
-
-
Abramov, A.Y.1
Jacobson, J.2
Wientjes, F.3
-
105
-
-
67649289870
-
Physiological and pharmacological features of the novel gasotransmitter: Hydrogen sulfide
-
Mancardi D, Penna C, Merlino A, et al. Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochim Biophys Acta 2009; 1787(7): 864-72.
-
(2009)
Biochim Biophys Acta
, vol.1787
, Issue.7
, pp. 864-872
-
-
Mancardi, D.1
Penna, C.2
Merlino, A.3
-
106
-
-
41749108929
-
The involvement of astrocytes and kynurenine pathway in Alzheimer's disease
-
Ting KK, Brew B, Guillemin G. The involvement of astrocytes and kynurenine pathway in Alzheimer's disease. Neurotox Res 2007; 12(4): 247-62.
-
(2007)
Neurotox Res
, vol.12
, Issue.4
, pp. 247-262
-
-
Ting, K.K.1
Brew, B.2
Guillemin, G.3
-
107
-
-
39149106106
-
Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
-
Dutheil F, Beaune P, Loriot MA. Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain. Biochimie 2008; 90(3): 426-36.
-
(2008)
Biochimie
, vol.90
, Issue.3
, pp. 426-436
-
-
Dutheil, F.1
Beaune, P.2
Loriot, M.A.3
-
108
-
-
0033588034
-
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
-
Node K, Huo Y, Ruan X, et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 1999; 285(5431): 1276-9.
-
(1999)
Science
, vol.285
, Issue.5431
, pp. 1276-1279
-
-
Node, K.1
Huo, Y.2
Ruan, X.3
-
109
-
-
33645106219
-
Cholesterol-metabolizing cytochromes P450
-
Pikuleva IA. Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos 2006; 34(4): 513-20.
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.4
, pp. 513-520
-
-
Pikuleva, I.A.1
-
110
-
-
2542481651
-
Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
-
Nagele RG, Wegiel J, Venkataraman V, et al. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging 2004; 25(5): 663-74.
-
(2004)
Neurobiol Aging
, vol.25
, Issue.5
, pp. 663-674
-
-
Nagele, R.G.1
Wegiel, J.2
Venkataraman, V.3
-
112
-
-
0037336701
-
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
-
Li Y, Liu L, Barger SW, Griffin WS. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J Neurosci 2003; 23(5): 1605-11.
-
(2003)
J Neurosci
, vol.23
, Issue.5
, pp. 1605-1611
-
-
Li, Y.1
Liu, L.2
Barger, S.W.3
Griffin, W.S.4
-
113
-
-
4644308783
-
Microglia: Phagocyte and glia cell
-
Vilhardt F. Microglia: phagocyte and glia cell. Int J Biochem Cell Biol 2005; 37(1): 17-21.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, Issue.1
, pp. 17-21
-
-
Vilhardt, F.1
-
114
-
-
71549135583
-
Neuropathology and the neuroinflammation idea
-
Mrak RE. Neuropathology and the neuroinflammation idea. J Alzheimers Dis 2009; 18(3): 473-81.
-
(2009)
J Alzheimers Dis
, vol.18
, Issue.3
, pp. 473-481
-
-
Mrak, R.E.1
-
115
-
-
76949087724
-
Neuroimmunomodulation in the pathogenesis of Alzheimer's disease
-
Morales I, Farias G, Maccioni RB. Neuroimmunomodulation in the pathogenesis of Alzheimer's disease. Neuroimmunomodulation 2010; 17(3): 202-4.
-
(2010)
Neuroimmunomodulation
, vol.17
, Issue.3
, pp. 202-204
-
-
Morales, I.1
Farias, G.2
Maccioni, R.B.3
-
116
-
-
67649628772
-
Heme oxygenase-1 and neurodegeneration: Expanding frontiers of engagement
-
Schipper HM, Song W, Zukor H, Hascalovici JR, Zeligman D. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem 2009; 110(2): 469-485.
-
(2009)
J Neurochem
, vol.110
, Issue.2
, pp. 469-485
-
-
Schipper, H.M.1
Song, W.2
Zukor, H.3
Hascalovici, J.R.4
Zeligman, D.5
-
117
-
-
77957969541
-
Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases
-
Jazwa A, Cuadrado A. Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Curr Drug Targets 2010; 11(12): 1517-31.
-
(2010)
Curr Drug Targets
, vol.11
, Issue.12
, pp. 1517-1531
-
-
Jazwa, A.1
Cuadrado, A.2
-
118
-
-
77957872827
-
Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease
-
Jaworski T, Kugler S, Van Leuven F. Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease. Int J Alzheimers Dis 2010; 2010: pii.573138.
-
(2010)
Int J Alzheimers Dis
, vol.2010
, pp. 573138
-
-
Jaworski, T.1
Kugler, S.2
van Leuven, F.3
-
119
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 2007; 8(9): 663-72.
