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Volumn 10, Issue , 2014, Pages 1103-1111

Profile of minocycline and its potential in the treatment of schizophrenia

Author keywords

Microglia; Minocycline; Neuroinflammation; Schizophrenia

Indexed keywords

HALOPERIDOL; MINOCYCLINE; OLANZAPINE; PLACEBO;

EID: 84902578330     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S64236     Document Type: Article
Times cited : (40)

References (113)
  • 1
    • 65649134782 scopus 로고    scopus 로고
    • Cytokines and schizophrenia: Micro-glia hypothesis of schizophrenia
    • Monji A, Kato T, Kanba S. Cytokines and schizophrenia: micro-glia hypothesis of schizophrenia. Psychiatry Clin Neurosci. 2009; 63(3):257-265.
    • (2009) Psychiatry Clin Neurosci , vol.63 , Issue.3 , pp. 257-265
    • Monji, A.1    Kato, T.2    Kanba, S.3
  • 2
    • 77957849121 scopus 로고    scopus 로고
    • Past and present progress in the pharmacologic treatment of schizophrenia
    • Kane JM, Correll CU. Past and present progress in the pharmacologic treatment of schizophrenia. J Clin Psychiatry. 2010;71(9):1115-1124.
    • (2010) J Clin Psychiatry , vol.71 , Issue.9 , pp. 1115-1124
    • Kane, J.M.1    Correll, C.U.2
  • 3
    • 62849099049 scopus 로고    scopus 로고
    • How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials
    • Leucht S, Arbter D, Engel RR, Kissling W, Davis JM. How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials. Mol Psychiatry. 2009;14(4):429-447.
    • (2009) Mol Psychiatry , vol.14 , Issue.4 , pp. 429-447
    • Leucht, S.1    Arbter, D.2    Engel, R.R.3    Kissling, W.4    Davis, J.M.5
  • 6
    • 80054906982 scopus 로고    scopus 로고
    • NMDA receptors, cognition and schizophrenia - testing the validity of the NMDA receptor hypofunction hypothesis
    • Gilmour G, Dix S, Fellini L, et al. NMDA receptors, cognition and schizophrenia - testing the validity of the NMDA receptor hypofunction hypothesis. Neuropharmacology. 2012;62(3):1401-1412.
    • (2012) Neuropharmacology , vol.62 , Issue.3 , pp. 1401-1412
    • Gilmour, G.1    Dix, S.2    Fellini, L.3
  • 7
    • 53249156222 scopus 로고    scopus 로고
    • Role of the central cholinergic system in the therapeutics of schizophrenia
    • Terry AV, Jr. Role of the central cholinergic system in the therapeutics of schizophrenia. Curr Neuropharmacol. 2008;6(3):286-292.
    • (2008) Curr Neuropharmacol , vol.6 , Issue.3 , pp. 286-292
    • Terry Jr., A.V.1
  • 8
    • 57349083232 scopus 로고    scopus 로고
    • Histamine H3 receptor antagonists go to clinics
    • Sander K, Kottke T, Stark H. Histamine H3 receptor antagonists go to clinics. Biol Pharm Bull. 2008;31(12):2163-2181.
    • (2008) Biol Pharm Bull , vol.31 , Issue.12 , pp. 2163-2181
    • Sander, K.1    Kottke, T.2    Stark, H.3
  • 9
    • 84868332431 scopus 로고    scopus 로고
    • Serotonergic mechanisms as targets for existing and novel antipsychotics
    • Meltzer HY. Serotonergic mechanisms as targets for existing and novel antipsychotics. Handb Exp Pharmacol. 2012;(212):87-124.
    • (2012) Handb Exp Pharmacol , Issue.212 , pp. 87-124
    • Meltzer, H.Y.1
  • 10
    • 84870168817 scopus 로고    scopus 로고
    • Role of dopamine D(2) receptors for antipsychotic activity
    • Ginovart N, Kapur S. Role of dopamine D(2) receptors for antipsychotic activity. Handb Exp Pharmacol. 2012;212:27-52.
    • (2012) Handb Exp Pharmacol , vol.212 , pp. 27-52
    • Ginovart, N.1    Kapur, S.2
  • 11
    • 84862498540 scopus 로고    scopus 로고
    • Schizophrenia genetics: Progress, at last
    • Mulle JG. Schizophrenia genetics: progress, at last. Curr Opin Genet Dev. 2012;22(3):238-244.
    • (2012) Curr Opin Genet Dev , vol.22 , Issue.3 , pp. 238-244
    • Mulle, J.G.1
  • 12
    • 77953438933 scopus 로고    scopus 로고
    • What is schizophrenia: A neurodevelopmental or neurodegenerative disorder or a combination of both? A critical analysis
    • Gupta S, Kulhara P. What is schizophrenia: a neurodevelopmental or neurodegenerative disorder or a combination of both? A critical analysis. Indian J Psychiatry. 2010;52(1):21-27.
