The Kinetochore

Cold Spring Harbor Perspectives in Biology

Volumn 6, Issue 7, 2014, Pages

  Cheeseman, Iain M ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; NONHISTONE PROTEIN;

CELL CYCLE CHECKPOINT; CENTROMERE; CHROMOSOME SEGREGATION; GENETICS; HUMAN; METABOLISM; MICROTUBULE; MITOSIS; PHYSIOLOGY; SPINDLE APPARATUS;

CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; SPINDLE APPARATUS;

EID: 84903793043     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a015826     Document Type: Article

References (135)

1. Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang F. 2010. CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell 19: 245-258.
2. Al-Bassam J, Chang F. 2011. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol 21: 604-614.
3. Amor DJ, Bentley K, Ryan J, Perry J, Wong L, Slater H, Choo KH. 2004. Human centromere repositioning "in progress". Proc Natl Acad Sci 101: 6542-6547.
4. Asbury CL, Gestaut DR, Powers AF, Franck AD, Davis TN. 2006. The Dam1 kinetochore complex harnesses micro-tubule dynamics to produce force and movement. Proc Natl Acad Sci 103: 9873-9878.
5. Bader JR, Vaughan KT. 2010. Dynein at the kinetochore: Timing, interactions and functions. Semin Cell Dev Biol 21: 269-275.
6. Barnhart MC, Kuich PH, Stellfox ME, Ward JA, Bassett EA, Black BE, Foltz DR. 2011. HJURP is aCENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J Cell Biol 194: 229-243.
7. Biggins S. 2013. The composition, functions, and regulation of the budding yeast kinetochore. Genetics 194: 817-846.
8. Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW. 1999. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev 13: 532-544.
9. Black BE, Cleveland DW. 2011. Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell 144: 471-479.
10. Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL, Cleveland DW. 2004. Structural determinants for generating centromeric chromatin. Nature 430: 578-582.
11. Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland DW. 2007. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell 25: 309-322.
12. Campbell CS, Mullins RD. 2007. In vivo visualization of type II plasmid segregation: Bacterial actin filaments pushing plasmids. J Cell Biol 179: 1059-1066.
13. Carroll CW, Milks KJ, Straight AF. 2010. Dual recognition of CENP-A nucleosomes is required for centromere assembly. J Cell Biol 189: 1143-1155.
14. Chan YW, Jeyaprakash AA, Nigg EA, Santamaria A. 2012. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. J Cell Biol 196: 563-571.
15. Cheeseman IM, Desai A. 2008. Molecular architecture of the kinetochore-microtubule interface. Nat Rev Mol Cell Biol 9: 33-46.
16. Cheeseman IM, Anderson S, Jwa M, Green EM, Kang J, Yates JR III, Chan CS, Drubin DG, Barnes G. 2002. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111: 163-172.
17. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR III, Oegema K, Desai A. 2004. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev 18: 2255-2268.
18. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. 2006. The Conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127: 983-997.
19. Chen RH, Waters JC, Salmon ED, Murray AW. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274: 242-246.
20. Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C. 2008. Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res 18: 268-280.
21. Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A. 2005. Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem 280: 29088-29095.
22. Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, et al. 2008. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133: 427-439.
23. Cleveland DW, Mao Y, Sullivan KF. 2003. Centromeres and kinetochores: from epigeneticsto mitotic checkpoint signaling. Cell 112: 407-421.
24. Collins KA, Castillo AR, Tatsutani SY, Biggins S. 2005. De novo kinetochore assembly requires the centromeric His-tone H3 variant. Mol Biol Cell 16: 5649-5660.
25. Cooke CA, Heck MM, Earnshaw WC. 1987. The inner centromere protein (INCENP) antigens: Movement from inner centromere to midbody during mitosis. J Cell Biol 105: 2053-2067.
26. Dambacher S, Deng W, Hahn M, Sadic D, Frohlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G. 2012. CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus 3: 101-110.
27. Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ. 2009. Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr Biol 19: 1467-1472.
28. Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ. 2002. Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 A resolution. J Mol Biol 319: 1097-1113.
29. De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, et al. 2005. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol 15: 214-225.
30. DeLuca JG, Musacchio A. 2012. Structural organization of the kinetochore-microtubule interface. Curr Opin Cell Biol 24: 48-56.
