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Volumn 10, Issue 1, 2011, Pages 57-67

Soothing the inflamed brain: Effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology

Author keywords

amyloid; Alzheimer's disease; Cyclooxygenase; Inflammation; Microglia; Non steroidal anti inflammatory drugs

Indexed keywords

AMYLOID BETA PROTEIN; CELECOXIB; CLUSTERIN; COMPLEMENT COMPONENT C3B RECEPTOR; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOOXYGENASE 1 INHIBITOR; DICLOFENAC; FLURBIPROFEN; HYDROXYCHLOROQUINE; IBUPROFEN; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREDNISONE; SULINDAC; TAU PROTEIN;

EID: 79960997729     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/187152711794488665     Document Type: Review
Times cited : (38)

References (126)
  • 3
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship
    • Nelson, P.T.; Braak, H.; Markesbery, W.R. Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J. Neuropathol. Exp. Neurol., 2009, 68, 1-14.
    • (2009) J.Neuropathol. Exp. Neurol , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 4
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy, J.; Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci., 1991, 12, 383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 5
    • 0025991945 scopus 로고
    • Amyloid protein and Alzheimer's disease
    • Selkoe, D.J. Amyloid protein and Alzheimer's disease. Sci. Am., 1991, 265, 68-71.
    • (1991) Sci.Am , vol.265 , pp. 68-71
    • Selkoe, D.J.1
  • 6
    • 0028171885 scopus 로고
    • Amyloid beta-protein precursor: New clues to the genesis of Alzheimer's disease
    • Selkoe, D.J. Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease. Curr. Opin. Neurobiol., 1994, 4, 708-716.
    • (1994) Curr.Opin. Neurobiol , vol.4 , pp. 708-716
    • Selkoe, D.J.1
  • 7
    • 77952526223 scopus 로고    scopus 로고
    • NEP-like Endopeptidases and Alzheimer's Disease
    • Marr, R.A.; Spencer, B.J. NEP-like Endopeptidases and Alzheimer's Disease. Curr. Alzheimer Res., 2010, 7(10), 223-229.
    • (2010) Curr.Alzheimer Res , vol.7 , Issue.10 , pp. 223-229
    • Marr, R.A.1    Spencer, B.J.2
  • 10
    • 41949101345 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease
    • Donahue, J.E.; Johanson, C.E. Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease. J. Neuropathol. Exp. Neurol., 2008, 67, 261-270.
    • (2008) J. Neuropathol. Exp. Neurol , vol.67 , pp. 261-270
    • Donahue, J.E.1    Johanson, C.E.2
  • 11
    • 0034515763 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism
    • Poirier, J. Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism. Ann. NY Acad. Sci., 2000, 924, 81-90.
    • (2000) Ann. NY Acad. Sci , vol.924 , pp. 81-90
    • Poirier, J.1
  • 12
    • 0024428072 scopus 로고
    • A4 protein in Alzheimer's disease: Primary and secondary cellular events in extracellular amyloid deposition
    • Rozemuller, J.M.; Eikelenboom, P.; Stam, F.C.; Beyreuther, K.; Masters, C.L. A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J. Neuropathol. Exp. Neurol., 1989, 48, 674-691
    • (1989) J. Neuropathol. Exp. Neurol , vol.48 , pp. 674-691
    • Rozemuller, J.M.1    Eikelenboom, P.2    Stam, F.C.3    Beyreuther, K.4    Masters, C.L.5
  • 14
    • 1542283611 scopus 로고    scopus 로고
    • Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    • Eikelenboom, P.; van Gool, W.A. Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J. Neural Transm., 2004, 111, 281-294.
    • (2004) J. Neural Transm , vol.111 , pp. 281-294
    • Eikelenboom, P.1    van Gool, W.A.2
  • 15
    • 67650741983 scopus 로고    scopus 로고
    • Binding and uptake of A beta1-42 by primary human astrocytes in vitro
    • Nielsen, H.M.; Veerhuis, R.; Holmqvist, B.; Janciauskiene, S. Binding and uptake of A beta1-42 by primary human astrocytes in vitro. Glia, 2009, 57, 978-988.
    • (2009) Glia , vol.57 , pp. 978-988
    • Nielsen, H.M.1    Veerhuis, R.2    Holmqvist, B.3    Janciauskiene, S.4
  • 16
    • 33750703652 scopus 로고    scopus 로고
    • IRAK-4--a shared NF-kappaB activator in innate and acquired immunity
    • Suzuki, N.; Saito, T. IRAK-4--a shared NF-kappaB activator in innate and acquired immunity. Trends Immunol., 2006, 27, 566-572.
