Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach

Protein Science

Volumn 9, Issue 10, 2000, Pages 1857-1865

  Pang, Yuan Ping ^a,b   Xu, Kun ^b   Yazal, Jamal El ^b   Prendergast, Franklyn G ^a,b  

^a MAYO CLINIC CANCER CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Cancer research; Coordination chemistry; Drug research; Farnesyltransferase; Metalloproteins; Molecular dynamics; Zinc

Indexed keywords

CATION; METALLOPROTEIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; ZINC;

ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESEARCH; CELL PROLIFERATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TUMOR CELL; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RATS; ZINC;

EID: 0033769641     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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