Is the antioxidative effectiveness of a bilberry extract influenced by encapsulation?

Journal of the Science of Food and Agriculture

Volumn 94, Issue 11, 2014, Pages 2301-2307

  Baum, Matthias ^a   Schantz, Markus ^a   Leick, Sabine ^b   Berg, Sonja ^c   Betz, Michael ^d   Frank, Kerstin ^e   Rehage, Heinz ^b   Schwarz, Karin ^c   Kulozik, Ulrich ^d   Schuchmann, Heike ^e   Richling, Elke ^a  

^a University of Koblenz Landau   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Anthocyanins; Antioxidants; Bilberry; DNA damage; Encapsulation; Glutathione; Pectin; ROS; Whey protein

Indexed keywords

MALUS X DOMESTICA; VACCINIUM MYRTILLUS;

ANTHOCYANIN; ANTIOXIDANT; GLUTATHIONE; MICROCAPSULE; MILK PROTEIN; PECTIN; REACTIVE OXYGEN METABOLITE; VACCINIUM MYRTILLUS EXTRACT; WHEY PROTEIN;

CACO 2 CELL LINE; CHEMISTRY; DNA DAMAGE; DRUG EFFECTS; FRUIT; HUMAN; MALUS; METABOLISM; MICROCAPSULE; OXIDATIVE STRESS; VACCINIUM MYRTILLUS;

ANTHOCYANINS; ANTIOXIDANTS; CACO-2 CELLS; CAPSULES; DNA DAMAGE; FRUIT; GLUTATHIONE; HUMANS; MALUS; MILK PROTEINS; OXIDATIVE STRESS; PECTINS; REACTIVE OXYGEN SPECIES; VACCINIUM MYRTILLUS;

EID: 84903574987     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.6558     Document Type: Article

References (64)

