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Volumn 196, Issue 2, 2009, Pages 168-179

Minocycline and neurodegenerative diseases

Author keywords

Alzheimer's disease; Amyotropic lateral sclerosis; Huntington's disease; Ischemia; Minocycline; Neurodegenerative diseases; Parkinson's disease; Spinal cord injury

Indexed keywords

CASPASE 3; CYTOCHROME C; INTERLEUKIN 1BETA CONVERTING ENZYME; METALLOPROTEINASE; MINOCYCLINE; TETRACYCLINE DERIVATIVE;

EID: 57549088119     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.09.040     Document Type: Review
Times cited : (387)

References (99)
  • 1
    • 0019292911 scopus 로고
    • Pharmacotherapeutics of the newer tetracyclines
    • Aronson A.L. Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 176 (1980) 1061-1068
    • (1980) J Am Vet Med Assoc , vol.176 , pp. 1061-1068
    • Aronson, A.L.1
  • 2
    • 42749084898 scopus 로고    scopus 로고
    • Combined treatment with atorvastatin and minocycline suppresses severity of EAE
    • Luccarini H., Ballerini C., Biagioli T., Biamonte F., Bellucci A., Rosi M.C., et al. Combined treatment with atorvastatin and minocycline suppresses severity of EAE. Exp Neurol 211 1 (2008) 214-226
    • (2008) Exp Neurol , vol.211 , Issue.1 , pp. 214-226
    • Luccarini, H.1    Ballerini, C.2    Biagioli, T.3    Biamonte, F.4    Bellucci, A.5    Rosi, M.C.6
  • 4
    • 31344476048 scopus 로고    scopus 로고
    • Tetracyclines: nonantibiotic properties and their clinical implications
    • Sapadin A., and Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 54 2 (2006) 258-265
    • (2006) J Am Acad Dermatol , vol.54 , Issue.2 , pp. 258-265
    • Sapadin, A.1    Fleischmajer, R.2
  • 5
    • 3242785662 scopus 로고    scopus 로고
    • Minocycline suppresses hypoxic activation of rodent microglia in culture
    • Suk K. Minocycline suppresses hypoxic activation of rodent microglia in culture. Neurosci Lett 366 2 (2004) 167-171
    • (2004) Neurosci Lett , vol.366 , Issue.2 , pp. 167-171
    • Suk, K.1
  • 7
    • 0041411243 scopus 로고    scopus 로고
    • Minocycline stain devil?
    • Good M.L., and Hussey D.L. Minocycline stain devil?. Br J Dermatol 149 2 (2003) 237-239
    • (2003) Br J Dermatol , vol.149 , Issue.2 , pp. 237-239
    • Good, M.L.1    Hussey, D.L.2
  • 9
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki J., Tikka T., Keinanen R., Goldsteins G., Chan P.H., and Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 96 (1999) 13496-13500
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 10
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • Sanchez, Mejia R.O., Ona V.O., Li M., and Friendlander R.M. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 48 6 (2001) 1393-1399
    • (2001) Neurosurgery , vol.48 , Issue.6 , pp. 1393-1399
    • Sanchez1    Mejia, R.O.2    Ona, V.O.3    Li, M.4    Friendlander, R.M.5
  • 11
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S., Stavrovskaya I.G., Drozda M., Kim B.Y., Ona V., Li M., et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417 6884 (2002) 74-78
    • (2002) Nature , vol.417 , Issue.6884 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3    Kim, B.Y.4    Ona, V.5    Li, M.6
  • 12
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D.C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., et al. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22 5 (2002) 1763-1771
    • (2002) J Neurosci , vol.22 , Issue.5 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6
  • 13
    • 33646382411 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
    • Heo K., Cho Y.J., Cho K.J., Kim H.W., Kim H.J., Shin H.Y., Lee B.I., and Kim G.W. Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Neurosci Lett 398 3 (2006 8) 195-200
    • (2006) Neurosci Lett , vol.398 , Issue.3 , pp. 195-200
    • Heo, K.1    Cho, Y.J.2    Cho, K.J.3    Kim, H.W.4    Kim, H.J.5    Shin, H.Y.6    Lee, B.I.7    Kim, G.W.8
  • 14
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M., Ona V.O., Li M., Ferrante R.J., Fink K.B., Zhu S., et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 6 7 (2000) 797-801
