-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
84872379077
-
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
-
Jack CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013, 12:207-216.
-
(2013)
Lancet Neurol
, vol.12
, pp. 207-216
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Petersen, R.C.4
Weiner, M.W.5
Aisen, P.S.6
Shaw, L.M.7
Vemuri, P.8
Wiste, H.J.9
Weigand, S.D.10
Lesnick, T.G.11
Pankratz, V.S.12
Donohue, M.C.13
Trojanowski, J.Q.14
-
3
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:280-292.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
Bennett, D.A.4
Craft, S.5
Fagan, A.M.6
Iwatsubo, T.7
Jack, C.R.8
Kaye, J.9
Montine, T.J.10
Park, D.C.11
Reiman, E.M.12
Rowe, C.C.13
Siemers, E.14
Stern, Y.15
Yaffe, K.16
Carrillo, M.C.17
Thies, B.18
Morrison-Bogorad, M.19
Wagster, M.V.20
Phelps, C.H.21
more..
-
4
-
-
79956084514
-
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:270-279.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 270-279
-
-
Albert, M.S.1
DeKosky, S.T.2
Dickson, D.3
Dubois, B.4
Feldman, H.H.5
Fox, N.C.6
Gamst, A.7
Holtzman, D.M.8
Jagust, W.J.9
Petersen, R.C.10
Snyder, P.J.11
Carrillo, M.C.12
Thies, B.13
Phelps, C.H.14
-
5
-
-
79956142378
-
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 263-269
-
-
McKhann, G.M.1
Knopman, D.S.2
Chertkow, H.3
Hyman, B.T.4
Jack, C.R.5
Kawas, C.H.6
Klunk, W.E.7
Koroshetz, W.J.8
Manly, J.J.9
Mayeux, R.10
Mohs, R.C.11
Morris, J.C.12
Rossor, M.N.13
Scheltens, P.14
Carrillo, M.C.15
Thies, B.16
Weintraub, S.17
Phelps, C.H.18
-
6
-
-
0019993831
-
Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study
-
Eikelenboom P, Stam FC. Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol 1982, 57:239-242.
-
(1982)
Acta Neuropathol
, vol.57
, pp. 239-242
-
-
Eikelenboom, P.1
Stam, F.C.2
-
7
-
-
0024543574
-
Complement activation in amyloid plaques in Alzheimer's dementia
-
Eikelenboom P, Hack CE, Rozemuller JM, Stam FC. Complement activation in amyloid plaques in Alzheimer's dementia. Virchows Arch B Cell Pathol Incl Mol Pathol 1989, 56:259-262.
-
(1989)
Virchows Arch B Cell Pathol Incl Mol Pathol
, vol.56
, pp. 259-262
-
-
Eikelenboom, P.1
Hack, C.E.2
Rozemuller, J.M.3
Stam, F.C.4
-
8
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 1989, 86:7611-7615.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
Stanley, L.C.2
Ling, C.3
White, L.4
MacLeod, V.5
Perrot, L.J.6
White, C.L.7
Araoz, C.8
-
9
-
-
1542283611
-
Neuroinflammatory perspectives on the two faces of Alzheimer's disease
-
Eikelenboom P, van Gool WA. Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J Neural Transm 2004, 111:281-294.
-
(2004)
J Neural Transm
, vol.111
, pp. 281-294
-
-
Eikelenboom, P.1
van Gool, W.A.2
-
10
-
-
0021912473
-
Interleukin-1 stimulation of astroglial proliferation after brain injury
-
Giulian D, Lachman LB. Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 1985, 228:497-499.
-
(1985)
Science
, vol.228
, pp. 497-499
-
-
Giulian, D.1
Lachman, L.B.2
-
11
-
-
0023772364
-
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
-
Giulian D, Woodward J, Young DG, Krebs JF, Lachman LB. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci 1988, 8:2485-2490.
-
(1988)
J Neurosci
, vol.8
, pp. 2485-2490
-
-
Giulian, D.1
Woodward, J.2
Young, D.G.3
Krebs, J.F.4
Lachman, L.B.5
-
12
-
-
0005775566
-
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
-
Goldgaber D, Harris HW, Hla T, Maciag T, Donnelly RJ, Jacobsen JS, Vitek MP, Gajdusek DC. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A 1989, 86:7606-7610.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7606-7610
-
-
Goldgaber, D.1
Harris, H.W.2
Hla, T.3
Maciag, T.4
Donnelly, R.J.5
Jacobsen, J.S.6
Vitek, M.P.7
Gajdusek, D.C.8
-
13
-
-
0023017916
-
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression
-
Perlmutter DH, Dinarello CA, Punsal PI, Colten HR. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest 1986, 78:1349-1354.
-
(1986)
J Clin Invest
, vol.78
, pp. 1349-1354
-
-
Perlmutter, D.H.1
Dinarello, C.A.2
Punsal, P.I.3
Colten, H.R.4
-
14
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 1985, 82:4245-4249.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
15
-
-
0023838532
-
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
-
Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 1988, 52:487-501.
-
(1988)
Cell
, vol.52
, pp. 487-501
-
-
Abraham, C.R.1
Selkoe, D.J.2
Potter, H.3
-
16
-
-
0024442083
-
Immune system response in Alzheimer's disease
-
McGeer PL, Akiyama H, Itagaki S, McGeer EG. Immune system response in Alzheimer's disease. Can J Neurol Sci 1989, 16:516-527.
-
(1989)
Can J Neurol Sci
, vol.16
, pp. 516-527
-
-
McGeer, P.L.1
Akiyama, H.2
Itagaki, S.3
McGeer, E.G.4
-
17
-
-
0024317005
-
Activation of the classical complement pathway in brain tissue of Alzheimer patients
-
McGeer PL, Akiyama H, Itagaki S, McGeer EG. Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci Lett 1989, 107:341-346.
-
(1989)
Neurosci Lett
, vol.107
, pp. 341-346
-
-
McGeer, P.L.1
Akiyama, H.2
Itagaki, S.3
McGeer, E.G.4
-
18
-
-
0026447529
-
Complement activation by beta-amyloid in Alzheimer disease
-
Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, Civin WH, Brachova L, Bradt B, Ward P. Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 1992, 89:10016-10020.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Webster, S.3
Schultz, J.4
McGeer, P.L.5
Styren, S.D.6
Civin, W.H.7
Brachova, L.8
Bradt, B.9
Ward, P.10
-
19
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.17
Mrak, R.18
Mackenzie, I.R.19
McGeer, P.L.20
O'Banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
Van Muiswinkel, F.L.31
Veerhuis, R.32
Walker, D.33
Webster, S.34
Wegrzyniak, B.35
Wenk, G.36
Wyss-Coray, T.37
more..
-
20
-
-
0036685522
-
Inflammation in neurodegenerative disease - a double-edged sword
-
Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease - a double-edged sword. Neuron 2002, 35:419-432.
-
(2002)
Neuron
, vol.35
, pp. 419-432
-
-
Wyss-Coray, T.1
Mucke, L.2
-
21
-
-
11444256801
-
Glia and their cytokines in progression of neurodegeneration
-
Mrak RE, Griffin WS. Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 2005, 26:349-354.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 349-354
-
-
Mrak, R.E.1
Griffin, W.S.2
-
22
-
-
79960997729
-
Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology
-
Hoozemans JJ, Veerhuis R, Rozemuller JM, Eikelenboom P. Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology. CNS Neurol Disord Drug Targets 2011, 10:57-67.
-
(2011)
CNS Neurol Disord Drug Targets
, vol.10
, pp. 57-67
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Rozemuller, J.M.3
Eikelenboom, P.4
-
23
-
-
0029811901
-
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
-
McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996, 47:425-432.
-
(1996)
Neurology
, vol.47
, pp. 425-432
-
-
McGeer, P.L.1
Schulzer, M.2
McGeer, E.G.3
-
24
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
in t' Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MM, Stricker BH. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001, 345:1515-1521.
-
(2001)
N Engl J Med
, vol.345
, pp. 1515-1521
-
-
in t' Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.J.4
van Duijn, C.M.5
Stijnen, T.6
Breteler, M.M.7
Stricker, B.H.8
-
25
-
-
0038268656
-
Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
-
Hoozemans JJ, Veerhuis R, Rozemuller AJ, Eikelenboom P. Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr Drug Targets 2003, 4:461-468.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 461-468
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Rozemuller, A.J.3
Eikelenboom, P.4
-
26
-
-
0006300658
-
Microglia, amyloid and dementia in alzheimer disease. A correlative study
-
Arends YM, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw JJ. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging 2000, 21:39-47.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 39-47
-
-
Arends, Y.M.1
Duyckaerts, C.2
Rozemuller, J.M.3
Eikelenboom, P.4
Hauw, J.J.5
-
27
-
-
0037333633
-
Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
-
Vehmas AK, Kawas CH, Stewart WF, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiol Aging 2003, 24:321-331.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 321-331
-
-
Vehmas, A.K.1
Kawas, C.H.2
Stewart, W.F.3
Troncoso, J.C.4
-
28
-
-
28344439699
-
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
-
Hoozemans JJ, van Haastert ES, Veerhuis R, Arendt T, Scheper W, Eikelenboom P, Rozemuller AJ. Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation 2005, 2:27.
-
(2005)
J Neuroinflammation
, vol.2
, pp. 27
-
-
Hoozemans, J.J.1
van Haastert, E.S.2
Veerhuis, R.3
Arendt, T.4
Scheper, W.5
Eikelenboom, P.6
Rozemuller, A.J.7
-
29
-
-
56349144614
-
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
-
Edison P, Archer HA, Gerhard A, Hinz R, Pavese N, Turkheimer FE, Hammers A, Tai YF, Fox N, Kennedy A, Rossor M, Brooks DJ. Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis 2008, 32:412-419.
