Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 885-896

  Mouton Liger, François ^a,b   Paquet, Claire ^a,b   Dumurgier, Julien ^a   Bouras, Constantin ^c   Pradier, Laurent ^d   Gray, Françoise ^a   Hugon, Jacques ^a,b  

^a HÔPITAL LARIBOISIÈRE   (France)

^b INSTITUT DU FER À MOULIN   (France)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d SANOFI   (France)

Author keywords

Alzheimer's disease; BACE1; EIF2 ; Neuroblastoma cell cultures; Oxidative stress; PKR

Indexed keywords

BETA SECRETASE 1; DOUBLE STRANDED RNA DEPENDANT PROTEIN KINASE; HYDROGEN PEROXIDE; INITIATION FACTOR 2ALPHA; JANUS KINASE; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; CELL LINE, TUMOR; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; FEMALE; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; OXIDATIVE STRESS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EUKARYOTA; MUS;

EID: 84859073666     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.01.009     Document Type: Article

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