Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain

Journal of Neurochemistry

Volumn 129, Issue 4, 2014, Pages 712-720

  Tiwari, Anjani K ^a,b   Yui, Joji ^a   Fujinaga, Masayuki ^a   Kumata, Katsushi ^a   Shimoda, Yoko ^a   Yamasaki, Tomoteru ^a   Xie, Lin ^a   Hatori, Akiko ^a   Maeda, Jun ^a   Nengaki, Nobuki ^a,c   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^c Japan   (Japan)

Author keywords

microglia activation; neuroinflammation; positron emission tomography; translocator protein (18 kDa)

Indexed keywords

2 [5 (4 METHOXYPHENYL) 2 OXO 1,3 BENZOXAZOL 3(2H) YL] N METHYL N PHENYLACETAMIDE C11; CARBON 11; METHYL IODIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MALE; METABOLITE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; UPREGULATION;

MUS; RATTUS;

MICROGLIA ACTIVATION; NEUROINFLAMMATION; POSITRON EMISSION TOMOGRAPHY; TRANSLOCATOR PROTEIN (18 KDA); [11C]MBMP;

ACETANILIDES; ANIMALS; ANIMALS, OUTBRED STRAINS; AUTORADIOGRAPHY; BENZOXAZOLES; BINDING, COMPETITIVE; BRAIN; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CARBON RADIOISOTOPES; IMAGING, THREE-DIMENSIONAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; LIGANDS; MALE; MICE; MICROGLIA; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; TISSUE DISTRIBUTION;

EID: 84899486540     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12670     Document Type: Article

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