-
2
-
-
7244258941
-
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
-
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, et al. (2004) Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem 279: 44945-44954.
-
(2004)
J Biol Chem
, vol.279
, pp. 44945-44954
-
-
Vetrivel, K.S.1
Cheng, H.2
Lin, W.3
Sakurai, T.4
Li, T.5
-
3
-
-
0142250857
-
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: Interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
-
Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, et al. (2003) Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis 14: 194-204.
-
(2003)
Neurobiol Dis
, vol.14
, pp. 194-204
-
-
Baulac, S.1
LaVoie, M.J.2
Kimberly, W.T.3
Strahle, J.4
Wolfe, M.S.5
-
4
-
-
0037339735
-
Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network
-
Siman R, Velji J (2003) Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network. J Neurochem 84: 1143-1153.
-
(2003)
J Neurochem
, vol.84
, pp. 1143-1153
-
-
Siman, R.1
Velji, J.2
-
5
-
-
33644862462
-
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
Kaether C, Schmitt S, Willem M, Haass C (2006) Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 7: 408-415.
-
(2006)
Traffic
, vol.7
, pp. 408-415
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
6
-
-
14844286856
-
Gamma-secretase complex assembly within the early secretory pathway
-
Capell A, Beher D, Prokop S, Steiner H, Kaether C, et al. (2005) Gamma-secretase complex assembly within the early secretory pathway. J Biol Chem 280: 6471-6478.
-
(2005)
J Biol Chem
, vol.280
, pp. 6471-6478
-
-
Capell, A.1
Beher, D.2
Prokop, S.3
Steiner, H.4
Kaether, C.5
-
7
-
-
0037698096
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
-
Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, et al. (2003) Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J Biol Chem 278: 26687-26694.
-
(2003)
J Biol Chem
, vol.278
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
Zhang, S.4
Ackerley, C.A.5
-
8
-
-
26444587508
-
Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, et al. (2005) Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 171: 87-98.
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
-
9
-
-
14244268498
-
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
-
Chyung JH, Raper DM, Selkoe DJ (2005) Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem 280: 4383-4392.
-
(2005)
J Biol Chem
, vol.280
, pp. 4383-4392
-
-
Chyung, J.H.1
Raper, D.M.2
Selkoe, D.J.3
-
10
-
-
19944373389
-
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
-
Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, et al. (2004) Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem 279: 51654-51660.
-
(2004)
J Biol Chem
, vol.279
, pp. 51654-51660
-
-
Hansson, C.A.1
Frykman, S.2
Farmery, M.R.3
Tjernberg, L.O.4
Nilsberth, C.5
-
11
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
-
Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, et al. (1997) Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 3: 1016-1020.
-
(1997)
Nat Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
-
12
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, et al. (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161: 1869-1879.
-
(2002)
Am J Pathol
, vol.161
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
Nam, E.E.4
Edgar, M.A.5
-
13
-
-
4644319713
-
Abeta localization in abnormal endosomes: Association with earliest Abeta elevations in AD and Down syndrome
-
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, et al. (2004) Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging 25: 1263-1272.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
-
14
-
-
0031017795
-
Light and electron microscopic localization of presenilin-1 in primate brain
-
Lah JJ, Heilman CJ, Nash NR, Rees HD, Yi H, et al. (1997) Light and electron microscopic localization of presenilin-1 in primate brain. J Neurosci 17: 1971-1980.
-
(1997)
J Neurosci
, vol.17
, pp. 1971-1980
-
-
Lah, J.J.1
Heilman, C.J.2
Nash, N.R.3
Rees, H.D.4
Yi, H.5
-
15
-
-
0031795935
-
Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
-
Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, et al. (1998) Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. J Neurochem 71: 2365-2372.
-
(1998)
J Neurochem
, vol.71
, pp. 2365-2372
-
-
Efthimiopoulos, S.1
Floor, E.2
Georgakopoulos, A.3
Shioi, J.4
Cui, W.5
-
16
-
-
0032720496
-
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons
-
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, et al. (1999) Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J Cell Biol 147: 277-294.
-
(1999)
J Cell Biol
, vol.147
, pp. 277-294
-
-
Annaert, W.G.1
Levesque, L.2
Craessaerts, K.3
Dierinck, I.4
Snellings, G.5
-
17
-
-
0033026550
-
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
-
Beher D, Elle C, Underwood J, Davis JB, Ward R, et al. (1999) Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. J Neurochem 72: 1564-1573.
-
(1999)
J Neurochem
, vol.72
, pp. 1564-1573
-
-
Beher, D.1
Elle, C.2
Underwood, J.3
Davis, J.B.4
Ward, R.5
-
18
-
-
0141957935
-
Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat
-
Ribaut-Barassin C, Dupont JL, Haeberle AM, Bombarde G, Huber G, et al. (2003) Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat. Neuroscience 120: 405-423.
-
(2003)
Neuroscience
, vol.120
, pp. 405-423
-
-
Ribaut-Barassin, C.1
Dupont, J.L.2
Haeberle, A.M.3
Bombarde, G.4
Huber, G.5
-
19
-
-
0141957946
-
Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: Implications for beta-amyloid precursor protein processing
-
Torp R, Ottersen OP, Cotman CW, Head E (2003) Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. Neuroscience 120: 291-300.
-
(2003)
Neuroscience
, vol.120
, pp. 291-300
-
-
Torp, R.1
Ottersen, O.P.2
Cotman, C.W.3
Head, E.4
-
20
-
-
0017396421
-
The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition
-
Cohen RS, Blomberg F, Berzins K, Siekevitz P (1977) The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition. J Cell Biol 74: 181-203.