    • (2006) Trends Immunol , vol.27 , pp. 566-572
    • Suzuki, N.1    Saito, T.2
  • 17
    • 0032509740 scopus 로고    scopus 로고
    • Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
    • Hauss-Wegrzyniak, B.; Dobrzanski, P.; Stoehr, J.D.; Wenk, G.L. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain. Res., 1998, 780, 294-303.
    • (1998) Brain. Res , vol.780 , pp. 294-303
    • Hauss-Wegrzyniak, B.1    Dobrzanski, P.2    Stoehr, J.D.3    Wenk, G.L.4
  • 19
    • 37349069999 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line
    • Udan, M.L.; Ajit, D.; Crouse, N.R.; Nichols, M.R. Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. J. Neurochem., 2008, 104, 524-533.
    • (2008) J. Neurochem , vol.104 , pp. 524-533
    • Udan, M.L.1    Ajit, D.2    Crouse, N.R.3    Nichols, M.R.4
  • 20
    • 33750576993 scopus 로고    scopus 로고
    • Role of toll-like receptor signalling in Abeta uptake and clearance
    • Tahara, K.; Kim, H.D.; Jin, J.J.; Maxwell, J.A.; Li, L.; Fukuchi, K. Role of toll-like receptor signalling in Abeta uptake and clearance. Brain, 2006, 129, 3006-3019.
    • (2006) Brain , vol.129 , pp. 3006-3019
    • Tahara, K.1    Kim, H.D.2    Jin, J.J.3    Maxwell, J.A.4    Li, L.5    Fukuchi, K.6
  • 21
    • 1542283611 scopus 로고    scopus 로고
    • Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    • Eikelenboom, P.; van Gool, W.A. Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J. Neural Transm., 2004, 111, 281-294.
    • (2004) J. Neural Transm , vol.111 , pp. 281-294
    • Eikelenboom, P.1    van Gool, W.A.2
  • 22
    • 0036775463 scopus 로고    scopus 로고
    • IRAK-4 as the central TIR signaling mediator in innate immunity
    • Suzuki, N.; Suzuki, S.; Yeh, W.C. IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol., 2002, 23, 503-506.
    • (2002) Trends Immunol , vol.23 , pp. 503-506
    • Suzuki, N.1    Suzuki, S.2    Yeh, W.C.3
  • 23
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
    • Griffin, W.S.; Sheng, J.G.; Roberts, G.W.; Mrak, R.E. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol., 1995, 54, 276-281.
    • (1995) J. Neuropathol. Exp. Neurol , vol.54 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 24
    • 42649084052 scopus 로고    scopus 로고
    • The role of interleukin-1 in neuroinflammation and Alzheimer disease: An evolving perspective
    • Shaftel, S.S.; Griffin, W.S.; O'Banion, M.K. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J. Neuroinflammation, 2008, 5, 7.
    • (2008) J. Neuroinflammation , vol.5 , pp. 7
    • Shaftel, S.S.1    Griffin, W.S.2    O'Banion, M.K.3
  • 26
    • 0034767903 scopus 로고    scopus 로고
    • Polymorphisms in inflammatory genes and the risk of Alzheimer disease
    • McGeer, P.L.; McGeer, E.G. Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Arch. Neurol., 2001, 58, 1790-1792.
    • (2001) Arch. Neurol , vol.58 , pp. 1790-1792
    • McGeer, P.L.1    McGeer, E.G.2
  • 27
    • 0037019859 scopus 로고    scopus 로고
    • The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: Implications for Alzheimer's disease
    • Hoozemans, J.J.; Veerhuis, R.; Janssen, I.; van Elk, E.J.; Rozemuller, A.J.; Eikelenboom, P. The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease. Brain Res., 2002, 951, 218-226.
    • (2002) Brain Res , vol.951 , pp. 218-226
    • Hoozemans, J.J.1    Veerhuis, R.2    Janssen, I.3    van Elk, E.J.4    Rozemuller, A.J.5    Eikelenboom, P.6
  • 28
    • 0031589751 scopus 로고    scopus 로고
    • NSAIDS inhibit the IL-1 betainduced IL-6 release from human post-mortem astrocytes: The involvement of prostaglandin E2
    • Blom, M.A.; vanTwillert, M.G.; de Vries, S.C.; Engels, F.; Finch, C.E.; Veerhuis, R.; Eikelenboom, P. NSAIDS inhibit the IL-1 betainduced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2. Brain Res., 1997, 777, 210-218.
    • (1997) Brain Res , vol.777 , pp. 210-218
    • Blom, M.A.1    Vantwillert, M.G.2    de Vries, S.C.3    Engels, F.4    Finch, C.E.5    Veerhuis, R.6    Eikelenboom, P.7
  • 29
    • 0029670368 scopus 로고    scopus 로고
    • Interleukin-1 beta uses common and distinct signaling pathways for induction of the interleukin-6 and tumor necrosis factor alpha genes in the human astrocytoma cell line U373
    • Lieb, K.; Kaltschmidt, C.; Kaltschmidt, B.; Baeuerle, P.A.; Berger, M.; Bauer, J.; Fiebich, B.L. Interleukin-1 beta uses common and distinct signaling pathways for induction of the interleukin-6 and tumor necrosis factor alpha genes in the human astrocytoma cell line U373. J. Neurochem., 1996, 66, 1496-1503.
