Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme

Journal of Biological Chemistry

Volumn 284, Issue 21, 2009, Pages 14177-14188

  Manolopoulou, Marika ^a   Guo, Qing ^a   Malito, Enrico ^a   Schilling, Alexander B ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC CHAMBERS; CLEAVAGE SITES; DISULFIDE BONDS; ELECTRON CAPTURE DISSOCIATION; FOURIER TRANSFORM ION CYCLOTRON RESONANCE; GAS-PHASE FRAGMENTATION; GLUCOSE HOMEOSTASIS; HIGH AFFINITY; INSULIN MOLECULES; INSULIN-DEGRADING ENZYMES; MASS ACCURACY; MOLECULAR BASIS; TIME-DEPENDENT ANALYSIS;

ENZYMES; GLUCOSE; INTEGRODIFFERENTIAL EQUATIONS; MASS SPECTROMETRY;

INSULIN;

HUMAN INSULIN; INSULINASE; CYSTEINE; INSULIN; MUTANT PROTEIN; PEPTIDE FRAGMENT;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISULFIDE BOND; ELECTRON CAPTURE DETECTION; ENZYME STRUCTURE; HORMONE BINDING; HUMAN; INSULIN DEGRADATION; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; HUMANS; INSULIN; INSULYSIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 67649805129     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900068200     Document Type: Article

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