-
(2008)
Neurobiol Dis
, vol.32
, pp. 412-419
-
-
Edison, P.1
Archer, H.A.2
Gerhard, A.3
Hinz, R.4
Pavese, N.5
Turkheimer, F.E.6
Hammers, A.7
Tai, Y.F.8
Fox, N.9
Kennedy, A.10
Rossor, M.11
Brooks, D.J.12
-
30
-
-
84855369203
-
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
-
Carter SF, Scholl M, Almkvist O, Wall A, Engler H, Langstrom B, Nordberg A. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J Nucl Med 2012, 53:37-46.
-
(2012)
J Nucl Med
, vol.53
, pp. 37-46
-
-
Carter, S.F.1
Scholl, M.2
Almkvist, O.3
Wall, A.4
Engler, H.5
Langstrom, B.6
Nordberg, A.7
-
31
-
-
51349124394
-
Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET
-
Esposito G, Giovacchini G, Liow JS, Bhattacharjee AK, Greenstein D, Schapiro M, Hallett M, Herscovitch P, Eckelman WC, Carson RE, Rapoport SI. Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET. J Nucl Med 2008, 49:1414-1421.
-
(2008)
J Nucl Med
, vol.49
, pp. 1414-1421
-
-
Esposito, G.1
Giovacchini, G.2
Liow, J.S.3
Bhattacharjee, A.K.4
Greenstein, D.5
Schapiro, M.6
Hallett, M.7
Herscovitch, P.8
Eckelman, W.C.9
Carson, R.E.10
Rapoport, S.I.11
-
32
-
-
0024472141
-
Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography
-
Hashimoto K, Inoue O, Suzuki K, Yamasaki T, Kojima M. Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Ann Nucl Med 1989, 3:63-71.
-
(1989)
Ann Nucl Med
, vol.3
, pp. 63-71
-
-
Hashimoto, K.1
Inoue, O.2
Suzuki, K.3
Yamasaki, T.4
Kojima, M.5
-
33
-
-
36049035022
-
11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain
-
Zhang MR, Kumata K, Maeda J, Yanamoto K, Hatori A, Okada M, Higuchi M, Obayashi S, Suhara T, Suzuki K. 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain. J Nucl Med 2007, 48:1853-1861.
-
(2007)
J Nucl Med
, vol.48
, pp. 1853-1861
-
-
Zhang, M.R.1
Kumata, K.2
Maeda, J.3
Yanamoto, K.4
Hatori, A.5
Okada, M.6
Higuchi, M.7
Obayashi, S.8
Suhara, T.9
Suzuki, K.10
-
34
-
-
36849083432
-
Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation
-
Brown AK, Fujita M, Fujimura Y, Liow JS, Stabin M, Ryu YH, Imaizumi M, Hong J, Pike VW, Innis RB. Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. J Nucl Med 2007, 48:2072-2079.
-
(2007)
J Nucl Med
, vol.48
, pp. 2072-2079
-
-
Brown, A.K.1
Fujita, M.2
Fujimura, Y.3
Liow, J.S.4
Stabin, M.5
Ryu, Y.H.6
Imaizumi, M.7
Hong, J.8
Pike, V.W.9
Innis, R.B.10
-
35
-
-
62449175342
-
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation
-
Chauveau F, Van Camp N, Dolle F, Kuhnast B, Hinnen F, Damont A, Boutin H, James M, Kassiou M, Tavitian B. Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med 2009, 50:468-476.
-
(2009)
J Nucl Med
, vol.50
, pp. 468-476
-
-
Chauveau, F.1
Van Camp, N.2
Dolle, F.3
Kuhnast, B.4
Hinnen, F.5
Damont, A.6
Boutin, H.7
James, M.8
Kassiou, M.9
Tavitian, B.10
-
36
-
-
70350348248
-
[11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis
-
Doorduin J, Klein HC, Dierckx RA, James M, Kassiou M, de Vries EF. [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol 2009, 11:386-398.
-
(2009)
Mol Imaging Biol
, vol.11
, pp. 386-398
-
-
Doorduin, J.1
Klein, H.C.2
Dierckx, R.A.3
James, M.4
Kassiou, M.5
de Vries, E.F.6
-
37
-
-
84899486540
-
Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain
-
Tiwari AK, Yui J, Fujinaga M, Kumata K, Shimoda Y, Yamasaki T, Xie L, Hatori A, Maeda J, Nengaki N, Zhang MR. Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain. J Neurochem 2014, 129:712-720.
-
(2014)
J Neurochem
, vol.129
, pp. 712-720
-
-
Tiwari, A.K.1
Yui, J.2
Fujinaga, M.3
Kumata, K.4
Shimoda, Y.5
Yamasaki, T.6
Xie, L.7
Hatori, A.8
Maeda, J.9
Nengaki, N.10
Zhang, M.R.11
-
38
-
-
70349283883
-
Evaluation of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat
-
Yanamoto K, Yamasaki T, Kumata K, Yui J, Odawara C, Kawamura K, Hatori A, Inoue O, Yamaguchi M, Suzuki K, Zhang MR. Evaluation of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat. Synapse 2009, 63:961-971.
-
(2009)
Synapse
, vol.63
, pp. 961-971
-
-
Yanamoto, K.1
Yamasaki, T.2
Kumata, K.3
Yui, J.4
Odawara, C.5
Kawamura, K.6
Hatori, A.7
Inoue, O.8
Yamaguchi, M.9
Suzuki, K.10
Zhang, M.R.11
-
39
-
-
84866291187
-
Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [11C]DAA1106
-
Yasuno F, Kosaka J, Ota M, Higuchi M, Ito H, Fujimura Y, Nozaki S, Takahashi S, Mizukami K, Asada T, Suhara T. Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [11C]DAA1106. Psychiatry Res 2012, 203:67-74.
-
(2012)
Psychiatry Res
, vol.203
, pp. 67-74
-
-
Yasuno, F.1
Kosaka, J.2
Ota, M.3
Higuchi, M.4
Ito, H.5
Fujimura, Y.6
Nozaki, S.7
Takahashi, S.8
Mizukami, K.9
Asada, T.10
Suhara, T.11
-
40
-
-
20044376683
-
[11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies
-
Gulyas B, Halldin C, Vas A, Banati RB, Shchukin E, Finnema S, Tarkainen J, Tihanyi K, Szilagyi G, Farde L. [11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies. J Neurol Sci 2005, 229-230:219-223.
-
(2005)
J Neurol Sci
, vol.229-230
, pp. 219-223
-
-
Gulyas, B.1
Halldin, C.2
Vas, A.3
Banati, R.B.4
Shchukin, E.5
Finnema, S.6
Tarkainen, J.7
Tihanyi, K.8
Szilagyi, G.9
Farde, L.10
-
41
-
-
67650088553
-
Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06
-
Fujimura Y, Zoghbi SS, Simeon FG, Taku A, Pike VW, Innis RB, Fujita M. Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06. J Nucl Med 2009, 50:1047-1053.
-
(2009)
J Nucl Med
, vol.50
, pp. 1047-1053
-
-
Fujimura, Y.1
Zoghbi, S.S.2
Simeon, F.G.3
Taku, A.4
Pike, V.W.5
Innis, R.B.6
Fujita, M.7
-
42
-
-
77956208191
-
18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain
-
Yui J, Maeda J, Kumata K, Kawamura K, Yanamoto K, Hatori A, Yamasaki T, Nengaki N, Higuchi M, Zhang MR. 18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain. J Nucl Med 2010, 51:1301-1309.
-
(2010)
J Nucl Med
, vol.51
, pp. 1301-1309
-
-
Yui, J.1
Maeda, J.2
Kumata, K.3
Kawamura, K.4
Yanamoto, K.5
Hatori, A.6
Yamasaki, T.7
Nengaki, N.8
Higuchi, M.9
Zhang, M.R.10
-
43
-
-
84891702940
-
In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients
-
Varrone A, Mattsson P, Forsberg A, Takano A, Nag S, Gulyas B, Borg J, Boellaard R, Al-Tawil N, Eriksdotter M, Zimmermann T, Schultze-Mosgau M, Thiele A, Hoffmann A, Lammertsma AA, Halldin C. In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients. Eur J Nucl Med Mol Imaging 2013, 40:921-931.
-
(2013)
Eur J Nucl Med Mol Imaging
, vol.40
, pp. 921-931
-
-
Varrone, A.1
Mattsson, P.2
Forsberg, A.3
Takano, A.4
Nag, S.5
Gulyas, B.6
Borg, J.7
Boellaard, R.8
Al-Tawil, N.9
Eriksdotter, M.10
Zimmermann, T.11
Schultze-Mosgau, M.12
Thiele, A.13
Hoffmann, A.14
Lammertsma, A.A.15
Halldin, C.16
-
44
-
-
53249151675
-
Labelling and biological evaluation of [(11)C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor
-
Evens N, Bosier B, Lavey BJ, Kozlowski JA, Vermaelen P, Baudemprez L, Busson R, Lambert DM, Van Laere K, Verbruggen AM, Bormans GM. Labelling and biological evaluation of [(11)C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor. Nucl Med Biol 2008, 35:793-800.
-
(2008)
Nucl Med Biol
, vol.35
, pp. 793-800
-
-
Evens, N.1
Bosier, B.2
Lavey, B.J.3
Kozlowski, J.A.4
Vermaelen, P.5
Baudemprez, L.6
Busson, R.7
Lambert, D.M.8
Van Laere, K.9
Verbruggen, A.M.10
Bormans, G.M.11
-
45
-
-
0029658881
-
20-[18F]fluoroarachidonic acid: tissue biodistribution and incorporation into phospholipids
-
Nagatsugi F, Hokazono J, Sasaki S, Maeda M. 20-[18F]fluoroarachidonic acid: tissue biodistribution and incorporation into phospholipids. Biol Pharm Bull 1996, 19:1316-1321.
