Molecular mechanisms of Go signaling

NeuroSignals

Volumn 17, Issue 1, 2009, Pages 23-41

  Jiang, Meisheng ^a   Bajpayee, Neil S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Central nervous system; Effectors; G protein; G protein coupled receptors; Go; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; CALCIUM CHANNEL; DIACYLGLYCEROL KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; NEUROMODULIN; POTASSIUM CHANNEL; RHO KINASE; SODIUM CHANNEL; SOMATOSTATIN;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; BRAIN DEVELOPMENT; BRAIN TISSUE; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; NONHUMAN; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; SCHIZOPHRENIA; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VAGUS NERVE STIMULATION; VISUAL SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CONSERVED SEQUENCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 60149091355     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000186688     Document Type: Review

References (185)

1. Birnbaumer L, Pohl SL, Rodbell M, Sundby F: The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone. J Biol Chem 1972;247:2038-2043.
2. Ross EM, Gilman AG: Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem 1977;252:6966-6969.
3. Gilman AG: G proteins: transducers of receptor-generated signals. Annu Rev Biochem 1987;56:615-649.
4. Fung BK, Hurley JB, Stryer L: Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc Natl Acad Sci USA 1981;78:152-156.
5. Moss J, Manganiello VC, Vaughan M: Substrate and effector specificity of a guanosine 3′,5′-monophosphate phosphodiesterase from rat liver. J Biol Chem 1977;252:5211-5215.
6. Gill DM, Meren R: ADP ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase. Proc Natl Acad Sci USA 1978;75:3050-3054.
7. Cassel D, Pfeuffer T: Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system. Proc Natl Acad Sci USA 1978;75:2669-2673.
8. Katada T, Amano T, Ui M: Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells. J Biol Chem 1982;257:3739-3746.
9. Katada T, Ui M: Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP ribosylation of a membrane protein. Proc Natl Acad Sci USA 1982;79:3129-3133.
10. Codina J, Hildebrandt J, Iyengar R, Birnbaumer L, Sekura RD, Manclark CR: Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. Proc Natl Acad Sci USA 1983;80:4276-4280.
11. Bokoch GM, Katada T, Northup JK, Hewlett EL, Gilman AG: Identification of the predominant substrate for ADP ribosylation by islet-activating protein. J Biol Chem 1983;258:2072-2075.
12. Neer EJ, Lok JM, Wolf LG: Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase. J Biol Chem 1984;259:14222-14229.
13. Sternweis PC, Robishaw JD: Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J Biol Chem 1984;259:13806-13813.
14. Milligan G, Klee WA: The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase. J Biol Chem 1985;260:2057-2063.
15. Itoh H, Kozasa T, Nagata S, Nakamura S, Katada T, Ui M, Iwai S, Ohtsuka E, Kawasaki H, Suzuki K, et al: Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci USA 1986;83:3776-3780.
16. Ferguson KM, Higashijima T, Smigel MD, Gilman AG: The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem 1986;261:7393-7399.
17. Strittmatter SM, Valenzuela D, Sudo Y, Linder ME, Fishman MC: An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism. J Biol Chem 1991;266:22465-22471.
18. Strittmatter SM, Valenzuela D, Vartanian T, Sudo Y, Zuber MX, Fishman MC: Growth cone transduction: Go and GAP-43. J Cell Sci Suppl 1991;15:27-33.
19. Cismowski MJ, Takesono A, Ma C, Lizano JS, Xie X, Fuernkranz H, Lanier SM, Duzic E: Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nat Biotechnol 1999;17:878-883.
20. Cismowski MJ, Ma C, Ribas C, Xie X, Spruyt M, Lizano JS, Lanier SM, Duzic E: Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration. J Biol Chem 2000;275:23421-23424.
21. Kemppainen RJ, Behrend EN: Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem 1998;273:3129-3131.
22. Graham TE, Prossnitz ER, Dorin RI: Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. J Biol Chem 2002;277:10876-10882.
23. Takesono A, Zahner J, Blumer KJ, Nagao T, Kurose H: Negative regulation of alpha-2-adrenergic receptor-mediated Gi signalling by a novel pathway. Biochem J 1999;343 Pt 1:77-85.