    • (2010) Indian J Psychiatry , vol.52 , Issue.1 , pp. 21-27
    • Gupta, S.1    Kulhara, P.2
  • 13
    • 84870064466 scopus 로고    scopus 로고
    • Neurodevelopmental model of schizophrenia: Update 2012
    • Rapoport JL, Giedd JN, Gogtay N. Neurodevelopmental model of schizophrenia: update 2012. Mol Psychiatry. 2012;17(12):1228-1238.
    • (2012) Mol Psychiatry , vol.17 , Issue.12 , pp. 1228-1238
    • Rapoport, J.L.1    Giedd, J.N.2    Gogtay, N.3
  • 14
    • 80052966999 scopus 로고    scopus 로고
    • Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: Evidence from human peripheral studies and CNS studies
    • Dean B. Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int J Neuropsychop-harmacol. 2011;14(7):997-1012.
    • (2011) Int J Neuropsychop-harmacol , vol.14 , Issue.7 , pp. 997-1012
    • Dean, B.1
  • 15
    • 80053892662 scopus 로고    scopus 로고
    • Anti-inflammatory signaling in schizophrenia
    • Meyer U. Anti-inflammatory signaling in schizophrenia. Brain Behav Immun. 2011;25(8):1507-1518.
    • (2011) Brain Behav Immun , vol.25 , Issue.8 , pp. 1507-1518
    • Meyer, U.1
  • 16
    • 84873524397 scopus 로고    scopus 로고
    • Neuroinflammation in schizophrenia especially focused on the role of microglia
    • Monji A, Kato TA, Mizoguchi Y, et al. Neuroinflammation in schizophrenia especially focused on the role of microglia. Prog Neuropsy-chopharmacol Biol Psychiatry. 2013;42(5):115-121.
    • (2013) Prog Neuropsy-chopharmacol Biol Psychiatry , vol.42 , Issue.5 , pp. 115-121
    • Monji, A.1    Kato, T.A.2    Mizoguchi, Y.3
  • 18
    • 57549088119 scopus 로고    scopus 로고
    • Minocycline and neurodegenerative diseases
    • Kim HS, Suh YH. Minocycline and neurodegenerative diseases. Behav Brain Res. 2009;196(2):168-179.
    • (2009) Behav Brain Res , vol.196 , Issue.2 , pp. 168-179
    • Kim, H.S.1    Suh, Y.H.2
  • 19
    • 84859971485 scopus 로고    scopus 로고
    • Minocycline: Therapeutic potential in psychiatry
    • Dean OM, Data-Franco J, Giorlando F, Berk M. Minocycline: therapeutic potential in psychiatry. CNS Drugs. 2012;26(5):391-401.
    • (2012) CNS Drugs , vol.26 , Issue.5 , pp. 391-401
    • Dean, O.M.1    Data-Franco, J.2    Giorlando, F.3    Berk, M.4
  • 21
    • 34249804458 scopus 로고    scopus 로고
    • Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia
    • Levkovitz Y, Levi U, Braw Y, Cohen H. Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia. Brain Res. 2007;1154:154-162.
    • (2007) Brain Res , vol.1154 , pp. 154-162
    • Levkovitz, Y.1    Levi, U.2    Braw, Y.3    Cohen, H.4
  • 22
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Mendlovich S, Riwkes S, et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry. 2010; 71(2):138-149.
    • (2010) J Clin Psychiatry , vol.71 , Issue.2 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3
  • 23
    • 84864999825 scopus 로고    scopus 로고
    • Minocycline benefts negative symptoms in early schizophrenia: A randomized double-blind placebo-controlled clinical trial in patients on standard treatment
    • Chaudhry IB, Hallak J, Husain N, et al. Minocycline benefts negative symptoms in early schizophrenia: a randomized double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol. 2012;26(9):1185-1193.
    • (2012) J Psychopharmacol , vol.26 , Issue.9 , pp. 1185-1193
    • Chaudhry, I.B.1    Hallak, J.2    Husain, N.3
  • 25
    • 32844463928 scopus 로고    scopus 로고
    • The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia
    • Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia. Mol Psychiatry. 2006;11(1):47-55.
    • (2006) Mol Psychiatry , vol.11 , Issue.1 , pp. 47-55
    • Ashdown, H.1    Dumont, Y.2    Ng, M.3    Poole, S.4    Boksa, P.5    Luheshi, G.N.6
  • 26
    • 39149119959 scopus 로고    scopus 로고
    • The role of pro-inflammatory factors in mediating the effects on the fetus of prenatal undernutrition: Implications for schizophrenia
    • Shen Q, Li ZQ, Sun Y, et al. The role of pro-inflammatory factors in mediating the effects on the fetus of prenatal undernutrition: implications for schizophrenia. Schizophr Res. 2008;99(1-3):48-55.
    • (2008) Schizophr Res , vol.99 , Issue.1 , pp. 48-55
    • Shen, Q.1    Li, Z.Q.2    Sun, Y.3
  • 27
    • 84873522724 scopus 로고    scopus 로고
    • Developmental neuroinflammation and schizophrenia
    • Meyer U. Developmental neuroinflammation and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013;42:20-34.
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.42 , pp. 20-34
    • Meyer, U.1
  • 28
    • 34548499635 scopus 로고    scopus 로고
    • Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia
    • Arion D, Unger T, Lewis DA, Levitt P, Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry. 2007;62(7):711-721.