-
(1996)
Biol Pharm Bull
, vol.19
, pp. 1316-1321
-
-
Nagatsugi, F.1
Hokazono, J.2
Sasaki, S.3
Maeda, M.4
-
46
-
-
84864134469
-
Microglia function in Alzheimer's disease
-
Solito E, Sastre M. Microglia function in Alzheimer's disease. Front Pharmacol 2012, 3:14.
-
(2012)
Front Pharmacol
, vol.3
, pp. 14
-
-
Solito, E.1
Sastre, M.2
-
47
-
-
33846571886
-
The origin and cell lineage of microglia: new concepts
-
Chan WY, Kohsaka S, Rezaie P. The origin and cell lineage of microglia: new concepts. Brain Res Rev 2007, 53:344-354.
-
(2007)
Brain Res Rev
, vol.53
, pp. 344-354
-
-
Chan, W.Y.1
Kohsaka, S.2
Rezaie, P.3
-
48
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
49
-
-
67650966680
-
Microglial physiology: unique stimuli, specialized responses
-
Ransohoff RM, Perry VH. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 2009, 27:119-145.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 119-145
-
-
Ransohoff, R.M.1
Perry, V.H.2
-
50
-
-
22244458574
-
Neuroscience: Brain under surveillance: the microglia patrol
-
Fetler L, Amigorena S. Neuroscience: Brain under surveillance: the microglia patrol. Science 2005, 309:392-393.
-
(2005)
Science
, vol.309
, pp. 392-393
-
-
Fetler, L.1
Amigorena, S.2
-
51
-
-
0024157709
-
Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease
-
Rogers J, Luber-Narod J, Styren SD, Civin WH. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 1988, 9:339-349.
-
(1988)
Neurobiol Aging
, vol.9
, pp. 339-349
-
-
Rogers, J.1
Luber-Narod, J.2
Styren, S.D.3
Civin, W.H.4
-
52
-
-
0025077080
-
Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain
-
Styren SD, Civin WH, Rogers J. Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol 1990, 110:93-104.
-
(1990)
Exp Neurol
, vol.110
, pp. 93-104
-
-
Styren, S.D.1
Civin, W.H.2
Rogers, J.3
-
53
-
-
0031974406
-
Microglial response to amyloid plaques in APPsw transgenic mice
-
Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 1998, 152:307-317.
-
(1998)
Am J Pathol
, vol.152
, pp. 307-317
-
-
Frautschy, S.A.1
Yang, F.2
Irrizarry, M.3
Hyman, B.4
Saido, T.C.5
Hsiao, K.6
Cole, G.M.7
-
54
-
-
0032983536
-
Association of microglia with amyloid plaques in brains of APP23 transgenic mice
-
Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, Jucker M. Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol 1999, 154:1673-1684.
-
(1999)
Am J Pathol
, vol.154
, pp. 1673-1684
-
-
Stalder, M.1
Phinney, A.2
Probst, A.3
Sommer, B.4
Staufenbiel, M.5
Jucker, M.6
-
55
-
-
0033080919
-
Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
-
Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 1999, 19:928-939.
-
(1999)
J Neurosci
, vol.19
, pp. 928-939
-
-
Combs, C.K.1
Johnson, D.E.2
Cannady, S.B.3
Lehman, T.M.4
Landreth, G.E.5
-
56
-
-
0034651101
-
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
-
Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 2000, 20:558-567.
-
(2000)
J Neurosci
, vol.20
, pp. 558-567
-
-
Combs, C.K.1
Johnson, D.E.2
Karlo, J.C.3
Cannady, S.B.4
Landreth, G.E.5
-
57
-
-
0030795049
-
Beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
-
Klegeris A, McGeer PL. Beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate. J Neurosci Res 1997, 49:229-235.
-
(1997)
J Neurosci Res
, vol.49
, pp. 229-235
-
-
Klegeris, A.1
McGeer, P.L.2
-
58
-
-
0030961544
-
Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
-
McDonald DR, Brunden KR, Landreth GE. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 1997, 17:2284-2294.
-
(1997)
J Neurosci
, vol.17
, pp. 2284-2294
-
-
McDonald, D.R.1
Brunden, K.R.2
Landreth, G.E.3
-
60
-
-
33746035655
-
Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
-
Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M. Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006, 27:402-409.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 402-409
-
-
Papadopoulos, V.1
Baraldi, M.2
Guilarte, T.R.3
Knudsen, T.B.4
Lacapere, J.J.5
Lindemann, P.6
Norenberg, M.D.7
Nutt, D.8
Weizman, A.9
Zhang, M.R.10
Gavish, M.11
-
61
-
-
33846205518
-
The peripheral benzodiazepine receptor (Translocator protein 18 kDa) in microglia: from pathology to imaging
-
Venneti S, Lopresti BJ, Wiley CA. The peripheral benzodiazepine receptor (Translocator protein 18 kDa) in microglia: from pathology to imaging. Prog Neurobiol 2006, 80:308-322.
-
(2006)
Prog Neurobiol
, vol.80
, pp. 308-322
-
-
Venneti, S.1
Lopresti, B.J.2
Wiley, C.A.3
-
62
-
-
42649115741
-
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair
-
Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther 2008, 118:1-17.
-
(2008)
Pharmacol Ther
, vol.118
, pp. 1-17
-
-
Chen, M.K.1
Guilarte, T.R.2
-
63
-
-
0022574416
-
The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane
-
Anholt RR, Pedersen PL, De Souza EB, Snyder SH. The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. J Biol Chem 1986, 261:576-583.
-
(1986)
J Biol Chem
, vol.261
, pp. 576-583
-
-
Anholt, R.R.1
Pedersen, P.L.2
De Souza, E.B.3
Snyder, S.H.4
-
64
-
-
0022443602
-
Evidence for species differences in 'peripheral' benzodiazepine receptors: an autoradiographic study
-
Cymerman U, Pazos A, Palacios JM. Evidence for species differences in 'peripheral' benzodiazepine receptors: an autoradiographic study. Neurosci Lett 1986, 66:153-158.
-
(1986)
Neurosci Lett
, vol.66
, pp. 153-158
-
-
Cymerman, U.1
Pazos, A.2
Palacios, J.M.3
-
65
-
-
84865624449
-
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
-
Ching AS, Kuhnast B, Damont A, Roeda D, Tavitian B, Dolle F. Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases. Insights Imaging 2012, 3:111-119.
-
(2012)
Insights Imaging
, vol.3
, pp. 111-119
-
-
Ching, A.S.1
Kuhnast, B.2
Damont, A.3
Roeda, D.4
Tavitian, B.5
Dolle, F.6
-
66
-
-
84863446652
-
Noninvasive molecular imaging of neuroinflammation
-
INMiND consortium
-
Jacobs AH, Tavitian B, . INMiND consortium Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab 2012, 32:1393-1415. INMiND consortium.
-
(2012)
J Cereb Blood Flow Metab
, vol.32
, pp. 1393-1415
-
-
Jacobs, A.H.1
Tavitian, B.2
-
67
-
-
67349181734
-
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
-
Venneti S, Lopresti BJ, Wang G, Hamilton RL, Mathis CA, Klunk WE, Apte UM, Wiley CA. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging 2009, 30:1217-1226.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1217-1226
-
-
Venneti, S.1
Lopresti, B.J.2
Wang, G.3
Hamilton, R.L.4
Mathis, C.A.5
Klunk, W.E.6
Apte, U.M.7
Wiley, C.A.8
-
68
-
-
11144353899
-
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain
-
Zhang MR, Maeda J, Ogawa M, Noguchi J, Ito T, Yoshida Y, Okauchi T, Obayashi S, Suhara T, Suzuki K. Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem 2004, 47:2228-2235.
-
(2004)
J Med Chem
, vol.47
, pp. 2228-2235
-
-
Zhang, M.R.1
Maeda, J.2
Ogawa, M.3
Noguchi, J.4
Ito, T.5
Yoshida, Y.6
Okauchi, T.7
Obayashi, S.8
Suhara, T.9
Suzuki, K.10
-
69
-
-
79953004994
-
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders
-
Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci 2011, 31:4720-4730.
-
(2011)
J Neurosci
, vol.31
, pp. 4720-4730
-
-
Maeda, J.1
Zhang, M.R.2
Okauchi, T.3
Ji, B.4
Ono, M.5
Hattori, S.6
Kumata, K.7
Iwata, N.8
Saido, T.C.9
Trojanowski, J.Q.10
Lee, V.M.11
Staufenbiel, M.12
Tomiyama, T.13
Mori, H.14
Fukumura, T.15
Suhara, T.16
Higuchi, M.17
-
70
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 1997, 94:13287-13292.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
71
-
-
0035845283
-
In-vivo measurement of activated microglia in dementia
-
Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB. In-vivo measurement of activated microglia in dementia. Lancet 2001, 358:461-467.
-
(2001)
Lancet
, vol.358
, pp. 461-467
-
-
Cagnin, A.1
Brooks, D.J.2
Kennedy, A.M.3
Gunn, R.N.4
Myers, R.5
Turkheimer, F.E.6
Jones, T.7
Banati, R.B.8
-
72
-
-
84868107574
-
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
-
Schuitemaker A, Kropholler MA, Boellaard R, van der Flier WM, Kloet RW, van der Doef TF, Knol DL, Windhorst AD, Luurtsema G, Barkhof F, Jonker C, Lammertsma AA, Scheltens P, van Berckel BN. Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study. Neurobiol Aging 2013, 34:128-136.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 128-136
-
-
Schuitemaker, A.1
Kropholler, M.A.2
Boellaard, R.3
van der Flier, W.M.4
Kloet, R.W.5
van der Doef, T.F.6
Knol, D.L.7
Windhorst, A.D.8
Luurtsema, G.9
Barkhof, F.10
Jonker, C.11
Lammertsma, A.A.12
Scheltens, P.13
van Berckel, B.N.14
-
73
-
-
58449115240
-
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
-
Wiley CA, Lopresti BJ, Venneti S, Price J, Klunk WE, DeKosky ST, Mathis CA. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 2009, 66:60-67.
