Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin

Free Radical Biology and Medicine

Volumn 50, Issue 6, 2011, Pages 710-721

  Tang, Ching Min ^a   Hwang, Chi Shin ^b,c   Chen, Shang Der ^d   Yang, Ding I ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI CITY HOSPITAL   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Alzheimer disease; Antioxidant; Cerebral ischemia; cGMP dependent protein kinase; Cortical neurons; Free radicals; Nitric oxide; Soluble guanylate cyclase

Indexed keywords

CERAMIDE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; KT 5823; MINOCYCLINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTEIN BCL 2; SPHINGOMYELIN PHOSPHODIESTERASE; THIOREDOXIN; THIOREDOXIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; FETUS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARBAZOLES; CELLS, CULTURED; CERAMIDES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DINITROCHLOROBENZENE; GENES, BCL-2; MINOCYCLINE; NEURONS; NEUROPROTECTIVE AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXADIAZOLES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; THIOREDOXINS;

BACTERIA (MICROORGANISMS); RATTUS;

EID: 79951678468     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.12.024     Document Type: Article

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