Novel reference region model reveals increased microglial and reduced vascular binding of11C-(R)-PK11195 in patients with Alzheimer's disease

Journal of Nuclear Medicine

Volumn 49, Issue 8, 2008, Pages 1249-1256

  Tomasi, Giampaolo ^a   Edison, Paul ^b,c   Bertoldo, Alessandra ^a   Roncaroli, Federico ^b   Singh, Poonam ^b   Gerhard, Alexander ^d   Cobelli, Claudio ^a   Brooks, David J ^b,c   Turkheimer, Federico E ^b,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

11C (R) PK11195; Alzheimer's disease; PET; Simplified reference region modeling; Vascular fibrosis

Indexed keywords

BENZODIAZEPINE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ALGORITHM; ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD VOLUME; CADAVER; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MICROGLIA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROBABILITY; SMOOTH MUSCLE; VASCULAR FIBROSIS; VASCULARIZATION;

ALZHEIMER DISEASE; BINDING SITES; BRAIN; CARBON RADIOISOTOPES; HUMANS; ISOQUINOLINES; MICROGLIA; MODELS, NEUROLOGICAL; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GABA-A;

EID: 48749114264     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.050583     Document Type: Article

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