    • (1996) J. Neurochem , vol.66 , pp. 1496-1503
    • Lieb, K.1    Kaltschmidt, C.2    Kaltschmidt, B.3    Baeuerle, P.A.4    Berger, M.5    Bauer, J.6    Fiebich, B.L.7
  • 30
    • 0029884354 scopus 로고    scopus 로고
    • Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells
    • Fiebich, B.L.; Lieb, K.; Hull, M.; Berger, M.; Bauer, J. Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells. Neuroreport, 1996, 7, 1209-1213.
    • (1996) Neuroreport , vol.7 , pp. 1209-1213
    • Fiebich, B.L.1    Lieb, K.2    Hull, M.3    Berger, M.4    Bauer, J.5
  • 31
    • 0036627865 scopus 로고    scopus 로고
    • The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications
    • Hoozemans, J.J.; Veerhuis, R.; Rozemuller, A.J.; Eikelenboom, P. The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications. Drugs Today (Barc.), 2002, 38, 429-443.
    • (2002) Drugs Today (Barc.) , vol.38 , pp. 429-443
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3    Eikelenboom, P.4
  • 33
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein
    • Barger, S.W.; Harmon, A.D. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature, 1997, 388, 878-881.
    • (1997) E. Nature , vol.388 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2
  • 34
    • 0033525735 scopus 로고    scopus 로고
    • Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
    • Rogers, J.T.; Leiter, L.M.; McPhee, J.; Cahill, C.M.; Zhan, S.S.; Potter, H.; Nilsson, L.N. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J. Biol. Chem., 1999, 274, 6421-6431.
    • (1999) J. Biol. Chem , vol.274 , pp. 6421-6431
    • Rogers, J.T.1    Leiter, L.M.2    McPhee, J.3    Cahill, C.M.4    Zhan, S.S.5    Potter, H.6    Nilsson, L.N.7
  • 35
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sheng, J.G.; Ito, K.; Skinner, R.D.; Mrak, R.E.; Rovnaghi, C.R.; Van Eldik, L.J.; Griffin, W.S. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol. Aging, 1996, 17, 761-766.
    • (1996) Neurobiol. Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    van Eldik, L.J.6    Griffin, W.S.7
  • 36
    • 0034042595 scopus 로고    scopus 로고
    • Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
    • Sheng, J.G.; Zhu, S.G.; Jones, R.A.; Griffin, W.S.; Mrak, R.E. Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp. Neurol., 2000, 163, 388-391.
    • (2000) Exp. Neurol , vol.163 , pp. 388-391
    • Sheng, J.G.1    Zhu, S.G.2    Jones, R.A.3    Griffin, W.S.4    Mrak, R.E.5
  • 42
    • 28344439699 scopus 로고    scopus 로고
    • Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
    • Hoozemans, J.J.; Van Haastert, E.S.; Veerhuis, R.; Arendt, T.; Scheper, W.; Eikelenboom, P.; Rozemuller, A.J. Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J. Neuroinflamm., 2005, 2, 27.
    • (2005) J. Neuroinflamm , vol.2 , pp. 27
    • Hoozemans, J.J.1    van Haastert, E.S.2    Veerhuis, R.3    Arendt, T.4    Scheper, W.5    Eikelenboom, P.6    Rozemuller, A.J.7
  • 44
    • 0038417096 scopus 로고    scopus 로고
    • Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro
    • Veerhuis, R.; Van Breemen, M.J.; Hoozemans, J.M.; Morbin, M.; Ouladhadj, J.; Tagliavini, F.; Eikelenboom, P. Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro. Acta Neuropathol. (Berl.), 2003, 105, 135-144.
    • (2003) Acta Neuropathol. (Berl) , vol.105 , pp. 135-144
    • Veerhuis, R.1    van Breemen, M.J.2    Hoozemans, J.M.3    Morbin, M.4    Ouladhadj, J.5    Tagliavini, F.6    Eikelenboom, P.7
  • 45
    • 1242341923 scopus 로고    scopus 로고
    • Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    • Blalock, E.M.; Geddes, J.W.; Chen, K.C.; Porter, N.M.; Markesbery, W.R.; Landfield, P.W. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. USA, 2004, 101, 2173-2178.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2173-2178
    • Blalock, E.M.1    Geddes, J.W.2    Chen, K.C.3    Porter, N.M.4    Markesbery, W.R.5    Landfield, P.W.6
  • 46
    • 0024616703 scopus 로고
    • Rheumatoid arthritis and senile dementia of the Alzheimer's type
    • Jenkinson, M.L.; Bliss, M.R.; Brain, A.T.; Scott, D.L. Rheumatoid arthritis and senile dementia of the Alzheimer's type. Br. J. Rheumatol., 1989, 28, 86-88.