    • (2007) Biol Psychiatry , vol.62 , Issue.7 , pp. 711-721
    • Arion, D.1    Unger, T.2    Lewis, D.A.3    Levitt, P.4    Mirnics, K.5
  • 29
    • 53949085543 scopus 로고    scopus 로고
    • Molecular profles of schizophrenia in the CNS at different stages of illness
    • Narayan S, Tang B, Head SR, et al. Molecular profles of schizophrenia in the CNS at different stages of illness. Brain Res. 2008;1239: 235-248.
    • (2008) Brain Res , vol.1239 , pp. 235-248
    • Narayan, S.1    Tang, B.2    Head, S.R.3
  • 30
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis A, Bechade C, Bernard D, Roumier A. Microglial control of neuronal death and synaptic properties. Glia. 2007;55(3):233-238.
    • (2007) Glia , vol.55 , Issue.3 , pp. 233-238
    • Bessis, A.1    Bechade, C.2    Bernard, D.3    Roumier, A.4
  • 31
    • 84866275034 scopus 로고    scopus 로고
    • Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    • Steiner J, Bogerts B, Sarnyai Z, et al. Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity. World J Biol Psychiatry. 2012; 13(7):482-492.
    • (2012) World J Biol Psychiatry , vol.13 , Issue.7 , pp. 482-492
    • Steiner, J.1    Bogerts, B.2    Sarnyai, Z.3
  • 32
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • Alliot F, Godin I, Pessac B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res. 1999;117(2):145-152.
    • (1999) Brain Res Dev Brain Res , vol.117 , Issue.2 , pp. 145-152
    • Alliot, F.1    Godin, I.2    Pessac, B.3
  • 34
    • 79952068402 scopus 로고    scopus 로고
    • Microglia in the developing brain: From immunity to behaviour
    • Schlegelmilch T, Henke K, Peri F. Microglia in the developing brain: from immunity to behaviour. Curr Opin Neurobiol. 2011;21(1):5-10.
    • (2011) Curr Opin Neurobiol , vol.21 , Issue.1 , pp. 5-10
    • Schlegelmilch, T.1    Henke, K.2    Peri, F.3
  • 35
    • 80054905220 scopus 로고    scopus 로고
    • A role for microglia in synaptic plasticity?
    • Tremblay ME, Majewska AK. A role for microglia in synaptic plasticity? Commun Integr Biol. 2011;4(2):220-222.
    • (2011) Commun Integr Biol , vol.4 , Issue.2 , pp. 220-222
    • Tremblay, M.E.1    Majewska, A.K.2
  • 37
    • 36349001518 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells
    • Nurun BN, Tanaka T, Kamino K, et al. Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells. Psychiatry Clin Neurosci. 2006;60 Suppl 1:S27-S33.
    • (2006) Psychiatry Clin Neurosci , vol.60 , Issue.1
    • Nurun, B.N.1    Tanaka, T.2    Kamino, K.3
  • 38
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegen-eration: Multiple triggers with a common mechanism
    • Block ML, Hong JS. Microglia and inflammation-mediated neurodegen-eration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77-98.
    • (2005) Prog Neurobiol , vol.76 , Issue.2 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 39
    • 0032821589 scopus 로고    scopus 로고
    • Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective
    • Lieberman JA. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psychiatry. 1999; 46(6):729-739.
    • (1999) Biol Psychiatry , vol.46 , Issue.6 , pp. 729-739
    • Lieberman, J.A.1
  • 40
    • 33750724751 scopus 로고    scopus 로고
    • Possible mechanisms of neurodegeneration in schizophrenia
    • Perez-Neri I, Ramirez-Bermudez J, Montes S, Rios C. Possible mechanisms of neurodegeneration in schizophrenia. Neurochem Res. 2006;31(10):1279-1294.
    • (2006) Neurochem Res , vol.31 , Issue.10 , pp. 1279-1294
    • Perez-Neri, I.1    Ramirez-Bermudez, J.2    Montes, S.3    Rios, C.4
  • 42
    • 0343396256 scopus 로고    scopus 로고
    • Haloperidol prevents ketamine and phencyclidine-induced HSP70 protein expression but not microglial activation
    • Nakki R, Nickolenko J, Chang J, Sagar SM, Sharp FR. Haloperidol prevents ketamine and phencyclidine-induced HSP70 protein expression but not microglial activation. Exp Neurol. 1996;137(2):234-241.
    • (1996) Exp Neurol , vol.137 , Issue.2 , pp. 234-241
    • Nakki, R.1    Nickolenko, J.2    Chang, J.3    Sagar, S.M.4    Sharp, F.R.5
  • 43
    • 33747759704 scopus 로고    scopus 로고
    • Distribution of HLA-DR-positive microglia in schizophrenia refects impaired cerebral lateralization
    • Steiner J, Mawrin C, Ziegeler A, et al. Distribution of HLA-DR-positive microglia in schizophrenia refects impaired cerebral lateralization. Acta Neuropathol. 2006;112(3):305-316.