24. Siderovski DP, Diverse-Pierluissi M, De Vries L: The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor. Trends Biochem Sci 1999;24:340-341.
25. De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG: The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 2000;40:235-271.
26. Diverse-Pierluissi MA, Fischer T, Jordan JD, Schiff M, Ortiz DF, Farquhar MG, De Vries L: Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. J Biol Chem 1999;274:14490-14494.
27. Xu X, Zeng W, Popov S, Berman DM, Davignon I, Yu K, Yowe D, Offermanns S, Muallem S, Wilkie TM: RGS proteins determine signaling specificity of Gq-coupled receptors. J Biol Chem 1999;274:3549-3556.
28. Hoffmann M, Ward RJ, Cavalli A, Carr IC, Milligan G: Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha-2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. J Neurochem 2001;78:797-806.
29. Murtagh JJ Jr, Eddy R, Shows TB, Moss J, Vaughan M: Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16. Mol Cell Biol 1991;11:1146-1155.
30. Jones DT, Reed RR: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem 1987;262:14241-14249.
31. Strathmann M, Wilkie TM, Simon MI: Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. Proc Natl Acad Sci USA 1990;87:6477-6481.
32. Hsu WH, Rudolph U, Sanford J, Bertrand P, Olate J, Nelson C, Moss LG, Boyd AE, Codina J, Birnbaumer L: Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. J Biol Chem 1990;265:11220-11226.
33. Van Meurs KP, Angus CW, Lavu S, Kung HF, Czarnecki SK, Moss J, Vaughan M: Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. Proc Natl Acad Sci USA 1987;84:3107-3111.
34. Damodaran S, Dlugos CA, Wood TD, Rabin RA: Effects of chronic ethanol administration on brain protein levels: a proteomic investigation using 2-D DIGE system. Eur J Pharmacol 2006;547:75-82.
35. Olate J, Martinez S, Purcell P, Jorquera H, Codina J, Birnbaumer L, Allende J: Molecular cloning and sequence determination of four different cDNA species coding for alpha-subunits of G proteins from Xenopus laevis oocytes. FEBS Lett 1990;268:27-31.
36. Yoon J, Shortridge RD, Bloomquist BT, Schneuwly S, Perdew MH, Pak WL: Molecular characterization of Drosophila gene encoding G0 alpha subunit homolog. J Biol Chem 1989;264:18536-18543.
37. De Sousa SM, Hoveland LL, Yarfitz S, Hurley JB: The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries. J Biol Chem 1989;264:18544-18551.
38. Thambi NC, Quan F, Wolfgang WJ, Spiegel A, Forte M: Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. J Biol Chem 1989;264:18552-18560.
39. Lochrie MA, Mendel JE, Sternberg PW, Simon MI: Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans. Cell Regul 1991;2:135-154.
40. Miura N, Atsumi S, Tabunoki H, Sato R: Expression and localization of three G protein alpha subunits, Go, Gq, and Gs, in adult antennae of the silkmoth (Bombyx mori). J Comp Neurol 2005;485:143-152.
41. Goldsmith P, Backlund PS Jr, Rossiter K, Carter A, Milligan G, Unson CG, Spiegel A: Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. Biochemistry 1988;27:7085-7090.
42. Lang J: Purification and characterization of subforms of the guanine-nucleotide-binding proteins G alpha i and G alpha o. Eur J Biochem 1989;183:687-692.
43. Scherer NM, Toro MJ, Entman ML, Birnbaumer L: G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins. Arch Biochem Biophys 1987;259:431-440.
44. Strathmann M, Simon MI: G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci USA 1990;87:9113-9117.
45. Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y: Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. Proc Natl Acad Sci USA 1991;88:2974-2978.
46. 2 dopamine receptors are coupled to their effectors by Go. Proc Natl Acad Sci USA 2001;98:3577-3582.
47. Linder ME, Pang IH, Duronio RJ, Gordon JI, Sternweis PC, Gilman AG: Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. J Biol Chem 1991;266:4654-4659.
48. Mumby SM, Heukeroth RO, Gordon JI, Gilman AG: G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci USA 1990;87:728-732.
49. Jones TL, Simonds WF, Merendino JJ Jr, Brann MR, Spiegel AM: Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment. Proc Natl Acad Sci USA 1990;87:568-572.