    • (1989) Br. J. Rheumatol , vol.28 , pp. 86-88
    • Jenkinson, M.L.1    Bliss, M.R.2    Brain, A.T.3    Scott, D.L.4
  • 47
    • 0028289083 scopus 로고
    • Inverse association of antiinflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study
    • Breitner, J.C.; Gau, B.A.; Welsh, K.A.; Plassman, B.L.; McDonald, W.M.; Helms, M.J.; Anthony, J.C. Inverse association of antiinflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology, 1994, 44, 227-232.
    • (1994) Neurology , vol.44 , pp. 227-232
    • Breitner, J.C.1    Gau, B.A.2    Welsh, K.A.3    Plassman, B.L.4    McDonald, W.M.5    Helms, M.J.6    Anthony, J.C.7
  • 48
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer, P.L.; Schulzer, M.; McGeer, E.G. Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology, 1996, 47, 425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 51
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • Scharf, S.; Mander, A.; Ugoni, A.; Vajda, F.; Christophidis, N. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology, 1999, 53, 197-201.
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 54
    • 0035845325 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: An 18-month randomised, double-blind, placebo- controlled study
    • van Gool, W.A.; Weinstein, H.C.; Scheltens, P.K.; Walstra, G.J. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo- controlled study. Lancet, 2001, 358, 455-460.
    • (2001) Lancet , vol.358 , pp. 455-460
    • van Gool, W.A.1    Weinstein, H.C.2    Scheltens, P.K.3    Walstra, G.J.4
  • 56
    • 0001643004 scopus 로고    scopus 로고
    • Results of a multicenter trial of rofecoxib and naproxen in Alzheimer's disease
    • Aisen, P.S. Results of a multicenter trial of rofecoxib and naproxen in Alzheimer's disease. Neurobiol. Aging, 2002, 23, S429.
    • (2002) Neurobiol. Aging , vol.23
    • Aisen, P.S.1
  • 57
    • 0042347804 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in Alzheimer's disease: Is hope still alive
    • van Gool, W.A.; Aisen, P.S.; Eikelenboom, P. Anti-inflammatory therapy in Alzheimer's disease: is hope still alive? J. Neurol., 2003, 250, 788-792.
    • (2003) J. Neurol , vol.250 , pp. 788-792
    • van Gool, W.A.1    Aisen, P.S.2    Eikelenboom, P.3
  • 58
    • 77949754244 scopus 로고    scopus 로고
    • In follow-up analysis of clinical trial, NSAIDs seem to preserve cognitive function in patients with healthy brains
    • Liano, C. In follow-up analysis of clinical trial, NSAIDs seem to preserve cognitive function in patients with healthy brains. Neurol. Today, 2009, 9, 21-22.
    • (2009) Neurol. Today , vol.9 , pp. 21-22
    • Liano, C.1
  • 59
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • Martin, B.K.; Szekely, C.; Brandt, J.; Piantadosi, S.; Breitner, J.C.; Craft, S.; Evans, D.; Green, R.; Mullan, M. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol., 2008, 65, 896-905.
    • (2008) Arch. Neurol , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 61
    • 33847339301 scopus 로고    scopus 로고
    • NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
    • McGeer, P.L.; McGeer, E.G. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol. Aging, 2007, 28, 639-647.
    • (2007) Neurobiol. Aging , vol.28 , pp. 639-647
    • McGeer, P.L.1    McGeer, E.G.2
  • 62
    • 0032452709 scopus 로고    scopus 로고
    • Mechanism of action of antiinflammatory drugs
    • Vane, J.R.; Botting, R.M. Mechanism of action of antiinflammatory drugs. Int. J. Tissue React., 1998, 20, 3-15.
    • (1998) Int. J. Tissue React , vol.20 , pp. 3-15
    • Vane, J.R.1    Botting, R.M.2
  • 63
    • 0030049390 scopus 로고    scopus 로고
    • Prostaglandin synthase 2
    • Herschman, H.R. Prostaglandin synthase 2. Biochim. Biophys. Acta, 1996, 1299, 125-140.
    • (1996) Biochim. Biophys Acta , vol.1299 , pp. 125-140
    • Herschman, H.R.1
  • 64
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
    • Yamagata, K.; Andreasson, K.I.; Kaufmann, W.E.; Barnes, C.A.; Worley, P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron, 1993, 11, 371-386.
