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Volumn 13, Issue 7, 2012, Pages 482-492

Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired bloodbrain barrier integrity

Author keywords

Bloodbrain barrier; Glutamate; Kynurenines; Major depression; Psychoimmunology; Schizophrenia

Indexed keywords

GLUTAMIC ACID; KETAMINE; KYNURENIC ACID; KYNURENINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINOLINIC ACID;

EID: 84866275034     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.583941     Document Type: Review
Times cited : (127)

References (119)
  • 1
    • 33846620518 scopus 로고    scopus 로고
    • Celecoxib as adjunctive therapy in schizophrenia: A double-blind, randomized and placebo-controlled trial
    • DOI 10.1016/j.schres.2006.11.016, PII S0920996406004956
    • Akhondzadeh S, Tabatabaee M, Amini H, Ahmadi Abhari SA, Abbasi SH, Behnam B. 2007. Celecoxib as adjunctive therapy in schizophrenia: a double-blind, randomized and placebo-controlled trial. Schizophr Res 90:179-185. (Pubitemid 46177578)
    • (2007) Schizophrenia Research , vol.90 , Issue.1-3 , pp. 179-185
    • Akhondzadeh, S.1    Tabatabaee, M.2    Amini, H.3    Ahmadi Abhari, S.A.4    Abbasi, S.H.5    Behnam, B.6
  • 2
    • 0032498818 scopus 로고    scopus 로고
    • Absence of neuroDEgeneration and neural injury in the cerebral cortex in a sample of elDErly patients with schizophrenia
    • Arnold SE, Trojanowski JQ, Gur RE, Blackwell P, Han LY, Choi C. 1998. Absence of neuroDEgeneration and neural injury in the cerebral cortex in a sample of elDErly patients with schizophrenia. Arch Gen Psychiatry 55:225-232.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 225-232
    • Arnold, S.E.1    Trojanowski, J.Q.2    Gur, R.E.3    Blackwell, P.4    Han, L.Y.5    Choi, C.6
  • 3
    • 0342546475 scopus 로고    scopus 로고
    • Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study
    • DOI 10.1016/S0006-3223(99)00159-6, PII S0006322399001596
    • Auer DP, Putz B, Kraft E, Lipinski B, Schill J, Holsboer F. 2000. Reduced glutamate in the anterior cingulate cortex in Depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 47:305-313. (Pubitemid 30109243)
    • (2000) Biological Psychiatry , vol.47 , Issue.4 , pp. 305-313
    • Auer, D.P.1    Putz, B.2    Kraft, E.3    Lipinski, B.4    Schill, J.5    Holsboer, F.6
  • 4
    • 0019945874 scopus 로고
    • Impairment of the blood-brain barrier as an aetiological factor in paranoid psychosis
    • Axelsson R, Martensson E, Alling C. 1982. Impairment of the blood-brain barrier as an aetiological factor in paranoid psychosis. Br J Psychiatry 141:273-281. (Pubitemid 12052487)
    • (1982) British Journal of Psychiatry , vol.141 , Issue.3 , pp. 273-281
    • Axelsson, R.1    Martensson, E.2    Alling, C.3
  • 5
    • 0033588276 scopus 로고    scopus 로고
    • Evidence for activation of microglia in patients with psychiatric illnesses
    • DOI 10.1016/S0304-3940(99)00545-5, PII S0304394099005455
    • Bayer TA, Buslei R, Havas L, Falkai P. 1999. Evidence for activation of microglia in patients with psychiatric illnesses. Neurosci Lett 271:126-128. (Pubitemid 29400683)
    • (1999) Neuroscience Letters , vol.271 , Issue.2 , pp. 126-128
    • Bayer, T.A.1    Buslei, R.2    Havas, L.3    Falkai, P.4
  • 6
    • 33845727067 scopus 로고    scopus 로고
    • What is the blood-brain barrier (not)?
    • DOI 10.1016/j.it.2006.11.007, PII S1471490606003292
    • Bechmann I, Galea I, Perry VH. 2007. What is the blood-brain barrier (not)? Trends Immunol 28:5-11. (Pubitemid 46001619)
    • (2007) Trends in Immunology , vol.28 , Issue.1 , pp. 5-11
    • Bechmann, I.1    Galea, I.2    Perry, V.H.3
  • 7
    • 11144263152 scopus 로고    scopus 로고
    • The mild encephalitis-hypothesis-new findings and studies
    • Bechter K. 2004. [The mild encephalitis-hypothesis-new findings and studies]. Psychiatr Prax 31(Suppl 1):S41-43.
    • (2004) Psychiatr Prax , vol.31 , Issue.SUPPL. 1
    • Bechter, K.1
  • 8
    • 59649084668 scopus 로고    scopus 로고
    • Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization
    • Beckmann M, Johansen-Berg H, Rushworth MF. 2009. Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. J Neurosci 29:1175-1190.
    • (2009) J Neurosci , vol.29 , pp. 1175-1190
    • Beckmann, M.1    Johansen-Berg, H.2    Rushworth, M.F.3
  • 9
    • 0021996790 scopus 로고
    • Kynurenine hydroxylase: A potential rate-limiting enzyme in tryptophan metabolism
    • BenDEr DA, McCreanor GM. 1985. Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism. Biochem Soc Trans 13:441-443. (Pubitemid 15096209)
    • (1985) Biochemical Society Transactions , vol.13 , Issue.2 , pp. 441-443
    • Bender, D.A.1    McCreanor, G.M.2
  • 10
    • 67651055423 scopus 로고    scopus 로고
    • Glial cells in schizophrenia: Pathophysiological significance and possible consequences for therapy
    • Bernstein HG, Steiner J, Bogerts B. 2009. Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy. Expert Rev Neurother 9:1059-1071.
