Oxidative damage to DNA: Do we have a reliable biomarker?

Environmental Health Perspectives

Volumn 104, Issue SUPPL. 3, 1996, Pages 465-469

  Collins, Andrew R ^a   Dušinská, Maria ^b   Gedik, Catherine M ^a   Štětina, Rudolf ^c  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

^c INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

8 OH guanine; Comet assay; DNA damage; DNA repair enzymes

Indexed keywords

7,8 DIHYDRO 8 OXO GUANINE; BIOLOGICAL MARKER; ENDONUCLEASE; GUANINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DNA DAMAGE; DNA STRAND BREAKAGE; EUKARYOTIC CELL; EXCISION REPAIR; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; LYMPHOCYTE; MUTAGENICITY; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RELIABILITY; STORAGE;

EUKARYOTA;

EID: 0030014152     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104s3465     Document Type: Conference Paper

References (33)

1. Miller AB. Diet and cancer. A review. Acta Oncol 29:87-95 (1990).
2. Steinmerz KA, Potter D. Vegetables, fruit and cancer. Cancer Causes and Control 2:325-357 (1991).
3. Dorgan JF, Schatzkin A. Antioxidant micronutrients in cancer prevention. Hematol Oncol Clin N Am 5:43-68 (1991).
4. Block G. The data support a role for antioxidants in reducing cancer risk. Nutr Rev 50:207-213 (1992).
5. Ames BN. Dietary carcinogens and anticarcinogens. Science 221:1256-1264 (1983).
6. Von Sonntag C. The chemical basis of radiation biology. London:Taylor and Francis, 1987.
7. Shibutani S, Takeshita M, Grollman A. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349:431-434 (1991).
8. Shigenaga MK, Aboujaoude EN, Chen Q, Ames BN. Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods Enzymol 234:16-33 (1994).
9. Halliwell B, Dizdaroglu M. The measurement of oxidative damage to DNA by HPLC and GC/MS techniques. Free Radic Res Commun 16:75-87 (1992).
10. Park E-M, Shigenaga MK, Degan P, Korn TS, Kitzler JW, Wehr CM, Kolachana P, Ames BN. The assay of excised oxidative DNA lesions; isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci USA 89:3375-3379 (1992).
11. Bessho T, Tano K, Kasai H, Ohtsuka E, Nishimura S. Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. J Biol Chem 258:19416-19421 (1993).
12. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362:709-715 (1993).
13. Loft S, Astrup A, Buemann B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J 8:534-537 (1994).
14. Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE. 8-hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 40:391-404 (1993).
15. Wilson VL, Taffe BG, Shields PG, Povey AC, Harris CC. Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation. Environ Health Perspect 99:261-263 (1993).
16. Takeuchi T, Nakajima M, Ohta Y, Mure K, Takeshita T, Morimoto K. Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes. Carcinogenesis 15:1519-1523 (1994).
17. 32P-postlabelling: 8-hydroxydeoxyguanosine as a marker of exposure. In: Postlabelling Methods for Detection of DNA Adducts (Phillips DH, Castegnaro M, Bartsch H, eds). Lyon:International Agency for Research on Cancer, 1993;105-114.
18. Epe B, Hegler J. Oxidative DNA damage: endonuclease fingerprinting. Methods Enzymol 232:122-131 (1994).
19. Czene S, Harms-Ringdahl M. Detection of single-strand breaks and formamidopyrimidine-DNA glycosylase-sensitive sites in DNA of cultured human fibroblasts. Mutat Res 336:235-242 (1995).
20. Collins AR, Duthie SJ, Dobson VL. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14:1733-1735 (1993).
21. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191 (1988).
22. Collins AR, Ma AG, Duthie SJ. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat Res 336:69-77 (1995).
23. Richter C, Park J-W, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85:6465-6467 (1988).
24. Boiteux S, Gajewski E, Laval J, Dizdaroglu M. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31:106-110 (1992).
25. Ahnström G, Erixon K. Measurement of strand breaks by alkaline denaturation and hydroxyapatite chromatography. In: DNA Repair; A Laboratory Manual of Research Procedures (Friedberg EC, Hanawalt PC, eds). New York:Marcel Dekker, 1981;403-418.
26. Claycamp HG. Phenol sensitisation of DNA to subsequent oxidative damage in 8-hydroxyguanine assays. Carcinogenesis 13:1289-1292 (1992).
27. Ravanat J-L, Turesky RJ, Gremaud E, Trudel LJ, Stadler RH. Determination of 8-oxoguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: overestimation of the background level of the oxidized base by the gas chromatography-mass spectrometry assay. Chem Res Toxicol 8:1039-1045 (1995).
28. Gedik CM, Ewen SWB, Collins AR. Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. Int J Radiat Biol 62:313-320 (1992).
29. de Kok TMCM, Vaarwerk FT, Zwingman I, van Maanen JMS, Kleinjans JCS. Peroxidation of linoleic, arachidonic and oleic acid in relation to the induction of oxidative damage and cytogenetic effects. Carcinogenesis 15:1399-1404 (1994).
30. Inoue T, Mu Z, Sumikawa K, Adachi K, Okuchi T. Effect of physical exercise on the content of 8-hydroxyguanosine in nuclear DNA prepared from human lymphocytes. Jpn J Cancer Res 84:720-725 (1993).
31. Dušinskd M, Collins A. Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. ATLA (in press).
32. Cerutti PA. Effects of ionizing radiation on mammalian cells. Naturwissenschaften 61:51-59 (1974).
33. Duthie SJ, Ma A, Ross MA, Collins AR. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res (in press).