Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia

Archives of General Psychiatry

Volumn 57, Issue 1, 2000, Pages 65-73

  Glantz, Leisa A ^a   Lewis, David A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NERVE CELL NETWORK; PREFRONTAL CORTEX; PYRAMIDAL NERVE CELL; SCHIZOPHRENIA; TISSUE DISTRIBUTION;

EID: 0033985644     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.57.1.65     Document Type: Article

References (73)

1. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 1992;49:975-982.
2. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, I: regional cerebral blood flow evidence. Arch Gen Psychiatry. 1986;43:114-124.
3. Steinberg JL, Devous MD, Paulman RG. Wisconsin card sorting activated regional cerebral blood flow in first break and chronic schizophrenic patients and normal controls. Schizophr Res. 1996;19:177-187.
4. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze V II, O'Leary DS, Ehrhardt JC, Yuh WTC. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA. 1994;272:1763-1769.
5. Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD. Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151:842-848.
6. Shelton RC, Karson CN, Doran AR, Pickar D, Bigelow LB, Weinberger DR. Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect. Am J Psychiatry. 1988;145:154-163.
7. Sullivan EV, Lim KO, Mathalon D, Marsh L, Beal DM, Harris D, Hoff AL, Faustman WO, Pfefferbaum A. A profile of cortical gray matter volume deficits characteristic of schizophrenia. Cereb Cortex. 1998;8:117-124.
8. Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry. 1992; 49:195-205.
9. Daviss SR, Lewis DA. Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons. Psychiatry Res. 1995;59:81-96.
10. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry. 1995;52:805-818.
11. Selemon LD, Rajkowska G, Goldman-Rakic PS. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method. J Comp Neurol. 1998;392:402-412.
12. Akbarian S, Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE Jr, Jones EG. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry. 1995;52:258-266.
13. Thune JJ, Hofsten DE, Uylings HBM, Pakkenberg B. Total neuron numbers in the prefrontal cortex in schizophrenia. Soc Neurosci Abstracts. 1998;24:985.
14. Goldman-Rakic PS, Selemon LD. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull. 1997;23:437-458.
15. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CTW, Frank JA, Tedeschi G, Weinberger DR. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 1996;153:1554-1563.
16. Bertolino A, Callicott JH, Nawroz S, Mattay VS, Duyn JH, Tecleschi G, Frank JA, Weinberger DR. Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia. Neuropsychopharmacology. 1998;18:1-9.
17. 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol Psychiatry. 1994;36:792-800.
18. Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW. Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry. 1997;154:688-690.
19. Pettegrew JW, Keshavan MS, Panchalingam K, Strychor S, Kaplan DB, Tretta MG, Allen M. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. Arch Gen Psychiatry. 1991;48:563-568.
20. Shioiri T, Kato T, Inubushi T, Murashita J, Takahashi S. Correlations of phosphomonoesters measured by phosphorus-31 magnetic resonance spectroscopy in the frontal lobes and negative symptoms in schizophrenia. Psychiatr Res Neuroimaging. 1994;55:223-235.
21. Stanley JA, Williamson PC, Drost DJ, Carr TJ, Rylett RJ, Malla A, Thompson RT. An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch Gen Psychiatry 1995;52:399-406.
22. 31P nuclear magnetic resonance spectroscopy: neurodevelopment and schizophrenia. Schizophr Bull. 1993;19:35-53.
23. Glantz LA, Lewis DA. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia: regional and diagnostic specificity. Arch Gen Psychiatry. 1997;54:943-952.