    • (2009) Expert Rev Neurother , vol.9 , pp. 1059-1071
    • Bernstein, H.G.1    Steiner, J.2    Bogerts, B.3
  • 12
    • 0036525701 scopus 로고    scopus 로고
    • 1 cholinergic muscarinic receptor from schizophrenic patients: Molecular interaction
    • Borda T, Perez Rivera R, Joensen L, Gomez RM, Sterin-Borda L. 2002. Antibodies against cerebral M1 cholinergic muscarinic receptor from schizophrenic patients: molecular interaction. J Immunol 168:3667-3674. (Pubitemid 34250439)
    • (2002) Journal of Immunology , vol.168 , Issue.7 , pp. 3667-3674
    • Borda, T.1    Perez Rivera, R.2    Joensen, L.3    Gomez, R.M.4    Sterin-Borda, L.5
  • 13
    • 0034750095 scopus 로고    scopus 로고
    • Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages
    • DOI 10.1016/S0165-5728(01)00418-0, PII S0165572801004180
    • Chiarugi A, Calvani M, Meli E, Traggiai E, Moroni F. 2001. Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-Derived macrophages. J Neuroimmunol 120:190-198. (Pubitemid 33016739)
    • (2001) Journal of Neuroimmunology , vol.120 , Issue.1-2 , pp. 190-198
    • Chiarugi, A.1    Calvani, M.2    Meli, E.3    Traggiai, E.4    Moroni, F.5
  • 15
    • 0037334173 scopus 로고    scopus 로고
    • Herpesviruses and Toxoplasma gondii in orbital frontal cortex of psychiatric patients
    • DOI 10.1016/S0920-9964(02)00160-3, PII S0920996402001603
    • Conejero-Goldberg C, Torrey EF, Yolken RH. 2003. Herpesviruses and Toxoplasma gondii in orbital frontal cortex of psychiatric patients. Schizophr Res 60:65-69. (Pubitemid 36018743)
    • (2003) Schizophrenia Research , vol.60 , Issue.1 , pp. 65-69
    • Conejero-Goldberg, C.1    Torrey, E.F.2    Yolken, R.H.3
  • 17
    • 60849135712 scopus 로고    scopus 로고
    • Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation
    • D'Mello C, Le T, Swain MG. 2009. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci 29:2089-2102.
    • (2009) J Neurosci , vol.29 , pp. 2089-2102
    • D'Mello, C.1    Le Swain, T.M.G.2
  • 18
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • DOI 10.1038/nrn2297, PII NRN2297
    • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. 2008. From inflammation to sickness and Depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46-56. (Pubitemid 350295688)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 21
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels ae elevated in the cerebrospinal fluid of patients with schizophrenia
    • DOI 10.1016/S0304-3940(01)02242-X, PII S030439400102242X
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindstrom LH, Engberg G. 2001. Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 313:96-98. (Pubitemid 32973903)
    • (2001) Neuroscience Letters , vol.313 , Issue.1-2 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindstrom, L.H.5    Engberg, G.6
  • 22
    • 0034611066 scopus 로고    scopus 로고
    • Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia
    • DOI 10.1016/S0165-1781(00)00104-9, PII S0165178100001049
    • Falke E, Han LY, Arnold SE. 2000. Absence of neuroDEgeneration in the thalamus and caudate of elDErly patients with schizophrenia. Psychiatry Res 93:103-110. (Pubitemid 30139477)
    • (2000) Psychiatry Research , vol.93 , Issue.2 , pp. 103-110
    • Falke, E.1    Han, L.-Y.2    Arnold, S.E.3
  • 23
    • 33847280378 scopus 로고    scopus 로고
    • Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10
    • DOI 10.1038/sj.mp.4001925, PII 4001925
    • Fellerhoff B, Laumbacher B, Mueller N, Gu S, Wank R. 2007. Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10. Mol Psychiatry 12:264-272. (Pubitemid 46328502)
    • (2007) Molecular Psychiatry , vol.12 , Issue.3 , pp. 264-272
    • Fellerhoff, B.1    Laumbacher, B.2    Mueller, N.3    Gu, S.4    Wank, R.5
  • 24
    • 33845628839 scopus 로고    scopus 로고
    • What is immune privilege (not)?
    • DOI 10.1016/j.it.2006.11.004, PII S1471490606003267
    • Galea I, Bechmann I, Perry VH. 2007. What is immune privilege (not)? Trends Immunol 28:12-18. (Pubitemid 44960159)
    • (2007) Trends in Immunology , vol.28 , Issue.1 , pp. 12-18
    • Galea, I.1    Bechmann, I.2    Perry, V.H.3
  • 27
    • 0033928598 scopus 로고    scopus 로고
    • Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis
    • Guillemin GJ, Smith DG, Kerr SJ, Smythe GA, Kapoor V, Armati PJ, Brew BJ. 2000. Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis. Redox Rep 5:108-111. (Pubitemid 30488525)
    • (2000) Redox Report , vol.5 , Issue.2-3 , pp. 108-111
    • Guillemin, G.J.1    Smith, D.G.2    Kerr, S.J.3    Smythe, G.A.4    Kapoor, V.5    Armati, P.J.6    Brew, B.J.7
  • 28
    • 11144314849 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
    • DOI 10.1002/glia.20090
    • Guillemin GJ, Smythe G, Takikawa O, Brew BJ. 2005. Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia 49: 15-23. (Pubitemid 40023649)
    • (2005) GLIA , vol.49 , Issue.1 , pp. 15-23
    • Guillemin, G.J.1    Smythe, G.2    Takikawa, O.3    Brew, B.J.4
  • 29
    • 68049131222 scopus 로고    scopus 로고
    • Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity
    • Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD. 2009. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry 66:407-414.