1. Zhang Z, Kou X, Fugal K and McLaughlin J, Comparison of HPLC methods for determination of anthocyanins and anthocyanidins in bilberry extracts. J Agric Food Chem 52:688-691 (2004).
2. Cooney JM, Jensen DJ and McGhie TK, LC-MS identification of anthocyanins in boysenberry extract and anthocyanin metabolites in human urine following dosing. J Sci Food Agric 84:237-245 (2004).
3. Merken HM and Beecher GR, Measurement of food flavonoids by high-performance liquid chromatography: a review. J Agric Food Chem 48:577-599 (2000).
4. Chalker-Scott L, Environmental significance of anthocyanins in plant stress responses. Photochem Photobiol 70:1-9 (1999).
5. Rahman MM, Ichiyanagi T, Komiyama T, Sato S and Konishi T, Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status. J Agric Food Chem 56:7545-7550 (2008).
6. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE and Prior RL, Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54:4069-4075 (2006).
7. Latti AK, Riihinen KR and Kainulainen PS, Analysis of anthocyanin variation in wild populations of bilberry (Vaccinium myrtillus L.) in Finland. J Agric Food Chem 56:190-196 (2008).
8. Nyman NA and Kumpulainen JT, Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J Agric Food Chem 49:4183-4187 (2001).
9. Muller D, Schantz M and Richling E, High performance liquid chromatography analysis of anthocyanins in bilberries (Vaccinium myrtillus L.), blueberries (Vaccinium corymbosum L.), and corresponding juices. J Food Sci 77:C340-C345 (2012).
10. Scalzo J, Currie A, Stephens J, Alspach P and McGhie T, The anthocyanin composition of different Vaccinium, Ribes and Rubus genotypes. BioFactors 34:13-21 (2008).
11. Clifford MN, Anthocyanins - nature, occurrence and dietary burden. J Sci Food Agric 80:1063-1072 (2000).
12. Pascual-Teresa S and Sanchez-Ballesta MT, Anthocyanins: from plant to health. Phytochem Rev 7:281-299 (2008).
13. McGhie TK and Walton MC, The bioavailability and absorption of anthocyanins: towards a better understanding. Mol Nutr Food Res 51:702-713 (2007).
14. Scalbert A, Manach C, Morand C, Remesy C and Jimenez L, Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287-306 (2005).
15. Battino M, Beekwilder J, Denoyes-Rothan B, Laimer M, McDougall GJ and Mezzetti B, Bioactive compounds in berries relevant to human health. Nutr Rev 67(Suppl. 1):S145-S150 (2009).
16. Wang H, Cao GH and Prior RL, Oxygen radical absorbing capacity of anthocyanins. J Agric Food Chem 45:304-309 (1997).
17. Kahkonen MP and Heinonen M, Antioxidant activity of anthocyanins and their aglycons. J Agric Food Chem 51:628-633 (2003).
18. Spormann TM, Albert FW, Rath T, Dietrich H, Will F, Stockis JP, et al., Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiol Biomarkers Prev 17:3372-3380 (2008).
19. Weisel T, Baum M, Eisenbrand G, Dietrich H, Will F, Stockis JP, et al., An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J 1:388-397 (2006).
20. Schantz M, Mohn C, Baum M and Richling E, Antioxidative efficiency of an anthocyanin rich bilberry extract in the human colon tumor cell lines Caco-2 and HT-29. J Berry Res 1:25-33 (2010).
21. Jing P, Bomser JA, Schwartzt SJ, He J, Magnuson BA and Giusti MM, Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. J Agric Food Chem 56:9391-9398 (2008).
22. Marko D, Puppel N, Tjaden Z, Jakobs S and Pahlke G, The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Mol Nutr Food Res 48:318-325 (2004).
23. Olsson ME, Gustavsson KE, Andersson S, Nilsson A and Duan RD, Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 52:7264-7271 (2004).
24. Hafeez BB, Siddiqui IA, Asim M, Malik A, Afaq F, Adhami VM, et al., A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-κB signaling. Cancer Res 68:8564-8572 (2008).
25. Katsube N, Iwashita K, Tsushida T, Yamaki K and Kobori M, Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem 51:68-75 (2003).
26. Min mice fed suboptimal levels of sulindac. J Agric Food Chem 54:9322-9328 (2006).
27. Min mouse model of intestinal carcinogenesis - relationship with tissue anthocyanin levels. Int J Cancer 119:2213-2220 (2006).
28. Simmonds NJ and Rampton DS, Inflammatory bowel disease - a radical view. Gut 34:865-868 (1993).
29. González-Barrio R, Borges G, Mullen W and Crozier A, Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem 58:3933-3939 (2010).
30. Gunasekaran S, Ko S and Xiao L, Use of whey proteins for encapsulation and controlled delivery applications. J Food Eng 83:31-40 (2007).
31. Chen LY and Subirade M, Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds. Biomaterials 27:4646-4654 (2006).
32. Fang Z and Bhandari B, Encapsulation of polyphenols - a review. Trends Food Sci Technol 21:510-523 (2010).
33. Cavalcanti RN, Santos DT and Meireles MAA, Non-thermal stabilization mechanisms of anthocyanins in model and food systems - an overview. Food Res Int 44:499-509 (2011).