-
(2009)
Arch Neurol
, vol.66
, pp. 60-67
-
-
Wiley, C.A.1
Lopresti, B.J.2
Venneti, S.3
Price, J.4
Klunk, W.E.5
DeKosky, S.T.6
Mathis, C.A.7
-
74
-
-
63849193695
-
Microglial activation and amyloid deposition in mild cognitive impairment: a PET study
-
Okello A, Edison P, Archer HA, Turkheimer FE, Kennedy J, Bullock R, Walker Z, Kennedy A, Fox N, Rossor M, Brooks DJ. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009, 72:56-62.
-
(2009)
Neurology
, vol.72
, pp. 56-62
-
-
Okello, A.1
Edison, P.2
Archer, H.A.3
Turkheimer, F.E.4
Kennedy, J.5
Bullock, R.6
Walker, Z.7
Kennedy, A.8
Fox, N.9
Rossor, M.10
Brooks, D.J.11
-
75
-
-
54149105539
-
Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
-
Yasuno F, Ota M, Kosaka J, Ito H, Higuchi M, Doronbekov TK, Nozaki S, Fujimura Y, Koeda M, Asada T, Suhara T. Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry 2008, 64:835-841.
-
(2008)
Biol Psychiatry
, vol.64
, pp. 835-841
-
-
Yasuno, F.1
Ota, M.2
Kosaka, J.3
Ito, H.4
Higuchi, M.5
Doronbekov, T.K.6
Nozaki, S.7
Fujimura, Y.8
Koeda, M.9
Asada, T.10
Suhara, T.11
-
76
-
-
84871920442
-
A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation
-
Kreisl WC, Jenko KJ, Hines CS, Lyoo CH, Corona W, Morse CL, Zoghbi SS, Hyde T, Kleinman JE, Pike VW, et al. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J Cereb Blood Flow Metab 2013, 33:53-58.
-
(2013)
J Cereb Blood Flow Metab
, vol.33
, pp. 53-58
-
-
Kreisl, W.C.1
Jenko, K.J.2
Hines, C.S.3
Lyoo, C.H.4
Corona, W.5
Morse, C.L.6
Zoghbi, S.S.7
Hyde, T.8
Kleinman, J.E.9
Pike, V.W.10
-
77
-
-
11144284910
-
Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population
-
Suribhatla S, Baillon S, Dennis M, Marudkar M, Muhammad S, Munro D, Spreadbury C, Lindesay J. Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population. Int J Geriatr Psychiatry 2004, 19:1140-1147.
-
(2004)
Int J Geriatr Psychiatry
, vol.19
, pp. 1140-1147
-
-
Suribhatla, S.1
Baillon, S.2
Dennis, M.3
Marudkar, M.4
Muhammad, S.5
Munro, D.6
Spreadbury, C.7
Lindesay, J.8
-
78
-
-
33748689296
-
Four subgroups of Alzheimer's disease based on patterns of atrophy using VBM and a unique pattern for early onset disease
-
Shiino A, Watanabe T, Maeda K, Kotani E, Akiguchi I, Matsuda M. Four subgroups of Alzheimer's disease based on patterns of atrophy using VBM and a unique pattern for early onset disease. Neuroimage 2006, 33:17-26.
-
(2006)
Neuroimage
, vol.33
, pp. 17-26
-
-
Shiino, A.1
Watanabe, T.2
Maeda, K.3
Kotani, E.4
Akiguchi, I.5
Matsuda, M.6
-
79
-
-
36348967745
-
Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study
-
Karas G, Scheltens P, Rombouts S, van Schijndel R, Klein M, Jones B, van der Flier W, Vrenken H, Barkhof F. Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study. Neuroradiology 2007, 49:967-976.
-
(2007)
Neuroradiology
, vol.49
, pp. 967-976
-
-
Karas, G.1
Scheltens, P.2
Rombouts, S.3
van Schijndel, R.4
Klein, M.5
Jones, B.6
van der Flier, W.7
Vrenken, H.8
Barkhof, F.9
-
80
-
-
34347373501
-
Cognitive differences between early- and late-onset Alzheimer's disease
-
Licht EA, McMurtray AM, Saul RE, Mendez MF. Cognitive differences between early- and late-onset Alzheimer's disease. Am J Alzheimers Dis Other Demen 2007, 22:218-222.
-
(2007)
Am J Alzheimers Dis Other Demen
, vol.22
, pp. 218-222
-
-
Licht, E.A.1
McMurtray, A.M.2
Saul, R.E.3
Mendez, M.F.4
-
81
-
-
77956263860
-
Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation
-
Owen DR, Howell OW, Tang SP, Wells LA, Bennacef I, Bergstrom M, Gunn RN, Rabiner EA, Wilkins MR, Reynolds R, Matthews PM, Parker CA. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab 2010, 30:1608-1618.
-
(2010)
J Cereb Blood Flow Metab
, vol.30
, pp. 1608-1618
-
-
Owen, D.R.1
Howell, O.W.2
Tang, S.P.3
Wells, L.A.4
Bennacef, I.5
Bergstrom, M.6
Gunn, R.N.7
Rabiner, E.A.8
Wilkins, M.R.9
Reynolds, R.10
Matthews, P.M.11
Parker, C.A.12
-
82
-
-
79851473610
-
Mixed-affinity binding in humans with 18-kDa translocator protein ligands
-
Owen DR, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, Innis RB, Pike VW, Reynolds R, Matthews PM, Parker CA. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med 2011, 52:24-32.
-
(2011)
J Nucl Med
, vol.52
, pp. 24-32
-
-
Owen, D.R.1
Gunn, R.N.2
Rabiner, E.A.3
Bennacef, I.4
Fujita, M.5
Kreisl, W.C.6
Innis, R.B.7
Pike, V.W.8
Reynolds, R.9
Matthews, P.M.10
Parker, C.A.11
-
83
-
-
84855340957
-
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
-
Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, Rhodes C, Pulford DJ, Bennacef I, Parker CA, StJean PL, Cardon LR, Mooser VE, Matthews PM, Rabiner EA, Rubio JP. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab 2012, 32:1-5.
-
(2012)
J Cereb Blood Flow Metab
, vol.32
, pp. 1-5
-
-
Owen, D.R.1
Yeo, A.J.2
Gunn, R.N.3
Song, K.4
Wadsworth, G.5
Lewis, A.6
Rhodes, C.7
Pulford, D.J.8
Bennacef, I.9
Parker, C.A.10
StJean, P.L.11
Cardon, L.R.12
Mooser, V.E.13
Matthews, P.M.14
Rabiner, E.A.15
Rubio, J.P.16
-
84
-
-
84861846497
-
Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [18F]-FEPPA
-
Mizrahi R, Rusjan PM, Kennedy J, Pollock B, Mulsant B, Suridjan I, De Luca V, Wilson AA, Houle S. Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [18F]-FEPPA. J Cereb Blood Flow Metab 2012, 32:968-972.
-
(2012)
J Cereb Blood Flow Metab
, vol.32
, pp. 968-972
-
-
Mizrahi, R.1
Rusjan, P.M.2
Kennedy, J.3
Pollock, B.4
Mulsant, B.5
Suridjan, I.6
De Luca, V.7
Wilson, A.A.8
Houle, S.9
-
85
-
-
84881426292
-
Influence of TSPO genotype on 11C-PBR28 standardized uptake values
-
Yoder KK, Nho K, Risacher SL, Kim S, Shen L, Saykin AJ. Influence of TSPO genotype on 11C-PBR28 standardized uptake values. J Nucl Med 2013, 54:1320-1322.
-
(2013)
J Nucl Med
, vol.54
, pp. 1320-1322
-
-
Yoder, K.K.1
Nho, K.2
Risacher, S.L.3
Kim, S.4
Shen, L.5
Saykin, A.J.6
-
86
-
-
32844465920
-
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
-
Gong JP, Onaivi ES, Ishiguro H, Liu QR, Tagliaferro PA, Brusco A, Uhl GR. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 2006, 1071:10-23.
-
(2006)
Brain Res
, vol.1071
, pp. 10-23
-
-
Gong, J.P.1
Onaivi, E.S.2
Ishiguro, H.3
Liu, Q.R.4
Tagliaferro, P.A.5
Brusco, A.6
Uhl, G.R.7
-
87
-
-
26844504226
-
Identification and functional characterization of brainstem cannabinoid CB2 receptors
-
Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 2005, 310:329-332.
-
(2005)
Science
, vol.310
, pp. 329-332
-
-
Van Sickle, M.D.1
Duncan, M.2
Kingsley, P.J.3
Mouihate, A.4
Urbani, P.5
Mackie, K.6
Stella, N.7
Makriyannis, A.8
Piomelli, D.9
Davison, J.S.10
Marnett, L.J.11
Di Marzo, V.12
Pittman, Q.J.13
Patel, K.D.14
Sharkey, K.A.15
-
88
-
-
34548069374
-
Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence
-
Esposito G, Iuvone T, Savani C, Scuderi C, De Filippis D, Papa M, Di Marzo V, Steardo L. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. J Pharmacol Exp Ther 2007, 322:1144-1152.