    • (2009) Biol Psychiatry , vol.66 , pp. 407-414
    • Harrison, N.A.1    Brydon, L.2    Walker, C.3    Gray, M.A.4    Steptoe, A.5    Critchley, H.D.6
  • 30
    • 70349513258 scopus 로고    scopus 로고
    • Emerging role of glutamate in the pathophysiology of major Depressive disorder
    • Hashimoto K. 2009. Emerging role of glutamate in the pathophysiology of major Depressive disorder. Brain Res Rev 61: 105-123.
    • (2009) Brain Res Rev , vol.61 , pp. 105-123
    • Hashimoto, K.1
  • 31
    • 0031897446 scopus 로고    scopus 로고
    • The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes
    • DOI 10.1016/S0924-977X(97)00050-3, PII S0924977X97000503
    • Heresco-Levy U, Javitt DC. 1998. The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur Neuropsychopharmacol 8:141-152. (Pubitemid 28210341)
    • (1998) European Neuropsychopharmacology , vol.8 , Issue.2 , pp. 141-152
    • Heresco-Levy, U.1    Javitt, D.C.2
  • 32
    • 0036901920 scopus 로고    scopus 로고
    • Effects of antidepressants on the production of cytokines
    • DOI 10.1017/S1461145702003164
    • Kenis G, Maes M. 2002. Effects of antidepressants on the production of cytokines. Int J Neuropsychopharmacol 5: 401-412. (Pubitemid 35470359)
    • (2002) International Journal of Neuropsychopharmacology , vol.5 , Issue.4 , pp. 401-412
    • Kenis, G.1    Maes, M.2
  • 33
    • 0023520891 scopus 로고
    • Quinolinate neurotoxicity in cortical cell culture
    • DOI 10.1016/0306-4522(87)90066-2
    • Kim JP, Choi DW. 1987. Quinolinate neurotoxicity in cortical cell culture. Neuroscience 23:423-432. (Pubitemid 18004221)
    • (1987) Neuroscience , vol.23 , Issue.2 , pp. 423-432
    • Kim, J.P.1    Choi, D.W.2
  • 34
    • 65449120384 scopus 로고    scopus 로고
    • Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients
    • Kim YK, Myint AM, Verkerk R, Scharpe S, Steinbusch H, Leonard B. 2009. Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients. Neuropsychobiology 59:123-129.
    • (2009) Neuropsychobiology , vol.59 , pp. 123-129
    • Kim, Y.K.1    Myint, A.M.2    Verkerk, R.3    Scharpe, S.4    Steinbusch, H.5    Leonard, B.6
  • 35
    • 77955421801 scopus 로고    scopus 로고
    • Cortical kynurenic acid bidirectionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry
    • Konradsson-Geuken A, Wu HQ, Gash CR, Alexander KS, Campbell A, Sozeri Y, et al. 2010. Cortical kynurenic acid bidirectionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. Neuroscience 169:1848-1859.
    • (2010) Neuroscience , vol.169 , pp. 1848-1859
    • Konradsson-Geuken, A.1    Wu, H.Q.2    Gash, C.R.3    Alexander, K.S.4    Campbell, A.5    Sozeri, Y.6
  • 36
    • 0031463617 scopus 로고    scopus 로고
    • Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics
    • DOI 10.1007/BF01294737
    • Kurumaji A, Wakai T, Toru M. 1997. DEcreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics. J Neural Transm 104:1361-1370. (Pubitemid 28031830)
    • (1997) Journal of Neural Transmission , vol.104 , Issue.11-12 , pp. 1361-1370
    • Kurumaji, A.1    Wakai, T.2    Toru, M.3
  • 37
    • 0034851624 scopus 로고    scopus 로고
    • Effects of ketamine in normal and schizophrenic volunteers
    • DOI 10.1016/S0893-133X(01)00243-3, PII S0893133X01002433
    • Lahti AC, Weiler MA, Tamara Michaelidis BA, Parwani A, Tamminga CA. 2001. Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology 25:455-467. (Pubitemid 32830950)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.4 , pp. 455-467
    • Lahti, A.C.1    Weiler, M.A.2    Michaelidis, T.3    Parwani, A.4    Tamminga, C.A.5
  • 38
    • 77949571369 scopus 로고    scopus 로고
    • Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major Depression
    • Laugeray A, Launay JM, Callebert J, Surget A, Belzung C, Barone PR. 2010. Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major Depression. Behav Brain Res 210:84-91.
    • (2010) Behav Brain Res , vol.210 , pp. 84-91
    • Laugeray, A.1    Launay, J.M.2    Callebert, J.3    Surget, A.4    Belzung, C.5    Barone, P.R.6
  • 40
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Mendlovich S, Riwkes S, Braw Y, Levkovitch-Verbin H, Gal G, et al. 2010. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry 71: 138-149.