31. DeLuca JG, Moree B, Hickey JM, Kilmartin JV, Salmon ED. 2002. hNuf2 inhibition blocks stable kinetochore-micro-tubule attachment and induces mitotic cell death in HeLa cells. J Cell Biol 159: 549-555.
32. DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED. 2006. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127: 969-982.
33. Desai A, Mitchison TJ. 1997. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol 13: 83-117.
34. Desai A, Rybina S, Muller-Reichert T, Shevchenko A, Shev-chenko A, Hyman A, Oegema K. 2003. KNL-1 directs assembly of the microtubule-binding interface of the ki-netochore in C. elegans. Genes Dev 17: 2421-2435.
35. Dumont S, Salmon ED, Mitchison TJ. 2012. Deformations within moving kinetochores reveal different sites ofactive and passive force generation. Science 337: 355-358.
36. Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G. 2009. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell 137: 485-497.
37. Dunleavy EM, Zhang W, Karpen GH. 2013. Solo or doppio: How many CENP-As make a centromeric nucleosome? Nat Struct Mol Biol 20: 648-650.
38. Earnshaw WC, Rothfield N. 1985. Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91: 313-321.
39. Elowe S. 2011. Bub1 and BubR1: At the interface between chromosome attachment and the spindle checkpoint. Mol Cell Biol 31: 3085-3093.
40. Flemming W. 1880. Beiträge zur Kenntnis der Zelle und ihrer Lebenserscheinungen. Arch Mikrosk Anat 18: 151-259.
41. Foley EA, Maldonado M, Kapoor TM. 2011. Formation of stable attachments between kinetochores and microtu-bules depends on the B56-PP2A phosphatase. Nat Cell Biol 13: 1265-1271.
42. Foltz DR, Jansen LE, Bailey AO, Yates JR 3rd, Bassett EA, Wood S, Black BE, Cleveland DW. 2009. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell 137: 472-484.
43. Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Ob-use C, Yanagida M. 2007. Priming of centromere for CENP-A recruitment by human hMis18a, hMis18b, and M18BP1. Dev Cell 12: 17-30.
44. Gaitanos TN, Santamaria A, Jeyaprakash AA, Wang B, Conti E, Nigg EA. 2009. Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J 28: 1442-1452.
45. Gascoigne KE, Cheeseman IM. 2011. Kinetochore assembly: If you build it, they will come. Curr Opin Cell Biol 23: 102-108.
46. Gascoigne KE, Cheeseman IM. 2013. CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state. J Cell Biol 201: 23-32.
47. Gascoigne KE, Takeuchi K, Suzuki A, Hori T, Fukagawa T, Cheeseman IM. 2011. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleo-somes. Cell 145: 410-422.
48. Gordon DJ, Resio B, Pellman D. 2012. Causes and consequences of aneuploidy in cancer. Nat Rev Genet 13: 189-203.
49. Grishchuk EL, Molodtsov MI, Ataullakhanov FI, McIntosh JR. 2005. Force production by disassembling microtu-bules. Nature 438: 384-388.
50. Grishchuk EL, Efremov AK, Volkov VA, Spiridonov IS, Gu-dimchuk N, Westermann S, Drubin D, Barnes G, McIn-tosh JR, Ataullakhanov FI. 2008. The Dam1 ring binds microtubules strongly enough to bea processive aswell as energy-efficient coupler for chromosome motion. Proc Natl Acad Sci 105: 15423-15428.
51. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. 2011. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinet-ochore attachment. Mol Biol Cell 22: 4236-4246.
52. Hanisch A, Sillje HH, Nigg EA. 2006. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J 25: 5504-5515.
53. Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yana-gida M. 2004. Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 118: 715-729.
54. Hewawasam G, Shivaraju M, Mattingly M, Venkatesh S, Martin-Brown S, Florens L, Workman JL, Gerton JL. 2010. Psh1 is an E3 ubiquitin ligase that targets the cen-tromeric histone variant Cse4. Mol Cell 40: 444-454.
55. Holland AJ, Cleveland DW. 2009. Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 10: 478-487.
56. Hori T, Amano M, Suzuki A, Backer CB, Welburn JP, Dong Y, McEwen BF, Shang WH, Suzuki E, Okawa K, et al. 2008. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. 135: 1039-1052.