50. Gallego C, Gupta SK, Winitz S, Eisfelder BJ, Johnson GL: Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions. Proc Natl Acad Sci USA 1992;89:9695-9699.
51. Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM: Lipid modifications of G proteins: alpha subunits are palmitoylated. Proc Natl Acad Sci USA 1993;90:3675-3679.
52. Mumby SM, Kleuss C, Gilman AG: Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci USA 1994;91:2800-2804.
53. Barclay E, O'Reilly M, Milligan G: Activation of an alpha-2A- adrenoceptor-Galphao1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor. Biochem J 2005;385:197-206.
54. Busconi L, Boutin PM, Denker BM: N-terminal binding domain of Galpha subunits: involvement of amino acids 11-14 of Galphao in membrane attachment. Biochem J 1997;323:239-244.
55. Chen CA, Manning DR: Regulation of G proteins by covalent modification. Oncogene 2001;20:1643-1652.
56. Kobayashi I, Shibasaki H, Takahashi K, Kikkawa S, Ui M, Katada T: Purification of GTP-binding proteins from bovine brain membranes. Identification of heterogeneity of the alpha-subunit of Go proteins. FEBS Lett 1989;257:177-180.
57. McIntire WE, Dingus J, Schey KL, Hildebrandt JD: Characterization of the major bovine brain Go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions. J Biol Chem 1998;273:33135-33141.
58. McIntire WE, Schey KL, Knapp DR, Hildebrandt JD: A major G protein alpha O isoform in bovine brain is deamidated at Asn346 and Asn347, residues involved in receptor coupling. Biochemistry 1998;37:14651-14658.
59. Exner T, Jensen ON, Mann M, Kleuss C, Nurnberg B: Posttranslational modification of Galphao1 generates Galphao3, an abundant G protein in brain. Proc Natl Acad Sci USA 1999;96:1327-1332.
60. McIntire WE, Dingus J, Wilcox MD, Hildebrandt JD: The relationship of G(o)alpha subunit deamidation to the tissue distribution, nucleotide binding properties, and betagamma dimer interactions of G(o)alpha subunit isoforms. J Neurochem 1999;73:633-640.
61. Huff RM, Axton JM, Neer EJ: Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex. J Biol Chem 1985;260:10864-10871.
62. Vardi N: Alpha subunit of Go localizes in the dendritic tips of ON bipolar cells. J Comp Neurol 1998;395:43-52.
63. Shinohara H, Kato K, Asano T: Differential localization of G proteins, Gi and Go, in the olfactory epithelium and the main olfactory bulb of the rat. Acta Anat (Basel) 1992;144:167-171.
64. Homburger V, Brabet P, Audigier Y, Pantaloni C, Bockaert J, Rouot B: Immunological localization of the GTP-binding protein Go in different tissues of vertebrates and invertebrates. Mol Pharmacol 1987;31:313-319.
65. Liang BT, Hellmich MR, Neer EJ, Galper JB: Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein. J Biol Chem 1986;261:9011-9021.
66. Asano T, Kamiya N, Semba R, Kato K: Ontogeny of the GTP-binding protein Go in rat brain and heart. J Neurochem 1988;51:1711-1716.
67. Milligan G, Tanfin Z, Goureau O, Unson C, Harbon S: Identification of both Gi2 and a novel, immunologically distinct, form of Go in rat myometrial membranes. FEBS Lett 1989;244:411-416.
68. Wolf WP, Spicher K, Haase H, Schulze W: Immunocytochemical localization of the G-protein subunit, G(o) alpha, in rat heart. Implications for a role of G(o) alpha in secretion of cardiac hormones. J Mol Cell Cardiol 1998;30:1149-1162.
69. Worley PF, Baraban JM, Van Dop C, Neer EJ, Snyder SH: Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems. Proc Natl Acad Sci USA 1986;83:4561-4565.
70. Gabrion J, Brabet P, Nguyen Than Dao B, Homburger V, Dumuis A, Sebben M, Rouot B, Bockaert J: Ultrastructural localization of the GTP-binding protein Go in neurons. Cell Signal 1989;1:107-123.
