Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin degrading enzyme

Journal of Chemical Information and Modeling

Volumn 54, Issue 5, 2014, Pages 1380-1390

  Da Cruz, Carlos H B ^a   Seabra, Gustavo ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; INTEGRODIFFERENTIAL EQUATIONS; MOLECULAR DYNAMICS; NEURODEGENERATIVE DISEASES; PEPTIDES;

ALZHEIMER'S DISEASE; INHIBITION MECHANISMS; INSULIN-DEGRADING ENZYMES; MOLECULAR DYNAMICS SIMULATIONS; NONCOMPETITIVE INHIBITIONS; REGULATORY MECHANISM; STRUCTURAL MODIFICATIONS; SUBSTRATE AFFINITY;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); INSULINASE; PEPTIDE FRAGMENT; PROTEINASE INHIBITOR;

ALLOSTERISM; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR DYNAMICS; PROTEIN DEGRADATION; THERMODYNAMICS; TIME;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; AMYLOID BETA-PEPTIDES; CATALYTIC DOMAIN; INSULYSIN; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEOLYSIS; THERMODYNAMICS; TIME FACTORS;

EID: 84901638722     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci400695m     Document Type: Article

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