Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

Journal of Molecular Biology

Volumn 395, Issue 2, 2010, Pages 430-443

  Guo, Qing ^a   Manolopoulou, Marika ^a   Bian, Yao ^a   Schilling, Alexander B ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

insulin degrading enzyme; mass spectrometry; metalloprotease; substrate specificity; X ray crystallography

Indexed keywords

AMYLIN; AMYLOID BETA PROTEIN[1-40]; EPIDERMAL GROWTH FACTOR; INSULINASE; SOMATOMEDIN B; TRANSFORMING GROWTH FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STOCHASTIC MODEL; X RAY CRYSTALLOGRAPHY;

EID: 73149099387     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.072     Document Type: Article

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