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.9
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
120
-
-
77953068390
-
Synergistic Interactions between Abeta, tau, and alpha-synuclein: Acceleration of neuropathology and cognitive decline
-
Clinton LK, Blurton-Jones M, Myczek K, et al. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci 2010; 30(21): 7281-9.
-
(2010)
J Neurosci
, vol.30
, Issue.21
, pp. 7281-7289
-
-
Clinton, L.K.1
Blurton-Jones, M.2
Myczek, K.3
-
121
-
-
67349143998
-
Classification and basic pathology of Alzheimer disease
-
Duyckaerts C, Delatour B, Potier MC. Classification and basic pathology of Alzheimer disease. Acta Neuropathol 2009; 118(1): 5-36.
-
(2009)
Acta Neuropathol
, vol.118
, Issue.1
, pp. 5-36
-
-
Duyckaerts, C.1
Delatour, B.2
Potier, M.C.3
-
122
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 2010; 142(3): 387-97.
-
(2010)
Cell
, vol.142
, Issue.3
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
-
123
-
-
67349142329
-
Mechanisms of tau-induced neurodegeneration
-
Iqbal K, Liu F, Gong CX, Alonso AC, Grundke-Iqbal I. Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 2009; 118(1): 53-69.
-
(2009)
Acta Neuropathol
, vol.118
, Issue.1
, pp. 53-69
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Alonso, A.C.4
Grundke-Iqbal, I.5
-
124
-
-
84862833600
-
Tau in Alzheimer disease and related tauopathies
-
Iqbal K, Liu F, Gong CX, Grundke-Iqbal I. Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res 2010; 7(8): 656-64.
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.8
, pp. 656-664
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Grundke-Iqbal, I.4
-
125
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996; 274(5284): 99-102.
-
(1996)
Science
, vol.274
, Issue.5284
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
-
126
-
-
79955969705
-
Autophagy failure in Alzheimer's diseaselocating the primary defect
-
Nixon RA, Yang DS. Autophagy failure in Alzheimer's diseaselocating the primary defect. Neurobiol Dis 2011; 43(1): 38-45.
-
(2011)
Neurobiol Dis
, vol.43
, Issue.1
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
127
-
-
38449091923
-
The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapy
-
Shacka JJ, Roth KA, Zhang J. The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci 2008; 13: 718-36.
-
(2008)
Front Biosci
, vol.13
, pp. 718-736
-
-
Shacka, J.J.1
Roth, K.A.2
Zhang, J.3
-
128
-
-
77952519104
-
Synaptic and endosomal localization of active gamma-secretase in rat brain
-
Frykman S, Hur JY, Franberg J, et al. Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS One 2010; 5(1): e8948.
-
(2010)
PLoS One
, vol.5
, Issue.1
-
-
Frykman, S.1
Hur, J.Y.2
Franberg, J.3
-
129
-
-
11444267601
-
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
-
Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 2005; 26(3): 373-82.
-
(2005)
Neurobiol Aging
, vol.26
, Issue.3
, pp. 373-382
-
-
Nixon, R.A.1
-
130
-
-
33846030132
-
The role of CDK5/P25 formation/inhibition in neurodegeneration
-
Camins A, Verdaguer E, Folch J, Canudas AM, Pallas M. The role of CDK5/P25 formation/inhibition in neurodegeneration. Drug News Perspect 2006; 19(8): 453-60.
-
(2006)
Drug News Perspect
, vol.19
, Issue.8
, pp. 453-460
-
-
Camins, A.1
Verdaguer, E.2
Folch, J.3
Canudas, A.M.4
Pallas, M.5
-
131
-
-
77952960864
-
GSK-3beta: A central kinase for neurodegenerative diseases
-
Petit-Paitel A. GSK-3beta: a central kinase for neurodegenerative diseases. Med Sci 2010; 26(5): 516-21.
-
(2010)
Med Sci
, vol.26
, Issue.5
, pp. 516-521
-
-
Petit-Paitel, A.1
-
132
-
-
77957958533
-
Cell death targets and potential modulators in Alzheimer's disease
-
Castro RE, Santos MM, Gloria PM, et al. Cell death targets and potential modulators in Alzheimer's disease. Curr Pharm Des 2010; 16(25): 2851-64.
-
(2010)
Curr Pharm Des
, vol.16
, Issue.25
, pp. 2851-2864
-
-
Castro, R.E.1
Santos, M.M.2
Gloria, P.M.3
-
133
-
-
79551663808
-
The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies
-
Hellwig CT, Passante E, Rehm M. The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. Curr Mol Med 2011; 11(1): 31-47.
-
(2011)
Curr Mol Med
, vol.11
, Issue.1
, pp. 31-47
-
-
Hellwig, C.T.1
Passante, E.2
Rehm, M.3
-
134
-
-
78649997930
-
The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities
-
Rohn TT. The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities. Apoptosis 2010; 15(11): 1403-9.
-
(2010)
Apoptosis
, vol.15
, Issue.11
, pp. 1403-1409
-
-
Rohn, T.T.1
|