    • (2010) J Clin Psychiatry , vol.71 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3    Braw, Y.4    Levkovitch-Verbin, H.5    Gal, G.6
  • 41
    • 67349166480 scopus 로고    scopus 로고
    • Behavioral immunization: Immunity to self-antigens contributes to psychological stress resilience
    • Lewitus GM, Schwartz M. 2009. Behavioral immunization: immunity to self-antigens contributes to psychological stress resilience. Mol Psychiatry 14:532-536.
    • (2009) Mol Psychiatry , vol.14 , pp. 532-536
    • Lewitus, G.M.1    Schwartz, M.2
  • 43
    • 41249083804 scopus 로고    scopus 로고
    • 7 receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms
    • DOI 10.1111/j.1471-4159.2007.05119.x
    • Lo JC, Huang WC, Chou YC, Tseng CH, Lee WL, Sun SH. 2008. Activation of P2X(7) receptors DEcreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms. J Neurochem 105:151-164. (Pubitemid 351444678)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.1 , pp. 151-164
    • Lo, J.-C.1    Huang, W.-C.2    Chou, Y.-C.3    Tseng, C.-H.4    Lee, W.-L.5    Sun, S.H.6
  • 44
    • 37349049304 scopus 로고    scopus 로고
    • The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects
    • DOI 10.1007/s11920-007-0063-1
    • Maeng S, Zarate CA Jr. 2007. The role of glutamate in mood disorders: results from the ketamine in major Depression study and the presumed cellular mechanism unDErlying its antidepressant effects. Curr Psychiatry Rep 9:467-474. (Pubitemid 350284937)
    • (2007) Current Psychiatry Reports , vol.9 , Issue.6 , pp. 467-474
    • Maeng, S.1    Zarate Jr., C.A.2
  • 45
    • 34547702304 scopus 로고    scopus 로고
    • T- and B-lymphocytes in patients with schizophrenia in acute psychotic episode and the course of the treatment
    • DOI 10.1016/j.psychres.2006.06.004, PII S0165178106001971
    • Maino K, Gruber R, Riedel M, Seitz N, Schwarz M, Müller N. 2007. T-and B-lymphocytes in patients with schizophrenia in acute psychotic Episode and the course of the treatment. Psychiatry Res 152:173-180. (Pubitemid 47212477)
    • (2007) Psychiatry Research , vol.152 , Issue.2-3 , pp. 173-180
    • Maino, K.1    Gruber, R.2    Riedel, M.3    Seitz, N.4    Schwarz, M.5    Muller, N.6
  • 46
    • 77954977417 scopus 로고    scopus 로고
    • Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia
    • Martins-DE-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, et al. 2010a. Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. J Psychiatr Res 44:1176-1189.
    • (2010) J Psychiatr Res , vol.44 , pp. 1176-1189
    • Martins-De-Souza, D.1    MacCarrone, G.2    Wobrock, T.3    Zerr, I.4    Gormanns, P.5    Reckow, S.6
  • 48
    • 71749092663 scopus 로고    scopus 로고
    • Depression and immunity: A role for T cells?
    • Miller AH. 2010. Depression and immunity: a role for T cells? Brain Behav Immun 24:1-8.
    • (2010) Brain Behav Immun , vol.24 , pp. 1-8
    • Miller, A.H.1
  • 49
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major Depression
    • Miller AH, Maletic V, Raison CL. 2009. Inflammation and its discontents: the role of cytokines in the pathophysiology of major Depression. Biol Psychiatry 65:732-741.
    • (2009) Biol Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 50
    • 1842419381 scopus 로고    scopus 로고
    • Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
    • DOI 10.1016/j.nbd.2003.12.015, PII S0969996104000026
    • Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S. 2004. Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol Dis 15:618-629. (Pubitemid 38429977)
    • (2004) Neurobiology of Disease , vol.15 , Issue.3 , pp. 618-629
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Barillo, M.M.4    Yolken, R.H.5    Weis, S.6
  • 51
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, Weis S. 2006. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 1073-1074:25-37.
    • (2006) Brain Res , vol.1073-1074 , pp. 25-37
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Weis, S.4
  • 52
    • 40949098991 scopus 로고    scopus 로고
    • Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Cwik M, Walkup J, Weis S. 2008. Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder. Neurochem Int 52:1297-1303.
    • (2008) Neurochem Int , vol.52 , pp. 1297-1303
    • Miller, C.L.1    Llenos, I.C.2    Cwik, M.3    Walkup, J.4    Weis, S.5
  • 56
    • 74549220751 scopus 로고    scopus 로고
    • COX-2 inhibitors as antidepressants and antipsychotics: Clinical evidence
    • Müller N. 2010. COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence. Curr Opin Investig Drugs 11:31-42.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 31-42
    • Müller, N.1
  • 57
    • 0031950741 scopus 로고    scopus 로고
    • Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders
    • DOI 10.1016/S0278-5846(97)00179-6, PII S0278584697001796
    • Müller N, Ackenheil M. 1998. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 22:1-33. (Pubitemid 28096427)
    • (1998) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.22 , Issue.1 , pp. 1-33
    • Muller, N.1    Ackenheil, M.2
  • 58
    • 44449179296 scopus 로고    scopus 로고
    • A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: Schizophrenia and major depression as inflammatory CNS disorders
    • DOI 10.1007/s00406-008-2012-3
    • Müller N, Schwarz MJ 2008 A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major Depression as inflammatory CNS disorders. Eur Arch Psychiatry Clin Neurosci 258(Suppl 2):97-106. (Pubitemid 351758763)
    • (2008) European Archives of Psychiatry and Clinical Neuroscience , vol.258 , Issue.SUPPL. 2 , pp. 97-106
    • Muller, N.1    Schwarz, M.J.2
  • 59
    • 70350161971 scopus 로고    scopus 로고
    • The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders-relation to drug treatment
    • Müller N, Myint AM, Schwarz MJ. 2009. The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders-relation to drug treatment. Dialogues Clin Neurosci 11:319-332.
