Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Science

Volumn 323, Issue 5919, 2009, Pages 1350-1353

  Liu, Dan ^a   Vader, Gerben ^b,c   Vromans, Martijn J M ^b   Lampson, Michael A ^a   Lens, Susanne M A ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE;

CHROMOSOME; ENZYME ACTIVITY; PHOSPHATE; SENSOR; SUBSTRATE;

ARTICLE; BIOSENSOR; CELL DIVISION; CENTROMERE; CHROMOSOME; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AUTOANTIGENS; BIOSENSING TECHNIQUES; CELL LINE, TUMOR; CENTROMERE; CHROMATIDS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, HUMAN; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 62149111407     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1167000     Document Type: Article

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25. We thank T. M. Kapoor (Rockefeller University) and R. H. Medema (University Medical Center, Utrecht) for their support during the initiation of these studies. We also thank B. E. Black, G. Kops, and R. H. Medema for critical reading of the manuscript and helpful comments and K. V. Le and T. Chiang for assistance with preparing reagents. This work was supported by grants from the American Cancer Society (IRG-78-002-30, M.A.L.), the National Institutes of Health (GM083988, M.A.L.), the Searle Scholars Program (M.A.L.), the Penn Genome Frontiers Institute (M.A.L.), and the Netherlands Organization for Scientific Research (Vidi 917.66.332, S.M.A.L.).