Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 13853-13858

  Song, Eun Suk ^a   Rodgers, David W ^a   Hersh, Louis B ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE SITE; ALLOSTERIC ACTIVATION; INSULIN-DEGRADING ENZYMES; METALLOPROTEASES; PEPTIDE ANALOGS; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES; SYNTHETIC PEPTIDE SUBSTRATE; TRANS EFFECT; TURNOVER NUMBER; WILD TYPES;

CATALYSIS; DIMERS; ENZYMES; INSULIN; INTEGRODIFFERENTIAL EQUATIONS; PEPTIDES; REACTION RATES;

SUBSTRATES;

AMYLOID BETA PROTEIN; DIMER; INSULINASE; MUTANT PROTEIN; BRADYKININ; DYNORPHIN; DYNORPHIN B; ENDORPHIN; INSULIN; PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; INSECT CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; ANIMAL; CHEMISTRY; CIRCULAR DICHROISM; DIMERIZATION; ENZYME SPECIFICITY; HUMAN; KINETICS; METABOLISM; MOLECULAR WEIGHT;

AMYLOID BETA-PEPTIDES; ANIMALS; BRADYKININ; CATALYSIS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; DIMERIZATION; DYNORPHINS; ENDORPHINS; HUMANS; INSULIN; KINETICS; MOLECULAR WEIGHT; MUTATION; PEPTIDES; SUBSTRATE SPECIFICITY;

EID: 79954581572     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.191668     Document Type: Article

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