24. Karson CN, Mrak RE, Schluterman KO, Sturner WQ, Sheng JG, Griffin WST. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for "hypofrontality." Mol Psychiatry. 1999;4:39-45.
25. Perrone-Bizzozero NI, Sower AC, Bird ED, Benowitz LI, Ivins KJ, Neve RL. Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia. Proc Natl Acad Sci U S A. 1996;93:14182-14187,
26. Honer WG, Falkai P, Chen C, Arango V, Mann JJ, Dwork AJ. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience. 1999;91:1247-1255.
27. Giguere M, Goldman-Rakic PS. Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys. J Comp Neurol. 1988;277:195-213.
28. Melchitzky DS, Sesack SR, Lewis DA. Parvalbumin-immunoreactive axon terminals in monkey and human prefrontal cortex: laminar, regional and target specificity of type I and type II synapses. J Comp Neurol. 1999;408:11-22.
29. Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry. 1990;47:1023-1028.
30. Manaye KF, Liang C-L, Hicks PB, German D, Young KA. Nerve cell numbers in thalamic anterior and mediodorsal nuclei are selectively reduced in schizophrenia. Soc Neurosci Abstracts. 1998;24:1236.
31. Popken GJ, Bunney WE Jr, Potkin SG, Jones EG. Neuron number and GABAergic and glutamatergic mRNA expression in subdivisions of the thalamic mediodorsal nucleus of schizophrenics. Soc Neurosci Abstracts. 1998;24:991.
32. Anderson SA, Classey JD, Condé F, Lund JS, Lewis DA. Synchronous development of pyramidal neuron dendritic spines and parvalbumin-immunoreactive chandelier neuron axon terminals in layer III of monkey prefrontal cortex. Neuroscience. 1995;67:7-22.
33. Bourgeois J-P, Goldman-Rakic PS, Rakic P. Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cereb Cortex. 1994;4:78-96.
34. Hutteniocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol. 1997;387:167-178.
35. DeFelipe J, Farinas I. The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Prog Neurobiol. 1992; 39:563-607.
36. Peters A, Palay SL, Webster DF. The Fine Structure of the Nervous System. New York, NY: Oxford University Press; 1991.
37. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Browniee LM, Vogel FS, Hughes JP, van Bell G. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part II: standardization of the neuropathological assessment of Alzheimer's disease. Neurology. 1991;41:479-486.
38. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Washington, DC: American Psychiatric Association; 1987.
39. Hayes TL, Lewis DA. Magnopyramidal neurons in the anterior motor speech region: dendritic features and interhemispheric comparisons. Arch Neurol. 1996; 53:1277-1283.
40. Lund JS. Organization of neurons in the visual cortex, area 17, of the monkey (Macaca mulatta), J Comp Neurol. 1973;147:455-496.
41. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci. 1987;7:1799-1808.
42. Woo T-U, Whitehead RE, Melchitzky DS, Lewis DA. A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci U S A. 1998;95:5341-5346.
43. Williams RS, Ferrante RJ, Caviness VS Jr. The Golgi rapid method in clinical neuropathology: the morphologic consequences of suboptimal fixation. J Neuropathol Exp Neurol. 1978;37:13-33.
44. Jacobs B, Driscoll L, Schall M. Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi study. J Comp Neurol. 1997; 386:661-680.
45. Garey LJ, Ong WY, Patel TS, Kanani M, Davis A, Mortimer AM, Barnes TRE, Hirsch SR. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry. 1998;65:446-453.
46. Pasternak JF, Woolsey TA. On the selectivity of the Golgi-Cox method. J Comp Neurol. 1975;160:307-312.
47. Pierri JN, Edgar CL, Lewis DA. Somal size of prefrontal cortical pyramidal neurons in the thalamic recipient zone of subjects with schizophrenia. Soc Neurosci Abstracts. 1998;24:987.