    • (2000) Nat Med , vol.6 , Issue.7 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3    Ferrante, R.J.4    Fink, K.B.5    Zhu, S.6
  • 15
    • 0041335559 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
    • Wang X., Zhu S., Drozda M., Zhang W., Stavrovskaya I.G., Cattane o.E., et al. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci USA 100 18 (2003) 10483-10487
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.18 , pp. 10483-10487
    • Wang, X.1    Zhu, S.2    Drozda, M.3    Zhang, W.4    Stavrovskaya, I.G.5    Cattane, o.E.6
  • 17
    • 35348819417 scopus 로고    scopus 로고
    • Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models
    • Choi Y.R., Kim H.S., Shin K.Y., Kim E.M., Kim H.S., Park C.H., et al. Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models. Neuropsychopharmacology 32 11 (2007) 2393-2404
    • (2007) Neuropsychopharmacology , vol.32 , Issue.11 , pp. 2393-2404
    • Choi, Y.R.1    Kim, H.S.2    Shin, K.Y.3    Kim, E.M.4    Kim, H.S.5    Park, C.H.6
  • 19
    • 2442715084 scopus 로고    scopus 로고
    • Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis
    • Gordon P.H., Moore D.H., Gelinas D.F., Qualls C., Meister M.E., Werner J., et al. Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis. Neurology 62 (2004) 1845-1847
    • (2004) Neurology , vol.62 , pp. 1845-1847
    • Gordon, P.H.1    Moore, D.H.2    Gelinas, D.F.3    Qualls, C.4    Meister, M.E.5    Werner, J.6
  • 20
    • 0026824718 scopus 로고
    • Host modulation with tetracyclines and their chemically modified analogues
    • Golub L.M., Soummalarien K., and Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent 2 (1992) 80-90
    • (1992) Curr Opin Dent , vol.2 , pp. 80-90
    • Golub, L.M.1    Soummalarien, K.2    Sorsa, T.3
  • 21
    • 0032198174 scopus 로고    scopus 로고
    • Chemical and biological dynamics of tetracyclines
    • Nelson M.L. Chemical and biological dynamics of tetracyclines. Adv Den Res 12 (1998) 5-11
    • (1998) Adv Den Res , vol.12 , pp. 5-11
    • Nelson, M.L.1
  • 22
    • 0010108822 scopus 로고
    • Tetracyclines and daunorubicin in metal ions in biological system
    • Sigel H. (Ed), Marcel Dekker, New York
    • Martin R.B. Tetracyclines and daunorubicin in metal ions in biological system. In: Sigel H. (Ed). Antibiotics and their complexes (1985), Marcel Dekker, New York 19-40
    • (1985) Antibiotics and their complexes , pp. 19-40
    • Martin, R.B.1
  • 23
    • 1642321822 scopus 로고    scopus 로고
    • Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection
    • Dommergues M.A., Plaisant F., Vemey C., and Gressens P. Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience 121 3 (2003) 619-628
    • (2003) Neuroscience , vol.121 , Issue.3 , pp. 619-628
    • Dommergues, M.A.1    Plaisant, F.2    Vemey, C.3    Gressens, P.4
  • 24
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • He Y., Appel S., and Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res 909 (2001) 187-193
    • (2001) Brain Res , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 25
    • 0036260089 scopus 로고    scopus 로고
    • Targeting leukocyte MMPs and transmigration minocycline as a potential therapy for multiple sclerosis
    • Brundula V., Rewcastle B., metz L.M., Bernard C.C., and Yong V.W. Targeting leukocyte MMPs and transmigration minocycline as a potential therapy for multiple sclerosis. Brain 125 (2002) 1297-1308
    • (2002) Brain , vol.125 , pp. 1297-1308
    • Brundula, V.1    Rewcastle, B.2    metz, L.M.3    Bernard, C.C.4    Yong, V.W.5
  • 26
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • Yong V.W., Power C., Forsyth P., and Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2 (2001) 502-511
    • (2001) Nat Rev Neurosci , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 27
    • 42749092175 scopus 로고    scopus 로고
    • Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia
    • Filipovic R., and Zecevic N. Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia. Exp Neurol 211 1 (2008) 41-51