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 65
    • 0028902109 scopus 로고
    • Characterization of inducible cyclooxygenase in rat brain
    • Breder, C.D.; Dewitt, D.; Kraig, R.P. Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol., 1995, 355, 296-315.
    • (1995) J. Comp. Neurol , vol.355 , pp. 296-315
    • Breder, C.D.1    Dewitt, D.2    Kraig, R.P.3
  • 66
    • 0033526660 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
    • Yasojima, K.; Schwab, C.; McGeer, E.G.; McGeer, P.L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res., 1999, 830, 226-236.
    • (1999) Brain Res , vol.830 , pp. 226-236
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 67
    • 0032896588 scopus 로고    scopus 로고
    • Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology
    • O'Banion, M.K. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit. Rev. Neurobiol., 1999, 13, 45-82.
    • (1999) Crit. Rev. Neurobiol , vol.13 , pp. 45-82
    • O'Banion, M.K.1
  • 68
    • 0036082805 scopus 로고    scopus 로고
    • Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
    • Chen, C.; Magee, J.C.; Bazan, N.G. Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. J. Neurophysiol., 2002, 87, 2851-2857.
    • (2002) J. Neurophysiol , vol.87 , pp. 2851-2857
    • Chen, C.1    Magee, J.C.2    Bazan, N.G.3
  • 69
    • 0029995029 scopus 로고    scopus 로고
    • COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
    • Kaufmann, W.E.; Worley, P.F.; Pegg, J.; Bremer, M.; Isakson, P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. USA, 1996, 93, 2317-2321.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2317-2321
    • Kaufmann, W.E.1    Worley, P.F.2    Pegg, J.3    Bremer, M.4    Isakson, P.5
  • 70
    • 0038391161 scopus 로고    scopus 로고
    • Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor
    • Shaw, K.N.; Commins, S.; O'Mara, S.M. Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor. Eur. J. Neurosci., 2003, 17, 2438-2446.
    • (2003) Eur. J. Neurosci , vol.17 , pp. 2438-2446
    • Shaw, K.N.1    Commins, S.2    O'Mara, S.M.3
  • 71
    • 0037432544 scopus 로고    scopus 로고
    • Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats
    • Rall, J.M.; Mach, S.A.; Dash, P.K. Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats. Brain Res., 2003, 968, 273-276.
    • (2003) Brain Res , vol.968 , pp. 273-276
    • Rall, J.M.1    Mach, S.A.2    Dash, P.K.3
  • 72
    • 0032725481 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
    • Yermakova, A.V.; Rollins, J.; Callahan, L.M.; Rogers, J.; O'Banion, M.K. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J. Neuropathol. Exp. Neurol., 1999, 58, 1135-1146.
    • (1999) J. Neuropathol. Exp. Neurol , vol.58 , pp. 1135-1146
    • Yermakova, A.V.1    Rollins, J.2    Callahan, L.M.3    Rogers, J.4    O'Banion, M.K.5
  • 75
    • 0028805463 scopus 로고
    • Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures
    • Minghetti, L.; Levi, G. Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures. J. Neurochem., 1995, 65, 2690-2698.
    • (1995) J. Neurochem , vol.65 , pp. 2690-2698
    • Minghetti, L.1    Levi, G.2
  • 77
    • 0033952635 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans
    • Tomimoto, H.; Akiguchi, I.; Wakita, H.; Lin, J.X.; Budka, H. Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. Acta. Neuropathol. (Berl.), 2000, 99, 26-30.
    • (2000) Acta. Neuropathol. (Berl) , vol.99 , pp. 26-30
    • Tomimoto, H.1    Akiguchi, I.2    Wakita, H.3    Lin, J.X.4    Budka, H.5
  • 78
    • 0034652417 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease
    • Walsh, D.T.; Perry, V.H.; Minghetti, L. Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease. Glia, 2000, 29, 392-396.
    • (2000) Glia , vol.29 , pp. 392-396
    • Walsh, D.T.1    Perry, V.H.2    Minghetti, L.3
  • 79
    • 0029953089 scopus 로고    scopus 로고
    • Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase- 2) in primary murine astrocyte cultures
    • O'Banion, M.K.; Miller, J.C.; Chang, J.W.; Kaplan, M.D.; Coleman, P.D. Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase- 2) in primary murine astrocyte cultures. J. Neurochem., 1996, 66, 2532-2540.
    • (1996) J. Neurochem , vol.66 , pp. 2532-2540
    • O'Banion, M.K.1    Miller, J.C.2    Chang, J.W.3    Kaplan, M.D.4    Coleman, P.D.5
  • 80
    • 0030614598 scopus 로고    scopus 로고
    • Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells
    • Fiebich, B.L.; Hull, M.; Lieb, K.; Gyufko, K.; Berger, M.; Bauer, J. Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells. J. Neurochem., 1997, 68, 704-709.
