Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Journal of Neuroscience

Volumn 32, Issue 33, 2012, Pages 11390-11395

  Chen, Yaomin ^a,b   Huang, Xiumei ^a,b,e   Zhang, Yun wu ^a   Rockenstein, Edward ^c   Bu, Guojun ^a   Golde, Todd E ^d   Masliah, Eliezer ^c   Xu, Huaxi ^a,b  

^a XIAMEN UNIVERSITY   (China)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNUCLEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; LEARNING DISORDER; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; CELLS, CULTURED; CREB-BINDING PROTEIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EMBRYO, MAMMALIAN; FORSKOLIN; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; GUANYLATE KINASE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROBLASTOMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPTOPHYSIN; TRANSFECTION;

EID: 84864987239     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0757-12.2012     Document Type: Article

References (28)

1. Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R (2000) A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's-secretase. J Biol Chem 275:37712-37717.
2. Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC (2001) BACE1 is the major-secretase for generation of A peptides by neurons. Nat Neurosci 4:233-234.
3. R) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc Natl Acad Sci U S A 106:3907-3912.
4. Cole SL, Vassar R (2007) The Alzheimer's disease-secretase enzyme, BACE1. Mol Neurodegener 2:22.
5. De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG (1995) Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J 14:4932-4938.
6. Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M (2010) A noncompetitive BACE1 inhibitor TAK-070 ameliorates A pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci 30:11157-11166.
7. Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114:1624-1634.
8. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680.
9. Harrison SM, Harper AJ, Hawkins J, Duddy G, Grau E, Pugh PL, Winter PH, Shilliam CS, Hughes ZA, Dawson LA, Gonzalez MI, Upton N, Pangalos MN, Dingwall C (2003) BACE1 (-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci 24:646-655.
10. Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H, Zhang YW (2010) The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's-amyloid level and tau phosphorylation. Hum Mol Genet 19: 3835-3843.
11. Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS (2008) BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease. Neurobiol Aging 29:861-873.
12. Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloidamyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25:11693-11709.
13. Lawlor PA, Bland RJ, Das P, Price RW, Holloway V, Smithson L, Dicker BL, During MJ, Young D, Golde TE (2007) Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal A levels. Mol Neurodegener 2:11.
14. Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J (2000) Human aspartic protease memapsin 2 cleaves the-secretase site of-amyloid precursor protein. Proc Natl Acad Sci U S A 97:1456-1460.
15. Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623.
16. Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R (2001) Mice deficient in BACE1, the Alzheimer's-secretase, have normal phenotype and abolished-amyloid generation. Nat Neurosci 4:231-232.
17. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7:695-702.
18. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E (2005) High-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloidlevels: implications for the treatment of Alzheimer disease. J Biol Chem 280:32957-32967.
19. Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC (2008) Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci USA105:5585-5590.
20. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y, Maeda R, Ohta M, Josselyn SA, Zhuo M, Kida S (2011) Upregulation of CREB-mediated transcription enhances both shortand long-term memory. J Neurosci 31:8786-8802.
21. Tamagno E, Bardini P, Obbili A, Vitali A, Borghi R, Zaccheo D, Pronzato MA, Danni O, Smith MA, Perry G, Tabaton M (2002) Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis 10:279-288.
22. Tong L, Thornton PL, Balazs R, Cotman CW (2001)-Amyloid-(1-42) impairs activity-dependent cAMP response element-binding protein signaling in neurons at concentrations in which cell is not compromised. J Biol Chem 276:17301-17306.
23. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, et al (1999)-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
24. Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW (2004) Increased-secretase activity and expression in rats following transient cerebral ischemia. Brain Res 1009:1-8.
25. Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y (2003) Elevated-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med 9:3-4.
26. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW (2007) Hypoxia-inducible factor 1 (HIF-1)-mediated hypoxia increases BACE1 expression and-amyloid generation. J Biol Chem 282:10873-10880.
27. Zhang YW, Xu H (2007) Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. Curr Mol Med 7:687-696.
28. Zheng H, Koo EH (2011) Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener 6:27.