    • (2008) Exp Neurol , vol.211 , Issue.1 , pp. 41-51
    • Filipovic, R.1    Zecevic, N.2
  • 29
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai B.J., Kazdasz S.T., Christie R.H., Carter C., Games D., Seubert P., et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 7 3 (2001) 369-372
    • (2001) Nat Med , vol.7 , Issue.3 , pp. 369-372
    • Bacskai, B.J.1    Kazdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6
  • 31
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • Tikka T.M., and Koistinaho J.E. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166 12 (2001) 7527-7533
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 33
    • 0036141148 scopus 로고    scopus 로고
    • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    • Coraci I.S., Husemann J., Berman J.W., Hulette C., Dufour J.H., Campanella G.K., et al. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol 160 January (1) (2002) 101-112
    • (2002) Am J Pathol , vol.160 , Issue.January 1 , pp. 101-112
    • Coraci, I.S.1    Husemann, J.2    Berman, J.W.3    Hulette, C.4    Dufour, J.H.5    Campanella, G.K.6
  • 34
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • Robert M.F. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 348 (2003) 1365-1375
    • (2003) N Engl J Med , vol.348 , pp. 1365-1375
    • Robert, M.F.1
  • 35
    • 2442653111 scopus 로고    scopus 로고
    • Apoptosis in acute and chronic neurological disorders
    • Ekshyyan O., and Aw T.Y. Apoptosis in acute and chronic neurological disorders. Front Biosci 9 (2004) 1567-1576
    • (2004) Front Biosci , vol.9 , pp. 1567-1576
    • Ekshyyan, O.1    Aw, T.Y.2
  • 36
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling D.P., Khodarahmi K., Liu J., McPhail L.T., McBride C.B., and Steeves J.D. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24 9 (2004) 2182-2190
    • (2004) J Neurosci , vol.24 , Issue.9 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6
  • 37
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    • Wang J., Wei Q., Wang C.Y., Hill W.D., Hess D.C., and Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279 19 (2004) 19948-219854
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19948-219854
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 38
    • 12144290904 scopus 로고    scopus 로고
    • Minocycline inhibits contrusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    • Teng Y.D., Choi H., Onario R.C., Zhu S., Desilets F.C., Lan S., et al. Minocycline inhibits contrusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proc Natl Acad Sci USA 101 (2004) 3071-3076
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3071-3076
    • Teng, Y.D.1    Choi, H.2    Onario, R.C.3    Zhu, S.4    Desilets, F.C.5    Lan, S.6
  • 39
    • 33751093803 scopus 로고    scopus 로고
    • Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline
    • Mansson R., Hansson M.J., Morota S., Uchino H., Ekdahl C.V.T., and Elmer E. Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline. Neurobiol Dis 25 (2007) 198-205
    • (2007) Neurobiol Dis , vol.25 , pp. 198-205
    • Mansson, R.1    Hansson, M.J.2    Morota, S.3    Uchino, H.4    Ekdahl, C.V.T.5    Elmer, E.6
  • 40
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., and Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 21 8 (2001) 2580-2588
    • (2001) J Neurosci , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 41
    • 0035940779 scopus 로고    scopus 로고
    • Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons
    • Lin S., Zhang Y., Dodel R., Farlow M.R., Paul S.M., and Du Y. Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons. Neurosci Lett 315 1-2 (2001) 61-64
    • (2001) Neurosci Lett , vol.315 , Issue.1-2 , pp. 61-64
    • Lin, S.1    Zhang, Y.2    Dodel, R.3    Farlow, M.R.4    Paul, S.M.5    Du, Y.6
  • 42
    • 35848946825 scopus 로고    scopus 로고
    • p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action