    • (1997) J. Neurochem , vol.68 , pp. 704-709
    • Fiebich, B.L.1    Hull, M.2    Lieb, K.3    Gyufko, K.4    Berger, M.5    Bauer, J.6
  • 81
    • 0035205575 scopus 로고    scopus 로고
    • Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: Possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C
    • Fiebich, B.L.; Schleicher, S.; Spleiss, O.; Czygan, M.; Hull, M. Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. J. Neurochem., 2001, 79, 950-958.
    • (2001) J. Neurochem , vol.79 , pp. 950-958
    • Fiebich, B.L.1    Schleicher, S.2    Spleiss, O.3    Czygan, M.4    Hull, M.5
  • 82
    • 0035693794 scopus 로고    scopus 로고
    • Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease
    • Yermakova, A.V.; O'Banion, M.K. Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol. Aging, 2001, 22, 823-836.
    • (2001) Neurobiol. Aging , vol.22 , pp. 823-836
    • Yermakova, A.V.1    O'Banion, M.K.2
  • 83
    • 0032605115 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in astrocytes of human brain after global ischemia
    • Maslinska, D.; Wozniak, R.; Kaliszek, A.; Modelska, I. Expression of cyclooxygenase-2 in astrocytes of human brain after global ischemia. Folia Neuropathol., 1999, 37, 75-79.
    • (1999) Folia Neuropathol , vol.37 , pp. 75-79
    • Maslinska, D.1    Wozniak, R.2    Kaliszek, A.3    Modelska, I.4
  • 84
    • 0034745370 scopus 로고    scopus 로고
    • Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: Implications for Alzheimer's disease
    • Hoozemans, J.J.; Veerhuis, R.; Janssen, I.; Rozemuller, A.J.; Eikelenboom, P. Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. Exp. Gerontol., 2001, 36, 559-570.
    • (2001) Exp. Gerontol , vol.36 , pp. 559-570
    • Hoozemans, J.J.1    Veerhuis, R.2    Janssen, I.3    Rozemuller, A.J.4    Eikelenboom, P.5
  • 85
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimerrelated changes
    • Braak, H.; Braak, E. Neuropathological stageing of Alzheimerrelated changes. Acta Neuropathol. (Berl.), 1991, 82, 239-259.
    • (1991) Acta Neuropathol. (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 87
    • 0036323485 scopus 로고    scopus 로고
    • Cyclin D1 and cyclin E are colocalized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    • Hoozemans, J.J.; Bruckner, M.K.; Rozemuller, A.J.; Veerhuis, R.; Eikelenboom, P.; Arendt, T. Cyclin D1 and cyclin E are colocalized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J. Neuropathol. Exp. Neurol., 2002, 61, 678-688.
    • (2002) J. Neuropathol. Exp. Neurol , vol.61 , pp. 678-688
    • Hoozemans, J.J.1    Bruckner, M.K.2    Rozemuller, A.J.3    Veerhuis, R.4    Eikelenboom, P.5    Arendt, T.6
  • 88
    • 0030951257 scopus 로고    scopus 로고
    • Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: Specific localization in affected neurones and axons
    • Oka, A.; Takashima, S. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Neuroreport, 1997, 8, 1161-1164.
    • (1997) Neuroreport , vol.8 , pp. 1161-1164
    • Oka, A.1    Takashima, S.2
  • 89
    • 1842576590 scopus 로고    scopus 로고
    • Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    • Hoozemans, J.J.; Veerhuis, R.; Rozemuller, A.J.; Arendt, T.; Eikelenboom, P. Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiol. Dis., 2004, 15, 492-499.
    • (2004) Neurobiol. Dis , vol.15 , pp. 492-499
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3    Arendt, T.4    Eikelenboom, P.5
  • 90
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti, L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol., 2004, 63, 901-910.
    • (2004) J. Neuropathol. Exp. Neurol , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 92
    • 0036231413 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity
    • Mirjany, M.; Ho, L.; Pasinetti, G.M. Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. J. Pharmacol. Exp. Ther., 2002, 301, 494-500.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , pp. 494-500
    • Mirjany, M.1    Ho, L.2    Pasinetti, G.M.3
  • 93
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt, T.; Rodel, L.; Gartner, U.; Holzer, M. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport, 1996, 7, 3047-3049.
    • (1996) Neuroreport , vol.7 , pp. 3047-3049
    • Arendt, T.1    Rodel, L.2    Gartner, U.3    Holzer, M.4
  • 95
    • 0037372292 scopus 로고    scopus 로고
    • Alterations in G(1) to S phase cellcycle regulators during amyotrophic lateral sclerosis
    • Ranganathan, S.; Bowser, R. Alterations in G(1) to S phase cellcycle regulators during amyotrophic lateral sclerosis. Am. J. Pathol., 2003, 162, 823-835.