57. Hori T, Shang WH, Takeuchi K, Fukagawa T. 2013. The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly. J Cell Biol 200: 45-60.
58. Howell BJ, McEwen BF, Canman JC, Hoffman DB, Farrar EM, Rieder CL, Salmon ED. 2001. Cytoplasmic dynein/ dynactin drives kinetochore protein transport to the spindle poles and has arole in mitotic spindle checkpoint inactivation. J Cell Biol 155: 1159-1172.
59. Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, Li Y, Wang J, Yao X, Shi Y, et al. 2011. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev 25: 901-906.
60. Jansen LET, Black BE, Foltz DR, Cleveland DW. 2007. Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol 176: 795-805.
61. Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA, Conti E. 2012. Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface. Mol Cell 46: 274-286.
62. Joglekar AP, Bouck DC, Molk JN, Bloom KS, Salmon ED. 2006. Molecular architecture of a kinetochore-microtu-bule attachment site. Nat Cell Biol 8: 581-585.
63. Kapoor TM, Lampson MA, Hergert P, Cameron L, Cimini D, Salmon ED, McEwen BF, Khodjakov A. 2006. Chromosomes can congress to the metaphase plate before biorientation. Science 311: 388-391.
64. Karess R. 2005. Rod-Zw10-Zwilch: A key player in the spindle checkpoint. Trends Cell Biol 15: 386-392.
65. Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y. 2013. A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science 340: 1110-1113.
66. Kim Y, Holland AJ, Lan W, Cleveland DW. 2010. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142: 444-455.
67. Kiyomitsu T, Obuse C, Yanagida M. 2007. Human Blinkin/ AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell 13: 663-676.
68. Kline-Smith SL, Khodjakov A, Hergert P, Walczak CE. 2004. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol Biol Cell 15: 1146-1159.
69. Kruse T, Zhang G, Larsen MS, Lischetti T, Streicher W, Kragh Nielsen T, Bjorn SP, Nilsson J. 2013. Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression. J Cell Sci 126: 1086-1092.
70. Lampert F, Hornung P, Westermann S. 2010. The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex. J Cell Biol 189: 641-649.
71. Lampson MA, Cheeseman IM. 2011. Sensing centromere tension: Aurora Band the regulation ofkinetochore function. Trends Cell Biol 21: 133-140.
72. Liu X, Winey M. 2012. The MPS1 family of protein kinases. Annu Rev Biochem 81: 561-585.
73. Liu S-T, Rattner JB, Jablonski SA, Yen TJ. 2006. Mapping the assembly pathways that specify formation of the trilami-nar kinetochore plates in human cells. J Cell Biol 175: 41-53.
74. Liu D, Vader G, Vromans MJ, Lampson MA, Lens SM. 2009. Sensing chromosome bi-orientationbyspatial separation of aurora B kinase from kinetochore substrates. Science 323: 1350-1353.
75. Liu D, Vleugel M, Backer CB, Hori T, Fukagawa T, Cheese-man IM, Lampson MA. 2010. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol 188: 809-820.
76. Liu D, Davydenko O, Lampson MA. 2012. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol 198: 491-499.
77. Maddox PS, Oegema K, Desai A, Cheeseman IM. 2004. "Holo"er than thou: Chromosome segregation and ki-netochore function in C. elegans. Chromosome Res 12: 641-653.
78. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A. 2007. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol 176: 757-763.
79. Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC. 2003. Human CLASP1 is an outer kinet-ochore component that regulates spindle microtubule dynamics. Cell 113: 891-904.
80. Mao Y, Abrieu A, Cleveland DW. 2003. Activating and silencing the mitotic checkpoint through CENP-E-depen-dent activation/inactivation of BubR1. Cell 114: 87-98.
81. Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, et al. 2006. Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J 25: 1273-1284.
82. Martin-Lluesma S, Stucke VM, Nigg EA. 2002. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297: 2267-2270.
83. Masumoto H, Masukata H, Muro Y, Nozaki N, Okazaki T. 1989. A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite. J Cell Biol 109: 1963-1973.
84. Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, Woehlke G, Mayer TU. 2007. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol 17: 488-498.
85. Mazumdar M, Misteli T. 2005. Chromokinesins: Multital-ented players in mitosis. Trends Cell Biol 15: 349-355.
86. McEwen BF, Chan GK, Zubrowski B, Savoian MS, Sauer MT, Yen TJ. 2001. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell 12: 2776-2789.
