CENP-T proteins are conserved centromere receptors of the Ndc80 complex

Nature Cell Biology

Volumn 14, Issue 6, 2012, Pages 604-613

  Schleiffer, Alexander ^a   Maier, Michael ^a   Litos, Gabriele ^a   Lampert, Fabienne ^a   Hornung, Peter ^a   Mechtler, Karl ^a   Westermann, Stefan ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CENTROMERE PROTEIN T; NDC80 COMPLEX; PROTEIN CNN1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CENTROMERE; CHROMOSOME; CONTROLLED STUDY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM-BINDING PROTEINS; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; HUMANS; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; SEQUENCE ALIGNMENT;

EUKARYOTA; SACCHAROMYCETALES;

EID: 84861637392     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2493     Document Type: Article

References (63)

1. Cheeseman, I. M. & Desai, A. Molecular architecture of the kinetochore-microtubule interface. Nat. Rev. Mol. Cell Biol. 9, 33-46 (2008).
2. Lampert, F. & Westermann, S. A blueprint for kinetochores-new insights into the molecular mechanics of cell division. Nat. Rev. Mol. Cell Biol. 12, 407-412 (2011).
3. Santaguida, S. & Musacchio, A. The life and miracles of kinetochores. EMBO J. 28, 2511-2531 (2009).
4. Liu, D., Vader, G., Vromans, M. J., Lampson, M. A. & Lens, S. M. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science 323, 1350-1353 (2009).
5. Musacchio, A. & Salmon, E. D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8, 379-393 (2007). (Pubitemid 46643240)
6. Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M. & Desai, A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127, 983-997 (2006). (Pubitemid 44792248)
7. Alushin, G. M. et al. The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature 467, 805-810 (2010).
8. Guse, A., Carroll, C. W., Moree, B., Fuller, C. J. & Straight, A. F. In vitro centromere and kinetochore assembly on de-ned chromatin templates. Nature 477, 354-358 (2011).
9. Carroll, C. W., Milks, K. J. & Straight, A. F. Dual recognition of CENP-A nucleosomes is required for centromere assembly. J. Cell Biol. 189, 1143-1155 (2010).
10. Foltz, D. R. et al. The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 8, 458-469 (2006).
11. Okada, M. et al. The CENP-H-I complex is required for the ef-cient incorporation of newly synthesized CENP-A into centromeres. Nat. Cell Biol. 8, 446-457 (2006).
12. Cheeseman, I. M. et al. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111, 163-172 (2002). (Pubitemid 35292437)
13. Westermann, S. et al. Architecture of the budding yeast kinetochore reveals a conserved molecular core. J. Cell Biol. 163, 215-222 (2003). (Pubitemid 37363122)
14. Liu, X., McLeod, I., Anderson, S., Yates, J. R. 3rd & He, X. Molecular analysis of kinetochore architecture in-ssion yeast. EMBO J. 24, 2919-2930 (2005). (Pubitemid 43079895)
15. Meraldi, P., McAinsh, A. D., Rheinbay, E. & Sorger, P. K. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol. 7, R23 (2006).
16. Westermann, S., Drubin, D. G. & Barnes, G. Structures and functions of yeast kinetochore complexes. Annu. Rev. Biochem. 76, 563-591 (2007).
17. Malik, H. S. & Henikoff, S. Major evolutionary transitions in centromere complexity. Cell 138, 1067-1082 (2009).
18. Hori, T., Okada, M., Maenaka, K. & Fukagawa, T. CENP-O class proteins form a stable complex and are required for proper kinetochore function. Mol. Biol. Cell 19, 843-854 (2008). (Pubitemid 351481802)
19. De Wulf, P., McAinsh, A. D. & Sorger, P. K. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 17, 2902-2921 (2003). (Pubitemid 37523155)
20. Hori, T. et al. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell 135, 1039-1052 (2008).
21. Gascoigne, K. E. et al. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell 145, 410-422 (2011).
22. Nishino, T. et al. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell 148, 487-501 (2012).
23. Burley, S. K., Xie, X., Clark, K. L. & Shu, F. Histone-like transcription factors in eukaryotes. Curr. Opin. Struct. Biol. 7, 94-102 (1997). (Pubitemid 27092384)
24. Luger, K., Mader, A. W., Richmond, R. K., Sargent, D. F. & Richmond, T. J. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260 (1997). (Pubitemid 27406632)
25. Sandman, K. & Reeve, J. N. Archaeal histones and the origin of the histone fold. Curr. Opin. Microbiol. 9, 520-525 (2006). (Pubitemid 44397634)
26. Talbert, P. B. & Henikoff, S. Histone variants-ancient wrap artists of the epigenome. Nat. Rev. Mol. Cell Biol. 11, 264-275 (2010).
27. Tanaka, K., Chang, H. L., Kagami, A. & Watanabe, Y. CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis. Dev. Cell 17, 334-343 (2009).