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 1144-1152
-
-
Esposito, G.1
Iuvone, T.2
Savani, C.3
Scuderi, C.4
De Filippis, D.5
Papa, M.6
Di Marzo, V.7
Steardo, L.8
-
89
-
-
38349087528
-
Cannabinoid CB2 receptors in human brain inflammation
-
Benito C, Tolon RM, Pazos MR, Nunez E, Castillo AI, Romero J. Cannabinoid CB2 receptors in human brain inflammation. Br J Pharmacol 2008, 153:277-285.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 277-285
-
-
Benito, C.1
Tolon, R.M.2
Pazos, M.R.3
Nunez, E.4
Castillo, A.I.5
Romero, J.6
-
90
-
-
77955323562
-
Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
-
Horti AG, Gao Y, Ravert HT, Finley P, Valentine H, Wong DF, Endres CJ, Savonenko AV, Dannals RF. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2). Bioorg Med Chem 2010, 18:5202-5207.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 5202-5207
-
-
Horti, A.G.1
Gao, Y.2
Ravert, H.T.3
Finley, P.4
Valentine, H.5
Wong, D.F.6
Endres, C.J.7
Savonenko, A.V.8
Dannals, R.F.9
-
91
-
-
84855812968
-
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in Tg APP 2576 mice
-
Martin-Moreno AM, Brera B, Spuch C, Carro E, Garcia-Garcia L, Delgado M, Pozo MA, Innamorato NG, Cuadrado A, de Ceballos ML. Prolonged oral cannabinoid administration prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in Tg APP 2576 mice. J Neuroinflammation 2012, 9:8.
-
(2012)
J Neuroinflammation
, vol.9
, pp. 8
-
-
Martin-Moreno, A.M.1
Brera, B.2
Spuch, C.3
Carro, E.4
Garcia-Garcia, L.5
Delgado, M.6
Pozo, M.A.7
Innamorato, N.G.8
Cuadrado, A.9
de Ceballos, M.L.10
-
92
-
-
84870489074
-
Activation of the CB2 receptor system reverses amyloid-induced memory deficiency
-
Wu J, Bie B, Yang H, Xu JJ, Brown DL, Naguib M. Activation of the CB2 receptor system reverses amyloid-induced memory deficiency. Neurobiol Aging 2013, 34:791-804.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 791-804
-
-
Wu, J.1
Bie, B.2
Yang, H.3
Xu, J.J.4
Brown, D.L.5
Naguib, M.6
-
93
-
-
84893494322
-
CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease
-
Koppel J, Vingtdeux V, Marambaud P, d'Abramo C, Jimenez H, Stauber M, Friedman R, Davies P. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Mol Med 2014, 20:29-36.
-
(2014)
Mol Med
, vol.20
, pp. 29-36
-
-
Koppel, J.1
Vingtdeux, V.2
Marambaud, P.3
d'Abramo, C.4
Jimenez, H.5
Stauber, M.6
Friedman, R.7
Davies, P.8
-
95
-
-
84862576493
-
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
-
Allen NJ, Bennett ML, Foo LC, Wang GX, Chakraborty C, Smith SJ, Barres BA. Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature 2012, 486:410-414.
-
(2012)
Nature
, vol.486
, pp. 410-414
-
-
Allen, N.J.1
Bennett, M.L.2
Foo, L.C.3
Wang, G.X.4
Chakraborty, C.5
Smith, S.J.6
Barres, B.A.7
-
96
-
-
72149090382
-
Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis
-
Hughes EG, Elmariah SB, Balice-Gordon RJ. Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis. Mol Cell Neurosci 2010, 43:136-145.
-
(2010)
Mol Cell Neurosci
, vol.43
, pp. 136-145
-
-
Hughes, E.G.1
Elmariah, S.B.2
Balice-Gordon, R.J.3
-
97
-
-
0035951508
-
Control of synapse number by glia
-
Ullian EM, Sapperstein SK, Christopherson KS, Barres BA. Control of synapse number by glia. Science 2001, 291:657-661.
-
(2001)
Science
, vol.291
, pp. 657-661
-
-
Ullian, E.M.1
Sapperstein, S.K.2
Christopherson, K.S.3
Barres, B.A.4
-
98
-
-
70449678738
-
Molecular dissection of reactive astrogliosis and glial scar formation
-
Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009, 32:638-647.
-
(2009)
Trends Neurosci
, vol.32
, pp. 638-647
-
-
Sofroniew, M.V.1
-
99
-
-
77957069073
-
Astrocytes in Alzheimer's disease
-
Verkhratsky A, Olabarria M, Noristani HN, Yeh CY, Rodriguez JJ. Astrocytes in Alzheimer's disease. Neurotherapeutics 2010, 7:399-412.
-
(2010)
Neurotherapeutics
, vol.7
, pp. 399-412
-
-
Verkhratsky, A.1
Olabarria, M.2
Noristani, H.N.3
Yeh, C.Y.4
Rodriguez, J.J.5
-
100
-
-
0024436506
-
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
-
Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 1989, 24:173-182.
-
(1989)
J Neuroimmunol
, vol.24
, pp. 173-182
-
-
Itagaki, S.1
McGeer, P.L.2
Akiyama, H.3
Zhu, S.4
Selkoe, D.5
-
101
-
-
47249162481
-
Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology
-
Hoozemans JJ, Rozemuller JM, van Haastert ES, Veerhuis R, Eikelenboom P. Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology. Curr Pharm Des 2008, 14:1419-1427.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 1419-1427
-
-
Hoozemans, J.J.1
Rozemuller, J.M.2
van Haastert, E.S.3
Veerhuis, R.4
Eikelenboom, P.5
-
102
-
-
0037088914
-
Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
-
Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN. Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Nucl Med 2002, 22:2246-2254.
-
(2002)
J Nucl Med
, vol.22
, pp. 2246-2254
-
-
Jantzen, P.T.1
Connor, K.E.2
DiCarlo, G.3
Wenk, G.L.4
Wallace, J.L.5
Rojiani, A.M.6
Coppola, D.7
Morgan, D.8
Gordon, M.N.9
-
103
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Nucl Med 2000, 20:5709-5714.
-
(2000)
J Nucl Med
, vol.20
, pp. 5709-5714
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
Chen, P.4
Beech, W.5
Teter, B.6
Tran, T.7
Ubeda, O.8
Ashe, K.H.9
Frautschy, S.A.10
Cole, G.M.11
-
104
-
-
0035691115
-
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
-
Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging 2001, 22:983-991.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 983-991
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
Gahtan, E.4
Ubeda, O.5
Beech, W.6
Overmier, J.B.7
Hsiao-Ashec, K.8
Frautschy, S.A.9
Cole, G.M.10
-
105
-
-
0041921071
-
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
-
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Nucl Med 2003, 23:7504-7509.
-
(2003)
J Nucl Med
, vol.23
, pp. 7504-7509
-
-
Yan, Q.1
Zhang, J.2
Liu, H.3
Babu-Khan, S.4
Vassar, R.5
Biere, A.L.6
Citron, M.7
Landreth, G.8
-
106
-
-
61349096009
-
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
-
Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 2009, 323:1211-1215.
-
(2009)
Science
, vol.323
, pp. 1211-1215
-
-
Kuchibhotla, K.V.1
Lattarulo, C.R.2
Hyman, B.T.3
Bacskai, B.J.4
-
107
-
-
84856235427
-
In vivo imaging of astrocytosis in Alzheimer's disease: an 11C-L-deuteriodeprenyl and PIB PET study
-
Santillo AF, Gambini JP, Lannfelt L, Langstrom B, Ulla-Marja L, Kilander L, Engler H. In vivo imaging of astrocytosis in Alzheimer's disease: an 11C-L-deuteriodeprenyl and PIB PET study. Eur J Nucl Med Mol Imaging 2011, 38:2202-2208.
-
(2011)
Eur J Nucl Med Mol Imaging
, vol.38
, pp. 2202-2208
-
-
Santillo, A.F.1
Gambini, J.P.2
Lannfelt, L.3
Langstrom, B.4
Ulla-Marja, L.5
Kilander, L.6
Engler, H.7
-
108
-
-
33644855958
-
Translational neuroimaging: positron emission tomography studies of monoamine oxidase
-
Fowler JS, Logan J, Volkow ND, Wang GJ. Translational neuroimaging: positron emission tomography studies of monoamine oxidase. Mol Imaging Biol 2005, 7:377-387.
-
(2005)
Mol Imaging Biol
, vol.7
, pp. 377-387
-
-
Fowler, J.S.1
Logan, J.2
Volkow, N.D.3
Wang, G.J.4
-
109
-
-
0030052403
-
Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry
-
Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih JC, Malherbe P, Da Prada M, Richards JG. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience 1996, 70:755-774.
-
(1996)
Neuroscience
, vol.70
, pp. 755-774
-
-
Saura, J.1
Bleuel, Z.2
Ulrich, J.3
Mendelowitsch, A.4
Chen, K.5
Shih, J.C.6
Malherbe, P.7
Da Prada, M.8
Richards, J.G.9
-
110
-
-
0023155136
-
Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET
-
Fowler JS, MacGregor RR, Wolf AP, Arnett CD, Dewey SL, Schlyer D, Christman D, Logan J, Smith M, Sachs H, Aquilonius SM, Bjurling P, Halldin C, Hartvig P, Leenders KL, Lundqvist H, Oreland L, Stalnacke CG, Langstrom B. Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET. Science 1987, 235:481-485.
-
(1987)
Science
, vol.235
, pp. 481-485
-
-
Fowler, J.S.1
MacGregor, R.R.2
Wolf, A.P.3
Arnett, C.D.4
Dewey, S.L.5
Schlyer, D.6
Christman, D.7
Logan, J.8
Smith, M.9
Sachs, H.10
Aquilonius, S.M.11
Bjurling, P.12
Halldin, C.13
Hartvig, P.14
Leenders, K.L.15
Lundqvist, H.16
Oreland, L.17
Stalnacke, C.G.18
Langstrom, B.19
-
111
-
-
0030768730
-
Age-related increases in brain monoamine oxidase B in living healthy human subjects
-
Fowler JS, Volkow ND, Wang GJ, Logan J, Pappas N, Shea C, MacGregor R. Age-related increases in brain monoamine oxidase B in living healthy human subjects. Neurobiol Aging 1997, 18:431-435.