    • (2009) Dialogues Clin Neurosci , vol.11 , pp. 319-332
    • Muller, N.1    Myint, A.M.2    Schwarz, M.J.3
  • 60
    • 0242720163 scopus 로고    scopus 로고
    • Cytokine-serotonin interaction through IDO: A neurodegeneration hypothesis of depression
    • DOI 10.1016/S0306-9877(03)00207-X
    • Myint AM, Kim YK. 2003. Cytokine-serotonin interaction through IDO: a neuroDEgeneration hypothesis of Depression. Med Hypotheses 61:519-525. (Pubitemid 37411894)
    • (2003) Medical Hypotheses , vol.61 , Issue.5-6 , pp. 519-525
    • Myint, A.M.1    Kim, Y.K.2
  • 64
    • 0031972945 scopus 로고    scopus 로고
    • 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity
    • Okuda S, Nishiyama N, Saito H, Katsuki H. 1998. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell DEath with apoptotic features and region selectivity. J Neurochem 70:299-307. (Pubitemid 28020856)
    • (1998) Journal of Neurochemistry , vol.70 , Issue.1 , pp. 299-307
    • Okuda, S.1    Nishiyama, N.2    Saito, H.3    Katsuki, H.4
  • 65
    • 79953200773 scopus 로고    scopus 로고
    • Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
    • Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB, et al. 2011. Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord 130:220-225.
    • (2011) J Affect Disord , vol.130 , pp. 220-225
    • Okusaga, O.1    Yolken, R.H.2    Langenberg, P.3    Lapidus, M.4    Arling, T.A.5    Dickerson, F.B.6
  • 66
    • 0029592136 scopus 로고
    • NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia
    • DOI 10.1038/sj.npp.1380292
    • Olney JW, Farber NB. 1995. NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia. Neuropsychopharmacology 13:335-345. (Pubitemid 26007689)
    • (1995) Neuropsychopharmacology , vol.13 , Issue.4 , pp. 335-345
    • Olney, J.W.1    Farber, N.B.2
  • 67
    • 0032694066 scopus 로고    scopus 로고
    • NMDA receptor hypofunction model of schizophrenia
    • Olney JW, Newcomer JW, Farber NB. 1999. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33:523-533.
    • (1999) J Psychiatr Res , vol.33 , pp. 523-533
    • Olney, J.W.1    Newcomer, J.W.2    Farber, N.B.3
  • 69
    • 44349129208 scopus 로고    scopus 로고
    • Does minocycline have antidepressant effect?
    • DOI 10.1016/j.biopha.2007.12.005, PII S0753332207002880
    • Pae CU, Marks DM, Han C, Patkar AA. 2008. Does minocycline have antidepressant effect? Biomed Pharmacother 62:308-311. (Pubitemid 351749775)
    • (2008) Biomedicine and Pharmacotherapy , vol.62 , Issue.5 , pp. 308-311
    • Pae, C.-U.1    Marks, D.M.2    Han, C.3    Patkar, A.A.4
  • 70
    • 67650445633 scopus 로고    scopus 로고
    • Receptor architecture of human cingulate cortex: Evaluation of the four-region neurobiological model
    • Palomero-Gallagher N, Vogt BA, Schleicher A, Mayberg HS, Zilles K. 2009. Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. Hum Brain Mapp 30:2336-2355.
    • (2009) Hum Brain Mapp , vol.30 , pp. 2336-2355
    • Palomero-Gallagher, N.1    Vogt, B.A.2    Schleicher, A.3    Mayberg, H.S.4    Zilles, K.5
  • 71
    • 24944576122 scopus 로고    scopus 로고
    • Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene
    • DOI 10.1016/j.neuroimage.2005.05.035, PII S1053811905003885
    • Papiol S, Molina V, Desco M, Rosa A, Reig S, Gispert JD, et al. 2005. Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene. Neuroimage 27:1002-1006. (Pubitemid 41317267)
    • (2005) NeuroImage , vol.27 , Issue.4 , pp. 1002-1006
    • Papiol, S.1    Molina, V.2    Desco, M.3    Rosa, A.4    Reig, S.5    Gispert, J.D.6    Sanz, J.7    Palomo, T.8    Fananas, L.9
  • 72
    • 0019967973 scopus 로고
    • An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
    • DOI 10.1016/0006-8993(82)91048-4
    • Perkins MN, Stone TW. 1982. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247:184-187. (Pubitemid 12028646)
    • (1982) Brain Research , vol.247 , Issue.1 , pp. 184-187
    • Perkins, M.N.1    Stone, T.W.2
  • 73
    • 40949107708 scopus 로고    scopus 로고
    • Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review
    • DOI 10.1016/j.biopsych.2007.09.024, PII S0006322307009481
    • Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E. 2008. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63:801-808. (Pubitemid 351410515)
    • (2008) Biological Psychiatry , vol.63 , Issue.8 , pp. 801-808
    • Potvin, S.1    Stip, E.2    Sepehry, A.A.3    Gendron, A.4    Bah, R.5    Kouassi, E.6
  • 74
    • 77953610372 scopus 로고    scopus 로고
    • Anti-NMDARezeptor-Enzephalitis: Ein interdisziplin ä res Krankheitsbild
    • Prüss H, Dalmau J, Arolt V, Wandinger KP. 2010. Anti-NMDARezeptor- Enzephalitis: Ein interdisziplin ä res Krankheitsbild. Nervenarzt 81:396-408.