    • Guo G., and Bhat N.R. p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. Neurochem Res. 32 12 (2007) 2160-2166
    • (2007) Neurochem Res. , vol.32 , Issue.12 , pp. 2160-2166
    • Guo, G.1    Bhat, N.R.2
  • 44
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • Wada T., and Penninger J.M. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23 16 (2004) 2838-2849
    • (2004) Oncogene , vol.23 , Issue.16 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2
  • 45
    • 0042673986 scopus 로고    scopus 로고
    • Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult
    • Piao C.S., Kim J.B., Han P.L., and Lee J.K. Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult. J Neurosci Res 73 4 (2003) 537-544
    • (2003) J Neurosci Res , vol.73 , Issue.4 , pp. 537-544
    • Piao, C.S.1    Kim, J.B.2    Han, P.L.3    Lee, J.K.4
  • 46
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • Yrjanheikki J., Keinanen R., Pellikka M., Hokfelt T., and Koisinaho J. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95 (1998) 15769-15774
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15769-15774
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3    Hokfelt, T.4    Koisinaho, J.5
  • 47
    • 36048936409 scopus 로고    scopus 로고
    • Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia
    • Tang X.N., Wang O., Koike M.A., Chang D., Goris M.L., Blankenbag F.G., et al. Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia. J Nucl Med 48 11 (2007) 1822-1828
    • (2007) J Nucl Med , vol.48 , Issue.11 , pp. 1822-1828
    • Tang, X.N.1    Wang, O.2    Koike, M.A.3    Chang, D.4    Goris, M.L.5    Blankenbag, F.G.6
  • 48
    • 42449146711 scopus 로고    scopus 로고
    • Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia
    • Iyirhiaro G.O., Brust T.B., Rashidian J., Galendar Z., Osman A., Phillips M., et al. Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. J Neurochem 105 (2008) 703-713
    • (2008) J Neurochem , vol.105 , pp. 703-713
    • Iyirhiaro, G.O.1    Brust, T.B.2    Rashidian, J.3    Galendar, Z.4    Osman, A.5    Phillips, M.6
  • 49
    • 34247597212 scopus 로고    scopus 로고
    • Hyperbaric oxygenation in peripheral nerve repair and regeneration
    • Sanchez E.C. Hyperbaric oxygenation in peripheral nerve repair and regeneration. Neurol Res 29 (2007) 184-198
    • (2007) Neurol Res , vol.29 , pp. 184-198
    • Sanchez, E.C.1
  • 50
    • 44649133204 scopus 로고    scopus 로고
    • Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration
    • Keilhoff G., Schild L., and Fansa H. Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration. Exp Neruol 212 (2008) 189-200
    • (2008) Exp Neruol , vol.212 , pp. 189-200
    • Keilhoff, G.1    Schild, L.2    Fansa, H.3
  • 51
    • 3543073536 scopus 로고    scopus 로고
    • Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model
    • Tusuji M., Wilson M.A., Lange M.S., and Johnston M.V. Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model. Exp Neurol 189 (2004) 2580-2588
    • (2004) Exp Neurol , vol.189 , pp. 2580-2588
    • Tusuji, M.1    Wilson, M.A.2    Lange, M.S.3    Johnston, M.V.4
  • 52
    • 0026475628 scopus 로고
    • Selective endothelial growth inhibition by tetracyclines that inhibit collagenase
    • Guerin C., Laterna J., Masnyk T., Golub L.M., and Brem H. Selective endothelial growth inhibition by tetracyclines that inhibit collagenase. Biochem Biophys Res Commun 188 (1992) 740-745
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 740-745
    • Guerin, C.1    Laterna, J.2    Masnyk, T.3    Golub, L.M.4    Brem, H.5
  • 53
    • 0025924722 scopus 로고
    • Angiogenesis inhibition by minocycline
    • Tamargo R.J., Bok R.A., and Brem H. Angiogenesis inhibition by minocycline. Cancer Res 51 (1991) 672-675
    • (1991) Cancer Res , vol.51 , pp. 672-675
    • Tamargo, R.J.1    Bok, R.A.2    Brem, H.3
  • 54
    • 34848857092 scopus 로고    scopus 로고
    • Minocycline treatment in acute stroke: an open-label, evaluator-blinded study
    • Lampl Y., Boaz M., Gilad R., Lorberboym M., Dabby R., Rapoport A., et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology 69 14 (2007) 1404-1410
