-
1
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe DJ (2001) Clearing the brain's amyloid cobwebs. Neuron 32: 177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
2
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, et al. (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58: 42-51.
-
(2008)
Neuron
, vol.58
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
Stewart, F.R.4
Verges, D.K.5
-
3
-
-
0030793522
-
Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization
-
LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G (1997) Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest 100: 310-320.
-
(1997)
J Clin Invest
, vol.100
, pp. 310-320
-
-
LaFerla, F.M.1
Troncoso, J.C.2
Strickland, D.K.3
Kawas, C.H.4
Jay, G.5
-
4
-
-
0031927628
-
Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
-
Guo Q, Fu W, Xie J, Luo H, Sells SF, et al. (1998) Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med 4: 957-962.
-
(1998)
Nat Med
, vol.4
, pp. 957-962
-
-
Guo, Q.1
Fu, W.2
Xie, J.3
Luo, H.4
Sells, S.F.5
-
5
-
-
7244236841
-
A modified beta-amyloid hypothesis: Intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade
-
Wirths O, Multhaup G, Bayer TA (2004) A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J Neurochem 91: 513-520.
-
(2004)
J Neurochem
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
6
-
-
0036772311
-
Intracellular A-beta amyloid, a sign for worse things to come?
-
Echeverria V, Cuello AC (2002) Intracellular A-beta amyloid, a sign for worse things to come? Mol Neurobiol 26: 299-316.
-
(2002)
Mol Neurobiol
, vol.26
, pp. 299-316
-
-
Echeverria, V.1
Cuello, A.C.2
-
8
-
-
25144501662
-
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
-
Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26: 1235-1244.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 1235-1244
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
9
-
-
0033621540
-
Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease
-
Mochizuki A, Tamaoka A, Shimohata A, Komatsuzaki Y, Shoji S (2000) Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease. Lancet 355: 42-43.
-
(2000)
Lancet
, vol.355
, pp. 42-43
-
-
Mochizuki, A.1
Tamaoka, A.2
Shimohata, A.3
Komatsuzaki, Y.4
Shoji, S.5
-
10
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, et al. (2000) Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156: 15-20.
-
(2000)
Am J Pathol
, vol.156
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
-
11
-
-
0032895651
-
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
-
Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, et al. (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 5: 560-564.
-
(1999)
Nat Med
, vol.5
, pp. 560-564
-
-
Chui, D.H.1
Tanahashi, H.2
Ozawa, K.3
Ikeda, S.4
Checler, F.5
-
12
-
-
0035120525
-
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
-
D'Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38: 120-134.
-
(2001)
Histopathology
, vol.38
, pp. 120-134
-
-
D'Andrea, M.R.1
Nagele, R.G.2
Wang, H.Y.3
Peterson, P.A.4
Lee, D.H.5
-
13
-
-
84935851672
-
Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid-beta protein
-
Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF (2009) Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid-beta protein. PloS One 4: e4627.
-
(2009)
PloS One
, vol.4
-
-
Kandimalla, K.K.1
Scott, O.G.2
Fulzele, S.3
Davidson, M.W.4
Poduslo, J.F.5
-
14
-
-
0032491435
-
The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
-
Giulian D, Haverkamp LJ, Yu J, Karshin W, Tom D, et al. (1998) The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease. J Biol Chem 273: 29719-29726.
-
(1998)
J Biol Chem
, vol.273
, pp. 29719-29726
-
-
Giulian, D.1
Haverkamp, L.J.2
Yu, J.3
Karshin, W.4
Tom, D.5
-
15
-
-
0032587143
-
Competition of Abeta amyloid peptide and apolipoprotein E for receptormediated endocytosis
-
Winkler K, Scharnagl H, Tisljar U, Hoschutzky H, Friedrich I, et al. (1999) Competition of Abeta amyloid peptide and apolipoprotein E for receptormediated endocytosis. J Lipid Res 40: 447-455.
-
(1999)
J Lipid Res
, vol.40
, pp. 447-455
-
-
Winkler, K.1
Scharnagl, H.2
Tisljar, U.3
Hoschutzky, H.4
Friedrich, I.5
-
16
-
-
33751076517
-
Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity
-
Diaz JC, Linnehan J, Pollard H, Arispe N (2006) Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity. Biol Res 39: 447-460.
-
(2006)
Biol Res
, vol.39
, pp. 447-460
-
-
Diaz, J.C.1
Linnehan, J.2
Pollard, H.3
Arispe, N.4
-
17
-
-
20244381121
-
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
-
Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, et al. (2005) Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. J Biol Chem 280: 13355-13363.
