Insulin-degrading enzyme

Clinical and Investigative Medicine

Volumn 19, Issue 3, 1996, Pages 149-160

  Authier, François ^a   Posner, Barry I ^b   Bergeron, John J M ^b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULINASE; METALLOPROTEINASE;

ANIMAL CELL; CELL FRACTIONATION; CELL SURFACE; CHEMICAL STRUCTURE; CHO CELL; ENDOCYTOSIS; ENZYME ACTIVITY; GENETIC CONSERVATION; IMMUNOFLUORESCENCE MICROSCOPY; INSULIN DEGRADATION; LIVER PARENCHYMA; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; INSULIN; INSULYSIN; MOLECULAR SEQUENCE DATA; SUBSTRATE SPECIFICITY;

EID: 0030002245     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (56)

1. Shii K, Yokono K, Baba S et al: Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes 1986; 35: 675-683
2. Ogawa W, Shii K, Yonezawa K et al: Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver. J Biol Chem 1992; 267: 1310-1316
3. Affholter JA, Fried VA, Roth RA: Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. Science 1988; 242: 1415-1418
4. Affholter JA, Hsieh CL, Francke U et al: Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol 1990; 4: 1125-1135
5. Finch PW, Wilson RE, Brown K et al: Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III. Nucleic Acids Res 1986; 14: 7695-7703
6. Ding L, Becker AB, Suzuki A et al: Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III. J Biol Chem 1992; 267: 2414-2420
7. Bennett RG, Hamel FG, Duckworth WC: Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase. Biochem Biophys Res Commun 1994; 202: 1047-1053
8. Kupfer SR, Wilson EM, French FS: Androgen and glucocorticoid receptors interact with insulin degrading enzyme. J Biol Chem 1994; 269: 20622-20628
9. Authier F, Rachubinski RA, Posner BI et al: Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin-degrading enzyme. J Biol Chem 1994; 269: 3010-3016
10. Authier F, Posner BI, Bergeron JJM: Hepatic endosomes are a major physiological locus of insulin and glucagon degradation in vivo. In Ciechanover A, Schwartz AL (eds): Cellular Proteolytic Systems, Wiley-Liss, New York, 1994: 89-113
11. Gould SJ, Keller GA, Schneider M et al: Peroxisomal protein import is conserved between yeast, plants, insects and mammals. EMBO J 1990; 9: 85-90
12. Authier F, Bergeron JJM, Ou WJ et al: Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase. Proc Natl Acad Sci USA 1995; 92: 3859-3863
13. Kuo WL, Gehm BD, Rosner MR et al: Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. J Biol Chem 1994; 269: 22599-22606
14. Affholter JA, Cascieri MA, Bayne ML et al: Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme. Biochemistry 1990; 29: 7727-7733
15. Garcia JV, Gehm BD, Rosner MR: An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin. J Cell Biol 1989; 109: 1301-1307
16. Garcia JV, Stoppelli MP, Decker SJ et al: An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity. J Cell Biol 1989; 108: 177-182
17. Muller D, Schulze C, Baumeister H et al: Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry. Biochemistry 1992; 31: 11138-11143
18. Kurochkin IV, Goto S: Alzheimer's ß-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 1994; 345: 33-37
19. Werlen RC, Offord RE, Rose K: Preparation and characterization of novel substrates of insulin protease (EC 3.4.99.45). Biochem J 1994; 302: 907-911
20. Fagan JM, Waxman L: Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin. Biochem J 1991; 277: 779-786
21. Muller D, Baumeister H, Buck F et al: Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme. Eur J Biochem 1991; 202: 285-292
22. Duck worth WC, Hamel FG, Peavy DE et al: Degradation products of insulin generated by hepatocytes and by insulin protease. J Biol Chem 1988; 263: 1826-1833
23. Rose K, Savoy LA, Muir AV et al: Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+-Mg2+-dependent ATPase. Biochem J 1988; 256: 847-851
24. Bergeron JJM, Cruz J, Khan MN et al: Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: the endosomal apparatus. Annu Rev Physiol 1985; 47: 383-403
25. Subramani S: Protein import into peroxisomes and biogenesis of the organelle. Annu Rev Cell Biol 1993; 9: 445-478
26. Kitabchi AE, Stentz FB: Degradation of insulin and proinsulin by various organ homogenates of rat. Diabetes 1912; 21: 1091-1101