    • (2007) Neurology , vol.69 , Issue.14 , pp. 1404-1410
    • Lampl, Y.1    Boaz, M.2    Gilad, R.3    Lorberboym, M.4    Dabby, R.5    Rapoport, A.6
  • 55
    • 33847214963 scopus 로고    scopus 로고
    • Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation
    • Marier K., Merkler D., Geber J., Taheri N., Kuhnert A., Williams S.K., et al. Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation. Neurobiol Dis 25 (2007) 514-525
    • (2007) Neurobiol Dis , vol.25 , pp. 514-525
    • Marier, K.1    Merkler, D.2    Geber, J.3    Taheri, N.4    Kuhnert, A.5    Williams, S.K.6
  • 56
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalitis: a comparative quantative study of axonal injury in active, inactive, and remyelinated lesions
    • Komek B., Storch M.K., Weissert R., Wallstroem E., Stefferl A., Olsson T., et al. Multiple sclerosis and chronic autoimmune encephalitis: a comparative quantative study of axonal injury in active, inactive, and remyelinated lesions. Am H Pathol 157 (2000) 267-276
    • (2000) Am H Pathol , vol.157 , pp. 267-276
    • Komek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6
  • 59
    • 46649096996 scopus 로고    scopus 로고
    • Combination treatment of Glatiramer Acetate and Minocycline affects phenotype expression of blood monocyte-derived dendritic cells in Multiple Sclerosis patients
    • Ruggieri M., Pica C., Lia A., Zimatore G.B., Modesto M., Di Liddo E., et al. Combination treatment of Glatiramer Acetate and Minocycline affects phenotype expression of blood monocyte-derived dendritic cells in Multiple Sclerosis patients. J Neuroimmunol 197 2 (2008) 140-146
    • (2008) J Neuroimmunol , vol.197 , Issue.2 , pp. 140-146
    • Ruggieri, M.1    Pica, C.2    Lia, A.3    Zimatore, G.B.4    Modesto, M.5    Di Liddo, E.6
  • 60
    • 33646598662 scopus 로고    scopus 로고
    • Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury
    • Festoff B.W., Ameenuddin S., Arnold P.M., Wong A., Santacruz K.S., and Citron B.A. Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. J Neurochem 97 (2006) 1314-1326
    • (2006) J Neurochem , vol.97 , pp. 1314-1326
    • Festoff, B.W.1    Ameenuddin, S.2    Arnold, P.M.3    Wong, A.4    Santacruz, K.S.5    Citron, B.A.6
  • 61
    • 0027979487 scopus 로고
    • Epidemiology of traumatic spinal cord injury and acute hospitalization and rehabilitation charges for spinal cord injuries in Oklahoma, 1988-90
    • Price C., Makintubee S., Herndon W., and Istre G.R. Epidemiology of traumatic spinal cord injury and acute hospitalization and rehabilitation charges for spinal cord injuries in Oklahoma, 1988-90. Am J Epidemiol 139 (1994) 37-47
    • (1994) Am J Epidemiol , vol.139 , pp. 37-47
    • Price, C.1    Makintubee, S.2    Herndon, W.3    Istre, G.R.4
  • 62
    • 4244176985 scopus 로고
    • Treatment of acute spinal cord injury with methylprednisole: results of a multicenter, randomized clinical trial
    • Bracken M.B. Treatment of acute spinal cord injury with methylprednisole: results of a multicenter, randomized clinical trial. J Neurotrauma 8 (1991) S47-S50
    • (1991) J Neurotrauma , vol.8
    • Bracken, M.B.1
  • 63
    • 0034024692 scopus 로고    scopus 로고
    • High dose methylprednisolone in the management of acute spinal cord injury-a systematic review from a clinical perspective
    • Short D.J., Masry W.S., and Jones P.W. High dose methylprednisolone in the management of acute spinal cord injury-a systematic review from a clinical perspective. Spinal Cord 38 (2000) 273-286
    • (2000) Spinal Cord , vol.38 , pp. 273-286
    • Short, D.J.1    Masry, W.S.2    Jones, P.W.3
  • 64
    • 0032790541 scopus 로고    scopus 로고
    • Activation of the caspase-3 apoptotic cascadein traumatic spinal cord injury
    • Springer J.E., Azbill R.D., and Knapp P.E. Activation of the caspase-3 apoptotic cascadein traumatic spinal cord injury. Nat Med 5 (1999) 943-946
    • (1999) Nat Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 65