-
(2005)
J Biol Chem
, vol.280
, pp. 13355-13363
-
-
Tickler, A.K.1
Smith, D.G.2
Ciccotosto, G.D.3
Tew, D.J.4
Curtain, C.C.5
-
18
-
-
33744956272
-
Coppermediated amyloid-beta toxicity is associated with an intermolecular histidine bridge
-
Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, et al. (2006) Coppermediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem 281: 15145-15154.
-
(2006)
J Biol Chem
, vol.281
, pp. 15145-15154
-
-
Smith, D.P.1
Smith, D.G.2
Curtain, C.C.3
Boas, J.F.4
Pilbrow, J.R.5
-
19
-
-
0026101636
-
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease
-
Hilbich C, Kisters-Woike B, Reed J, Masters CL, Beyreuther K (1991) Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol 218: 149-163.
-
(1991)
J Mol Biol
, vol.218
, pp. 149-163
-
-
Hilbich, C.1
Kisters-Woike, B.2
Reed, J.3
Masters, C.L.4
Beyreuther, K.5
-
20
-
-
0026453127
-
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein
-
Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, et al. (1992) Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry 31: 10716-10723.
-
(1992)
Biochemistry
, vol.31
, pp. 10716-10723
-
-
Fraser, P.E.1
Nguyen, J.T.2
Inouye, H.3
Surewicz, W.K.4
Selkoe, D.J.5
-
22
-
-
0024005801
-
Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact
-
Shivers BD, Hilbich C, Multhaup G, Salbaum M, Beyreuther K, et al. (1988) Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. Embo J 7: 1365-1370.
-
(1988)
Embo J
, vol.7
, pp. 1365-1370
-
-
Shivers, B.D.1
Hilbich, C.2
Multhaup, G.3
Salbaum, M.4
Beyreuther, K.5
-
23
-
-
0033747946
-
Examining the zinc binding site of the amyloid-beta peptide
-
Yang DS, McLaurin J, Qin K, Westaway D, Fraser PE (2000) Examining the zinc binding site of the amyloid-beta peptide. Eur J Biochem 267: 6692-6698.
-
(2000)
Eur J Biochem
, vol.267
, pp. 6692-6698
-
-
Yang, D.S.1
McLaurin, J.2
Qin, K.3
Westaway, D.4
Fraser, P.E.5
-
24
-
-
0033587478
-
Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease
-
Liu ST, Howlett G, Barrow CJ (1999) Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease. Biochemistry 38: 9373-9378.
-
(1999)
Biochemistry
, vol.38
, pp. 9373-9378
-
-
Liu, S.T.1
Howlett, G.2
Barrow, C.J.3
-
25
-
-
0027980901
-
-
Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, et al. (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265: 1464-1467.
-
Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, et al. (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265: 1464-1467.
-
-
-
-
26
-
-
0033601338
-
Cu(II) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
-
Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, et al. (1999) Cu(II) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 274: 37111-37116.
-
(1999)
J Biol Chem
, vol.274
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
Hartshorn, M.A.4
Tyndall, J.D.5
-
27
-
-
44349120174
-
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease
-
Barnham KJ, Kenche VB, Ciccotosto GD, Smith DP, Tew DJ, et al. (2008) Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease. Proc Natl Acad Sci U S A 105: 6813-6818.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6813-6818
-
-
Barnham, K.J.1
Kenche, V.B.2
Ciccotosto, G.D.3
Smith, D.P.4
Tew, D.J.5
-
28
-
-
0029038937
-
The brain slice preparation: A tribute to the pioneer Henry McIlwain
-
Collingridge GL (1995) The brain slice preparation: a tribute to the pioneer Henry McIlwain. J Neurosci Methods 59: 5-9.
-
(1995)
J Neurosci Methods
, vol.59
, pp. 5-9
-
-
Collingridge, G.L.1
-
29
-
-
0029863203
-
Metabolism of Alzheimer beta-amyloid precursor protein: Regulation by protein kinase A in intact cells and in a cell-free system
-
Xu H, Sweeney D, Greengard P, Gandy S (1996) Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proc Natl Acad Sci U S A 93: 4081-4084.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 4081-4084
-
-
Xu, H.1
Sweeney, D.2
Greengard, P.3
Gandy, S.4
-
30
-
-
4644341973
-
Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells
-
Fukuda M, Yamamoto A (2004) Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells. J Biochem 136: 245-253.
-
(2004)
J Biochem
, vol.136
, pp. 245-253
-
-
Fukuda, M.1
Yamamoto, A.2
-
31
-
-
9744244185
-
Determination of diffusion and partition coefficients of propofol in rat brain tissue: Implications for studies of drug action in vitro
-
Gredell JA, Turnquist PA, Maciver MB, Pearce RA (2004) Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth 93: 810-817.
