Rationally based efficacy tuning of selective dopamine D4 receptor ligands leading to the complete antagonist 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine (FAUC 213)

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2691-2694

  Lober S ^a   Hubner H ^a   Utz, W ^a   Gmeiner, P ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YLMETHYL]PYRAZOLO[1,5 A]PYRIDINE; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; FAUC 113; FAUC 213; FAUC 299; UNCLASSIFIED DRUG;

ANIMAL CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ISOMER; LETTER; LIGAND BINDING; MITOGENESIS; MOLECULAR MODEL; NONHUMAN;

ANIMALS; BINDING, COMPETITIVE; CATTLE; CHO CELLS; CORPUS STRIATUM; CRICETINAE; DOPAMINE ANTAGONISTS; HUMANS; LIGANDS; MITOGENS; MODELS, MOLECULAR; PIPERAZINES; PYRAZOLES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035899181     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015522j     Document Type: Letter

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