    • 0033964038 scopus 로고    scopus 로고
    • Cytokine chemikine expression in contused rat spinal cord
    • Le Y.L., Shih K., Bao P., Ghirmikar R.S., and Eng L.F. Cytokine chemikine expression in contused rat spinal cord. Neurochem Int 36 (2000) 417-425
    • (2000) Neurochem Int , vol.36 , pp. 417-425
    • Le, Y.L.1    Shih, K.2    Bao, P.3    Ghirmikar, R.S.4    Eng, L.F.5
  • 66
    • 34347356392 scopus 로고    scopus 로고
    • Update on the treatment of spinal cord injury
    • Baptiste D.C., and Fehlings M.G. Update on the treatment of spinal cord injury. Prog Brain Res 161 (2007) 217-233
    • (2007) Prog Brain Res , vol.161 , pp. 217-233
    • Baptiste, D.C.1    Fehlings, M.G.2
  • 67
    • 34447643571 scopus 로고    scopus 로고
    • Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury
    • Yune T.Y., Lee J.Y., Jung G.Y., Kim S.J., Jiang M.H., Kim Y.C., et al. Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J Neurosci 27 (2007) 7751-7761
    • (2007) J Neurosci , vol.27 , pp. 7751-7761
    • Yune, T.Y.1    Lee, J.Y.2    Jung, G.Y.3    Kim, S.J.4    Jiang, M.H.5    Kim, Y.C.6
  • 68
    • 0037067009 scopus 로고    scopus 로고
    • Minocycline delays onset and mortality in a transgenic model of ALS
    • Bosch L.V.D., Tilkin P., Lemmens G., and Robberecht W. Minocycline delays onset and mortality in a transgenic model of ALS. Neuroreport 13 8 (2002) 1067-1970
    • (2002) Neuroreport , vol.13 , Issue.8 , pp. 1067-1970
    • Bosch, L.V.D.1    Tilkin, P.2    Lemmens, G.3    Robberecht, W.4
  • 69
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • Kriz J., Nguyen M.D., and Julien J.P. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 10 3 (2002) 268-278
    • (2002) Neurobiol Dis , vol.10 , Issue.3 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.P.3
  • 70
    • 33746849034 scopus 로고    scopus 로고
    • Neuroprotective agents for clinical trials in ALS: a systematic assessment
    • Traynor B.J., Bruijn L., Conwit R., Beal F., O'Neill G., Fagan S.C., et al. Neuroprotective agents for clinical trials in ALS: a systematic assessment. Neurology 67 1 (2006) 20-27
    • (2006) Neurology , vol.67 , Issue.1 , pp. 20-27
    • Traynor, B.J.1    Bruijn, L.2    Conwit, R.3    Beal, F.4    O'Neill, G.5    Fagan, S.C.6
  • 71
    • 36148960127 scopus 로고    scopus 로고
    • Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
    • Gordon P.H., et al. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol 12 (2007) 1045-1053
    • (2007) Lancet Neurol , Issue.12 , pp. 1045-1053
    • Gordon, P.H.1
  • 72
    • 0042845880 scopus 로고    scopus 로고
    • Minocycline and doxycycline are not beneficial in a model of Huntington's disease
    • Smith D.L., Woodman B., Mahal A., Sathasivam K., Ghazi-Noori S., Lowden P.A., et al. Minocycline and doxycycline are not beneficial in a model of Huntington's disease. Ann Neurol 54 2 (2003) 186-196
    • (2003) Ann Neurol , vol.54 , Issue.2 , pp. 186-196
    • Smith, D.L.1    Woodman, B.2    Mahal, A.3    Sathasivam, K.4    Ghazi-Noori, S.5    Lowden, P.A.6
  • 73
    • 31644439986 scopus 로고    scopus 로고
    • Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntungton's disease mice
    • Stack E.C., Smith K.M., Ryu H., Cormier K., Chen M., Hagerty S.W., et al. Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntungton's disease mice. Biochim Biophys Acta 1762 (2006) 373-380
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 373-380
    • Stack, E.C.1    Smith, K.M.2    Ryu, H.3    Cormier, K.4    Chen, M.5    Hagerty, S.W.6
  • 75
    • 33747158449 scopus 로고    scopus 로고
    • Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage and neuronal loss in an excitotoxic animal model of Huntington's disease
    • Ryu J.K., Choi H.B., and Malarnon J.G. Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage and neuronal loss in an excitotoxic animal model of Huntington's disease. Neuroscience 141 (2006) 1836-1848
    • (2006) Neuroscience , vol.141 , pp. 1836-1848
    • Ryu, J.K.1    Choi, H.B.2    Malarnon, J.G.3
  • 76
