Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 47, 2007, Pages 18496-18501

  Arora, Karunesh ^a   Brooks III, Charles L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Conformational change pathway; Curve crossing; Free energy calculations; Ligand binding; Order parameter

Indexed keywords

ADENYLATE KINASE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEOMICS;

ADENYLATE KINASE; ALLOSTERIC REGULATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY;

EID: 36749008588     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0706443104     Document Type: Article

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