71. Galper JB, Klein W, Catterall WA: Muscarinic acetylcholine receptors in developing chick heart. J Biol Chem 1977;252:8692-8699.
72. Luetje CW, Tietje KM, Christian JL, Nathanson NM: Differential tissue expression and developmental regulation of guanine nucleotide binding regulatory proteins and their messenger RNAs in rat heart. J Biol Chem 1988;263:13357-13365.
73. Kawai Y, Arinze IJ: Differential localization and development-dependent expression of G-protein subunits, Go alpha and G beta, in rabbit heart. J Mol Cell Cardiol 1996;28:1555-1564.
74. Mullaney I, Milligan G: Elevated levels of the guanine nucleotide binding protein, Go, are associated with differentiation of neuroblastoma ! glioma hybrid cells. FEBS Lett 1989;244:113-118.
75. Brabet P, Pantaloni C, Rodriguez M, Martinez J, Bockaert J, Homburger V: Neuroblastoma differentiation involves the expression of two isoforms of the alpha-subunit of Go. J Neurochem 1990;54:1310-1320.
76. Brabet P, Pantaloni C, Bockaert J, Homburger V: Metabolism of two Go alpha isoforms in neuronal cells during differentiation. J Biol Chem 1991;266:12825-12828.
77. Ben-Shlomo I, Yu Hsu S, Rauch R, Kowalski HW, Hsueh AJ: Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci STKE 2003;2003:RE9.
78. Florio VA, Sternweis PC: Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins. J Biol Chem 1985;260:3477-3483.
79. Kurose H, Katada T, Haga T, Haga K, Ichiyama A, Ui M: Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem 1986;261:6423-6428.
80. Ueda H, Harada H, Nozaki M, Katada T, Ui M, Satoh M, Takagi H: Reconstitution of rat brain mu opioid receptors with purified guanine nucleotide-binding regulatory proteins, Gi and Go. Proc Natl Acad Sci USA 1988;85:7013-7017.
81. Lewis DL, Weight FF, Luini A: A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line. Proc Natl Acad Sci USA 1986;83:9035-9039.
82. Law SF, Manning D, Reisine T: Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors. J Biol Chem 1991;266:17885-17897.
83. Hescheler J, Rosenthal W, Trautwein W, Schultz G: The GTP-binding protein, Go, regulates neuronal calcium channels. Nature 1987;325:445-447.
84. 2+ channels in sensory neurons. Proc Natl Acad Sci USA 1988;85:3633-3637.
85. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, Wittig B: Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 1991;353:43-48.
86. Kleuss C, Scherubl H, Hescheler J, Schultz G, Wittig B: Different beta-subunits determine G-protein interaction with transmembrane receptors. Nature 1992;358:424-426.
87. Kleuss C, Scherubl H, Hescheler J, Schultz G, Wittig B: Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins. Science 1993;259:832-834.
88. Jiang M, Boulay G, Spicher K, Peyton MJ, Brabet P, Birnbaumer L, Rudolph U: Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. Receptors Channels 1997;5:187-192.
89. Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L: Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci USA 1998;95:3269-3274.
90. 2+ channels in mouse heart. Proc Natl Acad Sci USA 1997;94:1727-1732.
91. Dunlap K, Fischbach GD: Neurotransmitters decrease the calcium component of sensory neurone action potentials. Nature 1978;276:837-839.
92. Dunlap K, Fischbach GD: Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. J Physiol 1981;317:519-535.
93. Holz GG 4th, Rane SG, Dunlap K: GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. Nature 1986;319:670-672.
94. Scott RH, Dolphin AC: Regulation of calcium currents by a GTP analogue: potentiation of (-)-baclofen-mediated inhibition. Neurosci Lett 1986;69:59-64.
95. Hille B: Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci 1994;17:531-536.
96. 2+ channels in rat dorsal root ganglion neurons in vitro. Neuron 1989;2:1185-1193.
97. 2+ currents in rat sensory neurones by the G protein G(0): antisense oligonucleotide studies. J Physiol 1993;470:1-11.
98. 2+ current via G alpha o in rat sympathetic neurones. J Physiol 1994;477:415-422.
99. Jan LY, Jan YN: How might the diversity of potassium channels be generated? Trends Neurosci 1990;13:415-419.
100. Pfaffinger PJ, Martin JM, Hunter DD, Nathanson NM, Hille B: GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Nature 1985;317:536-538.