    • 0036523110 scopus 로고    scopus 로고
    • Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease
    • Ferrante R.J., Andreassen O.A., Dedeoglu A., Ferrante K.L., Jenkens B.G., Hersch S.M., et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 22 (2002) 1592-1599
    • (2002) J Neurosci , vol.22 , pp. 1592-1599
    • Ferrante, R.J.1    Andreassen, O.A.2    Dedeoglu, A.3    Ferrante, K.L.4    Jenkens, B.G.5    Hersch, S.M.6
  • 78
    • 12244265476 scopus 로고    scopus 로고
    • Minocycline for Huntington's disease: an open label study
    • Bonelli R.M., Heuberger C., and Reisecker F. Minocycline for Huntington's disease: an open label study. Neurology 60 5 (2003) 883-884
    • (2003) Neurology , vol.60 , Issue.5 , pp. 883-884
    • Bonelli, R.M.1    Heuberger, C.2    Reisecker, F.3
  • 79
    • 4444233214 scopus 로고    scopus 로고
    • Minocycline in Huntington's disease: a pilot study
    • Thomas N., Ashizawa T., and Jankovic J. Minocycline in Huntington's disease: a pilot study. Mov Disord 19 (2004) 692-695
    • (2004) Mov Disord , vol.19 , pp. 692-695
    • Thomas, N.1    Ashizawa, T.2    Jankovic, J.3
  • 80
    • 33847696170 scopus 로고    scopus 로고
    • Revisiting safety of minocycline as neuroprotection in Huntington's disease
    • Reynolds N. Revisiting safety of minocycline as neuroprotection in Huntington's disease. Mov Disord 22 2 (2007) 292
    • (2007) Mov Disord , vol.22 , Issue.2 , pp. 292
    • Reynolds, N.1
  • 82
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y., Ma Z., Lin S., Dodel R.C., Gao F., Bales K.R., et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci 98 25 (2001) 14669-14674
    • (2001) Proc Natl Acad Sci , vol.98 , Issue.25 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3    Dodel, R.C.4    Gao, F.5    Bales, K.R.6
  • 83
    • 33751106151 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic neurodegeneration in the Weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration
    • Peng J., Xie L., Stevenson F.F., Melov S., Di Monte D.A., and Anderson J.K. Nigrostriatal dopaminergic neurodegeneration in the Weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26 45 (2006) 11644-11651
    • (2006) J Neurosci , vol.26 , Issue.45 , pp. 11644-11651
    • Peng, J.1    Xie, L.2    Stevenson, F.F.3    Melov, S.4    Di Monte, D.A.5    Anderson, J.K.6
  • 84
    • 44649153832 scopus 로고    scopus 로고
    • A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results
    • Racette B., Deppen P., Dewey R.B., Scott B., Field J., Carter J., et al. A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clin Neuropharmacol 31 3 (2008) 141-150
    • (2008) Clin Neuropharmacol , vol.31 , Issue.3 , pp. 141-150
    • Racette, B.1    Deppen, P.2    Dewey, R.B.3    Scott, B.4    Field, J.5    Carter, J.6
  • 85
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81 2 (2001) 741-766
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 86
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh Y.H., and Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharm Rev 54 3 (2002) 469-525
    • (2002) Pharm Rev , vol.54 , Issue.3 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 87
    • 3042791295 scopus 로고    scopus 로고
    • Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning
    • Hunter C.L., Quintero E.M., Gilstrap L., Bhat N.R., and Grandhelm A.C. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci 19 12 (2004) 3305-3316
    • (2004) Eur J Neurosci , vol.19 , Issue.12 , pp. 3305-3316
    • Hunter, C.L.1    Quintero, E.M.2    Gilstrap, L.3    Bhat, N.R.4    Grandhelm, A.C.5
  • 88
    • 33646243562 scopus 로고    scopus 로고
    • Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice
    • Seabrook T.J., Jiang L., Maier M., and Lemere C. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 53 (2006) 776-782
    • (2006) Glia , vol.53 , pp. 776-782
    • Seabrook, T.J.1    Jiang, L.2    Maier, M.3    Lemere, C.4
  • 89
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    • Rogers J., Strohmeyer R., Kovelowski C.J., and Li R. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40 (2002) 260-269
