Facilitation of constitutive α(2A)-adrenoceptor activity by both single amino acid mutation (Thr373Lys) and G(αO) protein coexpression: Evidence for inverse agonism

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 2, 2000, Pages 654-663

  Pauwels, Petrus J ^a   Tardif, Stéphanie ^a   Wurch, Thierry ^a   Colpaert, Francis C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CLONIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MEDETOMIDINE; OXYMETAZOLINE; TALIPEXOLE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADRENERGIC AGONISTS; ADRENERGIC ANTAGONISTS; ANIMALS; CHO CELLS; CLONING, ORGANISM; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; IMMUNOCHEMISTRY; LIGANDS; POINT MUTATION; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 0033973624     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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