Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists

Journal of Medicinal Chemistry

Volumn 48, Issue 18, 2005, Pages 5771-5779

  Elsner, Jan ^a   Boeckler, Frank ^a   Heinemann, Frank W ^a   Hübner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOTETRAHYDROPYRAZOLO[1,5 A]PYRIDINE DERIVATIVE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 3 RECEPTOR STIMULATING AGENT; FAUC 54; PRAMIPEXOLE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; QUINPIROLE; RECEPTOR SUBTYPE; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG RECEPTOR BINDING; DRUG RESEARCH; ENANTIOMER; EVALUATION; HUMAN; HUMAN CELL; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; SYNTHESIS; THREE DIMENSIONAL IMAGING;

ANIMALS; BENZOTHIAZOLES; BINDING SITES; CHO CELLS; CORPUS STRIATUM; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; DOPAMINE AGONISTS; HUMANS; HYDROGEN BONDING; MITOSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THIAZOLES;

EID: 24744465202     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0503805     Document Type: Article

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