-
(1997)
Neurobiol Aging
, vol.18
, pp. 431-435
-
-
Fowler, J.S.1
Volkow, N.D.2
Wang, G.J.3
Logan, J.4
Pappas, N.5
Shea, C.6
MacGregor, R.7
-
112
-
-
0028145566
-
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
-
Saura J, Luque JM, Cesura AM, Da Prada M, Chan-Palay V, Huber G, Loffler J, Richards JG. Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience 1994, 62:15-30.
-
(1994)
Neuroscience
, vol.62
, pp. 15-30
-
-
Saura, J.1
Luque, J.M.2
Cesura, A.M.3
Da Prada, M.4
Chan-Palay, V.5
Huber, G.6
Loffler, J.7
Richards, J.G.8
-
113
-
-
0034718232
-
Oxidative stress in Alzheimer's disease
-
Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochim Biophys Acta 2000, 1502:139-144.
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 139-144
-
-
Smith, M.A.1
Rottkamp, C.A.2
Nunomura, A.3
Raina, A.K.4
Perry, G.5
-
114
-
-
79957881021
-
Staging anti-inflammatory therapy in Alzheimer's disease
-
Lichtenstein MP, Carriba P, Masgrau R, Pujol A, Galea E. Staging anti-inflammatory therapy in Alzheimer's disease. Front Aging Neurosci 2010, 2:142.
-
(2010)
Front Aging Neurosci
, vol.2
, pp. 142
-
-
Lichtenstein, M.P.1
Carriba, P.2
Masgrau, R.3
Pujol, A.4
Galea, E.5
-
115
-
-
78650415348
-
Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography
-
Gulyas B, Pavlova E, Kasa P, Gulya K, Bakota L, Varszegi S, Keller E, Horvath MC, Nag S, Hermecz I, Magyar K, Halldin C. Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography. Neurochem Int 2011, 58:60-68.
-
(2011)
Neurochem Int
, vol.58
, pp. 60-68
-
-
Gulyas, B.1
Pavlova, E.2
Kasa, P.3
Gulya, K.4
Bakota, L.5
Varszegi, S.6
Keller, E.7
Horvath, M.C.8
Nag, S.9
Hermecz, I.10
Magyar, K.11
Halldin, C.12
-
116
-
-
0038207690
-
Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease
-
Engler H, Lundberg PO, Ekbom K, Nennesmo I, Nilsson A, Bergstrom M, Tsukada H, Hartvig P, Langstrom B. Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease. Eur J Nucl Med Mol Imaging 2003, 30:85-95.
-
(2003)
Eur J Nucl Med Mol Imaging
, vol.30
, pp. 85-95
-
-
Engler, H.1
Lundberg, P.O.2
Ekbom, K.3
Nennesmo, I.4
Nilsson, A.5
Bergstrom, M.6
Tsukada, H.7
Hartvig, P.8
Langstrom, B.9
-
117
-
-
0027433206
-
Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327
-
Fowler JS, Volkow ND, Logan J, Schlyer DJ, MacGregor RR, Wang GJ, Wolf AP, Pappas N, Alexoff D, Shea C, Gatley SJ, Dorflinger E, Yoo K, Morawsky L, Fazzini E. Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327. Neurology 1993, 43:1984-1992.
-
(1993)
Neurology
, vol.43
, pp. 1984-1992
-
-
Fowler, J.S.1
Volkow, N.D.2
Logan, J.3
Schlyer, D.J.4
MacGregor, R.R.5
Wang, G.J.6
Wolf, A.P.7
Pappas, N.8
Alexoff, D.9
Shea, C.10
Gatley, S.J.11
Dorflinger, E.12
Yoo, K.13
Morawsky, L.14
Fazzini, E.15
-
118
-
-
0023125174
-
Cerebral perfusion imaging in Alzheimer's disease. Use of single photon emission computed tomography and iofetamine hydrochloride I 123
-
Johnson KA, Mueller ST, Walshe TM, English RJ, Holman BL. Cerebral perfusion imaging in Alzheimer's disease. Use of single photon emission computed tomography and iofetamine hydrochloride I 123. Arch Neurol 1987, 44:165-168.
-
(1987)
Arch Neurol
, vol.44
, pp. 165-168
-
-
Johnson, K.A.1
Mueller, S.T.2
Walshe, T.M.3
English, R.J.4
Holman, B.L.5
-
119
-
-
0026609568
-
Blinded clinical evaluation of positron emission tomography for diagnosis of probable Alzheimer's disease
-
Powers WJ, Perlmutter JS, Videen TO, Herscovitch P, Griffeth LK, Royal HD, Siegel BA, Morris JC, Berg L. Blinded clinical evaluation of positron emission tomography for diagnosis of probable Alzheimer's disease. Neurology 1992, 42:765-770.
-
(1992)
Neurology
, vol.42
, pp. 765-770
-
-
Powers, W.J.1
Perlmutter, J.S.2
Videen, T.O.3
Herscovitch, P.4
Griffeth, L.K.5
Royal, H.D.6
Siegel, B.A.7
Morris, J.C.8
Berg, L.9
-
120
-
-
71449091153
-
Arterial spin labelling at 3-T MR imaging for detection of individuals with Alzheimer's disease
-
Yoshiura T, Hiwatashi A, Noguchi T, Yamashita K, Ohyagi Y, Monji A, Nagao E, Kamano H, Togao O, Honda H. Arterial spin labelling at 3-T MR imaging for detection of individuals with Alzheimer's disease. Eur Radiol 2009, 19:2819-2825.
-
(2009)
Eur Radiol
, vol.19
, pp. 2819-2825
-
-
Yoshiura, T.1
Hiwatashi, A.2
Noguchi, T.3
Yamashita, K.4
Ohyagi, Y.5
Monji, A.6
Nagao, E.7
Kamano, H.8
Togao, O.9
Honda, H.10
-
121
-
-
0030877181
-
Quantitative assessment of cerebral blood flow in patients with Alzheimer's disease by SPECT
-
Bartenstein P, Minoshima S, Hirsch C, Buch K, Willoch F, Mosch D, Schad D, Schwaiger M, Kurz A. Quantitative assessment of cerebral blood flow in patients with Alzheimer's disease by SPECT. J Nucl Med 1997, 38:1095-1101.
-
(1997)
J Nucl Med
, vol.38
, pp. 1095-1101
-
-
Bartenstein, P.1
Minoshima, S.2
Hirsch, C.3
Buch, K.4
Willoch, F.5
Mosch, D.6
Schad, D.7
Schwaiger, M.8
Kurz, A.9
-
122
-
-
34548121631
-
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases
-
Sun GY, Horrocks LA, Farooqui AA. The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem 2007, 103:1-16.
-
(2007)
J Neurochem
, vol.103
, pp. 1-16
-
-
Sun, G.Y.1
Horrocks, L.A.2
Farooqui, A.A.3
-
123
-
-
0025358788
-
Arachidonic acid cascade and signal transduction
-
Shimizu T, Wolfe LS. Arachidonic acid cascade and signal transduction. J Neurochem 1990, 55:1-15.
-
(1990)
J Neurochem
, vol.55
, pp. 1-15
-
-
Shimizu, T.1
Wolfe, L.S.2
-
124
-
-
0037201940
-
Phospholipase A(2) regulation of arachidonic acid mobilization
-
Balsinde J, Winstead MV, Dennis EA. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett 2002, 531:2-6.
-
(2002)
FEBS Lett
, vol.531
, pp. 2-6
-
-
Balsinde, J.1
Winstead, M.V.2
Dennis, E.A.3
-
126
-
-
33745266737
-
Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
-
Park JY, Pillinger MH, Abramson SB. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin Immunol 2006, 119:229-240.
-
(2006)
Clin Immunol
, vol.119
, pp. 229-240
-
-
Park, J.Y.1
Pillinger, M.H.2
Abramson, S.B.3
-
127
-
-
0028338536
-
Diversity of group types, regulation, and function of phospholipase A2
-
Dennis EA. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 1994, 269:13057-13060.
-
(1994)
J Biol Chem
, vol.269
, pp. 13057-13060
-
-
Dennis, E.A.1
-
128
-
-
0033394501
-
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus
-
Weichel O, Hilgert M, Chatterjee SS, Lehr M, Klein J. Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 1999, 360:609-615.
-
(1999)
Naunyn Schmiedebergs Arch Pharmacol
, vol.360
, pp. 609-615
-
-
Weichel, O.1
Hilgert, M.2
Chatterjee, S.S.3
Lehr, M.4
Klein, J.5
-
129
-
-
0042536471
-
Neuronal and glial calcium signaling in Alzheimer's disease
-
Mattson MP, Chan SL. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 2003, 34:385-397.
-
(2003)
Cell Calcium
, vol.34
, pp. 385-397
-
-
Mattson, M.P.1
Chan, S.L.2
-
130
-
-
0029665941
-
Activation of phospholipase A2 by amyloid beta-peptides in vitro
-
Lehtonen JY, Holopainen JM, Kinnunen PK. Activation of phospholipase A2 by amyloid beta-peptides in vitro. Biochemistry 1996, 35:9407-9414.
-
(1996)
Biochemistry
, vol.35
, pp. 9407-9414
-
-
Lehtonen, J.Y.1
Holopainen, J.M.2
Kinnunen, P.K.3
-
131
-
-
0023923640
-
Glutamate transmission and toxicity in Alzheimer's disease
-
Greenamyre JT, Maragos WF, Albin RL, Penney JB, Young AB. Glutamate transmission and toxicity in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 1988, 12:421-430.
-
(1988)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.12
, pp. 421-430
-
-
Greenamyre, J.T.1
Maragos, W.F.2
Albin, R.L.3
Penney, J.B.4
Young, A.B.5
-
132
-
-
0842346368
-
Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
-
Montine KS, Quinn JF, Zhang J, Fessel JP, Roberts LJ, Morrow JD, Montine TJ. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids 2004, 128:117-124.
