Anion activation site of insulin-degrading enzyme

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 48-57

  Noinaj, Nicholas ^a,c   Song, Eun Suk ^a   Bhasin, Sonia ^a   Alper, Benjamin J ^b,d   Schmidt, Walter K ^b   Hersh, Louis B ^a   Rodgers, David W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Georgia ^*  (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d St Judes Children's Research Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC ACTIVATION; ATP-HYDROLYSIS ACTIVITY; BIOACTIVE PEPTIDES; C-TERMINAL DOMAINS; CHAMBER WALLS; ELECTROSTATIC ATTRACTIONS; HIGH CONCENTRATION; IN-VIVO; INSULIN-DEGRADING ENZYMES; INSULYSIN; MECHANISTIC LINK; ON DYNAMICS; POLYPHOSPHATES; SUBSTRATE BINDING; THERMAL FACTORS;

CONFORMATIONS; ENZYME ACTIVITY; INSULIN; NEGATIVE IONS; PEPTIDES; SODIUM; SODIUM CHLORIDE;

INTEGRODIFFERENTIAL EQUATIONS;

ADENOSINE TRIPHOSPHATE; ENZYME VARIANT; INSULINASE; SODIUM CHLORIDE;

ALLOSTERISM; ANION ACTIVATION SITE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DYNAMICS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIONS; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; INSULYSIN; INTRACELLULAR SPACE; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PROTEIN CONFORMATION; RATS;

EID: 84855286354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264614     Document Type: Article

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