    • (2003) Am. J. Pathol , vol.162 , pp. 823-835
    • Ranganathan, S.1    Bowser, R.2
  • 96
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent, I.; Jicha, G.; Rosado, M.; Dickson, D.W. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci., 1997, 17, 3588-3598.
    • (1997) J. Neurosci , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 97
    • 0030031514 scopus 로고    scopus 로고
    • Cyclin D1 is an essential mediator of apoptotic neuronal cell death
    • Kranenburg, O.; van der Eb, A.J.; Zantema, A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J., 1996, 15, 46-54.
    • (1996) EMBO J , vol.15 , pp. 46-54
    • Kranenburg, O.1    van der Eb, A.J.2    Zantema, A.3
  • 99
    • 0036227488 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)- 2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
    • Xiang, Z.; Ho, L.; Valdellon, J.; Borchelt, D.; Kelley, K.; Spielman, L.; Aisen, P.S.; Pasinetti, G.M. Cyclooxygenase (COX)- 2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging, 2002, 23, 327-334.
    • (2002) Neurobiol. Aging , vol.23 , pp. 327-334
    • Xiang, Z.1    Ho, L.2    Valdellon, J.3    Borchelt, D.4    Kelley, K.5    Spielman, L.6    Aisen, P.S.7    Pasinetti, G.M.8
  • 100
    • 8844263102 scopus 로고    scopus 로고
    • Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo
    • Wu Chen, R.; Zhang, Y.; Rose, M.E.; Graham, S.H. Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo. Brain Res. Mol. Brain Res., 2004, 132, 31-37.
    • (2004) Brain Res. Mol. Brain Res , vol.132 , pp. 31-37
    • Wuchen, R.1    Zhang, Y.2    Rose, M.E.3    Graham, S.H.4
  • 101
    • 36849092504 scopus 로고    scopus 로고
    • Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    • Candelario-Jalil, E.; de Oliveira, A.C.; Graf, S.; Bhatia, H.S.; Hull, M.; Munoz, E.; Fiebich, B.L. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J. Neuroinflammation, 2007, 4, 25.
    • (2007) J. Neuroinflammation , vol.4 , pp. 25
    • Candelario-Jalil, E.1    de Oliveira, A.C.2    Graf, S.3    Bhatia, H.S.4    Hull, M.5    Munoz, E.6    Fiebich, B.L.7
  • 102
    • 0029657725 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain
    • Stephenson, D.T.; Lemere, C.A.; Selkoe, D.J.; Clemens, J.A. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol. Dis., 1996, 3, 51-63.
    • (1996) Neurobiol. Dis , vol.3 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 104
    • 43249109884 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    • Choi, S.H.; Langenbach, R.; Bosetti, F. Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J., 2008, 22, 1491-1501.
    • (2008) FASEB J , vol.22 , pp. 1491-1501
    • Choi, S.H.1    Langenbach, R.2    Bosetti, F.3
  • 105
    • 77953953898 scopus 로고    scopus 로고
    • Cyclooxygenase-1 null mice show reduced neuroinflammation in response to betaβamyloid
    • Choi, S.H.; Bosetti, F. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to betaβamyloid. Aging, 2009, 1, 234-244.
    • (2009) Aging , vol.1 , pp. 234-244
    • Choi, S.H.1    Bosetti, F.2
  • 107
    • 0031900411 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
    • Mackenzie, I.R.; Munoz, D.G. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology, 1998, 50, 986-990.
    • (1998) Neurology , vol.50 , pp. 986-990
    • Mackenzie, I.R.1    Munoz, D.G.2
  • 109
    • 0033551134 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14- prostaglandin J2
    • Petrova, T.V.; Akama, K.T.; Van Eldik, L.J. Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14- prostaglandin J2. Proc. Natl. Acad. Sci. USA, 1999, 96, 4668-4673.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4668-4673
    • Petrova, T.V.1    Akama, K.T.2    van Eldik, L.J.3
  • 110
    • 0033944415 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions
    • Bernardo, A.; Levi, G.; Minghetti, L. Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions. Eur. J. Neurosci., 2000, 12, 2215-2223.
    • (2000) Eur. J. Neurosci , vol.12 , pp. 2215-2223
    • Bernardo, A.1    Levi, G.2    Minghetti, L.3
  • 111
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.J.; Glass, C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 1998, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 112
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C.; Ting, A.T.; Seed, B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 113
    • 10044225937 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma induces a clearance mechanism for the amyloidbeta peptide
    • Camacho, I.E.; Serneels, L.; Spittaels, K.; Merchiers, P.; Dominguez, D.; De Strooper, B. Peroxisome proliferator-activated receptor gamma induces a clearance mechanism for the amyloidbeta peptide. J. Neurosci., 2004, 24, 10908-10917.
