Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation

Journal of Nuclear Medicine

Volumn 50, Issue 3, 2009, Pages 468-476

  Chauveau, Fabien ^a,b,c   Van Camp, Nadja ^a,b   Dollé, Frederic ^a   Kuhnast, Bertrand ^a   Hinnen, Françoise ^a   Damont, Annelaure ^a   Boutin, Hervé ^a,b,d   James, Michelle ^e   Kassiou, Michael ^e,f   Tavitian, Bertrand ^a,b  

^a DIF   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LYON   (France)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF SYDNEY   (Australia)

Author keywords

11C DPA 713; 11C PK11195; 18F DPA 714; Neuroinflammation; PBR; Peripheral benzodiazepine receptor; PET; TSPO (18 kDa)

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; DPA 713; DPA 714; FLUORINE 18; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; N,N DIETHYL 2 [2 (4 METHOXYPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 ALPHA]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL 2 [2 (4 METHOXYPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 ALPHA]PYRIMIDIN 3 YL]ACETAMIDE C 11; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 ALPHA]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 ALPHA]PYRIMIDIN 3 YL]ACETAMIDE F 18; PYRAZOLOPYRIMIDINE DERIVATIVE; TRANSLOCATOR PROTEIN TSPO 18KDA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG BIOAVAILABILITY; DRUG UPTAKE; ENCEPHALITIS; IMAGE ANALYSIS; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO;

ACETAMIDES; ACUTE DISEASE; ANIMALS; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; FLUORINE RADIOISOTOPES; INFLAMMATION; ISOQUINOLINES; LIGANDS; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, GABA;

EID: 62449175342     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058669     Document Type: Article

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