48. Rajkowska G, Selemon LD, Goldman-Rakic PS. Neuronal and glial somal size in the prefrontal cortex. Arch Gen Psychiatry. 1998;55:215-224.
49. Horner CH, Arbuthnott E. Methods of estimation of spine density: are spines evenly distributed throughout the dendritic field? J Anat. 1991;177:179-184
50. Benes FM, Paskevich PA, Davidson J, Domesick VB. Synaptic rearrangements in medial prefrontal cortex of haloperidol-treated rats. Brain Res. 1985;348:15-20.
51. Vincent SL, McSparren J, Wang RY, Benes FM. Evidence for ultrastructural changes in cortical axodendritic synapses following long-term treatment with haloperidol or clozapine. Neuropsychopharmacology. 1991;5:147-155.
52. Brock JW, Prasad C. Alterations in dendritic spine density in the rat brain associated with protein malnutrition. Dev Brain Res. 1992;66:266-269.
53. Bryan GK, Riesen AH. Deprived somatosensory-motor experience in stumptailed monkey neocortex: dendritic spine density and dendritic branching of layer IIIb pyramidal cells. J Comp Neurol. 1989;286:208-217.
54. Horner CH. Plasticity of the dendritic spine. Prog Neurobiol. 1993;41:281-321.
55. Valverde F. Apical dendritic spines of the visual cortex and light deprivation in the mouse. Exp Brain Res. 1967;3:337-352.
56. Woolley CS, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci. 1990;10:4035-4039.
57. Moser M-B, Trommald M, Andersen P. An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses. Proc Natl Acad Sci U S A. 1994;91:12673-12675.
58. Parnavelas JG, Lynch G, Brecha N, Cotman CW, Globus A. Spine loss and regrowth in hippocampus following deafferentation. Nature. 1974;248:71-73.
59. Ingham CA, Hood SH, Taggart P, Arbuthnott GW. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. J Neurosci. 1998;18:4732-4743.
60. Globus A, Scheibel AB. Synaptic loci on parietal cortical neurops: terminations of corpus callosum fibers. Science. 1967;156:1127-1129.
61. Lewis DA. Development of the prefrontal cortex during adolescence: insights into vulnerable neural circuits in schizophrenia. Neuropsychopharmacology. 1997; 16:385-398.
62. Kuroda M, Murakami K, Shinkai M, Ojima H, Kishi K. Electron microscopic evidence that axon terminals from the mediodorsal thalamic nucleus make direct synaptic contacts with callosal cells in the prelimbic cortex of the rat. Brain Res. 1995;677:348-353.
63. 67 mRNA in a subpopulation of GABA neurons in the prefrontal cortex of schizophrenic subjects. Soc Neurosci Abstracts. 1998;24:986.
64. Lewis DA. Neural circuitry of the prefrontal cortex in schizophrenia. Arch Gen Psychiatry. 1995;52:269-273.
65. Jones EG. GABAergic neurons and their role in cortical plasticity in primates. Cereb Cortex. 1993;3:361-372.
66. Benson DL, Huntsman MM, Jones EG. Activity-dependent changes in GAD and preprotachykinin mRNAs in visual cortex of adult monkeys. Cereb Cortex. 1994; 4:40-51.
67. Ahmed B, Anderson JC, Douglas RJ. Martin KAC, Nelson JC. Polyneuronal innervation of spiny stellate neurons in cat visual cortex. J Comp Neurol 1994; 341:39-49.
68. Levitt JB, Lewis DA, Yoshioka T, Lund JS. Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 and 46). J Comp Neurol. 1993;338:360-376.
69. Pucak ML, Levitt JB, Lund JS, Lewis DA. Patterns of intrinsic and associational circuitry in monkey prefrontal cortex. J Comp Neurol. 1996;376:614-630.
70. Barbas H. Architecture and cortical connections of the prefrontal cortex in the rhesus monkey. Adv Neurol. 1992;57:91-115.
71. Goldman-Rakic PS, Schwartz ML. Interdigitation of contralateral and ipsilateral columnar projections to frontal association cortex in primates. Science. 1982; 216:755-757.
72. Goldman-Rakic PS. Cellular basis of working memory. Neuron. 1995;14:477-485.
73. Lewis DA, Anderson SA. The functional architecture of the prefrontal cortex and schizophrenia. Psychol Med. 1995;25:887-894.