-
(2004)
Br J Anaesth
, vol.93
, pp. 810-817
-
-
Gredell, J.A.1
Turnquist, P.A.2
Maciver, M.B.3
Pearce, R.A.4
-
32
-
-
25144489633
-
Mechanism of thioflavin T binding to amyloid fibrils
-
Khurana R, Coleman C, Ionescu-Zanetti C, Carter SA, Krishna V, et al. (2005) Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol 151: 229-238.
-
(2005)
J Struct Biol
, vol.151
, pp. 229-238
-
-
Khurana, R.1
Coleman, C.2
Ionescu-Zanetti, C.3
Carter, S.A.4
Krishna, V.5
-
35
-
-
53149109731
-
Serine racemase is predominantly localized in neurons in mouse brain
-
Miya K, Inoue R, Takata Y, Abe M, Natsume R, et al. (2008) Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol 510: 641-654.
-
(2008)
J Comp Neurol
, vol.510
, pp. 641-654
-
-
Miya, K.1
Inoue, R.2
Takata, Y.3
Abe, M.4
Natsume, R.5
-
36
-
-
39749112546
-
Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: The Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth
-
Morris AM, Watzky MA, Agar JN, Finke RG (2008) Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth. Biochemistry 47: 2413-2427.
-
(2008)
Biochemistry
, vol.47
, pp. 2413-2427
-
-
Morris, A.M.1
Watzky, M.A.2
Agar, J.N.3
Finke, R.G.4
-
37
-
-
2442641602
-
Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques
-
Poduslo JF, Curran GL, Peterson JA, McCormick DJ, Fauq AH, et al. (2004) Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochemistry 43: 6064-6075.
-
(2004)
Biochemistry
, vol.43
, pp. 6064-6075
-
-
Poduslo, J.F.1
Curran, G.L.2
Peterson, J.A.3
McCormick, D.J.4
Fauq, A.H.5
-
38
-
-
37249067994
-
The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity
-
Simakova O, Arispe NJ (2007) The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity. J Neurosci 27: 13719-13729.
-
(2007)
J Neurosci
, vol.27
, pp. 13719-13729
-
-
Simakova, O.1
Arispe, N.J.2
-
39
-
-
0037135272
-
Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists
-
Bi X, Gall CM, Zhou J, Lynch G (2002) Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 112: 827-840.
-
(2002)
Neuroscience
, vol.112
, pp. 827-840
-
-
Bi, X.1
Gall, C.M.2
Zhou, J.3
Lynch, G.4
-
40
-
-
0037066072
-
Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease
-
Nagele RG, D'Andrea MR, Anderson WJ, Wang HY (2002) Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110: 199-211.
-
(2002)
Neuroscience
, vol.110
, pp. 199-211
-
-
Nagele, R.G.1
D'Andrea, M.R.2
Anderson, W.J.3
Wang, H.Y.4
-
42
-
-
0035997228
-
Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site
-
Lee G, Pollard HB, Arispe N (2002) Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site. Peptides 23: 1249-1263.
-
(2002)
Peptides
, vol.23
, pp. 1249-1263
-
-
Lee, G.1
Pollard, H.B.2
Arispe, N.3
-
43
-
-
58149339635
-
Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity
-
Hung LW, Ciccotosto GD, Giannakis E, Tew DJ, Perez K, et al. (2008) Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. J Neurosci 28: 11950-11958.
-
(2008)
J Neurosci
, vol.28
, pp. 11950-11958
-
-
Hung, L.W.1
Ciccotosto, G.D.2
Giannakis, E.3
Tew, D.J.4
Perez, K.5
-
44
-
-
69249212835
-
Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity
-
In Press
-
Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, et al. (2009) Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity. Neurobiol Aging: In Press.
-
(2009)
Neurobiol Aging
-
-
Ciccotosto, G.D.1
Tew, D.J.2
Drew, S.C.3
Smith, D.G.4
Johanssen, T.5
-
45
-
-
0242268946
-
The genetics of adult-onset neuropsychiatric disease: Complexities and conundra?
-
Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St George-Hyslop P (2003) The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science 302: 822-826.
-
(2003)
Science
, vol.302
, pp. 822-826
-
-
Kennedy, J.L.1
Farrer, L.A.2
Andreasen, N.C.3
Mayeux, R.4
St George-Hyslop, P.5
-
46
-
-
33750825049
-
High sensitivity analysis of amyloidbeta peptide composition in amyloid deposits from human and PS2APP mouse brain
-
Guntert A, Dobeli H, Bohrmann B (2006) High sensitivity analysis of amyloidbeta peptide composition in amyloid deposits from human and PS2APP mouse brain. Neuroscience 143: 461-475.
-
(2006)
Neuroscience
, vol.143
, pp. 461-475
-
-
Guntert, A.1
Dobeli, H.2
Bohrmann, B.3
|