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Volumn 80, Issue 3, 2011, Pages 367-377

Quantifying ligand bias at seven-transmembrane receptors

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; LIGAND;

EID: 80051979129     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.072801     Document Type: Article
Times cited : (320)

References (37)
  • 3
    • 0031815337 scopus 로고    scopus 로고
    • Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
    • Berg K.A., Maayani S., Goldfarb J., Scaramellini C., Leff P, and Clarke W.P. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104. (Pubitemid 28337591)
    • (1998) Molecular Pharmacology , vol.54 , Issue.1 , pp. 94-104
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Scaramellini, C.4    Leff, P.5    Clarke, W.P.6
  • 5
    • 0000282255 scopus 로고
    • Imprecision in presentation of binding studies
    • Colquhoun D. (1985) Imprecision in presentation of binding studies. Trends Pharmacol Sci 6:197.
    • (1985) Trends Pharmacol Sci , vol.6 , pp. 197
    • Colquhoun, D.1
  • 6
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
    • De Lean A., Stadel JM, and Lefkowitz R.J. (1980) A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem 255:7108-7117. (Pubitemid 11232874)
    • (1980) Journal of Biological Chemistry , vol.255 , Issue.15 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 7
    • 0036968988 scopus 로고    scopus 로고
    • 2-adrenergic receptor
    • DOI 10.1038/sj.bjp.0704622
    • Del Carmine R., Ambrosio C., Sbraccia M., Cotecchia S., Ijzerman AP, and Costa T. (2002) Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor. Br J Pharmacol 135:1715-1722. (Pubitemid 36132706)
    • (2002) British Journal of Pharmacology , vol.135 , Issue.7 , pp. 1715-1722
    • Del, C.R.1    Ambrosio, C.2    Sbraccia, M.3    Cotecchia, S.4    Ijzerman, A.P.5    Costa, T.6
  • 10
    • 34447513030 scopus 로고    scopus 로고
    • Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening
    • DOI 10.1089/adt.2007.062
    • Eglen R.M., Bosse R, and Reisine T. (2007) Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening. Assay Drug Dev Technol 5:425-451. (Pubitemid 47067887)
    • (2007) Assay and Drug Development Technologies , vol.5 , Issue.3 , pp. 425-451
    • Eglen, R.M.1    Bosse, R.2    Reisine, T.3
  • 11
    • 45849112499 scopus 로고    scopus 로고
    • On the analysis of ligand-directed signaling at G protein-coupled receptors
    • Ehlert F.J. (2008) On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn Schmiedebergs Arch Pharmacol 377:549-577.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.377 , pp. 549-577
    • Ehlert, F.J.1
  • 15
    • 59149084759 scopus 로고    scopus 로고
    • Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes
    • Figueroa K.W., Griffin MT, and Ehlert F.J. (2009) Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes. J Pharmacol Exp Ther 328:331-342.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 331-342
    • Figueroa, K.W.1    Griffin, M.T.2    Ehlert, F.J.3
  • 16
    • 0002355204 scopus 로고
    • The use of beta-haloaklylamines in the differentiation of the receptors and in the determination of dissociation constants of receptor-agonist complexes
    • (Harper NJ and Simmonds AB eds) Academic Press, New York
    • Furchgott R.F. (1966) The use of beta-haloaklylamines in the differentiation of the receptors and in the determination of dissociation constants of receptor-agonist complexes, in Advances in Drug Research (Harper NJ and Simmonds AB eds) pp 21-55, Academic Press, New York.
    • (1966) Advances in Drug Research , pp. 21-55
    • Furchgott, R.F.1
  • 17
    • 33751162165 scopus 로고    scopus 로고
    • Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
    • Galandrin S and Bouvier M. (2006) Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70:1575-1584.
    • (2006) Mol Pharmacol , vol.70 , pp. 1575-1584
    • Galandrin, S.1    Bouvier, M.2
  • 20
    • 77951223981 scopus 로고    scopus 로고
    • Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
    • Gregory K.J., Hall N.E., Tobin A.B., Sexton PM, and Christopoulos A. (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285:7459-7474.