    • (2006) Acta Neuropathol , vol.112 , Issue.3 , pp. 305-316
    • Steiner, J.1    Mawrin, C.2    Ziegeler, A.3
  • 44
    • 35848950202 scopus 로고    scopus 로고
    • Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
    • Steiner J, Bielau H, Brisch R, et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res. 2008; 42(2):151-157.
    • (2008) J Psychiatr Res , vol.42 , Issue.2 , pp. 151-157
    • Steiner, J.1    Bielau, H.2    Brisch, R.3
  • 45
    • 0033588276 scopus 로고    scopus 로고
    • Evidence for activation of microglia in patients with psychiatric illnesses
    • Bayer TA, Buslei R, Havas L, Falkai P. Evidence for activation of microglia in patients with psychiatric illnesses. Neurosci Lett. 1999;271(2):126-128.
    • (1999) Neurosci Lett , vol.271 , Issue.2 , pp. 126-128
    • Bayer, T.A.1    Buslei, R.2    Havas, L.3    Falkai, P.4
  • 46
    • 0033983020 scopus 로고    scopus 로고
    • Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics
    • Radewicz K, Garey LJ, Gentleman SM, Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J Neuropathol Exp Neurol. 2000; 59(2):137-150.
    • (2000) J Neuropathol Exp Neurol , vol.59 , Issue.2 , pp. 137-150
    • Radewicz, K.1    Garey, L.J.2    Gentleman, S.M.3    Reynolds, R.4
  • 47
    • 22144498857 scopus 로고    scopus 로고
    • Quantitative analysis of activated microglia, ramifed and damage of processes in the frontal and temporal lobes of chronic schizophrenics
    • Wierzba-Bobrowicz T, Lewandowska E, Lechowicz W, Stepień T, Pasennik E. Quantitative analysis of activated microglia, ramifed and damage of processes in the frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol. 2005;43(2):81-89.
    • (2005) Folia Neuropathol , vol.43 , Issue.2 , pp. 81-89
    • Wierzba-Bobrowicz, T.1    Lewandowska, E.2    Lechowicz, W.3    Stepien, T.4    Pasennik, E.5
  • 48
    • 53249144430 scopus 로고    scopus 로고
    • Microglia activation in recent-onset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study
    • Van Berckel BN, Bossong MG, Boellaard R, et al. Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry. 2008;64(9):820-822.
    • (2008) Biol Psychiatry , vol.64 , Issue.9 , pp. 820-822
    • van Berckel, B.N.1    Bossong, M.G.2    Boellaard, R.3
  • 50
    • 84875101622 scopus 로고    scopus 로고
    • Roles of glial cells in schizophrenia: Possible targets for therapeutic approaches
    • Takahashi N, Sakurai T. Roles of glial cells in schizophrenia: possible targets for therapeutic approaches. Neurobiol Dis. 2013;53:49-60.
    • (2013) Neurobiol Dis , vol.53 , pp. 49-60
    • Takahashi, N.1    Sakurai, T.2
  • 51
  • 52
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science. 2003;302(5651):1760-1765.
    • (2003) Science , vol.302 , Issue.5651 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 54
    • 21844448903 scopus 로고    scopus 로고
    • Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro
    • Cacci E, Claasen JH, Kokaia Z. Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro. J Neurosci Res. 2005;80(6):789-797.
    • (2005) J Neurosci Res , vol.80 , Issue.6 , pp. 789-797
    • Cacci, E.1    Claasen, J.H.2    Kokaia, Z.3
  • 55
    • 33748906248 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
    • Iosif RE, Ekdahl CT, Ahlenius H, et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci. 2006;26(38):9703-9712.
    • (2006) J Neurosci , vol.26 , Issue.38 , pp. 9703-9712
    • Iosif, R.E.1    Ekdahl, C.T.2    Ahlenius, H.3
  • 56
    • 33751082632 scopus 로고    scopus 로고
    • Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus
    • Kaneko N, Kudo K, Mabuchi T, et al. Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus. Neuropsychopharmacology. 2006;31(12):2619-2626.
    • (2006) Neuropsychopharmacology , vol.31 , Issue.12 , pp. 2619-2626
    • Kaneko, N.1    Kudo, K.2    Mabuchi, T.3
  • 57
    • 77955050321 scopus 로고    scopus 로고
    • Celecoxib treatment in an early stage of schizophrenia: Results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment
    • Muller N, Krause D, Dehning S, et al. Celecoxib treatment in an early stage of schizophrenia: results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment. Schizophr Res. 2010;121(1-3):118-124.
    • (2010) Schizophr Res , vol.121 , Issue.1 , pp. 118-124
    • Muller, N.1    Krause, D.2    Dehning, S.3
  • 58
    • 0036272768 scopus 로고    scopus 로고
    • Benefcial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia
    • Muller N, Riedel M, Scheppach C, et al. Benefcial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia. Am J Psychiatry. 2002;159(6):1029-1034.