    • (2002) Glia , vol.40 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Kovelowski, C.J.3    Li, R.4
  • 90
    • 32344450850 scopus 로고    scopus 로고
    • Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation
    • Familian A., Boschuizen R.S., Eikelenboom P., and Veerhuis R. Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation. Glia 53 (2006) 233-240
    • (2006) Glia , vol.53 , pp. 233-240
    • Familian, A.1    Boschuizen, R.S.2    Eikelenboom, P.3    Veerhuis, R.4
  • 91
    • 33947281600 scopus 로고    scopus 로고
    • Minocycline does not affect amyloid beta phagocytosis by human microglial cells
    • Familian A., Eikelenboom P., and Veerhuis R. Minocycline does not affect amyloid beta phagocytosis by human microglial cells. Neurosci Lett 416 1 (2007) 87-91
    • (2007) Neurosci Lett , vol.416 , Issue.1 , pp. 87-91
    • Familian, A.1    Eikelenboom, P.2    Veerhuis, R.3
  • 92
    • 6044273035 scopus 로고    scopus 로고
    • Minocycline inhibits neuronal death and glial activationinduced by beta-amyloid peptide in rat hippocampus
    • Ryu J.K., Franciosi S., Sattayaprasert P., Kovelowski P., Kim S.U., and McLarnon J.G. Minocycline inhibits neuronal death and glial activationinduced by beta-amyloid peptide in rat hippocampus. Glia 48 (2004) 85-90
    • (2004) Glia , vol.48 , pp. 85-90
    • Ryu, J.K.1    Franciosi, S.2    Sattayaprasert, P.3    Kovelowski, P.4    Kim, S.U.5    McLarnon, J.G.6
  • 93
    • 33645733075 scopus 로고    scopus 로고
    • Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus
    • Ryu J.K., and McLarnon J.G. Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus. Exp Neurol 198 2 (2006) 552-557
    • (2006) Exp Neurol , vol.198 , Issue.2 , pp. 552-557
    • Ryu, J.K.1    McLarnon, J.G.2
  • 94
    • 0035798238 scopus 로고    scopus 로고
    • The molecular biology of memory storage: a dialogue between genes and synapses
    • Kandel E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294 5544 (2001) 1030-1038
    • (2001) Science , vol.294 , Issue.5544 , pp. 1030-1038
    • Kandel, E.R.1
  • 95
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6 5 (2000) 1099-1108
    • (2000) Mol Cell , vol.6 , Issue.5 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5    Schapira, M.6
  • 96
    • 0042521291 scopus 로고    scopus 로고
    • Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins
    • Chen A., Muzzio I.A., Malleret G., Bartsch D., Verbitsky M., Pavlidis P., et al. Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron 39 4 (2003) 655-669
    • (2003) Neuron , vol.39 , Issue.4 , pp. 655-669
    • Chen, A.1    Muzzio, I.A.2    Malleret, G.3    Bartsch, D.4    Verbitsky, M.5    Pavlidis, P.6
  • 97
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding H.P., Zhang Y., and Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397 6716 (1999) 271-274
    • (1999) Nature , vol.397 , Issue.6716 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 98
    • 45849104785 scopus 로고    scopus 로고
    • Minocycline provides protection against β-amyloid (25-35) induced alterations of the somatostatin signaling pathway in the rat temporal cortex
    • Burgos-Ramos E., Puebla-Jimenez L., and Arilla-Ferreiro E. Minocycline provides protection against β-amyloid (25-35) induced alterations of the somatostatin signaling pathway in the rat temporal cortex. Neuroscience 154 4 (2008) 1458-1466
    • (2008) Neuroscience , vol.154 , Issue.4 , pp. 1458-1466
    • Burgos-Ramos, E.1    Puebla-Jimenez, L.2    Arilla-Ferreiro, E.3
  • 99
    • 0030032533 scopus 로고    scopus 로고
    • Minocycline-induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome
    • Gough A., Chapman S., Wagstaff K., Emery P., and Elias E. Minocycline-induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome. Br Med J 312 (1996) 169-172
    • (1996) Br Med J , vol.312 , pp. 169-172
    • Gough, A.1    Chapman, S.2    Wagstaff, K.3    Emery, P.4    Elias, E.5


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