    • (2010) Nervenarzt , vol.81 , pp. 396-408
    • Prüss, H.1    Dalmau, J.2    Arolt, V.3    Wandinger, K.P.4
  • 75
    • 0032031630 scopus 로고    scopus 로고
    • Time course and localization patterns of interleukin-1β messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide
    • DOI 10.1016/S0306-4522(97)00350-3, PII S0306452297003503
    • Quan N, Whiteside M, Herkenham M. 1998. Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysacchariDE. Neuroscience 83:281-293. (Pubitemid 28068057)
    • (1998) Neuroscience , vol.83 , Issue.1 , pp. 281-293
    • Quan, N.1    Whiteside, M.2    Herkenham, M.3
  • 77
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: Inflammation and the pathogenesis of depression
    • DOI 10.1016/j.it.2005.11.006, PII S1471490605002887
    • Raison CL, Capuron L, Miller AH. 2006. Cytokines sing the blues: inflammation and the pathogenesis of Depression. Trends Immunol 27:24-31. (Pubitemid 43083561)
    • (2006) Trends in Immunology , vol.27 , Issue.1 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 78
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and Depression
    • Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, et al. 2010. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and Depression. Mol Psychiatry 15:393-403.
    • (2010) Mol Psychiatry , vol.15 , pp. 393-403
    • Raison, C.L.1    Dantzer, R.2    Kelley, K.W.3    Lawson, M.A.4    Woolwine, B.J.5    Vogt, G.6
  • 81
    • 0035795038 scopus 로고    scopus 로고
    • The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: Relevance to neuroimmune surveillance of the oral cavity
    • DOI 10.1016/S0165-5728(01)00270-3, PII S0165572801002703
    • Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN. 2001. The glossopharyngeal nerve as a novel pathway in immune-tobrain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol 115:91-100. (Pubitemid 32245657)
    • (2001) Journal of Neuroimmunology , vol.115 , Issue.1-2 , pp. 91-100
    • Romeo, H.E.1    Tio, D.L.2    Rahman, S.U.3    Chiappelli, F.4    Taylor, A.N.5
  • 82
    • 57049176460 scopus 로고    scopus 로고
    • Curiosity to kill the KAT (kynurenine aminotransferase): Structural insights into brain kynurenic acid synthesis
    • Rossi F, Schwarcz R, Rizzi M. 2008. Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis. Curr Opin Struct Biol 18:748-755.
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 748-755
    • Rossi, F.1    Schwarcz, R.2    Rizzi, M.3
  • 84
    • 0020702374 scopus 로고
    • Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
    • Schwarcz R, Whetsell WO Jr, Mangano RM. 1983. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219:316-318. (Pubitemid 13222319)
    • (1983) Science , vol.219 , Issue.4582 , pp. 316-318
    • Schwarcz, R.1    Whetsell Jr., W.O.2    Mangano, R.M.3
  • 87
    • 0035436668 scopus 로고    scopus 로고
    • Borna disease virus infection in psychiatric patients: Are we on the right track?
    • DOI 10.1016/S1473-3099(01)00021-4, PII S1473309901000214
    • Schwemmle M. 2001. Borna disease virus infection in psychiatric patients: are we on the right track? Lancet Infect Dis 1: 46-52. (Pubitemid 33586040)
    • (2001) Lancet Infectious Diseases , vol.1 , Issue.1 , pp. 46-52
    • Schwemmle, M.1
  • 88
    • 77953383846 scopus 로고    scopus 로고
    • Breaching the blood-brain barrier as a gate to psychiatric disorder
    • Shalev H, Serlin Y, Friedman A. 2009. Breaching the blood-brain barrier as a gate to psychiatric disorder. Cardiovasc Psychiatry Neurol 2009:278531.
    • (2009) Cardiovasc Psychiatry Neurol , vol.2009 , pp. 278531
    • Shalev, H.1    Serlin, Y.2    Friedman, A.3
  • 89
    • 33750604501 scopus 로고    scopus 로고
    • Association study of IL10, IL1β, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: Suggestive association with rs16944 at IL1β
    • DOI 10.1016/j.schres.2006.06.037, PII S0920996406003069
    • Shirts BH, Wood J, Yolken RH, Nimgaonkar VL. 2006. Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: suggestive association with rs16944 at IL1beta. Schizophr Res 88:235-244. (Pubitemid 44693237)
    • (2006) Schizophrenia Research , vol.88 , Issue.1-3 , pp. 235-244
    • Shirts, B.H.1    Wood, J.2    Yolken, R.H.3    Nimgaonkar, V.L.4
  • 91
    • 47349112101 scopus 로고    scopus 로고
    • Cortical expression of glial fibrillary acidic protein and glutamine synthetase is Decreased in schizophrenia
    • Steffek AE, McCullumsmith RE, Haroutunian V, Meador-Woodruff JH. 2008. Cortical expression of glial fibrillary acidic protein and glutamine synthetase is Decreased in schizophrenia. Schizophr Res 103:71-82.