    • (2002) Am J Psychiatry , vol.159 , Issue.6 , pp. 1029-1034
    • Muller, N.1    Riedel, M.2    Scheppach, C.3
  • 59
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotec-tive in global brain ischemia
    • Yrjänheikki J, Keinänen R, Pellikka M, Hökfelt T, Koistinaho J. Tetracyclines inhibit microglial activation and are neuroprotec-tive in global brain ischemia. Proc Natl Acad Sci U S A. 1998; 95(26):15769-15774.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.26 , pp. 15769-15774
    • Yrjänheikki, J.1    Keinänen, R.2    Pellikka, M.3    Hökfelt, T.4    Koistinaho, J.5
  • 60
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH, Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A. 1999;96(23):13496-13500.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjänheikki, J.1    Tikka, T.2    Keinänen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 61
    • 1642321822 scopus 로고    scopus 로고
    • Early microglial activation following neonatal excitotoxic brain damage in mice: A potential target for neuroprotection
    • Dommeguess MA, Plaisant F, Vermey C, Gressens P. Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience. 2003;121(3):619-628.
    • (2003) Neuroscience , vol.121 , Issue.3 , pp. 619-628
    • Dommeguess, M.A.1    Plaisant, F.2    Vermey, C.3    Gressens, P.4
  • 62
    • 0035871840 scopus 로고    scopus 로고
    • Minocy-cline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocy-cline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001;21(8):2580-2588.
    • (2001) J Neurosci , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 63
    • 0036289498 scopus 로고    scopus 로고
    • Minocy-cline markedly protects the neonatal brain against hypoxic-ischemic injury
    • Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocy-cline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002;52(1):54-61.
    • (2002) Ann Neurol , vol.52 , Issue.1 , pp. 54-61
    • Arvin, K.L.1    Han, B.H.2    Du, Y.3    Lin, S.Z.4    Paul, S.M.5    Holtzman, D.M.6
  • 64
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M, Ona VO, Li M, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000;6(7):797-801.
    • (2000) Nat Med , vol.6 , Issue.7 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3
  • 65
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine mouse model of Parkinson disease
    • Wu DC, Jackson-Lewis V, Vila M, et al. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine mouse model of Parkinson disease. J Neurosci. 2002; 22(5):1763-1771.
    • (2002) J Neurosci , vol.22 , Issue.5 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3
  • 66
    • 69249208444 scopus 로고    scopus 로고
    • Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice
    • Homsi S, Federico F, Croci N, et al. Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice. Brain Res. 2009;1291:122-132.
    • (2009) Brain Res , vol.1291 , pp. 122-132
    • Homsi, S.1    Federico, F.2    Croci, N.3
  • 67
    • 38749087581 scopus 로고    scopus 로고
    • Protective effect of minocy-cline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity
    • Ahuja M, Bishnoi M, Chopra K. Protective effect of minocy-cline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology. 2008;244(2-3):111-122.
    • (2008) Toxicology , vol.244 , Issue.2 , pp. 111-122
    • Ahuja, M.1    Bishnoi, M.2    Chopra, K.3
  • 68
    • 72049132915 scopus 로고    scopus 로고
    • Mitochondria and calcium fux as targets of neuroprotection caused by minocycline in cerebellar granule cells
    • Garcia-Martinez EM, Sanz-Blasco S, Karachitos A, et al. Mitochondria and calcium fux as targets of neuroprotection caused by minocycline in cerebellar granule cells. Biochem Pharmacol. 2010;79(2):239-250.
    • (2010) Biochem Pharmacol , vol.79 , Issue.2 , pp. 239-250
    • Garcia-Martinez, E.M.1    Sanz-Blasco, S.2    Karachitos, A.3
  • 69
    • 0038643584 scopus 로고    scopus 로고
    • White matter changes in schizophrenia: Evidence for myelin-related dysfunction
    • Davis KL, Stewart DG, Friedman JI, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry. 2003;60(5):443-456.
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.5 , pp. 443-456
    • Davis, K.L.1    Stewart, D.G.2    Friedman, J.I.3
  • 70
    • 23944446932 scopus 로고    scopus 로고
    • White matter abnormalities in early-onset schizophrenia: A voxel-based diffusion tensor imaging study
    • Kumra S, Ashtari M, Cervellione KL, et al. White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry. 2005;44(9):934-941.
    • (2005) J Am Acad Child Adolesc Psychiatry , vol.44 , Issue.9 , pp. 934-941
    • Kumra, S.1    Ashtari, M.2    Cervellione, K.L.3
  • 71
    • 34248145966 scopus 로고    scopus 로고
    • Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia
    • Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley R W. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. Arch Gen Psychiatry. 2007;64(5):521-529.
    • (2007) Arch Gen Psychiatry , vol.64 , Issue.5 , pp. 521-529
    • Salisbury, D.F.1    Kuroki, N.2    Kasai, K.3    Shenton, M.E.4    McCarley, R.W.5
  • 72
    • 40049102475 scopus 로고    scopus 로고
    • What happens after the frst episode? A review of progressive brain changes in chronically ill patients with schizophrenia
    • Hulshoff Pol HE, Kahn RS. What happens after the frst episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr Bull. 2008;34(2):354-366.
