Age-related increases in brain monoamine oxidase B in living healthy human subjects

Neurobiology of Aging

Volumn 18, Issue 4, 1997, Pages 431-435

  Fowler, J S ^a,b   Volkow, N D ^a,b   Wang, G J ^a   Logan, J ^a   Pappas, N ^a   Shea, C ^a   MacGregor, R ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Aging; Human brain; MAO B; Positron emission tomography (PET)

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BRAIN MONOAMINE; GLUCOSE;

ADULT; AGED; AGING; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN REGION; BRAIN TOMOGRAPHY; CINGULATE GYRUS; DRUG METABOLISM; FEMALE; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AGE DISTRIBUTION; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BRAIN; CEREBELLUM; FEMALE; FLUORODEOXYGLUCOSE F18; FRONTAL LOBE; GYRUS CINGULI; HUMANS; MALE; MATHEMATICS; MIDDLE AGED; MONOAMINE OXIDASE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030768730     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(97)00037-7     Document Type: Article

References (34)

1. Adolfsson R., Gottfries C. G., Oreland L., Wiberg A., Winblad B. Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci. 27:1980;1029-1034.
2. Alexoff D. L., Shea C., Fowler J. S., King P., Gatley S. J., Schlyer D. J., Wolf A. P. Plasma input function determination for PET using a commercial laboratory robot. Nucl. Med. Biol. 22:1995;893-904.
3. Bench C. J., Lammertsma A. A., Dolan R. J., Brooks D. J., Frackowiak R. S. J. Cerebral monoamine oxidase (MAO B) activity in normal subjects, Alzheimer's disease and Parkinson's disease. J. Cereb. Blood Flow Metab. 13:1993;S246.
4. Bignami A., Dahl D. Gliosis. Kennmann H., Ranson B. R. Neuroglia. 1995;843-858 Oxford University Press, New York.
5. Blomqvist G. On the construction of functional maps in positron emission tomography. J. Cereb. Blood Flow Metab. 4:1984;629-632.
6. Carlsson A. Brain neurotransmitters in aging and dementia. Gerontology. 33:1987;159-167.
7. Chawluk J. B., Dann R., Alavi A., Hurtig H. I., Gur R. E., Resnick S., Zimmerman R. A., Reivich M. The effect of focal cerebral atrophy in positron emission tomographic studies of normal aging. Nucl. Med. Biol. 17:1990;797-804.
8. Cohen G. Monoamine oxidase and oxidative stress at dopaminergic synapses. J. Neural. Transm. Suppl. 32:1990;229-238.
9. Fowler C. J., Wiberg A., Oreland L., Marcusson J., Winblad B. The effect of age on the activity and molecular properties of human brain monoamine oxidase. J. Neural. Transm. 49:1980;1-20.
10. Fowler J. S., Volkow N. D., Wang G.-J., Pappas N., Logan J., MacGregor R., Alexoff D., Shea C., Schlyer D., Wolf A. P., Warner D., Zezulkova I., Cilento R. Inhibition of monoamine oxidase B in the brains of smokers. Nature. 379:1996;733-736.
11. 11C]L-deprenyl-D2 for MAO B mapping in human brain . J. Nucl. Med. 36:1995;1255-1262.
12. Fowler J. S., Volkow N. D., Logan J., Schlyer D. J., MacGregor R. R., Wang G.-J., Wolf A. P., Pappas N., Alexoff D., Shea C., Gatley S. J., Dorflinger E., Yoo K., Morawsky L., Fazzini E. Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease the degree and reversibility of human brain MAO B inhibition by Ro 19 6327 . Neurology. 43:1993;1984-1992.
13. Galva M. D., Bondiolotti G. P., Olasma M., Picotti G. B. Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex. J. Neural. Transm. [Gen. Sect.]. 101:1995;83-94.
14. Hoff A., Riordan R., Alpert R., Volkow N. D. Cognitive function in chronic cocaine abusers. J. Clin. Exp. Neuropsychol. 13:1991;60-61.