101. Andrade R, Malenka RC, Nicoll RA: A G protein couples serotonin and GABAB receptors to the same channels in hippocampus. Science 1986;234:1261-1265.
102. VanDongen AM, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM: Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science 1988;242:1433-1437.
103. + channel in heart. Nature 1987;325:321-326.
104. Wickman KD, Iniguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE: Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature 1994;368:255-257.
105. Reuveny E, Slesinger PA, Inglese J, Morales JM, Iniguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY: Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature 1994;370:143-146.
106. + channels. FEBS Lett 1997;405:291-298.
107. Lei Q, Jones MB, Talley EM, Schrier AD, McIntire WE, Garrison JC, Bayliss DA: Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits. Proc Natl Acad Sci USA 2000;97:9771-9776.
108. + channel, GIRK. Neuron 2002;33:87-99.
109. Cohen-Armon M, Sokolovsky M: Depolarization-induced changes in the muscarinic receptor in rat brain and heart are mediated by pertussis-toxin- sensitive G-proteins. J Biol Chem 1991;266:2595-2605.
110. + channel gating in depolarization-induced activation of G-proteins. J Biol Chem 1993;268:9824-9838.
111. 32P]GTP- azidoanilide. J Biol Chem 1999;274:7431-7440.
112. + channel via the Go guanine nucleotide-binding regulatory protein. Proc Natl Acad Sci USA 1996;93:8107-8111.
113. +. J Membr Biol 1998;162:225-232.
114. Katada T, Oinuma M, Ui M: Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities. J Biol Chem 1986;261:8182-8191.
115. Wong YH, Conklin BR, Bourne HR: Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science 1992;255:339-342.
116. + channels. Eur J Biochem 1990;191:499-506.
117. Ghil S, Choi JM, Kim SS, Lee YD, Liao Y, Birnbaumer L, Suh-Kim H: Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go. Proc Natl Acad Sci USA 2006;103:19158-19163.
118. Mendel JE, Korswagen HC, Liu KS, Hajdu-Cronin YM, Simon MI, Plasterk RH, Sternberg PW: Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 1995;267:1652-1655.
119. Segalat L, Elkes DA, Kaplan JM: Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science 1995;267:1648-1651.
120. Miller KG, Emerson MD, Rand JB: Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans. Neuron 1999;24:323-333.
121. Nurrish S, Segalat L, Kaplan JM: Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Neuron 1999;24:231-242.
122. Matsuki M, Kunitomo H, Iino Y: Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Proc Natl Acad Sci USA 2006;103:1112-1117.
123. Mendel J: Go directly (or indirectly) to Gq. Neuron 1999;24:287-288.
124. Kroll SD, Chen J, De Vivo M, Carty DJ, Buku A, Premont RT, Iyengar R: The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation. J Biol Chem 1992;267:23183-23188.
125. Kroll SD, Omri G, Landau EM, Iyengar R: Activated alpha subunit of Go protein induces oocyte maturation. Proc Natl Acad Sci USA 1991;88:5182-5186.
126. Baffy G, Yang L, Raj S, Manning DR, Williamson JR: G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem 1994;269:8483-8487.
127. Van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ: G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem 1996;271:1266-1269.
128. Jordan JD, Carey KD, Stork PJ, Iyengar R: Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. J Biol Chem 1999;274:21507-21510.
129. Ram PT, Horvath CM, Iyengar R: Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science 2000;287:142-144.
130. Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R: Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GA-PII. J Biol Chem 2005;280:11413-11421.
131. He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R: The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 2005;280:33426-33434.
132. Antonelli V, Bernasconi F, Wong YH, Vallar L: Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain. Mol Biol Cell 2000;11:1129-1142.
133. Bernasconi F, Malgaroli A, Vallar L: Independent regulation of Rap1 and mitogen-activated protein kinase by the alpha chain of Go. Neurosignals 2006;15:180-189.
134. Crespo P, Xu N, Simonds WF, Gutkind JS: Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature 1994;369:418-420.
135. Gutkind JS: The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998;273:1839-1842.
136. Toutant M, Aunis D, Bockaert J, Homburger V, Rouot B: Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cells. FEBS Lett 1987;215:339-344.
137. Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U, Wollheim CB: Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits. EMBO J 1995;14:3635-3644.
138. Gasman S, Chasserot-Golaz S, Popoff MR, Aunis D, Bader MF: Trimeric G proteins control exocytosis in chromaffin cells. Go regulates the peripheral actin network and catecholamine secretion by a mechanism involving the small GTP-binding protein Rho. J Biol Chem 1997;272:20564-20571.
139. Vitale N, Gensse M, Chasserot-Golaz S, Aunis D, Bader MF: Trimeric G proteins control regulated exocytosis in bovine chromaffin cells: sequential involvement of Go associated with secretory granules and Gi3 bound to the plasma membrane. Eur J Neurosci 1996;8:1275-1285.
140. Gasman S, Chasserot-Golaz S, Hubert P, Aunis D, Bader MF: Identification of a potential effector pathway for the trimeric Go protein associated with secretory granules. Go stimulates a granule-bound phosphatidylinositol 4-kinase by activating RhoA in chromaffin cells. J Biol Chem 1998;273:16913-16920.
141. Ahnert-Hilger G, Schafer T, Spicher K, Grund C, Schultz G, Wiedenmann B: Detection of G-protein heterotrimers on large dense core and small synaptic vesicles of neuroendocrine and neuronal cells. Eur J Cell Biol 1994;65:26-38.
142. Ahnert-Hilger G, Nurnberg B, Exner T, Schafer T, Jahn R: The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles. EMBO J 1998;17:406-413.
143. Holtje M, von Jagow B, Pahner I, Lautenschlager M, Hortnagl H, Nurnberg B, Jahn R, Ahnert-Hilger G: The neuronal monoamine transporter VMAT2 is regulated by the trimeric GTPase Go(2). J Neurosci 2000;20:2131-2141.
144. Winter S, Brunk I, Walther DJ, Holtje M, Jiang M, Peter JU, Takamori S, Jahn R, Birnbaumer L, Ahnert-Hilger G: Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence. J Neurosci 2005;25:4672-4680.
145. Holtje M, Hofmann F, Lux R, Veh RW, Just I, Ahnert-Hilger G: Glutamate uptake and release by astrocytes is enhanced by Clostridium botulinum C3 protein. J Biol Chem 2008;283:9289-9299.
146. Strittmatter SM, Valenzuela D, Kennedy TE, Neer EJ, Fishman MC: G0 is a major growth cone protein subject to regulation by GAP-43. Nature 1990;344:836-841.
147. Meiri KF, Pfenninger KH, Willard MB: Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones. Proc Natl Acad Sci USA 1986;83:3537-3541.
148. Skene JH, Jacobson RD, Snipes GJ, McGuire CB, Norden JJ, Freeman JA: A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes. Science 1986;233:783-786.
149. Benowitz LI, Shashoua VE, Yoon MG: Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerve. J Neurosci 1981;1:300-307.
150. Skene JH, Willard M: Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. J Cell Biol 1981;89:86-95.
151. Strittmatter SM, Fishman MC: The neuronal growth cone as a specialized transduction system. Bioessays 1991;13:127-134.
152. Strittmatter SM, Fishman MC, Zhu XP: Activated mutants of the alpha subunit of G(o) promote an increased number of neurites per cell. J Neurosci 1994;14:2327-2338.
153. Xie R, Li L, Goshima Y, Strittmatter SM: An activated mutant of the alpha subunit of G(o) increases neurite outgrowth via protein kinase C. Brain Res Dev Brain Res 1995;87:77-86.
154. Kindt KS, Tam T, Whiteman S, Schafer WR: Serotonin promotes G(o)-dependent neuronal migration in Caenorhabditis elegans. Curr Biol 2002;12:1738-1747.
155. Horgan AM, Copenhaver PF: G protein-mediated inhibition of neuronal migration requires calcium influx. J Neurosci 1998;18:4189-4200.
156. Zheng JQ, Poo MM: Calcium signaling in neuronal motility. Annu Rev Cell Dev Biol 2007;23:375-404.
157. Guillen A, Semeriva M, Bockaert J, Homburger V: The transduction signalling protein Go during embryonic development of Drosophila melanogaster. Cell Signal 1991;3:341-352.