    • (2008) Schizophr Bull , vol.34 , Issue.2 , pp. 354-366
    • Hulshoff, P.H.E.1    Kahn, R.S.2
  • 73
    • 29144436379 scopus 로고    scopus 로고
    • Apoptotic mechanisms and the synaptic pathology of schizophrenia
    • Glantz LA, Gilmore JH, Lieberman JA, Jarskog LF. Apoptotic mechanisms and the synaptic pathology of schizophrenia. Schizophr Res. 2006;81(1):47-63.
    • (2006) Schizophr Res , vol.81 , Issue.1 , pp. 47-63
    • Glantz, L.A.1    Gilmore, J.H.2    Lieberman, J.A.3    Jarskog, L.F.4
  • 74
    • 0031716026 scopus 로고    scopus 로고
    • Dopamine agonists and neuro-protection in Parkinson's disease
    • Olanow CW, Jenner P, Brooks D. Dopamine agonists and neuro-protection in Parkinson's disease. Ann Neurol. 1998;44(3 Suppl 1): S167-S174.
    • (1998) Ann Neurol , vol.44 , Issue.1-3
    • Olanow, C.W.1    Jenner, P.2    Brooks, D.3
  • 75
    • 0036827988 scopus 로고    scopus 로고
    • Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42
    • Medina S, Martinez M, Hernanz A. Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42. Free Radic Res. 2002;36(11):1179-1184.
    • (2002) Free Radic Res , vol.36 , Issue.11 , pp. 1179-1184
    • Medina, S.1    Martinez, M.2    Hernanz, A.3
  • 76
    • 2642513275 scopus 로고    scopus 로고
    • Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFN-gamma and TNF-alpha on apoptosis
    • Buntinx M, Moreels M, Vandenabeele F, et al. Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFN-gamma and TNF-alpha on apoptosis. J Neurosci Res. 2004;76(6):834-845.
    • (2004) J Neurosci Res , vol.76 , Issue.6 , pp. 834-845
    • Buntinx, M.1    Moreels, M.2    Vandenabeele, F.3
  • 77
    • 1442326012 scopus 로고    scopus 로고
    • Minocycline: Neuroprotective mechanisms in Parkinson's disease
    • Thomas M, Le WD. Minocycline: neuroprotective mechanisms in Parkinson's disease. Curr Pharm Des. 2004;10(6):679-686.
    • (2004) Curr Pharm Des , vol.10 , Issue.6 , pp. 679-686
    • Thomas, M.1    Le, W.D.2
  • 78
    • 33745457705 scopus 로고    scopus 로고
    • Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
    • Alano CC, Kauppinen TM, Valls AV, Swanson RA. Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci U S A. 2006;103(25):9685-9690.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.25 , pp. 9685-9690
    • Alano, C.C.1    Kauppinen, T.M.2    Valls, A.V.3    Swanson, R.A.4
  • 79
    • 0036260089 scopus 로고    scopus 로고
    • Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis
    • Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong V W. Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain. 2002;125 Pt 6:1297-1308.
    • (2002) Brain , vol.125 , Issue.PART 6 , pp. 1297-1308
    • Brundula, V.1    Rewcastle, N.B.2    Metz, L.M.3    Bernard, C.C.4    Yong, V.W.5
  • 80
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    • Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem. 2004;279(19):19948-19954.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19948-19954
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 81
    • 26444451053 scopus 로고    scopus 로고
    • Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis
    • Castanares M, Vera Y, Erkkila K, et al. Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis. Biochem Biophys Res Commun. 2005;337(2):663-669.
    • (2005) Biochem Biophys Res Commun , vol.337 , Issue.2 , pp. 663-669
    • Castanares, M.1    Vera, Y.2    Erkkila, K.3
  • 82
    • 10744226569 scopus 로고    scopus 로고
    • Minocycline inhibits cas-pase activation and reactivation, increases the ratio of XIAP to SMAC/ DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
    • Scarabelli TM, Stephanou A, Pasini E, et al. Minocycline inhibits cas-pase activation and reactivation, increases the ratio of XIAP to SMAC/ DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. J Am Coll Cardiol. 2004;43(5):865-874.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.5 , pp. 865-874
    • Scarabelli, T.M.1    Stephanou, A.2    Pasini, E.3
  • 83
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M, Ona VO, Li M, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000;6(7):797-801.
    • (2000) Nat Med , vol.6 , Issue.7 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3
  • 84
    • 12144290904 scopus 로고    scopus 로고
    • Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional defcits after spinal cord injury
    • Teng YD, Choi H, Onario RC, et al. Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional defcits after spinal cord injury. Proc Natl Acad Sci U S A. 2004;101(9):3071-3076.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.9 , pp. 3071-3076
    • Teng, Y.D.1    Choi, H.2    Onario, R.C.3
  • 85
    • 80053461285 scopus 로고    scopus 로고
    • Increased apoptosis and different regulation of pro-apoptosis protein bax and antiapoptosis protein bcl-2 in the olfactory bulb of a rat model of depression
    • Yang D, Liu X, Zhang R, et al. Increased apoptosis and different regulation of pro-apoptosis protein bax and antiapoptosis protein bcl-2 in the olfactory bulb of a rat model of depression. Neurosci Lett. 2011;504(1):18-22.