    • (2010) J Biol Chem , vol.285 , pp. 7459-7474
    • Gregory, K.J.1    Hall, N.E.2    Tobin, A.B.3    Sexton, P.M.4    Christopoulos, A.5
  • 21
    • 0036208442 scopus 로고    scopus 로고
    • Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
    • DOI 10.1124/mol.61.4.768
    • Holloway A.C., Qian H., Pipolo L., Ziogas J., Miura S., Karnik S., Southwell B.R., Lew MJ, and Thomas W.G. (2002) Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Mol Pharmacol 61:768-777. (Pubitemid 34273156)
    • (2002) Molecular Pharmacology , vol.61 , Issue.4 , pp. 768-777
    • Holloway, A.C.1    Qian, H.2    Pipolo, L.3    Ziogas, J.4    Miura, S.-I.5    Karnik, S.6    Southwell, B.R.7    Lew, M.J.8    Thomas, W.G.9
  • 22
    • 0029054965 scopus 로고
    • Agonist-receptor efficacy. II. Agonist trafficking of receptor signals
    • Kenakin T. (1995) Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 232-238
    • Kenakin, T.1
  • 23
    • 0033213906 scopus 로고    scopus 로고
    • Efficacy in drug receptor theory: Outdated concept or under-valued tool?
    • Kenakin T. (1999) Efficacy in drug receptor theory: Outdated concept or under-valued tool? Trends Pharmacol Sci 20:400-405.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 400-405
    • Kenakin, T.1
  • 24
    • 36348946976 scopus 로고    scopus 로고
    • Functional selectivity through protean and biased agonism: Who steers the ship?
    • Kenakin T. (2007) Functional selectivity through protean and biased agonism: Who steers the ship? Mol Pharmacol 72:1393-1401.
    • (2007) Mol Pharmacol , vol.72 , pp. 1393-1401
    • Kenakin, T.1
  • 25
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin T and Miller L.J. (2010) Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev 62:265-304.
    • (2010) Pharmacol Rev , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 26
    • 77956249652 scopus 로고    scopus 로고
    • Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening
    • Koole C., Wootten D., Simms J., Valant C., Sridhar R., Woodman O.L., Miller L.J., Summers R.J., Christopoulos A, and Sexton P.M. (2010) Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening. Mol Pharmacol 78:456-465.
    • (2010) Mol Pharmacol , vol.78 , pp. 456-465
    • Koole, C.1    Wootten, D.2    Simms, J.3    Valant, C.4    Sridhar, R.5    Woodman, O.L.6    Miller, L.J.7    Summers, R.J.8    Christopoulos, A.9    Sexton, P.M.10
  • 30
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seven-transmembrane receptors
    • Rajagopal S., Rajagopal K, and Lefkowitz R.J. (2010) Teaching old receptors new tricks: Biasing seven-transmembrane receptors. Nat Rev Drug Discov 9:373-386.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 31
    • 78149243364 scopus 로고    scopus 로고
    • Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
    • Reiner S., Ambrosio M., Hoffmann C, and Lohse M.J. (2010) Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. J Biol Chem 285:36188-36198.
    • (2010) J Biol Chem , vol.285 , pp. 36188-36198
    • Reiner, S.1    Ambrosio, M.2    Hoffmann, C.3    Lohse, M.J.4
  • 32
    • 80052020428 scopus 로고    scopus 로고
    • Historical overview of the concept of functional selectivity
    • (Neve K ed) Springer, New York
    • Roth B.L. (2009) Historical overview of the concept of functional selectivity, in Functional Selectivity of G Protein-Coupled Receptor Ligands (Neve K ed) pp 3-7, Springer, New York.
    • (2009) Functional Selectivity of G Protein-Coupled Receptor Ligands , pp. 3-7
    • Roth, B.L.1
  • 33
    • 0010673662 scopus 로고
    • A modification of receptor theory
    • Stephenson R.P. (1956) A modification of receptor theory. Br J Pharmacol Chemother 11:379-393.
    • (1956) Br J Pharmacol Chemother , vol.11 , pp. 379-393
    • Stephenson, R.P.1
  • 36
    • 79952488185 scopus 로고    scopus 로고
    • Therapeutic potential of β-arrestin- And G protein-biased agonists
    • Whalen E.J., Rajagopal S, and Lefkowitz R.J. (2011) Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med 17:126-139.
    • (2011) Trends Mol Med , vol.17 , pp. 126-139
    • Whalen, E.J.1    Rajagopal, S.2    Lefkowitz, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.