A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension

Genes and Development

Volumn 18, Issue 18, 2004, Pages 2255-2268

  Cheeseman, Iain M ^a   Niessen, Sherry ^b   Anderson, Scott ^b   Hyndman, Francie ^a   Yates III, John R ^b   Oegema, Karen ^a   Desai, Arshad ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Caenorhabditis elegans; Centromere; Microtubule; Mitosis; Spindle

Indexed keywords

HYBRID PROTEIN; PROTEIN KNL; PROTEIN KNL 1; PROTEIN KNL 3; PROTEIN MIS; PROTEIN NDC; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CENTROMERE; CHROMATIN; CHROMOSOME SEGREGATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; CONSERVED SEQUENCE; EMBRYO, NONMAMMALIAN; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN INTERACTION MAPPING; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; PROTOZOA;

EID: 4444241998     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1234104     Document Type: Article

References (35)

1. Bharadwaj, R., Qi, W., and Yu, H. 2004. Identification of two novel components of the human NDC80 kinetochore complex. J. Biol. Chem. 279: 13076-13085.
2. Buchwitz, B.J., Ahmad, K., Moore, L.L., Roth, M.B., and Henikoff, S. 1999. A histone-H3-like protein in C. elegans. Nature 401: 547-548.
3. Cheeseman, I.M. and Desai, A. 2004. Cell division: Feeling tense enough? Nature 428: 32-33.
4. Cheeseman, I.M., Brew, C., Wolyniak, M., Desai, A., Anderson, S., Muster, N., Yates, J.R., Huffaker, T.C., Drubin, D.G., and Barnes, G. 2001. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. J. Cell Biol. 155: 1137-1146.
5. Cleveland, D.W., Mao, Y., and Sullivan, K.F. 2003. Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling. Cell 112: 407-421.
6. DeLuca, J.G., Moree, B., Hickey, J.M., Kilmartin, J.V., and Salmon, E.D. 2002. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 159: 549-555.
7. DeLuca, J.G., Howell, B.J., Canman, J.C., Hickey, J.M., Fang, G., and Salmon, E.D. 2003. Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. Curr. Biol. 13: 2103-2109.
8. Desai, A., Rybina, S., Muller-Reichert, T., Shevchenko, A., Shevchenko, A., Hyman, A., and Oegema, K. 2003. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes & Dev. 17: 2421-2435.
9. De Wulf, P., McAinsh, A.D., and Sorger, P.K. 2003. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes & Dev. 17: 2902-2921.
10. Goshima, G. and Yanagida, M. 2000. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell 100: 619-633.
11. Goshima, G., Kiyomitsu, T., Yoda, K., and Yanagida, M. 2003. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J. Cell Biol. 160: 25-39.
12. Grill, S.W., Gonczy, P., Stelzer, E.H., and Hyman, A.A. 2001. Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo. Nature 409: 630-633.
13. Hannak, E., Kirkham, M., Hyman, A.A., and Oegema, K. 2001. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J. Cell Biol. 155: 1109-1116.
14. Hannak, E., Oegema, K., Kirkham, M., Gonczy, P., Habermann, B., and Hyman, A.A. 2002. The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is γ-tubulin dependent. J. Cell Biol. 157: 591-602.
15. Howe, M., McDonald, K.L., Albertson, D.G., and Meyer, B.J. 2001. HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. J. Cell Biol. 153: 1227-1238.
16. Janke, C., Ortiz, J., Lechner, J., Shevchenko, A., Magiera, M.M., Schramm, C., and Schiebel, E. 2001. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J. 20: 777-791.
17. Kirkham, M., Muller-Reichert, T., Oegema, K., Grill, S., and Hyman, A.A. 2003. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell 112: 575-587.
18. Kitagawa, R. and Rose, A.M. 1999. Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Nat. Cell Biol. 1: 514-521.
19. Maddox, P.S., Oegema, K., Desai, A., and Cheeseman, I.M. 2004. 'Holo'er than thou: Chromosome segregation and kinetochore function in C. elegans. Chromosome Res. 12: 641-653.
20. McCleland, M.L., Gardner, R.D., Kallio, M.J., Daum, J.R., Gorbsky, G.J., Burke, D.J., and Stukenberg, P.T. 2003. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes & Dev. 17: 101-114.
21. McCleland, M.L., Kallio, M.J., Barrett-Wilt, G.A., Kestner, C.A., Shabanowitz, J., Hunt, D.F., Gorbsky, G.J., and Stukenberg, P.T. 2004. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr. Biol. 14: 131-137.
22. Moore, L.L. and Roth, M.B. 2001. HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres. J. Cell Biol. 153: 1199-1208.
23. Morgenstern, J.P. and Land, H. 1990. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18: 3587-3596.
24. Nekrasov, V.S., Smith, M.A., Peak-Chew, S., and Kilmartin, J.V. 2003. Interactions between centromere complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 4931-4946.
25. Nicklas, R.B. 1988. The forces that move chromosomes in mitosis. Annu. Rev. Biophys. Biophys. Chem. 17: 431-449.
26. Oegema, K., Desai, A., Rybina, S., Kirkham, M., and Hyman, A.A. 2001. Functional analysis of kinetochore assembly in Caenorhabditis elegans. J. Cell Biol. 153: 1209-1225.
27. Pinsky, B.A., Tatsutani, S.Y., Collins, K.A., and Biggins, S. 2003. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev. Cell 5: 735-745.
28. Praitis, V., Casey, E., Collar, D., and Austin, J. 2001. Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157: 1217-1226.
29. Rigaut, G., Shevchenko, A., Rutz, B., Wilm, M., Mann, M., and Séraphin, B. 1999. A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotech. 17: 1030-1032.
30. Scharfenberger, M., Ortiz, J., Grau, N., Janke, C., Schiebel, E., and Lechner, J. 2003. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. EMBO J. 22: 6584-6597.
31. Shah, J.V., Botvinick, E., Bonday, Z., Furnari, F., Berns, M., and Cleveland, D.W. 2004. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr. Biol. 14: 942-952.
32. Starr, D.A., Saffery, R., Li, Z., Simpson, A.E., Choo, K.H., Yen, T.J., and Goldberg, M.L. 2000. HZwint-1, a novel human kinetochore component that interacts with HZW10. J. Cell Sci. 113: 1939-1950.
33. Takimoto, M., Wei, G., Dosaka-Akita, H., Mao, P., Kondo, S., Sakuragi, N., Chiba, I., Miura, T., Itoh, N., Sasao, T., et al. 2002. Frequent expression of new cancer/testis gene D40/ AF15q14 in lung cancers of smokers. Br. J. Cancer 86: 1757-1762.
34. Westermann, S., Cheeseman, I.M., Anderson, S., Yates III, J.R., Drubin, D.G., and Barnes, G. 2003. Architecture of the budding yeast kinetochore reveals a conserved molecular core. J. Cell Biol. 163: 215-222.
35. Wigge, P.A. and Kilmartin, J.V. 2001. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J. Cell Biol. 152: 349-360.