    • (2011) Neurosci Lett , vol.504 , Issue.1 , pp. 18-22
    • Yang, D.1    Liu, X.2    Zhang, R.3
  • 86
    • 77956124441 scopus 로고    scopus 로고
    • Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2
    • Kernt M, Neubauer AS, Eibl KH, et al. Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2. Clin Ophthalmol. 2010;4:591-604.
    • (2010) Clin Ophthalmol , vol.4 , pp. 591-604
    • Kernt, M.1    Neubauer, A.S.2    Eibl, K.H.3
  • 87
    • 79951678468 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin
    • Tang CM, Hwang CS, Chen SD, Yang DI. Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: roles of Bcl-2 and thioredoxin. Free Radic Biol Med. 2011;50(6):710-721.
    • (2011) Free Radic Biol Med , vol.50 , Issue.6 , pp. 710-721
    • Tang, C.M.1    Hwang, C.S.2    Chen, S.D.3    Yang, D.I.4
  • 88
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cyto-chrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S, Stavrovskaya IG, Drozda M, et al. Minocycline inhibits cyto-chrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 2002;417(6884):74-78.
    • (2002) Nature , vol.417 , Issue.6884 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3
  • 89
    • 0041335559 scopus 로고    scopus 로고
    • Minocycline inhibits caspase- independent and dependent mitochondrial cell death pathways in models of Huntington's disease
    • Wang X, Zhu S, Drozda M, et al. Minocycline inhibits caspase- independent and dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A. 2003;100(18): 10483-10487.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.18 , pp. 10483-10487
    • Wang, X.1    Zhu, S.2    Drozda, M.3
  • 90
    • 27744553138 scopus 로고    scopus 로고
    • In vitro properties of 5-(benzylsulfonyl)-4-bromo-2- methyl- 3(2H)-pyridazinone: A novel permeability transition pore inhibitor
    • Fuks B, Talaga P, Huart C, et al. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2- methyl- 3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005;519(1-2):24-30.
    • (2005) Eur J Pharmacol , vol.519 , Issue.1-2 , pp. 24-30
    • Fuks, B.1    Talaga, P.2    Huart, C.3
  • 91
    • 46349097952 scopus 로고    scopus 로고
    • Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore
    • Leung AW, Halestrap AP. Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta. 2008;1777(7-8):946-952.
    • (2008) Biochim Biophys Acta , vol.1777 , Issue.7-8 , pp. 946-952
    • Leung, A.W.1    Halestrap, A.P.2
  • 92
    • 18144393838 scopus 로고    scopus 로고
    • Mino-cycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage
    • Morimoto N, Shimazawa M, Yamashima T, Nagai H, Hara H. Mino-cycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res. 2005;1044(1):8-15.
    • (2005) Brain Res , vol.1044 , Issue.1 , pp. 8-15
    • Morimoto, N.1    Shimazawa, M.2    Yamashima, T.3    Nagai, H.4    Hara, H.5
  • 93
    • 23244453399 scopus 로고    scopus 로고
    • Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radical-scavenging activity
    • Kraus RL, Pasieczny R, Lariosa-Willingham K, Turner MS, Jiang A, Trauger J W. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem. 2005;94(3):819-827.
    • (2005) J Neurochem , vol.94 , Issue.3 , pp. 819-827
    • Kraus, R.L.1    Pasieczny, R.2    Lariosa-Willingham, K.3    Turner, M.S.4    Jiang, A.5    Trauger, J.W.6
  • 94
    • 43949112985 scopus 로고    scopus 로고
    • Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors
    • Wiedholz LM, Owens WA, Horton RE, et al. Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors. Mol Psychiatry. 2008;13(6):631-640.
    • (2008) Mol Psychiatry , vol.13 , Issue.6 , pp. 631-640
    • Wiedholz, L.M.1    Owens, W.A.2    Horton, R.E.3
  • 95
    • 59449092174 scopus 로고    scopus 로고
    • Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat
    • Woolley ML, Waters KA, Gartlon JE, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009;202(1-3):343-354.
    • (2009) Psychopharmacology (Berl) , vol.202 , Issue.1 , pp. 343-354
    • Woolley, M.L.1    Waters, K.A.2    Gartlon, J.E.3
  • 96
    • 28644431719 scopus 로고    scopus 로고
    • Phosphorylation of AMPA receptors: Mechanisms and synaptic plasticity
    • Wang JQ, Arora A, Yang L, et al. Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity. Mol Neurobiol. 2005; 32(3):237-249.
    • (2005) Mol Neurobiol , vol.32 , Issue.3 , pp. 237-249
    • Wang, J.Q.1    Arora, A.2    Yang, L.3
  • 97
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopamin-ergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y, Ma Z, Lin S, et al. Minocycline prevents nigrostriatal dopamin-ergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A. 2001;98(25):14669-14674.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.25 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3
  • 98
    • 33846849030 scopus 로고    scopus 로고
    • Neuron death and inflammation in a rat model of intracerebral hemorrhage: Effects of delayed minocycline treatment
    • Wasserman JK, Schlichter LC. Neuron death and inflammation in a rat model of intracerebral hemorrhage: effects of delayed minocycline treatment. Brain Res. 2007;1136(1):208-218.
