Elucidation of interactions of alzheimer amyloid β peptides (Aβ40 and Aβ42) with insulin degrading enzyme: A molecular dynamics study

Biochemistry

Volumn 49, Issue 18, 2010, Pages 3947-3956

  Bora, Ram Prasad ^a   Prabhakar, Rajeev ^a  

^a Department of Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALZHEIMER; ALZHEIMER AMYLOID; AQUEOUS SOLUTIONS; ATOMISTIC LEVELS; CATALYTIC CHAMBERS; DEGRADING MECHANISM; HYDROGEN BONDINGS; IN-LINE; INSULIN-DEGRADING ENZYMES; MD SIMULATION; METALLOPEPTIDASES; MONOMERIC FORMS; NMR STRUCTURES; STRUCTURAL CHARACTERISTICS; X-RAY STRUCTURE;

ENZYMES; GLYCOPROTEINS; HYDROGEN BONDS; INSULIN; MOLECULAR DYNAMICS; PEPTIDES; PHOTODEGRADATION; ZINC;

INTEGRODIFFERENTIAL EQUATIONS;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ASPARTIC ACID; GLUTAMINE; INSULINASE; LYSINE; METALLOPROTEINASE; ZINC; ZINC ION;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIMULATION; X RAY ANALYSIS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; BINDING SITES; HUMANS; HYDROGEN BONDING; INSULYSIN; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 77951918022     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1002103     Document Type: Article

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