15. Irwin I., DeLanney L., Chan P., Sandy M. S., DiMonte D. A., Langston J. W. Nigrostriatal monoamine oxidase A and B in aging squirrel monkeys and C57B1/6 mice. Neurobiology of Aging. 18:1997;235-241.
16. Kornhuber J., Konradi C., Mack-Burkjardt F., Riederer P., Heinsen H., Beckmann H. Ontogenesis of monoamine oxidase A and B in the human brain frontal cortex. Brain Res. 499:1989;81-86.
17. 11C]deuterium-deprenyl in temporal lobe epilepsy. Epilepsia. 36:1995;712-721.
18. 18F]N-methylspiroperidol binding in the basal ganglia comparison of simulations and experimental results from PET studies in baboons . Synapse. 9:1991;195-207.
19. Magistretti P. J., Pellerin L. Cellular bases of brain energy metabolism and their relevance to functional brain imaging Evidence for a prominent role of astrocytes . Cerebral Cortex. 6:1996;50-61.
20. Mann J. J., Petito C., Stanley M., McBride P. A., Chin J., Philogene A. Amine receptor binding and MAO activity in postmortem human brain tissue Effect of age, gender and postmortem delay . Burrows G. D., Norman T. R., Dennerstein L. Clinical and Pharmacological Studies in Psychiatric Disorders. 1985;37-39 John Libbey & Co. Ltd. London.
21. Martin A. J., Friston K. J., Colerbatch J. G., Frackowiak R. S. J. Decreases in regional cerebral blood flow with normal aging. J. Cereb. Blood Flow. Metab. 11:1991;684-689.
22. McGeer P. L., McGeer E. G., Suzuki J. S. Aging and extrapyramidal function. Arch. Neurol. 34:1977;33-35.
23. Moeller J. R., Ishikawa T., Dhawan V., Spetsieris P., Mandel F., Alexander G. E., Grady C., Pietrini P., Eidelberg D. The metabolic topography of normal aging. J. Cereb. Blood Flow. Metab. 16:1996;395-398.
24. Morris J. C., Storandt M., McKeel D. W., Rubin E. H., Price J. L., Grant E. A., Berg L. normal. Neurology. 46:1996;707-719.
25. Palmer A. M., DeKosky S. T. Monoamine neurons in aging and Alzheimer's disease. J. Neural. Transm. [Gen. Sect.]. 91:1993;135-159.
26. Patlak C., Fenstermacher J. D., Blasberg R. G. Graphical evaluation of blood-to-brain transfer constants from multiple time-activity data. J. Cereb. Blood Flow Metab. 3:1983;1-7.
27. Robinson D. S., Davis J. M., Nies A., Ravaris C. L., Sylwester D. Relation of sex and aging to monoamine oxidase activity of human brain, plasma and platelets. Arch. Gen. Psychiatry. 24:1971;536-539.
28. 2 with monoamine oxidase B sites . J. Neurochem. 61:1993;881-889.
29. Saura J., Luque A. M., Cesura M., Da Prada M., Chan-Palay V., Huber G., Loeffler J., Richards J. G. Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience. 62:1994;15-30.
30. Shih J. C. Monoamine oxidase in aging human brain. Singer T. P., von Korff R. W., Murphey D. L. Monoamine oxidase structure, function and altered functions . 1979;Academic Press, New York.
31. Strolin-Benedetti M., Dostert P. Monoamine oxidase, brain ageing and degenerative diseases. Biochem. Pharmacol. 38:1989;555-561.
32. Terry R. D., DeTeresa R., Hansen L. A. Neocortical cell counts in normal human adult aging. Ann Neurol. 21:1987;530-539.
33. Wang G.-J., Volkow N. D., Wolf A. P., Brodie J. D., Hitzemann R. J. Intersubject variability of brain glucose metabolic measurements in young normal males. J. Nucl. Med. 35:1994;1457-1466.
34. Westlund K. N., Denney R. M., Rose R. M., Abell C. W. Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience. 25:1988;439-456.