Human Blinkin/AF15q14 Is Required for Chromosome Alignment and the Mitotic Checkpoint through Direct Interaction with Bub1 and BubR1

Developmental Cell

Volumn 13, Issue 5, 2007, Pages 663-676

  Kiyomitsu, Tomomi ^a   Obuse, Chikashi ^a   Yanagida, Mitsuhiro ^a  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

CELLBIO

Indexed keywords

BLINKIN PROTEIN; BUB1 RELATED PROTEIN; ONCOPROTEIN; PROTEIN BUB1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTROMERE; CHROMOSOME; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; MITOSIS; MITOSIS SPINDLE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TETRATRICOPEPTIDE REPEAT;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CHROMOSOME SEGREGATION; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 35649019314     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2007.09.005     Document Type: Article

References (47)

1. Acquaviva C., Herzog F., Kraft C., and Pines J. The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint. Nat. Cell Biol. 6 (2004) 892-898
2. Bolanos-Garcia V.M., Beaufils S., Renault A., Grossmann J.G., Brewerton S., Lee M., Venkitaraman A., and Blundell T.L. The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity. Biophys. J. 89 (2005) 2640-2649
3. Cheeseman I.M., Niessen S., Anderson S., Hyndman F., Yates III J.R., Oegema K., and Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18 (2004) 2255-2268
4. Cheeseman I.M., Chappie J.S., Wilson-Kubalek E.M., and Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127 (2006) 983-997
5. Chen R.H., Waters J.C., Salmon E.D., and Murray A.W. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274 (1996) 242-246
6. D'Andrea L.D., and Regan L. TPR proteins: the versatile helix. Trends Biochem. Sci. 28 (2003) 655-662
7. De Antoni A., Pearson C.G., Cimini D., Canman J.C., Sala V., Nezi L., Mapelli M., Sironi L., Faretta M., Salmon E.D., et al. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr. Biol. 15 (2005) 214-225
8. DeLuca J.G., Dong Y., Hergert P., Strauss J., Hickey J.M., Salmon E.D., and McEwen B.F. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol. Biol. Cell 16 (2005) 519-531
9. Desai A., Rybina S., Muller-Reichert T., Shevchenko A., Shevchenko A., Hyman A., and Oegema K. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17 (2003) 2421-2435
10. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
11. Gillett E.S., Espelin C.W., and Sorger P.K. Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J. Cell Biol. 164 (2004) 535-546
12. Goshima G., Kiyomitsu T., Yoda K., and Yanagida M. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J. Cell Biol. 160 (2003) 25-39
13. Haraguchi T., Kaneda T., and Hiraoka Y. Dynamics of chromosomes and microtubules visualized by multiple-wavelength fluorescence imaging in living mammalian cells: effects of mitotic inhibitors on cell cycle progression. Genes Cells 2 (1997) 369-380
14. Hayette S., Tigaud I., Vanier A., Martel S., Corbo L., Charrin C., Beillard E., Deleage G., Magaud J.P., and Rimokh R. AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). Oncogene 19 (2000) 4446-4450
15. Hirano T., Kinoshita N., Morikawa K., and Yanagida M. Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+. Cell 60 (1990) 319-328
16. Hoyt M.A., Totis L., and Roberts B.T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66 (1991) 507-517
17. Hwang L.H., Lau L.F., Smith D.L., Mistrot C.A., Hardwick K.G., Hwang E.S., Amon A., and Murray A.W. Budding yeast Cdc20: a target of the spindle checkpoint. Science 279 (1998) 1041-1044
18. Johnson V.L., Scott M.I., Holt S.V., Hussein D., and Taylor S.S. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J. Cell Sci. 117 (2004) 1577-1589
19. Kallio M., Weinstein J., Daum J.R., Burke D.J., and Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141 (1998) 1393-1406
20. Kerres A., Vietmeier-Decker C., Ortiz J., Karig I., Beuter C., Hegemann J., Lechner J., and Fleig U. The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association. Mol. Biol. Cell 15 (2004) 5255-5267
21. Kim S.H., Lin D.P., Matsumoto S., Kitazono A., and Matsumoto T. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science 279 (1998) 1045-1047
22. Kline S.L., Cheeseman I.M., Hori T., Fukagawa T., and Desai A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J. Cell Biol. 173 (2006) 9-17
23. Kops G.J., Weaver B.A., and Cleveland D.W. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat. Rev. Cancer 5 (2005) 773-785
24. Li R., and Murray A.W. Feedback control of mitosis in budding yeast. Cell 66 (1991) 519-531
25. Li Y., and Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 274 (1996) 246-248
26. Martin-Lluesma S., Stucke V.M., and Nigg E.A. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297 (2002) 2267-2270
27. McAinsh A.D., Meraldi P., Draviam V.M., Toso A., and Sorger P.K. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J. 25 (2006) 4033-4049
28. Meraldi P., and Sorger P.K. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J. 24 (2005) 1621-1633
29. Meraldi P., Draviam V.M., and Sorger P.K. Timing and checkpoints in the regulation of mitotic progression. Dev. Cell 7 (2004) 45-60
30. Millband D.N., and Hardwick K.G. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Mol. Cell. Biol. 22 (2002) 2728-2742
31. Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8 (2007) 379-393
32. Nekrasov V.S., Smith M.A., Peak-Chew S., and Kilmartin J.V. Interactions between centromere complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14 (2003) 4931-4946
33. Nousiainen M., Sillje H.H., Sauer G., Nigg E.A., and Korner R. Phosphoproteome analysis of the human mitotic spindle. Proc. Natl. Acad. Sci. USA 103 (2006) 5391-5396
34. Obuse C., Iwasaki O., Kiyomitsu T., Goshima G., Toyoda Y., and Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat. Cell Biol. 6 (2004) 1135-1141
35. Pinsky B.A., and Biggins S. The spindle checkpoint: tension versus attachment. Trends Cell Biol. 15 (2005) 486-493
36. Przewloka M.R., Zhang W., Costa P., Archambault V., D'Avino P.P., Lilley K.S., Laue E.D., McAinsh A.D., and Glover D.M. Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster. PLoS ONE 2 (2007) e478
37. Rieder C.L., Schultz A., Cole R., and Sluder G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127 (1994) 1301-1310
38. Sudakin V., Chan G.K., and Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154 (2001) 925-936
39. Takimoto M., Wei G., Dosaka-Akita H., Mao P., Kondo S., Sakuragi N., Chiba I., Miura T., Itoh N., Sasao T., et al. Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. Br. J. Cancer 86 (2002) 1757-1762
40. Tang Z., Bharadwaj R., Li B., and Yu H. Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev. Cell 1 (2001) 227-237
41. Taylor S.S., Ha E., and McKeon F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol. 142 (1998) 1-11
42. Taylor S.S., Hussein D., Wang Y., Elderkin S., and Morrow C.J. Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J. Cell Sci. 114 (2001) 4385-4395
43. Tirode F., Malaguti C., Romero F., Attar R., Camonis J., and Egly J.M. A conditionally expressed third partner stabilizes or prevents the formation of a transcriptional activator in a three-hybrid system. J. Biol. Chem. 272 (1997) 22995-22999
44. Toyoda Y., and Yanagida M. Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance. Mol. Biol. Cell 17 (2006) 2287-2302
45. Wigge P.A., Jensen O.N., Holmes S., Soues S., Mann M., and Kilmartin J.V. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J. Cell Biol. 141 (1998) 967-977
46. Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 14 (2002) 706-714
47. Yu H., and Tang Z. Bub1 multitasking in mitosis. Cell Cycle 4 (2005) 262-265