87. McIntosh JR, Volkov V, Ataullakhanov FI, Grishchuk EL. 2010. Tubulin depolymerization may be an ancient biological motor. J Cell Sci 123: 3425-3434.
88. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. 2005. The yeast DASH complex forms closed rings on microtu-bules. Nat Struct Mol Biol 12: 138-143.
89. Moree B, Meyer CB, Fuller CJ, Straight AF. 2011. CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly. J Cell Biol 194: 855-871.
90. Musacchio A, Salmon ED. 2007. The spindle-assembly checkpoint in space and time. Nat Rev Cancer 8: 379-393.
91. Nasmyth K, Haering CH. 2009. Cohesin: Its roles and mechanisms. Annu Rev Genet 43: 525-558.
92. Nishino T, Takeuchi K, Gascoigne KE, Suzuki A, Hori T, Oyama T, Morikawa K, Cheeseman IM, Fukagawa T. 2012. CENP-T-W-S-X forms a unique centromeric chro-matin structure with a histone-like fold. Cell 148: 487-501.
93. Nishino T, Rago F, Hori T, Tomii K, Cheeseman IM, Fuka-gawa T. 2013. CENP-T provides a structural platform for outer kinetochore assembly. EMBO J 32: 424-436.
94. Nogales E, Wang HW. 2006. Structural intermediates in microtubule assembly and disassembly: How and why? Curr Opin Cell Biol 18: 179-184.
95. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M. 2004. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kineto-chore protein Zwint-1. Nat Cell Biol 6: 1135-1141.
96. Palmer DK, O'Day K, Wener MH, Andrews BS, Margolis RL. 1987. A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones. J Cell Biol 104: 805-815.
97. Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL. 1991. Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive his-tone. Proc Natl Acad Sci 88: 3734-3738.
98. Peters JM. 2006. The anaphase promoting complex/cyclo-some: A machine designed to destroy. Nat Rev Mol Cell Biol 7: 644-656.
99. Petrovic A, Pasqualato S, Dube P, Krenn V, Santaguida S, Cittaro D, Monzani S, Massimiliano L, Keller J, Tarricone A, et al. 2010. The MIS12 complex is aprotein interaction hub for outer kinetochore assembly. J Cell Biol 190: 835-852.
100. Pfarr CM, Coue M, Grissom PM, Hays TS, Porter ME, Mc-Intosh JR. 1990. Cytoplasmic dynein is localized to ki-netochores during mitosis. Nature 345: 263-265.
101. Powers AF, Franck AD, Gestaut DR, Cooper J, Gracyzk B, Wei RR, Wordeman L, Davis TN, Asbury CL. 2009. The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion. Cell 136: 865-875.
102. Przewloka MR, Venkei Z, Bolanos-Garcia VM, Debski J, Dadlez M, Glover DM. 2011. CENP-C is a structural platform for kinetochore assembly. Curr Biol 21: 399-405.
103. Putkey FR, Cramer T, Morphew MK, Silk AD, Johnson RS, McIntosh JR, Cleveland DW. 2002. Unstable ki-netochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 3: 351-365.
104. Raaijmakers JA, Tanenbaum ME, Maia AF, Medema RH. 2009. RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. J Cell Sci 122: 2436-2445.
105. Rago F, Cheeseman IM. 2013. Review series: The functions and consequences offorce atkinetochores. J Cell Biol 200: 557-565.
106. Ranjitkar P, Press MO, Yi X, Baker R, MacCoss MJ, Biggins S. 2010. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Mol Cell 40: 455-464.
107. Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W. 2005. CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol 25: 3967-3981.
108. Salje J, Gayathri P, Lowe J. 2010. The ParMRC system: Molecular mechanisms of plasmid segregation by actin-like filaments. Nat Rev Microbiol 8: 683-692.
109. Schleiffer A, Maier M, Litos G, Lampert F, Hornung P, Mechtler K, Westermann S. 2012. CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14: 604-613.
110. Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, et al. 2012. The kinet-ochore-bound Ska1 complex tracks depolymerizing mi-crotubules and binds to curved protofilaments. Dev Cell 23: 968-980.
