Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3502-3511

  Vangveravong, Suwanna ^a   Zhang, Zhanbin ^a   Taylor, Michelle ^b   Bearden, Melissa ^b   Xu, Jinbin ^a   Cui, Jinquan ^a   Wang, Wei ^a   Luedtke, Robert R ^b   MacH, Robert H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Aripiprazole; Dopamine D2 receptor; Dopamine partial agonist

Indexed keywords

1(2 METHOXY 4 METHYLPHENYL)PIPERAZINE; 7 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPOXY]QUINOLIN 2(1H)ONE OXALATE; 7 [4 (3 METHYL 4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 8 YL)BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (2 HYDROXYPHENYL)PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (2 METHOXY 4 METHYLPHENYL)PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (2 OXO 2,3 DIHYDRO 1H BENZO[D]IMIDAZOL 1 YL)PIPERIDIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (2,4 DIMETHOXYPHENYL)PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 (5 CHLORO 2 OXO 2,3 DIHYDRO 1H BENZO[D]IMIDAZOL 1 YL)PIPERIDIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [4 [4 [2 (2 FLUOROETHOXY)PHENYL]PIPERAZIN 1 YL]BUTOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [5 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PENTYLOXY] 3,4 DIHYDROQUINOLIN 2(1H)ONE OXALATE; 7 [5 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PENTYLOXY]QUINOLIN 2(1H)ONE OXALATE; ADENYLATE CYCLASE; ARIPIPRAZOLE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; STRUCTURE ANALYSIS;

DOPAMINE ANTAGONISTS; LIGANDS; PIPERAZINES; PROTEIN BINDING; QUINOLONES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, SIGMA;

EID: 79957447359     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.021     Document Type: Article

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