    • (2008) Schizophr Res , vol.103 , pp. 71-82
    • Steffek, A.E.1    McCullumsmith, R.E.2    Haroutunian, V.3    Meador-Woodruff, J.H.4
  • 92
    • 33747759704 scopus 로고    scopus 로고
    • Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
    • DOI 10.1007/s00401-006-0090-8
    • Steiner J, Mawrin C, Ziegeler A, Bielau H, Ullrich O, Bernstein HG, Bogerts B. 2006. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathol 112:305-316. (Pubitemid 44275885)
    • (2006) Acta Neuropathologica , vol.112 , Issue.3 , pp. 305-316
    • Steiner, J.1    Mawrin, C.2    Ziegeler, A.3    Bielau, H.4    Ullrich, O.5    Bernstein, H.-G.6    Bogerts, B.7
  • 93
    • 35848950202 scopus 로고    scopus 로고
    • Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
    • DOI 10.1016/j.jpsychires.2006.10.013, PII S0022395606002184
    • Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, et al. 2008. Immunological aspects in the neurobiology of suicide: Elevated microglial DEnsity in schizophrenia and Depression is associated with suicide. J Psychiatr Res 42:151-157. (Pubitemid 350061255)
    • (2008) Journal of Psychiatric Research , vol.42 , Issue.2 , pp. 151-157
    • Steiner, J.1    Bielau, H.2    Brisch, R.3    Danos, P.4    Ullrich, O.5    Mawrin, C.6    Bernstein, H.-G.7    Bogerts, B.8
  • 95
    • 77955935999 scopus 로고    scopus 로고
    • S100B serum levels in schizophrenia are presumably related to visceral obesity and insulin resistance
    • (article ID 480707)
    • Steiner J, Myint AM, Schiltz K, Westphal S, Bernstein HG, Walter M, et al. 2010b. S100B serum levels in schizophrenia are presumably related to visceral obesity and insulin resistance. Cardiovasc Psychiatry Neurol (article ID 480707):11 pp.
    • (2010) Cardiovasc Psychiatry Neurol , pp. 11
    • Steiner, J.1    Myint, A.M.2    Schiltz, K.3    Westphal, S.4    Bernstein, H.G.5    Walter, M.6
  • 96
    • 57049096895 scopus 로고    scopus 로고
    • Neuron-astrocyte signaling in the Development and plasticity of neural circuits
    • Stevens B. 2008. Neuron-astrocyte signaling in the Development and plasticity of neural circuits. Neurosignals 16:278-288.
    • (2008) Neurosignals , vol.16 , pp. 278-288
    • Stevens, B.1
  • 97
    • 34447547642 scopus 로고    scopus 로고
    • Glutamate and dopamine dysregulation in schizophrenia - A synthesis and selective review
    • DOI 10.1177/0269881106073126
    • Stone JM, Morrison PD, Pilowsky LS. 2007. Glutamate and dopamine dysregulation in schizophrenia a synthesis and selective review. J Psychopharmacol 21:440-452. (Pubitemid 47077295)
    • (2007) Journal of Psychopharmacology , vol.21 , Issue.4 , pp. 440-452
    • Stone, J.M.1    Morrison, P.D.2    Pilowsky, L.S.3
  • 98
    • 0036690151 scopus 로고    scopus 로고
    • Endogenous kynurenines as targets for drug discovery and development
    • DOI 10.1038/nrd870
    • Stone TW, Darlington LG. 2002. Endogenous kynurenines as targets for drug discovery and Development. Nat Rev Drug Discov 1:609-620. (Pubitemid 37361524)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.8 , pp. 609-620
    • Stone, T.W.1    Darlington, L.G.2
  • 99
    • 0026338235 scopus 로고
    • Gadolinium-DTPA enhanced gradient echo magnetic resonance scans in first Episode of psychosis and chronic schizophrenic patients
    • Szymanski S, Ashtari M, Zito J, DEgreef G, Bogerts B, Lieberman J. 1991. Gadolinium-DTPA enhanced gradient echo magnetic resonance scans in first Episode of psychosis and chronic schizophrenic patients. Psychiatry Res 40:203-207.
    • (1991) Psychiatry Res , vol.40 , pp. 203-207
    • Szymanski, S.1    Ashtari, M.2    Zito, J.3    Degreef, G.4    Bogerts, B.5    Lieberman, J.6
  • 101
    • 0034571241 scopus 로고    scopus 로고
    • Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases
    • Togo T, Akiyama H, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K. 2000. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res 885:117-121.
    • (2000) Brain Res , vol.885 , pp. 117-121
    • Togo, T.1    Akiyama, H.2    Kondo, H.3    Ikeda, K.4    Kato, M.5    Iseki, E.6    Kosaka, K.7
  • 102
    • 0022069816 scopus 로고
    • Permeability of the blood-brain barrier in psychiatric patients
    • Torrey EF, Albrecht P, Behr DE 1985. Permeability of the blood-brain barrier in psychiatric patients. Am J Psychiatry 142:657-658.