34. Oehme A, Valotis A, Krammer G, Zimmermann I and Schreier P, Preparation and characterization of shellac-coated anthocyanin pectin beads as dietary colonic delivery system. Mol Nutr Food Res 55:S75-S85 (2011).
35. Oidtmann J, Schantz M, Mäder K, Baum M, Berg S, Betz M, et al., Preparation and comparative release characteristics of three anthocyanin encapsulation systems. J Agric Food Chem 60:844-851 (2012).
36. Fridrich D, Kern M, Pahlke G, Volz N, Will F, Dietrich H, et al., Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells. Mol Nutr Food Res 51:594-601 (2007).
37. 2 during interaction of phenolic compounds with cell culture media. J Agric Food Chem 50:3156-3160 (2002).
38. Schaefer S, Baum M, Eisenbrand G, Dietrich H, Will F and Janzowski C, Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines. Mol Nutr Food Res 50:24-33 (2006).
39. Collins AR, Dusinska M, Gedik CM and Stetina R, Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect 104:465-469 (1996).
40. Singh NP, McCoy MT, Tice RR and Schneider EL, A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191 (1988).
41. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al., Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206-221 (2000).
42. Wang H and Joseph JA, Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616 (1999).
43. Bellion P, Olk M, Will F, Dietrich H, Baum M, Eisenbrand G, et al., Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29. Mol Nutr Food Res 53:1226-1236 (2009).
44. O'Brien J, Wilson I, Orton T and Pognan F, Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 267:5421-5426 (2000).
45. Kern M, Fridrich D, Reichert J, Skrbek S, Nussher A, Hofem S, et al., Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. Mol Nutr Food Res 51:1163-1172 (2007).
46. Woodward G, Kroon P, Cassidy A and Kay C, Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. J Agric Food Chem 57:5271-5278 (2009).
47. Yi WG, Fischer J, Krewer G and Akoh CC, Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53:7320-7329 (2005).
48. Cheng H, Li S, Fan Y, Gao X, Hao M, Wang J, et al., Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells. Med Oncol 28:175-181 (2011).
49. Yan J and Katz A, PectaSol-C modified citrus pectin induces apoptosis and inhibition of proliferation in human and mouse androgen-dependent and -independent prostate cancer cells. Integr Cancer Ther 9:197-203 (2010).
50. Bernkop-Schnurch A, Majzoob S, Atyabi F, Dorkoosh F, Kafedjiiski K and Loretz B, Pectin-cysteine conjugate: synthesis and in-vitro evaluation of its potential for drug delivery. J Pharm Pharmacol 58:1601-1610 (2006).
51. Cross ML and Gill HS, Modulation of immune function by a modified bovine whey protein concentrate. Immunol Cell Biol 77:345-350 (1999).
52. Ghosh A, Ali MA, Selvanesan L and Dias GJ, Structure-function characteristics of the biomaterials based on milk-derived proteins. Int J Biol Macromol 46:404-411 (2011).
53. Milbury PE, Graf B, Curran-Celentano JM and Blumberg JB, Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci 48:2343-2349 (2007).
54. Bellion P, Hofmann T, Pool-Zobel BL, Will F, Dietrich H, Knaup B, et al., Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line Caco-2. J Agric Food Chem 56:6310-6317 (2008).
55. Kent KD, Harper WJ and Bomser JA, Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol Vitro 17:27-33 (2003).
56. Marshall K, Therapeutic applications of whey protein. Altern Med Rev 9:136-156 (2004).
57. Kahle K, Kraus M, Scheppach W, Ackermann M, Ridder F and Richling E, Studies on apple and blueberry fruit constituents: do the polyphenols reach the colon after ingestion? Mol Nutr Food Res 50:418-423 (2006).
58. He J, Wallace TC, Keatley KE, Failla ML and Giusti MM, Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat. J Agric Food Chem 57:3141-3148 (2009).
59. Ye JL, Meng XJ, Yan CL and Wang CB, Effect of purple sweet potato anthocyanins on β-amyloid-mediated PC-12 cells death by inhibition of oxidative stress. Neurochem Res 35:357-365 (2010).
60. Kulisic-Bilusic T, Schnäbele K, Schmöller I, Dragovic-Uzelac V, Krisko A, Dejanovic B, et al., Antioxidant activity versus cytotoxic and nuclear factor kappa B regulatory activities on HT-29 cells by natural fruit juices. Eur Food Res Technol 228:417-424 (2009).
61. Tsuda T, Horio F, Uchida K, Aoki H and Osawa T, Dietary cyanidin 3-O-β-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133:2125-2130 (2003).
62. Mas T, Susperregui J, Berke B, Cheze C, Moreau S, Nuhrich A, et al., DNA triplex stabilization property of natural anthocyanins. Phytochemistry 53:679-687 (2000).
63. Acquaviva R, Russo A, Galvano F, Galvano G, Barcellona ML, Li Volti G, et al., Cyanidin and cyanidin 3-O-β-d-glucoside as DNA cleavage protectors and antioxidants. Cell Biol Toxicol 19:243-252 (2003).
64. Bao L, Yao XS, Yau CC, Tsi D, Chia CS, Nagai H, et al., Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice. J Agric Food Chem 56:7803-7807 (2008).