    • (2004) J. Neurosci , vol.24 , pp. 10908-10917
    • Camacho, I.E.1    Serneels, L.2    Spittaels, K.3    Merchiers, P.4    Dominguez, D.5    de Strooper, B.6
  • 116
    • 0036826903 scopus 로고    scopus 로고
    • Selective inhibition of Abeta42 production by NSAID R-enantiomers
    • Morihara, T.; Chu, T.; Ubeda, O.; Beech, W.; Cole, G.M. Selective inhibition of Abeta42 production by NSAID R-enantiomers. J. Neurochem., 2002, 83, 1009-1012.
    • (2002) J. Neurochem , vol.83 , pp. 1009-1012
    • Morihara, T.1    Chu, T.2    Ubeda, O.3    Beech, W.4    Cole, G.M.5
  • 117
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and beta βamyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    • Jantzen, P.T.; Connor, K.E.; DiCarlo, G.; Wenk, G.L.; Wallace, J.L.; Rojiani, A.M.; Coppola, D.; Morgan, D.; Gordon, M.N. Microglial activation and beta βamyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J. Neurosci., 2002, 22, 2246-2254.
    • (2002) J. Neurosci , vol.22 , pp. 2246-2254
    • Jantzen, P.T.1    Connor, K.E.2    Dicarlo, G.3    Wenk, G.L.4    Wallace, J.L.5    Rojiani, A.M.6    Coppola, D.7    Morgan, D.8    Gordon, M.N.9
  • 118
    • 0041876229 scopus 로고    scopus 로고
    • Evidence that nonsteroidal antiinflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity
    • Weggen, S.; Eriksen, J.L.; Sagi, S.A.; Pietrzik, C.U.; Ozols, V.; Fauq, A.; Golde, T.E.; Koo, E.H. Evidence that nonsteroidal antiinflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J. Biol. Chem., 2003, 278, 31831-31837.
    • (2003) J. Biol. Chem , vol.278 , pp. 31831-31837
    • Weggen, S.1    Eriksen, J.L.2    Sagi, S.A.3    Pietrzik, C.U.4    Ozols, V.5    Fauq, A.6    Golde, T.E.7    Koo, E.H.8
  • 119
    • 6344233805 scopus 로고    scopus 로고
    • Selected non-steroidal antiinflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism
    • Beher, D.; Clarke, E.E.; Wrigley, J.D.; Martin, A.C.; Nadin, A.; Churcher, I.; Shearman, M.S. Selected non-steroidal antiinflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism. J. Biol. Chem., 2004, 279, 43419-43426.
    • (2004) J. Biol. Chem , vol.279 , pp. 43419-43426
    • Beher, D.1    Clarke, E.E.2    Wrigley, J.D.3    Martin, A.C.4    Nadin, A.5    Churcher, I.6    Shearman, M.S.7
  • 121
    • 7244226629 scopus 로고    scopus 로고
    • Non-steroidal antiinflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action
    • Gasparini, L.; Ongini, E.; Wenk, G. Non-steroidal antiinflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. J. Neurochem., 2004, 91, 521-536.
    • (2004) J. Neurochem , vol.91 , pp. 521-536
    • Gasparini, L.1    Ongini, E.2    Wenk, G.3
  • 122
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease--a double-edged sword
    • Wyss-Coray, T.; Mucke, L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron, 2002, 35, 419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 123
    • 0038268656 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    • Hoozemans, J.J.; Veerhuis, R.; Rozemuller, A.J.; Eikelenboom, P. Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr. Drug Targets, 2003, 4, 461-468.
    • (2003) Curr. Drug Targets , vol.4 , pp. 461-468
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3    Eikelenboom, P.4
  • 124
    • 72849109858 scopus 로고    scopus 로고
    • NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
    • Varvel, N.H.; Bhaskar, K.; Kounnas, M.Z.; Wagner, S.L.; Yang, Y.; Lamb, B.T.; Herrup, K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J. Clin. Invest., 2009, 119, 3692-3702.
    • (2009) J. Clin. Invest , vol.119 , pp. 3692-3702
    • Varvel, N.H.1    Bhaskar, K.2    Kounnas, M.Z.3    Wagner, S.L.4    Yang, Y.5    Lamb, B.T.6    Herrup, K.7
  • 125
    • 0033637884 scopus 로고    scopus 로고
    • Betaβamyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
    • Wu, Q.; Combs, C.; Cannady, S.B.; Geldmacher, D.S.; Herrup, K. Betaβamyloid activated microglia induce cell cycling and cell death in cultured cortical neurons. Neurobiol. Aging, 2000, 21, 797-806.
    • (2000) Neurobiol. Aging , vol.21 , pp. 797-806
    • Wu, Q.1    Combs, C.2    Cannady, S.B.3    Geldmacher, D.S.4    Herrup, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.