BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of alzheimer's disease: Differential aβ antibody labeling of early-onset axon terminal pathology

Neurotoxicity Research

Volumn 21, Issue 2, 2012, Pages 160-174

  Cai, Yan ^a,b   Zhang, Xue Mei ^b,c   MacKlin, Lauren N ^b   Cai, Huaibin ^d   Luo, Xue Gang ^a   Oddo, Salvatore ^e   Laferla, Frank M ^f   Struble, Robert G ^b   Rose, Gregory M ^b   Patrylo, Peter R ^b   Yan, Xiao Xin ^a,b  

^a Central South University   (China)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Amyloid plaque; Axonal pathology; Dementia; Synaptoplasticity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; BETA SECRETASE;

AGING; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; ENZYME INDUCTION; ENZYME LOCALIZATION; FOREBRAIN; IMMUNOREACTIVITY; MALE; MOUSE; NERVE ENDING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, TRANSGENIC; NEURONS; PLAQUE, AMYLOID; PRESYNAPTIC TERMINALS; UP-REGULATION;

ANIMALIA; MUS;

EID: 84856433133     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-011-9256-9     Document Type: Article

References (34)

1. Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I (2011) Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain. J Alzheimers Dis 20:1015-1028
2. Bigl M, Apelt J, Luschekina EA, Lange-Dohna C, Rossner S, Schliebs R (2000) Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology. Neurosci Lett 292:107-110
3. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945 (Pubitemid 27471397)
4. Burgold S, Bittner T, Dorostkar MM, Kieser D, Fuhrmann M, Mitteregger G, Kretzschmar H, Schmidt B, Herms J (2011) In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta Neuropathol 121:327-335
5. Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC (2001) BACE1 is the major beta-secretase for generation of Aβ peptides by neurons. Nat Neurosci 4:233-234 (Pubitemid 32194867)
6. Cai Y, Xiong K, Zhang XM, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Chu Y, Kordower JH, Yan XX (2010) β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation. Eur J Neurosci 32:1223-1238
7. Castellani RJ, Rolston RK, Smith MA (2010) Alzheimer Disease. Dis Mon 56:484-546
8. Duyckaerts C, Delatour B, Potier MC (2009) Classification and basic pathology of Alzheimer disease. Acta Neuropathol 118:5-36
9. Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL Jr, Robakis NK (1996) Identification and neuron specific expression of the S182/presenilin-1 protein in human and rodent brain. J Neurosci Res 45:308-320 (Pubitemid 26322820)
10. Fiala JC (2007) Mechanisms of amyloid plaque pathogenesis. Acta Neuropathol 114:551-571 (Pubitemid 50003186)
11. Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E (2010) Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol 119:523-541
12. Herrup K (2010) Reimagining Alzheimer's disease-an age-based hypothesis. J Neurosci 30:16755-16762
13. Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y (2008) Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res 1216:92-103
14. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102 (Pubitemid 26332733)
15. Irizarry MC, Locascio JJ, Hyman BT (2001) beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging. Am J Pathol 158:173-177 (Pubitemid 32096482)
16. Kim KS, Wegiel J, Sapienza V, Chen J, Hong H, Wisniewski HM (1997) Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Res 757:159-163 (Pubitemid 27244634)
17. Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25:11693-11709 (Pubitemid 43098462)
18. Lazarov O, Lee M, Peterson DA, Sisodia SS (2002) Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 22:9785-9793 (Pubitemid 35332862)
19. Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS (1996) Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J Neurosci 16:7513-7525 (Pubitemid 26389690)
20. Lublin AL, Gandy S (2010) Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. Mt Sinai J Med 77:43-49
21. Mastrangelo MA, Bowers WJ (2008) Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci 9:article 81
22. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409-421 (Pubitemid 36937044)
23. Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH (2010) Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30:14946-14954
24. Robertson RT, Baratta J, Yu J, LaFerla FM (2009) Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 164:1334-1346
25. Sheng JG, Price DL, Koliatsos VE (2002) Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 22:9794-9799 (Pubitemid 35332863)
26. Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX (2010) Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis 22:393-399
27. Thal DR, Capetillo-Zarate E, Del Tredici K, Braak, H (2006) The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 6 re1
28. van Groen T, Liu L, Ikonen S, Kadish I (2003) Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions. Neuroscience 119:1185-1197 (Pubitemid 36776463)
29. Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Mazur-Kolecka B, Imaki H, Wegiel J, Mehta PD, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Pirttilla T, Frey H, Lehtimäki T, Kivimäki T, Visser FE, Kamphorst W, Potempska A, Bolton D, Currie JR, Miller DL (2007) Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration. Acta Neuropathol 113:389-402 (Pubitemid 46421628)
30. Xiong K, Luo DW, Patrylo PR, Luo XG, Struble RG, Clough RW, Yan XX (2008) Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers. Exp Neurol 211:271-282
31. Yan XX, Li T, Rominger CM, Prakash SR, Wong PC, Olson RE, Zaczek R, Li YW (2004) Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. J Neurosci 24:2942-2952 (Pubitemid 38410617)
32. Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX (2009) BACE1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30:2271-2283
33. Zhang XM, Xiong K, Cai Y, Cai H, Luo XG, Feng JC, Clough RW, Patrylo PR, Struble RG, Yan XX (2010) Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex. Eur J Neurosci 31:710-721
34. Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R (2007) Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci 27:3639-3649 (Pubitemid 46557686)