A simple method for quantifying functional selectivity and agonist bias

ACS Chemical Neuroscience

Volumn 3, Issue 3, 2012, Pages 193-203

  Kenakin, Terry ^a   Watson, Christian ^b   Muniz Medina, Vanessa ^b   Christopoulos, Arthur ^c   Novick, Steven ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Biased agonism; drug discovery; functional selectivity; receptor methods; receptor theory; stimulus bias

Indexed keywords

CARBACHOL; CHEMOKINE RECEPTOR CCR5; INOSITOL PHOSPHATE; MEMBRANE RECEPTOR; OXOTREMORINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCULATION; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME SYNTHESIS; INTERNALIZATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RATING SCALE; RECEPTOR AFFINITY; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

BIASED AGONISM; DRUG DISCOVERY; FUNCTIONAL SELECTIVITY; RECEPTOR METHODS; RECEPTOR THEORY; STIMULUS BIAS;

ANIMALS; CARBACHOL; CHO CELLS; CRICETINAE; CRICETULUS; GUINEA PIGS; ILEUM; ORGAN CULTURE TECHNIQUES; OXOTREMORINE; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84858775788     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200111m     Document Type: Article

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