    • (2007) Brain Res , vol.1136 , Issue.1 , pp. 208-218
    • Wasserman, J.K.1    Schlichter, L.C.2
  • 99
    • 33750338069 scopus 로고    scopus 로고
    • Protective effects of minocy-cline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
    • Zhang L, Kitaichi K, Fujimoto Y, et al. Protective effects of minocy-cline on behavioral changes and neurotoxicity in mice after administration of methamphetamine. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(8):1381-1393.
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , Issue.8 , pp. 1381-1393
    • Zhang, L.1    Kitaichi, K.2    Fujimoto, Y.3
  • 100
    • 34249804458 scopus 로고    scopus 로고
    • Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia
    • Levkovitz Y, Levi U, Braw Y, Cohen H. Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia. Brain Res. 2007;1154:154-162.
    • (2007) Brain Res , vol.1154 , pp. 154-162
    • Levkovitz, Y.1    Levi, U.2    Braw, Y.3    Cohen, H.4
  • 101
    • 84885779392 scopus 로고    scopus 로고
    • Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways
    • Monte AS, de Souza GC, McIntyre RS, et al. Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathways. J Psychopharmacol. 2013;27(11):1032-1043.
    • (2013) J Psychopharmacol , vol.27 , Issue.11 , pp. 1032-1043
    • Monte, A.S.1    de Souza, G.C.2    McIntyre, R.S.3
  • 102
    • 33847276567 scopus 로고    scopus 로고
    • Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: A positron emission tomography study in conscious monkeys
    • Hashimoto K, Tsukada H, Nishiyama S, Fukumoto D, Kakiuchi T, Iyo M. Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a positron emission tomography study in conscious monkeys. Biol Psychiatry. 2007;61(5):577-581.
    • (2007) Biol Psychiatry , vol.61 , Issue.5 , pp. 577-581
    • Hashimoto, K.1    Tsukada, H.2    Nishiyama, S.3    Fukumoto, D.4    Kakiuchi, T.5    Iyo, M.6
  • 103
    • 34547884686 scopus 로고    scopus 로고
    • Minocycline attenuates hyperlocomotion and prepulse inhibition defcits in mice after administration of the NMDA receptor antagonist dizocilpine
    • Zhang L, Shirayama Y, Iyo M, Hashimoto K. Minocycline attenuates hyperlocomotion and prepulse inhibition defcits in mice after administration of the NMDA receptor antagonist dizocilpine. Neu-ropsychopharmacology. 2007;32(9):2004-2010.
    • (2007) Neu-ropsychopharmacology , vol.32 , Issue.9 , pp. 2004-2010
    • Zhang, L.1    Shirayama, Y.2    Iyo, M.3    Hashimoto, K.4
  • 104
    • 38749139293 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive defcits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline
    • Fujita Y, Ishima T, Kunitachi S, et al. Phencyclidine-induced cognitive defcits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(2):336-339.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , Issue.2 , pp. 336-339
    • Fujita, Y.1    Ishima, T.2    Kunitachi, S.3
  • 105
    • 38349123277 scopus 로고    scopus 로고
    • Improvement by minocy-cline of methamphetamine-induced impairment of recognition memory in mice
    • Mizoguchi H, Takuma K, Fukakusa A, et al. Improvement by minocy-cline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl). 2008;196(2):233-241.
    • (2008) Psychopharmacology (Berl) , vol.196 , Issue.2 , pp. 233-241
    • Mizoguchi, H.1    Takuma, K.2    Fukakusa, A.3
  • 107
  • 109
    • 81955168013 scopus 로고    scopus 로고
    • Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms
    • Kelly DL, Vyas G, Richardson CM, et al. Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms. Schizophr Res. 2011;133(1-3):257-258.
    • (2011) Schizophr Res , vol.133 , Issue.1 , pp. 257-258
    • Kelly, D.L.1    Vyas, G.2    Richardson, C.M.3
  • 111
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Mendlovich S, Riwkes S, et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry. 2010;71(2):138-149.
    • (2010) J Clin Psychiatry , vol.71 , Issue.2 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3
  • 112
    • 84864999825 scopus 로고    scopus 로고
    • Minocycline benefits negative symptoms in early schizophrenia: A randomized double-blind placebo-controlled clinical trial in patients on standard treatment
    • Chaudhry IB, Hallak J, Husain N, et al. Minocycline benefits negative symptoms in early schizophrenia: a randomized double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol. 2012;26(9):1185-1193.
    • (2012) J Psychopharmacol , vol.26 , Issue.9 , pp. 1185-1193
    • Chaudhry, I.B.1    Hallak, J.2    Husain, N.3
  • 113
    • 78651256932 scopus 로고    scopus 로고
    • Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans
    • Sofuoglu M, Mooney M, Kosten T, Waters A, Hashimoto K. Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans. Psychopharmacology (Berl). 2011;213(1):61-68.
    • (2011) Psychopharmacology (Berl) , vol.213 , Issue.1 , pp. 61-68
    • Sofuoglu, M.1    Mooney, M.2    Kosten, T.3    Waters, A.4    Hashimoto, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.