111. Screpanti E, De Antoni A, Alushin GM, Petrovic A, Melis T, Nogales E, Musacchio A. 2011. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kineto-chore. Curr Biol 21: 391-398.
112. Silva MC, Bodor DL, Stellfox ME, Martins NM, Hochegger H, Foltz DR, Jansen LE. 2012. Cdk activity couples epi-genetic centromere inheritance to cell cycle progression. Dev Cell 22: 52-63.
113. Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang KT, Mu-sacchio A. 2002. Crystal structure of the tetrameric Mad1-Mad2 core complex: Implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J 21: 2496-2506.
114. Steuer ER, Wordeman L, Schroer TA, Sheetz MP. 1990. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature 345: 266-268.
115. Stumpff J, von Dassow G, Wagenbach M, Asbury C, Worde-man L. 2008. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell 14: 252-262.
116. Sudakin V, Chan GK, Yen TJ. 2001. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 154: 925-936.
117. Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ. 2012. Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell 23: 745-755.
118. Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, et al. 2011. Crystal structure of the human centromeric nucle-osome containing CENP-A. Nature 476: 232-235.
119. Tanaka TU, Rachidi N, Janke C, Pereira G, Galova M, Schie-bel E, Stark MJR, Nasmyth K. 2002. Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108: 317-329.
120. Theis M, Slabicki M, Junqueira M, Paszkowski-Rogacz M, Sontheimer J, Kittler R, Heninger AK, Glatter T, Kruus-maa K, Poser I, et al. 2009. Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. EMBO J 28: 1453-1465.
121. Tien JF, Umbreit NT, Gestaut DR, Franck AD, Cooper J, Wordeman L, Gonen T, Asbury CL, Davis TN. 2010. Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling andis regulated by aurora B. J Cell Biol 189: 713-723.
122. Trinkle-Mulcahy L, Andrews PD, Wickramasinghe S, Slee-man J, Prescott A, Lam YW, Lyon C, Swedlow JR, Lamond AI. 2003. Time-lapse imaging reveals dynamic relocaliza-tion of PP1g throughout the mammalian cell cycle. Mol Biol Cell 14: 107-117.
123. Vader G, Medema RH, Lens SM. 2006. The chromosomal passenger complex: Guiding Aurora-B through mitosis. J Cell Biol 173: 833-837.
124. Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, De-Luca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, et al. 2009. Protein architecture of the human kinetochore mi-crotubule attachment site. Cell 137: 672-684.
125. Waters JC, Chen RH, Murray AW, Salmon ED. 1998. Localization of Mad2 to kinetochores depends on micro-tubule attachment, not tension. J Cell Biol 141: 1181-1191.
126. Wei RR, Sorger PK, Harrison SC. 2005. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci 102: 5363-5367.
127. Wei RR, Al-Bassam J, Harrison SC. 2007. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol 14: 54-59.
128. Welburn JP, Grishchuk EL, Backer CB, Wilson-Kubalek EM, Yates JR III, Cheeseman IM. 2009. The human kineto-chore Ska1 complex facilitates microtubule depolymeri-zation-coupled motility. Dev Cell 16: 374-385.
129. Welburn JP, Vleugel M, Liu D, Yates JR III, Lampson MA, Fukagawa T, Cheeseman IM. 2010. Aurora B phosphor-ylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell 38: 383-392.
130. Westermann S, Avila-Sakar A, Wang HW, Niederstrasser H, Wong J, Drubin DG, Nogales E, Barnes G. 2005. Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17: 277-290.
131. Westermann S, Wang HW, Avila-Sakar A, Drubin DG, No-gales E, Barnes G. 2006. The Dam1 kinetochore ring complex moves processivelyon depolymerizing microtu-bule ends. Nature 440: 565-569.
132. Wigge PA, Jensen ON, Holmes S, Souès S, Mann M, Kilmar-tin JV. 1998. Analysis ofthe Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol 141: 967-977.
133. Wigge PA, Kilmartin JV. 2001. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152: 349-360.
134. Winey M, Mamay CL, O'Toole ET, Mastronarde DN, Giddings TH Jr, McDonald KL, McIntosh JR. 1995. Three-dimensional ultrastructural analysis of the Sac-charomyces cerevisiae mitotic spindle. J Cell Biol 129: 1601-1615.
135. Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. 1992. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature 359: 536-539.