158. Wolfgang WJ, Quan F, Thambi N, Forte M: Restricted spatial and temporal expression of G-protein alpha subunits during Drosophila embryogenesis. Development 1991;113:527-538.
159. Guillen A, Jallon JM, Fehrentz JA, Pantaloni C, Bockaert J, Homburger V: A Go-like protein in Drosophila melanogaster and its expression in memory mutants. Embo J 1990;9:1449-1455.
160. Ferris J, Ge H, Liu L, Roman G: G(o) signaling is required for Drosophila associative learning. Nat Neurosci 2006;9:1036-1040.
161. Katanaev VL, Ponzielli R, Semeriva M, Tomlinson A: Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 2005;120:111-122.
162. Katanaev VL, Tomlinson A: Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc Natl Acad Sci USA 2006;103:6524-6529.
163. Brouillet E, Trembleau A, Galanaud D, Volovitch M, Bouillot C, Valenza C, Prochiantz A, Allinquant B: The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction. J Neurosci 1999;19:1717-1727.
164. Nishimoto I, Okamoto T, Matsuura Y, Takahashi S, Okamoto T, Murayama Y, Ogata E: Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o). Nature 1993;362:75-79.
165. Okamoto T, Takeda S, Giambarella U, Murayama Y, Matsui T, Katada T, Matsuura Y, Nishimoto I: Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. Embo J 1996;15:3769-3777.
166. Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, Nishimoto I: Expression of V642 APP mutant causes cellular apoptosis as Alzheimer
167. Zhao B, Chrest FJ, Horton WE Jr, Sisodia SS, Kusiak JW: Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. J Neurosci Res 1997;47:253-263.
168. Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I: G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J 1997;16:4897-4907.
169. McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL: DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21-activated kinase PAK3. J Neurosci 2003;23:6914-6927.
170. Smine A, Xu X, Nishiyama K, Katada T, Gambetti P, Yadav SP, Wu X, Shi YC, Yasuhara S, Homburger V, Okamoto T: Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1. J Biol Chem 1998;273:16281-16288.
171. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L: Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996;274:1710-1713.
172. Roth KA: Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion. J Neuropathol Exp Neurol 2001;60:829-838.
173. 2 receptors have to do with it? Trends Neurosci 2006;29:167-174.
174. Okada F, Crow TJ, Roberts GW: G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain. J Neural Transm Gen Sect 1990;79:227-234.
175. Okada F, Crow TJ, Roberts GW: G proteins (Gi, Go) in the medial temporal lobe in schizophrenia: preliminary report of a neurochemical correlate of structural change. J Neural Transm Gen Sect 1991;84:147-153.
176. Okada F, Tokumitsu Y, Takahashi N, Crow TJ, Roberts GW: Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain. J Neural Transm Gen Sect 1994;95:95-104.
177. Yang CQ, Kitamura N, Nishino N, Shirakawa O, Nakai H: Isotype-specific G protein abnormalities in the left superior temporal cortex and limbic structures of patients with chronic schizophrenia. Biol Psychiatry 1998;43:12-19.
178. Tani M, Mui K, Minami Y, Kiriike N: Association of a GTP-binding protein Go alpha subunit mutation with schizophrenia. Mol Psychiatry 2001;6:359.
179. Schiller PH: The ON and OFF channels of the visual system. Trends Neurosci 1992;15:86-92.
180. Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, Nakanishi S: Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Biol Chem 1993;268:11868-11873.
181. Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, et al: Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell 1995;80:757-765.
182. Dhingra A, Lyubarsky A, Jiang M, Pugh EN Jr, Birnbaumer L, Sterling P, Vardi N: The light response of ON bipolar neurons requires G(alpha)o. J Neurosci 2000;20:9053-9058.
183. Dhingra A, Jiang M, Wang TL, Lyubarsky A, Savchenko A, Bar-Yehuda T, Sterling P, Birnbaumer L, Vardi N: Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci 2002;22:4878-4884.
184. Duan SZ, Christe M, Milstone DS, Mortensen RM: Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun 2007;357:139-143.
185. Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U: Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G(alpha)o* protein. Am J Physiol 2008;294:H1335-H1347.