-
(1977)
J Cell Biol
, vol.74
, pp. 181-203
-
-
Cohen, R.S.1
Blomberg, F.2
Berzins, K.3
Siekevitz, P.4
-
21
-
-
0020955120
-
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
-
Huttner WB, Schiebler W, Greengard P, De Camilli P (1983) Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 96: 1374-1388.
-
(1983)
J Cell Biol
, vol.96
, pp. 1374-1388
-
-
Huttner, W.B.1
Schiebler, W.2
Greengard, P.3
De Camilli, P.4
-
22
-
-
34250831492
-
Rat brain gamma-secretase activity is highly influenced by detergents
-
Franberg J, Welander H, Aoki M, Winblad B, Tjernberg LO, et al. (2007) Rat brain gamma-secretase activity is highly influenced by detergents. Biochemistry 46: 7647-7654.
-
(2007)
Biochemistry
, vol.46
, pp. 7647-7654
-
-
Franberg, J.1
Welander, H.2
Aoki, M.3
Winblad, B.4
Tjernberg, L.O.5
-
23
-
-
27644550495
-
Flow cytometry as a method for studying effects of stressors on primary rat neurons
-
Behbahani H, Rickle A, Concha H, Ankarcrona M, Winblad B, et al. (2005) Flow cytometry as a method for studying effects of stressors on primary rat neurons. J Neurosci Res 82: 432-441.
-
(2005)
J Neurosci Res
, vol.82
, pp. 432-441
-
-
Behbahani, H.1
Rickle, A.2
Concha, H.3
Ankarcrona, M.4
Winblad, B.5
-
24
-
-
77749319891
-
Affinity pulldown of gamma-secretase and associated proteins from human and rat brain
-
Epub ahead of print
-
Teranishi Y, Hur JY, Welander H, Franberg J, Aoki M, et al. (2009) Affinity pulldown of gamma-secretase and associated proteins from human and rat brain. J Cell Mol Med. Epub ahead of print.
-
(2009)
J Cell Mol Med
-
-
Teranishi, Y.1
Hur, J.Y.2
Welander, H.3
Franberg, J.4
Aoki, M.5
-
25
-
-
0345276568
-
Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
-
Scheff SW, Price DA (2003) Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol Aging 24: 1029-1046.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1029-1046
-
-
Scheff, S.W.1
Price, D.A.2
-
26
-
-
33750805030
-
Molecular anatomy of a trafficking organelle
-
Takamori S, Holt M, Stenius K, Lemke EA, Gronborg M, et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127: 831-846.
-
(2006)
Cell
, vol.127
, pp. 831-846
-
-
Takamori, S.1
Holt, M.2
Stenius, K.3
Lemke, E.A.4
Gronborg, M.5
-
27
-
-
0026539090
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
-
Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255: 728-730.
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
28
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269: 17386-17389.
-
(1994)
J Biol Chem
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
29
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
-
Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160: 113-123.
-
(2003)
J Cell Biol
, vol.160
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
30
-
-
33746593662
-
Alzheimer's disease beta-amyloid peptides are released in association with exosomes
-
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, et al. (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A 103: 11172-11177.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
-
31
-
-
50349083093
-
Dendritic spine loss and synaptic alterations in Alzheimer's disease
-
Knobloch M, Mansuy IM (2008) Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 37: 73-82.
-
(2008)
Mol Neurobiol
, vol.37
, pp. 73-82
-
-
Knobloch, M.1
Mansuy, I.M.2
-
32
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42: 23-36.
-
(2004)
Neuron
, vol.42
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
-
33
-
-
58149472205
-
The synaptic vesicle cluster: A source of endocytic proteins during neurotransmitter release
-
Shupliakov O (2009) The synaptic vesicle cluster: a source of endocytic proteins during neurotransmitter release. Neuroscience 158: 204-210.
-
(2009)
Neuroscience
, vol.158
, pp. 204-210
-
-
Shupliakov, O.1
-
34
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, et al. (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58: 42-51.
-
(2008)
Neuron
, vol.58
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
Stewart, F.R.4
Verges, D.K.5
-
35
-
-
5444256890
-
Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors
-
Chun J, Yin YI, Yang G, Tarassishin L, Li YM (2004) Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. J Org Chem 69: 7344-7347.
-
(2004)
J Org Chem
, vol.69
, pp. 7344-7347
-
-
Chun, J.1
Yin, Y.I.2
Yang, G.3
Tarassishin, L.4
Li, Y.M.5
-
36
-
-
10344255689
-
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
-
Tarassishin L, Yin YI, Bassit B, Li YM (2004) Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A 101: 17050-17055.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17050-17055
-
-
Tarassishin, L.1
Yin, Y.I.2
Bassit, B.3
Li, Y.M.4
-
37
-
-
0037134505
-
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
-
Edbauer D, Willem M, Lammich S, Steiner H, Haass C (2002) Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). J Biol Chem 277: 13389-13393.
-
(2002)
J Biol Chem
, vol.277
, pp. 13389-13393
-
-
Edbauer, D.1
Willem, M.2
Lammich, S.3
Steiner, H.4
Haass, C.5
-
38
-
-
0028176821
-
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
-
Kurochkin IV, Goto S (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 345: 33-37.
-
(1994)
FEBS Lett
, vol.345
, pp. 33-37
-
-
Kurochkin, I.V.1
Goto, S.2
|