28. Amano, M. et al. The CENP-S complex is essential for the stable assembly of outer kinetochore structure. J. Cell Biol. 186, 173-182 (2009).
29. Yan, Z. et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol. Cell 37, 865-878 (2010).
30. McAinsh, A. D. & Meraldi, P. The CCAN complex: linking centromere speci-cation to control of kinetochore-microtubule dynamics. Semin. Cell Dev. Biol. 22, 946-952 (2011).
31. Petrovic, A. et al. The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J. Cell Biol. 190, 835-852 (2010).
32. Maskell, D. P., Hu, X. W. & Singleton, M. R. Molecular architecture and assembly of the yeast kinetochore MIND complex. J. Cell Biol. 190, 823-834 (2010).
33. Hornung, P. et al. Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. J. Mol. Biol. 405, 548-559 (2011).
34. Ciferri, C. et al. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133, 427-439 (2008). (Pubitemid 351622013)
35. Kiermaier, E., Woehrer, S., Peng, Y., Mechtler, K. & Westermann, S. A Dam1-based arti-cial kinetochore is suf-cient to promote chromosome segregation in budding yeast. Nat. Cell Biol. 11, 1109-1115 (2009).
36. Lace-eld, S., Lau, D. T. & Murray, A. W. Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast. Nat. Cell Biol. 11, 1116-1120 (2009).
37. Westermann, S. et al. The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440, 565-569 (2006).
38. Wigge, P. A. et al. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J. Cell Biol. 141, 967-977 (1998). (Pubitemid 28243964)
39. Screpanti, E. et al. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr. Biol. 21, 391-398 (2011).
40. Suzuki, A. et al. Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins. J. Cell Biol. 193, 125-140 (2011).
41. Akiyoshi, B. et al. Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Nature 468, 576-579 (2010).
42. Bock, L. J. et al. Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat. Cell Biol. http://dx.doi.org/10.1038/ ncb2495 (2012).
43. Powers, A. F. et al. The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion. Cell 136, 865-875 (2009).
44. Kiyomitsu, T., Obuse, C. & Yanagida, M. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev. Cell 13, 663-676 (2007). (Pubitemid 350019284)
45. Cheeseman, I. M. et al. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18, 2255-2268 (2004). (Pubitemid 39209574)
46. Cole, C., Barber, J. D. & Barton, G. J. The Jpred 3 secondary structure prediction server. Nucleic Acids Res. 36, W197-W201 (2008).
47. Sayers, E. W. et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 39, D38-D51 (2011).
48. Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402 (1997). (Pubitemid 27359211)
49. Johnson, L. S., Eddy, S. R. & Portugaly, E. Hidden Markov model speed heuristic and iterative HMM search procedure. BMC Bioinformatics 11, 431 (2010).
50. Berman, H. M. et al. The Protein Data Bank. Nucleic Acids Res. 28, 235-242 (2000). (Pubitemid 30047768)
51. Soding, J., Biegert, A. & Lupas, A. N. The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res. 33, W244-W248 (2005). (Pubitemid 44529917)
52. Finn, R. D. et al. The Pfam protein families database. Nucleic Acids Res. 38, D211-D222 (2010).
53. Letunic, I., Doerks, T. & Bork, P. SMART 6: recent updates and new developments. Nucleic Acids Res. 37, D229-D232 (2009).
54. Lupas, A., Van Dyke, M. & Stock, J. Predicting coiled coils from protein sequences. Science 252, 1162-1164 (1991). (Pubitemid 21917026)
55. Wootton, J. C. & Federhen, S. Analysis of compositionally biased regions in sequence databases. Methods Enzymol. 266, 554-571 (1996).
56. Katoh, K. & Toh, H. Recent developments in the MAFFT multiple sequence alignment program. Brief Bioinform. 9, 286-298 (2008). (Pubitemid 351890825)
57. Waterhouse, A. M., Procter, J. B., Martin, D. M., Clamp, M. & Barton, G. J. Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 25, 1189-1191 (2009).
58. Bailey, T. L. et al. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 37, W202-W208 (2009).
59. Hayashi, T. et al. Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 118, 715-729 (2004). (Pubitemid 39221731)
60. Remmert, M., Biegert, A., Hauser, A. & Soding, J. HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nat. Methods 9, 173-175 (2012).
61. Lampert, F., Hornung, P. & Westermann, S. The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex. J. Cell Biol. 189, 641-649 (2010).
62. Rodal, A. A., Manning, A. L., Goode, B. L. & Drubin, D. G. Negative regulation of yeast WASp by two SH3 domain-containing proteins. Curr. Biol. 13, 1000-1008 (2003). (Pubitemid 36726035)
63. Mendoza, M. A., Panizza, S. & Klein, F. Analysis of protein-DNA interactions during meiosis by quantitative chromatin immunoprecipitation (qChIP). Methods Mol. Biol. 557, 267-283 (2009).