-
(2004)
Chem Phys Lipids
, vol.128
, pp. 117-124
-
-
Montine, K.S.1
Quinn, J.F.2
Zhang, J.3
Fessel, J.P.4
Roberts, L.J.5
Morrow, J.D.6
Montine, T.J.7
-
133
-
-
0025332027
-
Anti-inflammatory drugs and Alzheimer disease
-
McGeer PL, McGeer E, Rogers J, Sibley J. Anti-inflammatory drugs and Alzheimer disease. Lancet 1990, 335:1037.
-
(1990)
Lancet
, vol.335
, pp. 1037
-
-
McGeer, P.L.1
McGeer, E.2
Rogers, J.3
Sibley, J.4
-
134
-
-
84899519009
-
Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?
-
doi:10.3389/fnagi.2010.00019
-
Imbimbo BP, Solfrizzi V, Panza F. Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?. Front Aging Neurosci 2010, 2. doi:10.3389/fnagi.2010.00019.
-
(2010)
Front Aging Neurosci
, vol.2
-
-
Imbimbo, B.P.1
Solfrizzi, V.2
Panza, F.3
-
135
-
-
3242803587
-
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
-
Szekely CA, Thorne JE, Zandi PP, Ek M, Messias E, Breitner JC, Goodman SN. Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 2004, 23:159-169.
-
(2004)
Neuroepidemiology
, vol.23
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
Ek, M.4
Messias, E.5
Breitner, J.C.6
Goodman, S.N.7
-
136
-
-
0037167542
-
Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
-
Cache County Study I
-
Zandi PP, Anthony JC, Hayden KM, Mehta K, Mayer L, Breitner JC, . Cache County Study I Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 2002, 59:880-886. Cache County Study I.
-
(2002)
Neurology
, vol.59
, pp. 880-886
-
-
Zandi, P.P.1
Anthony, J.C.2
Hayden, K.M.3
Mehta, K.4
Mayer, L.5
Breitner, J.C.6
-
137
-
-
37849044699
-
NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type
-
Szekely CA, Breitner JC, Fitzpatrick AL, Rea TD, Psaty BM, Kuller LH, Zandi PP. NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type. Neurology 2008, 70:17-24.
-
(2008)
Neurology
, vol.70
, pp. 17-24
-
-
Szekely, C.A.1
Breitner, J.C.2
Fitzpatrick, A.L.3
Rea, T.D.4
Psaty, B.M.5
Kuller, L.H.6
Zandi, P.P.7
-
138
-
-
66649131390
-
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
-
Breitner JC, Haneuse SJ, Walker R, Dublin S, Crane PK, Gray SL, Larson EB. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology 2009, 72:1899-1905.
-
(2009)
Neurology
, vol.72
, pp. 1899-1905
-
-
Breitner, J.C.1
Haneuse, S.J.2
Walker, R.3
Dublin, S.4
Crane, P.K.5
Gray, S.L.6
Larson, E.B.7
-
139
-
-
34547590424
-
Does NSAID use modify cognitive trajectories in the elderly? The Cache County study
-
Hayden KM, Zandi PP, Khachaturian AS, Szekely CA, Fotuhi M, Norton MC, Tschanz JT, Pieper CF, Corcoran C, Lyketsos CG, Breitner JC, Welsh-Bohmer KA. Does NSAID use modify cognitive trajectories in the elderly? The Cache County study. Neurology 2007, 69:275-282.
-
(2007)
Neurology
, vol.69
, pp. 275-282
-
-
Hayden, K.M.1
Zandi, P.P.2
Khachaturian, A.S.3
Szekely, C.A.4
Fotuhi, M.5
Norton, M.C.6
Tschanz, J.T.7
Pieper, C.F.8
Corcoran, C.9
Lyketsos, C.G.10
Breitner, J.C.11
Welsh-Bohmer, K.A.12
-
140
-
-
1842840885
-
Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population
-
Cornelius C, Fastbom J, Winblad B, Viitanen M. Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population. Neuroepidemiology 2004, 23:135-143.
-
(2004)
Neuroepidemiology
, vol.23
, pp. 135-143
-
-
Cornelius, C.1
Fastbom, J.2
Winblad, B.3
Viitanen, M.4
-
141
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use
-
Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997, 48:626-632.
-
(1997)
Neurology
, vol.48
, pp. 626-632
-
-
Stewart, W.F.1
Kawas, C.2
Corrada, M.3
Metter, E.J.4
-
142
-
-
77953060906
-
Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model
-
Van Dam D, Coen K, De Deyn PP. Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. J Psychopharmacol 2010, 24:383-388.
-
(2010)
J Psychopharmacol
, vol.24
, pp. 383-388
-
-
Van Dam, D.1
Coen, K.2
De Deyn, P.P.3
-
143
-
-
41949119161
-
Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice
-
McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res 2008, 1207:225-236.
-
(2008)
Brain Res
, vol.1207
, pp. 225-236
-
-
McKee, A.C.1
Carreras, I.2
Hossain, L.3
Ryu, H.4
Klein, W.L.5
Oddo, S.6
LaFerla, F.M.7
Jenkins, B.G.8
Kowall, N.W.9
Dedeoglu, A.10
-
144
-
-
39749188810
-
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
-
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain 2008, 131:651-664.
-
(2008)
Brain
, vol.131
, pp. 651-664
-
-
Kotilinek, L.A.1
Westerman, M.A.2
Wang, Q.3
Panizzon, K.4
Lim, G.P.5
Simonyi, A.6
Lesne, S.7
Falinska, A.8
Younkin, L.H.9
Younkin, S.G.10
Rowan, M.11
Cleary, J.12
Wallis, R.A.13
Sun, G.Y.14
Cole, G.15
Frautschy, S.16
Anwyl, R.17
Ashe, K.H.18
-
145
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001, 414:212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Bulter, T.11
Kang, D.E.12
Marquez-Sterling, N.13
Golde, T.E.14
Koo, E.H.15
-
146
-
-
0037200076
-
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein
-
Avramovich Y, Amit T, Youdim MB. Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. J Biol Chem 2002, 277:31466-31473.
-
(2002)
J Biol Chem
, vol.277
, pp. 31466-31473
-
-
Avramovich, Y.1
Amit, T.2
Youdim, M.B.3
-
147
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
-
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A 2006, 103:443-448.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.10
Walter, J.11
Klockgether, T.12
van Leuven, F.13
Heneka, M.T.14
-
148
-
-
19344361883
-
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models
-
Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models. Neuropsychopharmacology 2005, 30:1111-1120.
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. 1111-1120
-
-
Morihara, T.1
Teter, B.2
Yang, F.3
Lim, G.P.4
Boudinot, S.5
Boudinot, F.D.6
Frautschy, S.A.7
Cole, G.M.8
-
149
-
-
46049108790
-
No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
-
Szekely CA, Green RC, Breitner JC, Ostbye T, Beiser AS, Corrada MM, Dodge HH, Ganguli M, Kawas CH, Kuller LH, Psaty BM, Resnick SM, Wolf PA, Zonderman AB, Welsh-Bohmer KA, Zandi PP. No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology 2008, 70:2291-2298.
-
(2008)
Neurology
, vol.70
, pp. 2291-2298
-
-
Szekely, C.A.1
Green, R.C.2
Breitner, J.C.3
Ostbye, T.4
Beiser, A.S.5
Corrada, M.M.6
Dodge, H.H.7
Ganguli, M.8
Kawas, C.H.9
Kuller, L.H.10
Psaty, B.M.11
Resnick, S.M.12
Wolf, P.A.13
Zonderman, A.B.14
Welsh-Bohmer, K.A.15
Zandi, P.P.16
-
150
-
-
0035968743
-
Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation
-
Thomas T, Nadackal TG, Thomas K. Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation. Neuroreport 2001, 12:3263-3267.
-
(2001)
Neuroreport
, vol.12
, pp. 3263-3267
-
-
Thomas, T.1
Nadackal, T.G.2
Thomas, K.3
-
151
-
-
45149105232
-
Substrate-targeting gamma-secretase modulators
-
Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Substrate-targeting gamma-secretase modulators. Nature 2008, 453:925-929.
-
(2008)
Nature
, vol.453
, pp. 925-929
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
Moore, B.11
Rangachari, V.12
Cusack, B.13
Eriksen, J.14
Jansen-West, K.15
Verbeeck, C.16
Yager, D.17
Eckman, C.18
Ye, W.19
Sagi, S.20
Cottrell, B.A.21
Torpey, J.22
Rosenberry, T.L.23
Fauq, A.24
Wolfe, M.S.25
Schmidt, B.26
Walsh, D.M.27
Koo, E.H.28
Golde, T.E.29
more..
-
152
-
-
0034081386
-
Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs
-
Alafuzoff I, Overmyer M, Helisalmi S, Soininen H. Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs. J Alzheimers Dis 2000, 2:37-46.
-
(2000)
J Alzheimers Dis
, vol.2
, pp. 37-46
-
-
Alafuzoff, I.1
Overmyer, M.2
Helisalmi, S.3
Soininen, H.4
-
153
-
-
0034047831
-
Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease
-
Halliday GM, Shepherd CE, McCann H, Reid WG, Grayson DA, Broe GA, Kril JJ. Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease. Arch Neurol 2000, 57:831-836.
-
(2000)
Arch Neurol
, vol.57
, pp. 831-836
-
-
Halliday, G.M.1
Shepherd, C.E.2
McCann, H.3
Reid, W.G.4
Grayson, D.A.5
Broe, G.A.6
Kril, J.J.7
-
154
-
-
0028103819
-
Inflammatory mechanisms in Alzheimer's disease: implications for therapy
-
Aisen PS, Davis KL. Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 1994, 151:1105-1113.
-
(1994)
Am J Psychiatry
, vol.151
, pp. 1105-1113
-
-
Aisen, P.S.1
Davis, K.L.2
-
155
-
-
0027268393
-
Clinical trial of indomethacin in Alzheimer's disease
-
Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, Kaszniak AW, Zalinski J, Cofield M, Mansukhani L, Willson P, Kogan F. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993, 43:1609-1611.