    • (1985) Am J Psychiatry , vol.142 , pp. 657-658
    • Torrey, E.F.1    Albrecht, P.2    Behr, D.E.3
  • 104
    • 34548032814 scopus 로고    scopus 로고
    • Antibodies to Toxoplasma gondii in patients with schizophrenia: A meta-analysis
    • DOI 10.1093/schbul/sbl050
    • Torrey EF, Bartko JJ, Lun ZR, Yolken RH. 2007. Antibodies to Toxoplasma gondii in patients with schizophrenia: a metaanalysis. Schizophr Bull 33:729-736. (Pubitemid 47343710)
    • (2007) Schizophrenia Bulletin , vol.33 , Issue.3 , pp. 729-736
    • Torrey, E.F.1    Bartko, J.J.2    Lun, Z.-R.3    Yolken, R.H.4
  • 107
    • 53249144430 scopus 로고    scopus 로고
    • Microglia activation in recentonset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study
    • van Berckel BN, Bossong MG, Boellaard R, Kloet R, Schuitemaker A, Caspers E, et al. 2008. Microglia activation in recentonset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry 64:820-822.
    • (2008) Biol Psychiatry , vol.64 , pp. 820-822
    • Van Berckel, B.N.1    Bossong, M.G.2    Boellaard, R.3    Kloet, R.4    Schuitemaker, A.5    Caspers, E.6
  • 109
    • 77955961228 scopus 로고    scopus 로고
    • The neurobiology of psycheDElic drugs: Implications for the treatment of mood disorders
    • Vollenweider FX, Kometer M. 2010. The neurobiology of psycheDElic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 11:642-651.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 642-651
    • Vollenwei Der, F.X.1    Kometer, M.2
  • 110
    • 1642384783 scopus 로고
    • Ü ber die Einwirkung fieberhafter Erkrankungen auf Psychosen
    • Wagner-Jauregg J. 1887. Ü ber die Einwirkung fieberhafter Erkrankungen auf Psychosen. Allge Z Psychiatr 27:93-131.
    • (1887) Allge Z Psychiatr , vol.27 , pp. 93-131
    • Wagner-Jauregg, J.1
  • 111
    • 81155159912 scopus 로고    scopus 로고
    • The relationship between aberrant neuronal activation patterns in the pregenual anterior cingulate, altered glutamatergic metabolism and anhedonia in Major Depression
    • Walter M, Henning A, Grimm S, Beck J, Schulte RF, Dydak U, et al. 2009. The relationship between aberrant neuronal activation patterns in the pregenual anterior cingulate, altered glutamatergic metabolism and anhedonia in Major Depression. Arch Gen Psychiatry 40:1482-1494.
    • (2009) Arch Gen Psychiatry , vol.40 , pp. 1482-1494
    • Walter, M.1    Henning, A.2    Grimm, S.3    Beck, J.4    Schulte, R.F.5    Dydak, U.6
  • 112
    • 77952569813 scopus 로고    scopus 로고
    • Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models
    • Watanabe Y, Someya T, Nawa H. 2010. Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models. Psychiatry Clin Neurosci 64:217-230.
    • (2010) Psychiatry Clin Neurosci , vol.64 , pp. 217-230
    • Watanabe, Y.1    Someya, T.2    Nawa, H.3
  • 113
    • 22144498857 scopus 로고    scopus 로고
    • Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics
    • Wierzba-Bobrowicz T, Lewandowska E, Lechowicz W, Stepien T, Pasennik E. 2005. Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol 43:81-89. (Pubitemid 40975402)
    • (2005) Folia Neuropathologica , vol.43 , Issue.2 , pp. 81-89
    • Wierzba-Bobrowicz, T.1    Lewandowska, E.2    Lechowicz, W.3    Stepien, T.4    Pasennik, E.5
  • 114
    • 63849150247 scopus 로고    scopus 로고
    • Endothelial signaling in paracellular and transcellular leukocyte transmigration
    • Wittchen ES. 2009. Endothelial signaling in paracellular and transcellular leukocyte transmigration. Front Biosci 14:2522-2545.
    • (2009) Front Biosci , vol.14 , pp. 2522-2545
    • Wittchen, E.S.1
  • 115
    • 47749129978 scopus 로고    scopus 로고
    • Polymorphisms in inflammation-related genes are associated with susceptibility to major Depression and antidepressant response
    • Wong ML, Dong C, Maestre-Mesa J, Licinio J. 2008. Polymorphisms in inflammation-related genes are associated with susceptibility to major Depression and antidepressant response. Mol Psychiatry 13:800-812.
    • (2008) Mol Psychiatry , vol.13 , pp. 800-812
    • Wong, M.L.1    Dong, C.2    Maestre-Mesa, J.3    Licinio, J.4
  • 116
    • 56049092225 scopus 로고    scopus 로고
    • Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: The therapeutic potentials for schizophrenia
    • Yang CR, Svensson KA. 2008. Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia. Pharmacol Ther 120:317-332.
    • (2008) Pharmacol Ther , vol.120 , pp. 317-332
    • Yang, C.R.1    Svensson, K.A.2
  • 117
    • 0028859619 scopus 로고
    • Viruses, schizophrenia, and bipolar disorder
    • Yolken RH, Torrey EF. 1995. Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 8:131-145.
    • (1995) Clin Microbiol Rev , vol.8 , pp. 131-145
    • Yolken, R.H.1    Torrey, E.F.2


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