27. Akiyama H, Yokono K, Shii K et al: Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme. Biochem Biophys Res Commun 1990; 170: 1325-1330
28. 125I-insulin to a cytosolic insulin-degrading enzyme. J Biol Chem 1985; 260: 6503-6506
29. Baumeister H, Muller D, Rehbein M et al: The rat insulin-degrading enzyme: molecular cloning and characterization of tissue-specific transcripts. FEBS Lett 1993; 317: 250-254
30. Kuo WL, Montag AG, Rosner MR: Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology 1993; 132: 604-611
31. Kuo WL, Gehm BD, Rosner MR: Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol 1990; 4: 1580-1591
32. Bondy CA, Zhou J, Chin E et al: Cellular distribution of insulin-degrading enzyme gene expression. J Clin Invest 1994; 93: 966-973
33. Abrahamsen MS, Clark TG, Mascolo P et al: Developmental gene expression in Eimeria bovis. Mol Biochem Parasitol 1993; 57: 1-14
34. Stoppelli MP, Garcia JV, Decker SJ: Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster. Proc Natl Acad Sci USA 1988; 85: 3469-3473
35. Duckworth WC: Insulin degradation: mechanisms, products, and significance. Endocr Rev 1988; 9: 319-345
36. Standl E, Kolb HJ: Insulin degrading enzyme activity and insulin binding of erythrocytes in normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Diahetologia 1984; 27: 17-22
37. Becker AB, Roth RA: An unusual active site identified in a family of zinc metalloendopeptidases. Proc Natl Acad Sci USA 1992; 89: 3835-3839
38. Witte C, Jensen RE, Yaffe MP et al: MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J 1988; 7: 1439-1447
39. Schulte U, Arretz M, Schneider H et al: A family of mitochondrial proteins involved in bioenergetics and biogenesis. Nature 1989; 339: 147-149
40. Meulenberg JJM, Sellink E, Riegman NH et al: Nucleotide sequence and structure of the Klebsiella pneumoniae pqq operon. Mol Gen Genet 1992; 232: 284-294
41. Chen NY, Jiang SQ, Klein DA et al: Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase. J Biol Chem 1993; 268: 9448-9465
42. Pierotti AR, Prat A, Chesneau V et al: N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Proc Natl Acad Sci USA 1994; 91: 6078-6082
43. Backer AB, Roth RA: Identification of glutamate-169 as the third zinc-binding residue in proteinase III, a member of the family of insulin-degrading enzymes. Biochem J 1993; 292: 137-142
44. Gehm BD, Kuo WL, Perlman RK et al: Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding. J Biol Chem 1993; 268: 7943-7948
45. Perlman RK, Gehm BD, Kuo WL et al: Functional analysis of conserved residues in the active site of insulin-degrading enzyme. J Biol Chem 1993; 268: 21538-21544
46. Perlman RK, Rosner MR: Identification of zinc ligands of the insulin-degrading enzyme. J Biol Chem 1994; 269: 33140-33145
47. Rawlings ND, Barrett AJ: Evolutionary families of peptidases. Biochem J 1993; 290: 205-218
48. 1 complex evolutionary relics of a processing protease? TIBS 1995; 20: 171-175
49. Kole HK, Smith DR, Lenard J: Characterization and partial purification of an insulinase from Neurospora crassa. Arch Biochem Biophys 1992; 297: 199-204
50. Kuo WL, Gehm BD, Rosner MR: Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway. Mol Endocrinol 1991; 5: 1467-1476
51. Shii K, Roth RA: Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease. Proc Natl Acad Sci USA 1986; 83: 4147-4151
52. Beyer RE: A study of insulin metabolism in an insulin tolerant strain of mice. Acta Endocrinol 1955; 19: 309-332
53. Kayalar C, Wong WT: Metalloendoprotease inhibitors which block the differentiation of L6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme. J Biol Chem 1989; 264: 8928-8934
54. 125I]-insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. Endocrinology 1987; 120: 829-831
55. Authier F, Mort JS, Bell AW et al: Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D. J Biol Chem 1995; 270: 15798-15807
56. Kayalar C, Wong WT, Hendrickson L: Differentiation of BC3H1 and primary skeletal muscle cells and the activity of their endogenous insulin-degrading enzyme are inhibited by the same metalloendoprotease inhibitors. J Cell Biochem 1990; 44: 137-151