-
(1993)
Neurology
, vol.43
, pp. 1609-1611
-
-
Rogers, J.1
Kirby, L.C.2
Hempelman, S.R.3
Berry, D.L.4
McGeer, P.L.5
Kaszniak, A.W.6
Zalinski, J.7
Cofield, M.8
Mansukhani, L.9
Willson, P.10
Kogan, F.11
-
156
-
-
0033551547
-
A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
-
Scharf S, Mander A, Ugoni A, Vajda F, Christophidis N. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 1999, 53:197-201.
-
(1999)
Neurology
, vol.53
, pp. 197-201
-
-
Scharf, S.1
Mander, A.2
Ugoni, A.3
Vajda, F.4
Christophidis, N.5
-
157
-
-
0037046179
-
Randomized pilot study of nimesulide treatment in Alzheimer's disease
-
Aisen PS, Schmeidler J, Pasinetti GM. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 2002, 58:1050-1054.
-
(2002)
Neurology
, vol.58
, pp. 1050-1054
-
-
Aisen, P.S.1
Schmeidler, J.2
Pasinetti, G.M.3
-
158
-
-
33845803191
-
Long-term efficacy and safety of celecoxib in Alzheimer's disease
-
Soininen H, West C, Robbins J, Niculescu L. Long-term efficacy and safety of celecoxib in Alzheimer's disease. Dement Geriatr Cogn Disord 2007, 23:8-21.
-
(2007)
Dement Geriatr Cogn Disord
, vol.23
, pp. 8-21
-
-
Soininen, H.1
West, C.2
Robbins, J.3
Niculescu, L.4
-
159
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
-
Alzheimer's Disease Cooperative Study
-
Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, Farlow MR, Jin S, Thomas RG, Thal LJ, . Alzheimer's Disease Cooperative Study Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 2003, 289:2819-2826. Alzheimer's Disease Cooperative Study.
-
(2003)
JAMA
, vol.289
, pp. 2819-2826
-
-
Aisen, P.S.1
Schafer, K.A.2
Grundman, M.3
Pfeiffer, E.4
Sano, M.5
Davis, K.L.6
Farlow, M.R.7
Jin, S.8
Thomas, R.G.9
Thal, L.J.10
-
160
-
-
0345830739
-
Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study
-
Rofecoxib Protocol 091 Study Group
-
Reines SA, Block GA, Morris JC, Liu G, Nessly ML, Lines CR, Norman BA, Baranak CC, . Rofecoxib Protocol 091 Study Group Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology 2004, 62:66-71. Rofecoxib Protocol 091 Study Group.
-
(2004)
Neurology
, vol.62
, pp. 66-71
-
-
Reines, S.A.1
Block, G.A.2
Morris, J.C.3
Liu, G.4
Nessly, M.L.5
Lines, C.R.6
Norman, B.A.7
Baranak, C.C.8
-
161
-
-
66849143701
-
A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease
-
Pasqualetti P, Bonomini C, Dal Forno G, Paulon L, Sinforiani E, Marra C, Rossini PM, Zanetti O. A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease. Aging Clin Exp Res 2009, 21:102-110.
-
(2009)
Aging Clin Exp Res
, vol.21
, pp. 102-110
-
-
Pasqualetti, P.1
Bonomini, C.2
Dal Forno, G.3
Paulon, L.4
Sinforiani, E.5
Marra, C.6
Rossini, P.M.7
Zanetti, O.8
-
162
-
-
33847373072
-
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
-
ADAPT Research Group
-
ADAPT Research Group Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). PLoS Clin Trials 2006, 1:e33. ADAPT Research Group.
-
(2006)
PLoS Clin Trials
, vol.1
-
-
-
163
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
Dominantly Inherited Alzheimer Network
-
Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC, . Dominantly Inherited Alzheimer Network Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012, 367:795-804. Dominantly Inherited Alzheimer Network.
-
(2012)
N Engl J Med
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.3
Fagan, A.M.4
Goate, A.5
Fox, N.C.6
Marcus, D.S.7
Cairns, N.J.8
Xie, X.9
Blazey, T.M.10
Holtzman, D.M.11
Santacruz, A.12
Buckles, V.13
Oliver, A.14
Moulder, K.15
Aisen, P.S.16
Ghetti, B.17
Klunk, W.E.18
McDade, E.19
Martins, R.N.20
Masters, C.L.21
Mayeux, R.22
Ringman, J.M.23
Rossor, M.N.24
Schofield, P.R.25
Sperling, R.A.26
Salloway, S.27
Morris, J.C.28
more..
-
164
-
-
84863300949
-
Early-onset familial Alzheimer's disease (EOFAD)
-
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S. Early-onset familial Alzheimer's disease (EOFAD). Can J Neurol Sci 2012, 39:436-445.
-
(2012)
Can J Neurol Sci
, vol.39
, pp. 436-445
-
-
Wu, L.1
Rosa-Neto, P.2
Hsiung, G.Y.3
Sadovnick, A.D.4
Masellis, M.5
Black, S.E.6
Jia, J.7
Gauthier, S.8
-
165
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010, 9:119-128.
-
(2010)
Lancet Neurol
, vol.9
, pp. 119-128
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Shaw, L.M.4
Aisen, P.S.5
Weiner, M.W.6
Petersen, R.C.7
Trojanowski, J.Q.8
-
166
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 1998, 95:6448-6453.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
167
-
-
84875912433
-
Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
-
Jucaite A, Cselenyi Z, Arvidsson A, Ahlberg G, Julin P, Varnas K, Stenkrona P, Andersson J, Halldin C, Farde L. Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects. EJNMMI Res 2012, 2:15.
-
(2012)
EJNMMI Res
, vol.2
, pp. 15
-
-
Jucaite, A.1
Cselenyi, Z.2
Arvidsson, A.3
Ahlberg, G.4
Julin, P.5
Varnas, K.6
Stenkrona, P.7
Andersson, J.8
Halldin, C.9
Farde, L.10
-
168
-
-
33847333156
-
Reference and target region modeling of [11C]-(R)-PK11195 brain studies
-
Turkheimer FE, Edison P, Pavese N, Roncaroli F, Anderson AN, Hammers A, Gerhard A, Hinz R, Tai YF, Brooks DJ. Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J Nucl Med 2007, 48:158-167.
-
(2007)
J Nucl Med
, vol.48
, pp. 158-167
-
-
Turkheimer, F.E.1
Edison, P.2
Pavese, N.3
Roncaroli, F.4
Anderson, A.N.5
Hammers, A.6
Gerhard, A.7
Hinz, R.8
Tai, Y.F.9
Brooks, D.J.10
-
169
-
-
84904386126
-
Reproducibility of the 11C-PBR28 PET Signal
-
Reproducibility of the 11C-PBR28 PET Signal. [http://www.clinicaltrials.gov/ct2/show/NCT02086240].
-
-
-
-
170
-
-
84904386127
-
Study of [11C]PBR28 TSPO PET as a disease marker in MS patients
-
Study of [11C]PBR28 TSPO PET as a disease marker in MS patients. [http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=16651].
-
-
-
-
171
-
-
48749114264
-
Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease
-
Tomasi G, Edison P, Bertoldo A, Roncaroli F, Singh P, Gerhard A, Cobelli C, Brooks DJ, Turkheimer FE. Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease. J Nucl Med 2008, 49:1249-1256.
-
(2008)
J Nucl Med
, vol.49
, pp. 1249-1256
-
-
Tomasi, G.1
Edison, P.2
Bertoldo, A.3
Roncaroli, F.4
Singh, P.5
Gerhard, A.6
Cobelli, C.7
Brooks, D.J.8
Turkheimer, F.E.9
-
172
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
European Alzheimer's Disease Initiative Investigators
-
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, , et al. European Alzheimer's Disease Initiative Investigators Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009, 41:1094-1099. European Alzheimer's Disease Initiative Investigators.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
Campion, D.4
Sleegers, K.5
Hiltunen, M.6
Combarros, O.7
Zelenika, D.8
Bullido, M.J.9
Tavernier, B.10
Letenneur, L.11
Bettens, K.12
Berr, C.13
Pasquier, F.14
Fiévet, N.15
Barberger-Gateau, P.16
Engelborghs, S.17
De Deyn, P.18
Mateo, I.19
Franck, A.20
Helisalmi, S.21
Porcellini, E.22
Hanon, O.23
de Pancorbo, M.M.24
Lendon, C.25
Dufouil, C.26
Jaillard, C.27
Leveillard, T.28
Alvarez, V.29
Bosco, P.30
more..
-
173
-
-
84861318502
-
Genome-wide association study of Alzheimer's disease
-
Alzheimer's Disease Neuroimaging Initiative
-
Kamboh MI, Demirci FY, Wang X, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Jun G, Baldwin C, Logue MW, Buros J, Farrer L, Pericak-Vance MA, Haines JL, Sweet RA, Ganguli M, Feingold E, Dekosky ST, Lopez OL, Barmada MM, . Alzheimer's Disease Neuroimaging Initiative Genome-wide association study of Alzheimer's disease. Transl Psychiatry 2012, 2:e117. Alzheimer's Disease Neuroimaging Initiative.
-
(2012)
Transl Psychiatry
, vol.2
-
-
Kamboh, M.I.1
Demirci, F.Y.2
Wang, X.3
Minster, R.L.4
Carrasquillo, M.M.5
Pankratz, V.S.6
Younkin, S.G.7
Saykin, A.J.8
Jun, G.9
Baldwin, C.10
Logue, M.W.11
Buros, J.12
Farrer, L.13
Pericak-Vance, M.A.14
Haines, J.L.15
Sweet, R.A.16
Ganguli, M.17
Feingold, E.18
Dekosky, S.T.19
Lopez, O.L.20
Barmada, M.M.21
more..
|